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L'accesso al farmaco

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Book Series: Memorie del Dipartimento di Giurisprudenza - Università di Torino ISBN: 9788867056187 Year: Pages: 179 Language: Italian
Publisher: Ledizioni
Subject: Therapeutics
Added to DOAB on : 2017-07-26 15:19:19
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“Il farmaco è un bene di rilevanza giuridica sia in quanto strumentale alla tutela della salute sia in quanto possibile oggetto di rapporti economici. Si comprende pertanto come la disciplina del farmaco si collochi al crocevia di differenti interessi e come il rapporto tra questo bene e il suo diritto possa declinarsi attraverso molteplici prospettive”. (Dal testo)

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Acupuncture – Basic Research and Clinical Application

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ISBN: 9783038972341 9783038972358 Year: Pages: 170 DOI: 10.3390/books978-3-03897-235-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2018-10-09 11:13:34
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This book focuses on the investigation, development, and modernization of acupuncture in basic research settings as well as in clinical applications. The book contains 13 chapters reporting the latest evidence-based results of acupuncture research and exploring acupuncture in general. Altogether, 44 authors from all over the world contributed to this book.

Adipokines 2.0

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ISBN: 9783039285860 / 9783039285877 Year: Pages: 406 DOI: 10.3390/books978-3-03928-587-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
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Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.

Keywords

adipokines --- secreted frizzled-related protein 5 --- leptin --- ghrelin --- excessive gestational weight gain --- neonatal anthropometry --- obesity --- proteolysis --- Tango bioassay --- biologic activity --- chemerin receptors --- excessive gestational weight gain --- neonatal anthropometry --- leptin --- ghrelin --- Nonalcoholic fatty liver disease --- fatty liver --- free fatty acids --- label-free proteomic profiling --- adipokine --- obesity --- visceral fat --- sick fat --- annexins --- adipose tissue --- adiponectin --- cholesterol --- glucose homeostasis --- inflammation --- insulin --- lipid metabolism --- obesity --- triglycerides --- adipokine --- chemerin --- leukocyte --- cancer --- adipokines --- PCOS --- polycystic ovary morphology --- follicular fluid --- human granulosa cells --- chemerin --- chemerin receptors --- hypothalamus --- oestrous cycle --- early pregnancy --- pig --- alpha-fetoprotein --- liver steatosis --- hypertension --- adipokines --- SGBS adipocytes --- glucose restriction --- in vitro fat regain --- weight regain --- complement factors --- cathepsins --- extracellular remodeling --- adipokine --- rheumatic diseases --- inflammation --- osteoarthritis --- rheumatoid arthritis --- ovary --- testis --- adipose tissue --- polycystic ovary syndrome --- preeclempsia --- gestational diabetes --- testicular pathologies --- rheumatoid arthritis --- tocilizumab --- lipids --- adipokines --- adiponectin --- resistin --- leptin --- cancer --- obesity --- adipokine --- chemerin --- chemokine-like receptor 1 --- G protein-coupled receptor 1 --- C-C chemokine receptor-like 2 --- critical illness --- sepsis --- adipokines --- biomarker --- prognosis --- ICU --- adipokine --- adipose-brain axis --- brain health --- neurodegeneration --- depression --- energy metabolism --- inflammation --- hypothalamus --- microglia --- adiponectin --- adipokine --- myokine --- fitness --- metabolically healthy obese --- early-life programming --- epicardial adipose tissue (EAT) --- prostaglandin E2 (PGE2) --- EP3 receptor --- EP4 receptor --- exchange protein directly activated by cAMP isoform 2 (EPAC2) --- stimulating growth factor 2 (ST2) --- interleukin(IL)-33 --- Cardiovascular Diseases (CVDs) --- fat mass --- n/a

Advanced Technology for Delivering Therapeutics

Authors: ---
ISBN: 9789535131212 9789535131229 Year: Pages: 184 DOI: 10.5772/62564 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:50

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The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical & other researchers involved in designing newer drug delivery systems both in academia and industry.

