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Nutraceuticals and the Skin: Roles in Health and Disease

Authors: --- ---
ISBN: 9783038971863 9783038971870 Year: Pages: 224 DOI: 10.3390/books978-3-03897-187-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Public Health
Added to DOAB on : 2018-10-08 12:14:17
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[The skin is the largest organ of the body and serves as a barrier between the inner and external environments. As such, any problems in the skin can have serious effects on systemic health and well-being. Several studies have established that both nutritional and dietary factors play an important role in the maintenance of normal skin integrity, and can execute a causative, preventative and/or treatment role in a number of skin related conditions. Nutritional factors have been studied for their involvement in skin ageing, acne, inflammation and several chronic immune-mediated disorders such as atopic dermatitis, psoriasis, diabetes, obesity, wounds and various types of skin cancer. The skin condition, in turn, can affect nutritional choices and subsequent nutritional and health status.There are a multitude of mechanisms by which nutraceuticals can counteract adverse skin conditions. Consumption of a diet rich in nutrients and vitamins (nutraceuticals and antioxidants), particularly those derived from fruits and vegetables, not only supports health in general, but also skin maintenance and repair in particular. Epidemiological evidence links consumption of these diets with prevention and mitigation of disease progression. For example, nutraceuticals with anti-oxidative or metal chelating properties are being actively evaluated as natural tools to modulate, prevent or inhibit oxidative processes or modulate advanced glycation end products. However, many other properties of dietary compounds with relevance to skin remain to be characterized.For this Special Issue of Nutrients, we have compiled invited manuscripts describing original research, or reviewing scientific literature examining the role of diets and/or specific nutraceuticals in the prevention and treatment of skin disorders. These articles describe the beneficial effects of plant extracts and plant-derived compounds and their ability to ameliorate diverse skin-related conditions including UV damage, aging, atopic dermatitis, psoriasis, and skin cancer. A comprehensive article summarizes the results of current clinical trials on nutraceuticals for various skin afflicitons. Finally, the outcome and research methods used for studies on nutraceuticals and skin function, and their compliance with European regulations is analyzed. Taken together, this compilation of articles provides an up-to-date view of research into the application of nutraceuticals for skin health, for the researcher and anyone interested in the application of natural, plant-derived agents for treatment of skin disease.]

Keywords

nutrients --- skin cancers --- skin care

New Therapies and Immunological Findings in Melanoma and Other Skin Cancers

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889457120 Year: Pages: 137 DOI: 10.3389/978-2-88945-712-0 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology --- Oncology
Added to DOAB on : 2019-01-23 14:53:43
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New therapies are currently being developed in the field of skin cancer. In particular, advances in melanoma now represent the frontline of cancer immunotherapy, as immunological findings in the disease have led to the development of highly effective immune-checkpoint inhibitors. However, these immune-checkpoint inhibitors are only effective in a subset of patients, and may not work in other skin cancer types, thus highlighting the need for further innovation in the field of skin cancer treatment.The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments.

Touch

Authors: --- --- ---
Book Series: Law and the Senses ISBN: 9781912656363 9781912656349 9781912656660 9781912656363 9781912656370 Year: Pages: 296 DOI: 10.16997/book37 Language: English
Publisher: University of Westminster Press
Subject: Law --- Social Sciences --- Arts in general
Added to DOAB on : 2020-02-05 11:21:20
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Described by Aristotle as the most vital of senses, touch contains both the physical and the metaphysical in its ability to express the determination of being. To manifest itself, touch makes a movement outwards, beyond the body, and relies on a specific physical involvement other senses do not require: to touch is already to be active and to activate. This fundamental ontology makes touch the most essential of all senses. This volume in the Law and the Senses series attempts to illuminate and reconsider the complex and interflowing relations and contradictions between the tactful intrusion of the law and the untactful movement of touch. Compelling contributors from arts, literature and social science disciplines alongside artist presentations explore touch’s boundaries and formal and informal ‘laws’ of the senses. Each contribution unveils a multi-faceted new dimension to the force of touch, its ability to form, deform and reform what it touches. In unique ways, each of the several contributions to this volume recognises the trans-corporeality of touch to traverse the boundaries on the body and entangle other bodies and spaces, thus challenging the very notion of corporeal integrity and human being.

