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Arthropod Venom Components and Their Potential Usage

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ISBN: 9783039285402 9783039285419 Year: Pages: 404 DOI: 10.3390/books978-3-03928-541-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Public Health --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.

Keywords

ant --- venom --- mass spectrometry analysis --- pilosulin-like peptide --- phospholipases D --- metalloproteases --- Loxosceles spp. --- recombinant toxins --- hybrid immunogen --- neutralizing antibodies --- antivenoms --- LyeTxI-b --- Staphylococcus aureus --- keratitis --- AMP --- mastoparan --- Acinetobacter baumannii --- stent --- cantharidin --- blister beetle --- Berberomeloe majalis --- nematicide --- ixodicide --- antifeedant --- scorpion venom --- insecticidal peptide --- mass spectrometric analysis --- de novo sequencing --- Centruroides limpidus Karch --- proteome --- scorpion --- transcriptome --- venom toxicity --- brown spider --- venom --- Loxosceles --- toxins --- biotools --- drug targets --- novel therapeutics --- spider toxin --- directed disulfide bond formation --- Nav channel activity --- Nav1.7 --- pain target --- automated patch-clamp --- bee venom --- alternative treatment --- skin --- cutaneous disease --- mechanism --- chemotherapy --- cold allodynia --- mechanical allodynia --- melittin --- neuropathic pain --- oxaliplatin --- natural antibiotics --- piperidine heterocyclic amines --- industrial biotechnology --- LTQ Orbitrap Hybrid Mass Spectrometer --- myrmecology --- venom --- pain --- ants --- wasps --- bees --- Hymenoptera --- envenomation --- toxins --- peptides --- pharmacology --- Dinoponera quadriceps --- Formicidae --- Hymenoptera venom --- proteomics --- venom allergens --- ICK-like toxins --- melittin --- insect immune system --- apoptosis --- heart contractility --- Tenebrio molitor --- bee venom --- bioinformatics --- computational docking --- homology modelling --- ion channel structure --- protein–peptide interactions --- tertiapin --- venom peptides --- virtual screening --- small hive beetle --- solitary wasp --- venom --- antimicrobial peptide --- linear cationic ?-helical peptide --- amphipathic ?-helix structure --- channel-like pore-forming activity --- antimicrobial peptide --- venom --- arthropod --- malaria --- Chagas disease --- human African trypanosomiasis --- leishmaniasis --- toxoplasmosis --- venom peptides --- FMRF-amide --- insect neurotoxin --- protons --- pH regulation --- acid-sensing ion channels --- acid-gated currents --- chronic pain --- ICK peptide --- knottins --- NaV --- spider venom --- voltage-gated sodium channel --- n/a

Signal Processing and Analysis of Electrical Circuit

Authors: --- ---
ISBN: 9783039282944 9783039282951 Year: Pages: 604 DOI: 10.3390/books978-3-03928-295-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

This Special Issue with 35 published articles shows the significance of the topic “Signal Processing and Analysis of Electrical Circuit”. This topic has been gaining increasing attention in recent times. The presented articles can be categorized into four different areas: signal processing and analysis methods of electrical circuits; electrical measurement technology; applications of signal processing of electrical equipment; fault diagnosis of electrical circuits. It is a fact that the development of electrical systems, signal processing methods, and circuits has been accelerating. Electronics applications related to electrical circuits and signal processing methods have gained noticeable attention in recent times. The methods of signal processing and electrical circuits are widely used by engineers and scientists all over the world. The constituent papers represent a significant contribution to electronics and present applications that can be used in industry. Further improvements to the presented approaches are required for realizing their full potential.

Keywords

VMD --- signal analysis --- ICEEMD --- IMF --- random noise --- attenuation --- commutator motor --- fault diagnosis --- method --- technique --- signal processing --- acoustic --- Inner and outer product --- tensor --- FPGA --- hardware --- direct digital synthesizer (DDS) --- frequency tuning word (FTW) --- stability --- accuracy --- demodulation --- phase-locked loop --- Chebyshev filter --- measurement noise suppression --- class AB operation --- CMOS --- current mirror --- current buffer --- quasi floating gate --- low power --- CMOS --- dynamic comparator --- offset calibration --- high speed --- low noise --- low power --- ADC --- all-pass filter --- CMOS --- time delay --- broadband --- true-time-delay --- electrochemical impedance spectroscopy --- FRA --- multichannel acquisition --- impedance spectrometry --- microcontroller --- intelligent vehicles --- LiDAR odometry --- range sensing --- simultaneous localization and mapping (SLAM) --- tilt sensor --- sensor data fusion --- complementary filters --- overlap-add processing --- spectral analysis --- variational mode decomposition (VMD) --- duffing chaotic oscillator (DCO) --- permutation entropy (PE) --- feature extraction --- frequency characteristic --- underwater acoustic signal --- ship-radiated noise --- PM/PWM --- capacitance-to-time conversion --- differential capacitive sensor --- brick-wall filter --- fuzzy logic --- induction motor --- Shannon entropy --- short-circuit fault --- APF --- CNFET --- pole-frequency --- chirality --- phase angle --- tuning --- DC–DC converter --- switched capacitor --- power management integrated circuit --- CMOS technology --- frequency standard comparator --- dual Mixing Time difference --- phase difference --- correlation function --- chebyshev polynomial --- compressed sensing --- estimated sparsity --- least squares solution --- stochastic gradient --- reconstruction probability --- direct position determination --- array signal processing --- Doppler shifts --- matrix eigen-perturbation theory --- system errors --- Cramér–Rao bound --- differential power analysis (DPA), SIMON --- fault injection --- double rate --- power randomization --- intention of movement classification --- EMG-Signals --- Support Vector Machines --- asynchronous --- delay cell --- passive resistor --- SAR ADC --- loop delay circuit --- Resistance-to-Period converter --- robust read-out circuits --- ratiometric technique --- Fresnel lens --- wingbeat --- insects --- optoelectronics --- bees --- wasps --- fruit flies --- e-traps --- analog-to-digital converter --- successive approximation register --- direct sampling --- time-interleaved --- channel-selection-embedded bootstrap --- segmented pre-quantization and bypass --- LVDS --- high-speed serial interface --- transmitter --- receiver --- low-power --- image fusion --- multi-sensor fusion --- night vision --- hierarchical heterogeneous multi-DAG workflow --- multigroup scan --- ultrasonic phased array --- heterogeneous earliest finish time --- resolver --- discrete wavelet transform --- singular value decomposition --- automatic calibration --- noise reduction --- ripple voltage measurement --- DAC --- comparator --- peak-ripple estimation --- binary search --- low-cost --- secret image sharing --- digital image --- n-out-of-n scheme --- color palette --- colluder attack --- image restoration --- impulse noise --- ADMM --- HOCTVL1 --- spatially adapted regularization parameter --- rod electrode --- electrostatic induction --- method of images --- induced charge --- induced current --- 3D-IC design --- NILT --- TSV noise coupling --- RDL --- chain matrix --- interconnect line --- n/a

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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english (2)


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2020 (2)