Advances in Marine Chitin and Chitosan

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ISBN: 9783038421306 9783038421290 Year: Pages: XIV, 470 DOI: 10.3390/books978-3-03842-129-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2016-05-20 15:15:59
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Recently, biomass-based polymers from renewable resources have received increasing focus owing to the depletion of petroleum resources. Natural polysaccharides such as cellulose, hemicellulose, and starch are among the candidates from natural resources for biomass polysaccharide products including bioplastics. Although several kinds of neutral or anionic polysaccharides such as chitin, alginic acid, hyaluronic acid, heparin, and chondroitin sulfate exist in nature, natural cationic polysaccharides are quite limited. Chitin is second only to cellulose as the most natural abundant polysaccharide in the world. Chitosan, the product from the N-deacetylatation of chitin, appears to be the only natural cationic polysaccharide. Therefore, chitin and chitosan due to their unique properties are expected to continue to offer a vast number of possible applications for not only chemical or industrial use, but also biomedicine. The research history on chitins, one of the most major and abundant natural polysaccharides on earth, started around 1970. Since the 1980s, chitin and chitosan research (including D-glucosamine, N-acetyl-D-glucosamine, and their oligomers) has progressed significantly over several stages in both fundamental research and industrial fields.

Advances in Micro-Bioreactor Design for Organ Cell Studies

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ISBN: 9783038972334 9783038972327 Year: Pages: 168 DOI: 10.3390/books978-3-03897-232-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics
Added to DOAB on : 2018-12-06 11:44:20
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Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions on a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or using bioreactors for the production of biologics. This book highlights these issues with a strong focus on new engineering design. The initial chapters cover the conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for clinical and therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumor models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and the integration of sensors are covered in separate chapters. We believe the book will have substantial value for researchers active in bioreactor engineering, drug development and cell physiology, as well as readers interested in these topics.

Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

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ISBN: 9783039287529 / 9783039287536 Year: Pages: 206 DOI: 10.3390/books978-3-03928-753-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
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Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections.

Keywords

furosemide --- electrospinning --- hydroxypropyl cellulose --- poly (vinylpyrrolidone) --- storage and loss moduli --- scanning electron microscopic images --- gellan gum --- pectin --- resveratrol --- mucoadhesive microspheres --- cytotoxicity --- in vitro permeability --- Caco-2 cells --- triple co-culture model --- Carbopol --- clobetasol --- Eudragit® E PO --- interpolyelectrolyte complex --- mucoadhesion --- oral lichen planus --- oral lyophilisates --- maltodextrin --- resuspendibility --- chitosan --- acrylated chitosan --- nanoparticles --- mucoadhesion --- mucosal membranes --- mucoadhesive polymers --- retention --- buccal mucosa drug delivery --- cyclodextrins --- films --- l-arginine --- mucoadhesive polymer --- omeprazole --- paediatric --- clotrimazole --- liposphere --- alkyl lactate --- xanthan gum --- Candida albicans --- mucoadhesion --- poly(2-ethyl-2-oxazoline) --- Carbopol® --- mucoadhesion --- interpolymer complexes --- thiolated hyaluronic acid --- hydrogel --- mucoadhesive --- biocompatibility --- controlled release --- drug delivery --- wound healing --- pluronic f127 --- thermoresponsive polymers --- thermogelling polymers --- detachment force --- rheology --- texture profile analysis --- chitosan derivatives --- mucosal drug delivery --- mucoadhesion --- trimethyl chitosan --- thiolated chitosan --- chitosan-catechol --- acrylated chitosan --- nanoparticles --- pioglitazone --- PLGA-PEG --- transmucosal permeations --- Alzheimer’s disease

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

Authors: --- ---
ISBN: 9783039282883 9783039282890 Year: Pages: 406 DOI: 10.3390/books978-3-03928-289-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Keywords