Keywords

touch --- arts --- body --- skin --- perception --- law

Tattooed Skin and Health

Authors: --- ---
ISBN: 9783318027761 9783318027778 Year: Language: English
Publisher: Karger Grant: Knowledge Unlatched - 103009
Subject: Medicine (General)
Added to DOAB on : 2019-11-26 11:24:34
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With about 10–20% of the adult population in Europe being tattooed, there is a strong demand for publications discussing the various issues related to tattooed skin and health. Until now, only a few scientific studies on tattooing have been published. This book discusses different aspects of the various medical risks associated with tattoos, such as allergic reactions from red tattoos, papulo-nodular reactions from black tattoos as well as technical and psycho-social complications, in addition to bacterial and viral infections. Further sections are dedicated to the composition of tattoo inks, and a case is made for the urgent introduction of national and international regulations. Distinguished authors, all specialists in their particular fields, have contributed to this publication which provides a comprehensive view of the health implications associated with tattooing.

Skin-Related Neglected Tropical Diseases (Skin-NTDs)—A New Challenge

Authors: ---
ISBN: 9783039212538 9783039212545 Year: Pages: 218 DOI: 10.3390/books978-3-03921-254-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue explores the range of clinical manifestations and epidemiology of both skin NTDs and common skin disease in endemic regions, the use of common diagnostic and management pathways, the different technologies that play a role in diagnosis and training, the role of patient involvement at a community level, as well as the assessment of the results of different initiatives in the field.

Keywords

Mycobacterium ulcerans --- animal reservoir --- transmission --- scabies --- Cushing syndrome --- iatrogenic --- topical corticosteroids --- teledermatology --- eHealth --- mHealth --- long range diagnosis --- dermatology --- telepathology --- technology --- skin disease --- podoconiosis --- lymphedema --- neglected tropical diseases --- NTDs --- mental health --- community engagement --- patient involvement --- stigma --- teledermatology --- Africa --- primary health care --- skin diseases --- tele-expertise --- yaws --- Treponema pallidum --- onchodermatitis --- onchocercal skin disease --- onchocerciasis --- ivermectin --- mycetoma --- clinical presentation --- review --- scabies --- neglected tropical diseases --- impetigo --- mass drug administration --- ivermectin --- integration --- neglected tropical diseases --- disease mapping --- mass drug administration --- morbidity management --- skin diseases --- mobile phone application --- NTDs --- dermatology --- mHealth --- leprosy --- leprosy --- leprosy diagnosis --- PCR --- slit skin smears --- point of care test --- skin biopsy --- early diagnosis --- scabies --- outbreak --- drought --- emergency state --- scabies --- diagnosis --- digital handheld microscope --- resource-poor setting --- Amerindian communities --- Amazon lowland --- case management --- integration --- mass drug administration --- neglected tropical diseases --- skin infections --- skin NTDs --- surveillance --- training --- tropical skin diseases --- n/a --- Mite-Gallery Unit (MGU) --- Entodermoscopy (EDS) --- Dry Dermatoscopy (d-DS) --- Wet Dermatoscopy (w-DS) --- Enhanced Dermatoscopy (e-DS) --- subcutaneous mycosis --- actinomycetoma --- eumycetoma --- sporotrichosis Community dermatology

Innate Immune Cell Determinants of T Cell Immunity: From Basic Mechanisms to Clinical Implications

