Search results: Found 2

Listing 1 - 2 of 2
Sort by
Recent Progress in Bunyavirus Research

Authors: ---
ISBN: 9783038423935 9783038423928 Year: Pages: VIII, 224 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-06-14 11:52:43
License:

Loading...
Export citation

Choose an application

Abstract

The Bunyaviridae is the largest family of RNA viruses, with over 350 isolates worldwide distributed into five genera (i.e., Hantavirus, Orthobunyavirus, Nairovirus, Tospovirus, and Phlebovirus). Many of these viruses are significant human or agricultural pathogens. The increasing number of reports on new emerging bunyaviruses and infection episodes makes it essential that we obtain a comprehensive understanding of bunyaviruses and their infection mechanisms. Although all bunyaviruses possesses a tripartite, negative-sense (or ambi-sense) RNA genome, they exhibit substantial differences in their structure, genome organization and replication strategies, which make functional interpolation across genus boundaries difficult.Fortunately, the bunyavirus field has witnessed many exciting new findings and breakthroughs in recent years. These discoveries span a wide spectrum of research areas, including structural characterization of viruses and viral proteins, the identification of new viruses, investigations into host switch and vectors of transmission, genome-based analysis of virus evolution and phylogenetic lineages, the development of new research tools, such as replicons and reverse genetics, molecular characterization of the virus life cycle at the cell level (i.e., cell entry, replication, transcription, translation, genome packaging, reassortment, and virus assembly, etc.), studies of virus–host interactions and host antiviral defense, the development of vaccines/drugs and the use of bunyaviruses for novel applications.This book includes both research and review papers that together provide a glimpse into the latest research on bunyaviruses and, at the same time, highlight some of the important research achievements made in recent years. Study topics of both a fundamental and applied nature are collated. An informed perspective for future research directions is provided and can stimulate research in some of the understudied areas.

Prospects for Schistosomiasis Elimination

Authors: ---
ISBN: 9783039213573 9783039213580 Year: Pages: 308 DOI: 10.3390/books978-3-03921-358-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

Current efforts to limit the ravages of schistosomiasis are pushing the world closer to eliminating a chronic infection that has been associated with human life in the tropics since time immemorial. This notwithstanding, the disease remains a scourge for large populations in sub-Saharan Africa, Latin America, and Southeast Asia, and the main part of this book is made up by papers dealing with its current distribution, discussing ways and means to establish and implement improved control approaches. While chemotherapy limits the symptoms caused by schistosomiasis, the number of infected people will not decrease until the parasite's life cycle is interrupted. To that end, some papers focus on the intermediate snail host, which is notoriously difficult to control, while others discuss human hygiene and sanitation. The latter approach not only prevents infection through avoiding people being infected from the snail, but more importantly, also stops people infecting the snail by leaving contagious feces and urine in nature. With morbidity reduced by chemotherapy, the immediate target now is the interruption of transmission to be achieved by new tools, such as the novel chemotherapies, improved diagnostics (for humans, animals, and snails), and vaccines discussed in several of the papers. As made clear in this book, a complex infection requires new tools as well as work on many fronts, above all; however, a clear idea is needed as to how to skillfully combine the tools available and sustain implemented control activities.

Keywords

schistosomiasis --- Schistosoma --- vaccine --- zoonosis --- Asia --- Africa --- domestic animals --- buffalo --- cattle --- sheep --- goats --- Côte d’Ivoire --- coverage rate --- praziquantel --- preventive chemotherapy --- Schistosoma haematobium --- Schistosoma mansoni --- schistosomiasis --- diagnosis --- control and elimination --- DNA --- polymerase chain reaction --- schistosomiasis --- control --- elimination --- Africa --- operational research --- goals --- guidelines --- schistosomiasis --- vector control --- snail resistance --- gene drive --- transgenic snail --- schistosomiasis --- Kato-Katz --- POC-CCA --- young adults --- soil-transmitted helminths --- n/a --- Mayuge --- MDA coverage --- praziquantel --- S. mansoni --- systematic non-compliance --- treatment-opportunities --- Uganda --- climate change --- schistosomiasis --- distribution --- intermediate snail host --- transmission --- modelling --- schistosomiasis --- soil-transmitted-helminthiasis --- mapping --- preventive chemotherapy --- transmission control --- Gabon --- Central Africa --- schistosomiasis --- vaccine --- Sm14 --- FABP --- Schistosoma japonicum --- Oncomelania hupensis --- snail --- 28S ribosomal DNA --- PCR --- loop-mediated isothermal amplification (LAMP) --- pooled samples --- China --- schistosomiasis --- elimination --- praziquantel --- artemether --- combination therapy --- phylogeography --- Bulinus truncatus --- planorbidae --- Africa --- schistosomiasis --- neglected tropical diseases --- WIPO Re:Search --- BIO Ventures for Global Health --- cross-sector collaboration --- capacity-building --- drug discovery --- public-private partnerships --- GIS --- remote-sensing --- satellite --- international space station --- ECOSTRESS --- worldview --- spatio-temporal epidemiology --- climate change --- parasite --- schistosomiasis, leishmaniasis --- n/a --- schistosomiasis --- systems epidemiology --- systems thinking --- complexity --- neglected tropical diseases --- interdisciplinarity --- Schistosomiasis mansoni --- Caribbean --- elimination --- snail control --- Biomphalaria glabrata --- Schistosoma mekongi --- Neotricula aperta --- snail --- Cambodia --- Lao PDR --- elimination --- Asia --- control --- elimination --- epidemiology --- Schistosoma japonicum --- Schistosoma malayensis --- Schistosoma mekongi --- schistosomiasis --- Schistosomiasis --- Philippines --- schistosomiasis elimination --- S. japonicum zoonosis --- bovines --- schistosomiasis elimination --- snail control --- high-sensitivity diagnostics --- chemotherapy --- vaccine development --- health education --- sanitation

Listing 1 - 2 of 2
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (2)


License

CC by-nc-nd (2)


Language

english (2)


Year
From To Submit

2019 (1)

2017 (1)