MC3R --- MC4R --- mixed pharmacology --- tetrapeptides --- melanocortins --- Plk1 --- selectivity --- polo-box domain --- peptide --- triazole --- PKA --- stapled peptide --- PKI --- pseudosubstrate --- kinase inhibitor --- IP20 --- polycationic -amino acids --- small antimicrobial peptides --- sepsis --- peptidomimetics --- VEGF165 --- neuropilin-1 --- molecular dynamics --- structure–activity relationship --- OBOC --- combinatorial chemistry --- opioid --- drug screen --- molecular rotor dye --- high throughput screening --- sensor chip --- peptide --- peptide-drug conjugate --- mixed-mode pharmacology --- GLP-1 --- GnRH --- LHRH --- chemical linker --- cancer --- diabetes --- obesity --- drug discovery --- melanocortin-4 receptor --- obesity --- peptide agonist --- cardiovascular profile --- G?S signaling --- receptor desensitization --- receptor internalization --- peptidomimetics --- azapeptides --- aza-amino acids --- ?-hairpin --- ?-sheet --- programmed cell death ligand protein 1 --- pharmacophore --- peptide --- small molecule --- anticancer peptide --- therapeutic peptides --- support vector machine --- random forest --- machine learning --- classification --- peptides --- endosomolytic --- amphiphilic --- fusogenic --- influenza hemagglutinin --- RBC lysis --- peptide permeability --- stapled peptide --- macrocyclic peptide --- D-amino acid --- helix-breaker --- adaptogenic --- autophagy --- ?-ginkgotide --- cytoprotective --- cysteine-rich peptides --- disulfide-rich scaffold --- hyperdisulfide --- hypoxia --- LIR motif --- ginkgo nuts --- ?-helix mimetics --- bis-benzamide scaffold --- protein–protein interaction --- prostate cancer --- androgen receptor --- coactivator PELP1 --- Ranalexin --- peptide therapeutics --- antibiotics --- configuration --- antimicrobial activity --- cancer vaccine --- synthetic vaccine --- adjuvant --- Toll-like receptor --- Pam2Cys --- N-acetylated Pam2Cys --- bioconjugation --- lipidation --- prostaglandin F2? --- preterm labor --- myometrium contractions --- peptidomimetic --- structure-activity --- opioids --- multifunctional ligands --- peptide design --- free energy calculation --- d-amino acid scan --- alanine scan

Advances in Prevention of Foodborne Pathogens of Public Health Concern during Manufacturing

Authors: ---
ISBN: 9783039219322 9783039219339 Year: Pages: 168 DOI: 10.3390/books978-3-03921-933-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-12-09 11:49:16
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According to a report from the U.S. Centers for Disease Control and Prevention (CDC), achieving safe and healthier foods was one of the top ten achievements of public health in the 20th century. However, considerable persisting challenges currently exist in developed nations and developing economies for further assuring the safety and security of the food supplies. According to CDC estimates, as many as 3000 American adults, as an example, and based on a recent epidemiological estimate of the World Health Organization, around 420,000 individuals around the globe, lose their lives annually due to foodborne diseases. This emphasizes the need for innovative and emerging interventions, for further prevention or mitigation of the risk of foodborne microbial pathogens during food processing and manufacturing. The current publication discusses recent advancements and progress in the elimination and decontamination of microbial pathogens during various stages of manufacturing and production. Special emphasis is placed on hurdle validation studies, investigating decontamination of non-typhoidal Salmonella enterica serovars, various serogroups of Shiga toxin-producing Escherichia coli, public health-significant serotypes of Listeria monocytogenes, and pathogenic species of Cronobacter.

Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454822 Year: Pages: 245 DOI: 10.3389/978-2-88945-482-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics --- Medicine (General) --- Oncology
Added to DOAB on : 2019-01-23 14:53:42
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Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.

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