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Neuroanatomy and transgenic technologies

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195138 Year: Pages: 139 DOI: 10.3389/978-2-88919-513-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2015-12-03 13:02:24
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Abstract

Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.

Neural Circuits Revealed

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195619 Year: Pages: 181 DOI: 10.3389/978-2-88919-561-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Deciphering anatomical and functional maps in the nervous system is a main challenge for both clinical and basic neuroscience. Modern approaches to mark and manipulate neurons are bringing us closer than ever to better understand nervous system wiring diagrams. Here we present both original research and review material on current work in this area. Together, this eBook aims to provide a comprehensive snapshot of some of the tools and technologies currently available to investigate brain wiring and function, as well as discuss ongoing challenges the field will be confronted with in the future.

Spectral near field data of LED systems for optical simulations

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Book Series: Spektrum der Lichttechnik / Karlsruher Institut für Technologie (KIT), Lichttechnisches Institut ISSN: 21951152 ISBN: 9783731507505 Year: Volume: 17 Pages: VIII, 212 p. DOI: 10.5445/KSP/1000078518 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-28 18:37:01
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This book presents, validates and applies a fast, accurate and general measurement and modeling technique to obtain spectral near field data of LED systems for optical simulations in order to address the steadily increasing requirements of modern high quality LED systems. It requires only a minimum of goniophotometric near field measurements and no time-consuming angularly resolved spectral measurements. The obtained results can be used directly in state-of-the-art ray tracers.

Cancer Metabolomics 2018

Authors: --- ---
ISBN: 9783039213450 / 9783039213467 Year: Pages: 184 DOI: 10.3390/books978-3-03921-346-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
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The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Governing Integrated Water Resources Management: Mutual Learning and Policy Transfer

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ISBN: 9783039281565 / 9783039281572 Year: Pages: 284 DOI: 10.3390/books978-3-03928-157-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Philosophy
Added to DOAB on : 2020-01-30 16:39:46
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Integrated Water Resources Management (IWRM) has become a global paradigm for the governance of surface, coastal and groundwaters. This Special Issue contains twelve articles related to the transfer of IWRM policy principles. The articles explore three dimensions of transfer—causes, processes, outcomes—and offer a theoretically inspiring, methodologically rich and geographically diverse engagement with IWRM policy transfer around the globe. As such, they can also productively inform a future research agenda on the ‘dimensional’ aspects of IWRM governance. Regarding the causes, the contributions apply, criticise, extend or revise existing approaches to policy transfer in a water governance context, asking why countries adopt IWRM principles and what mechanisms are in place to understand the adoption of these principles in regional or national contexts. When it comes to processes, articles in this Special Issue unpack the process of policy transfer and implementation and explore how IWRM principles travel across borders, levels and scales. Finally, this set of papers looks into the outcomes of IWRM policy transfer and asks what impact IWRM principles, once implemented, gave on domestic water governance, water quality and water supply, and how effective IWRM is at addressing critical water issues in specific countries.

Keywords

dam --- local communities --- lived experiences --- environmental narratives --- Cambodia --- transitions --- water management regimes --- water resource management --- niches --- visions --- agency --- ocean governance --- fisheries management --- ecosystem-based management --- overfishing --- sustainable fishing --- European Union --- Turkey --- Europeanisation --- institutions --- policy transfer --- Water Framework Directive --- drinking water --- agriculture --- EU policy --- governance --- integrated scientific support --- water quality --- nitrates --- pesticides --- environmental policy --- policy coherence --- environmental governance --- integrated catchment management --- catchment --- conservation authorities --- governance --- governmentality --- integrated water resources management (IWRM) --- watershed councils --- Ontario --- Oregon --- Integrated Water Resources Management --- Integrated Urban Water Management --- urban water security --- governance --- Singapore --- Hong Kong --- process tracing --- Water Framework Directive --- policy implementation --- integrated water resources management --- river basin planning --- public participation --- water governance --- scale --- top-down and bottom-up --- estuaries --- governance --- sustainability --- governance models --- integrated water resources management --- IWRM --- Water Framework Directive --- WFD --- participation --- United Kingdom --- England --- water governance --- IWRM --- integrated water resources management --- drivers --- EU water framework directive --- implementation --- coordination --- participation --- Germany --- water governance --- polycentricity --- integrated water resources management --- IWRM --- policy transfer --- water governance --- Water Framework Directive --- learning

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