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199075 Year: Pages: 143 DOI: 10.3389/978-2-88919-907-5 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-01-19 14:05:46
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Long-lasting T cell immunity is delivered by an array of individual T lymphocytes expressing clonally distributed and highly specific antigen receptors recognizing an almost infinite number of antigens that might enter in contact with the host. Following antigen-specific priming in lymphnodes, naïve CD4 and CD8 T lymphocytes proliferate generating clones of effector cells that migrate to peripheral tissues and deliver unique antigen-specific effector functions. Moreover, a proportion of these effector lymphocytes survive as memory T cells that can be rapidly mobilized upon new exposure to the same antigen, even years after their primary induction. Innate immune cells play crucial roles in the induction and maintenance of this efficient protection system. Following the seminal discovery of Steinman and Cohen in 1974 describing a rare cell type capable of initiating antigen-specific responses in lymphnodes, Dendritic Cells (DC) have taken up the stage for several decades as professional Antigen Presenting Cells (APC). Although DC possess all attributes to prime naïve T lymphocytes, other immune cell subsets become crucial accessory cells during secondary and even primary activation. For instance, Monocytes (Mo) are rapidly recruited to inflammatory sites and have recently been recognized as capable of shaping T cell immunity, either directly through Ag presentation, or indirectly through the secretion of soluble factors. In addition, upon sensing of T cell-derived cytokines, Mo differentiate into functionally different APC types that further impact on the quality and persistence of memory T cell responses in peripheral tissues. Other innate immune cells, including Myeloid Derived Suppressor Cells, Granulocytes and iNKT lymphocytes, are known to modulate T cell activation by interacting with and modifying the function of professional APC. Notably, innate immune cell determinants also account for the tissue-specific regulation of T cell immunity. Hence, the newly discovered family of Innate Lymphoid Cells, has been recognized to shape CD4+ T cell responses at mucosal surfaces. Although the actions of innate immune cells fulfills the need of initiating and maintaining protective T cell responses, the excessive presence or activity of individual determinants may be detrimental to the host, because it could promote tissue destruction as in autoimmunity and allergy, or conversely, prevent the induction of immune responses against malignant tissues, and even modulate the response to therapeutic agents. Thus, understanding how defined innate immune cell subsets control T cell immunity is of fundamental relevance to understand human health, and of practical relevance for preventing and curing human diseases. In this research topic, we intend to provide an excellent platform for the collection of manuscripts addressing in depth how diverse innate immune cell subsets impact on T cell responses through molecularly defined pathways and evaluating the rational translation of basic research into clinical applications.

Flexible and Stretchable Electronics

Authors: --- ---
ISBN: 9783038424369 9783038424376 Year: Pages: VIII, 172 DOI: 10.3390/books978-3-03842-437-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2017-06-27 09:51:34
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Flexible and stretchable electronics are receiving tremendous attention as future electronics due to their flexibility and light weight, especially as applications in wearable electronics. Flexible electronics are usually fabricated on heat sensitive flexible substrates such as plastic, fabric or even paper, while stretchable electronics are usually fabricated from an elastomeric substrate to survive large deformation in their practical application. Therefore, successful fabrication of flexible electronics needs low temperature processable novel materials and a particular processing development because traditional materials and processes are not compatible with flexible/stretchable electronics. Huge technical challenges and opportunities surround these dramatic changes from the perspective of new material design and processing, new fabrication techniques, large deformation mechanics, new application development and so on. Here, we invited talented researchers to join us in this new vital field that holds the potential to reshape our future life, by contributing their words of wisdom from their particular perspective.

Chapter 9 Race as a Cultural Construction (Book chapter)

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ISBN: 9781138894471 Year: DOI: 10.4324/9781315179940 Language: English
Publisher: Taylor & Francis
Added to DOAB on : 2020-09-01 00:05:52
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Race and Human Diversity is an introduction to the study of human diversity in both its biological and cultural dimensions. Robert L. Anemone examines the biological basis of human difference and how humans have biologically and culturally adapted to life in different environments. The book discusses the history of the race concept, evolutionary theory, human genetics, and the connections between racial classifications and racism. It invites students to question the existence of race as biology, but to recognize race as a social construction with significant implications for the lived experience of individuals and populations. This second edition has been thoroughly revised, with new material on human genetic diversity, developmental plasticity and epigenetics. There is additional coverage of the history of eugenics; race in US history, citizenship and migration; affirmative action; and white privilege and the burden of race. Fully accessible for undergraduate students with no prior knowledge of genetics or statistics, this is a key text for any student taking an introductory class on race or human diversity.

Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

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ISBN: 9783039213559 9783039213566 Year: Pages: 322 DOI: 10.3390/books978-3-03921-356-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

Marine Natural Products and Obesity

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ISBN: 9783039211913 9783039211920 Year: Pages: 194 DOI: 10.3390/books978-3-03921-192-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

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