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Modern molecular -omics tools (metagenomics, metaproteomics etc.) have greatly contributed to the rapid advancement of our understanding of microbial diversity and function in the world’s oceans. These tools are now increasingly applied to host-associated environments to describe the symbiotic microbiome and obtain a holistic view of marine host-microbial interactions. Whilst all eukaryotic hosts are likely to benefit from their microbial associates, marine sessile eukaryotes, including macroalgae, seagrasses and various invertebrates (sponges, acidians, corals, hydroids etc), rely in particular on the function of their microbiome. For example, marine sessile eukaryotes are under constant grazing, colonization and fouling pressure from the millions of micro- and macroorganisms in the surrounding seawater. Host-associated microorganisms have been shown to produce secondary metabolites as defense molecules against unwanted colonization or pathogens, thus having an important function in host health and survival. Similarly microbial symbionts of sessile eukaryotes are often essential players in local nutrient cycling thus benefiting both the host and the surrounding ecosystem. Various research fields have contributed to generating knowledge of host-associated systems, including microbiology, biotechnology, molecular biology, ecology, evolution and biotechnology. Through a focus on model marine sessile host systems we believe that new insight into the interactions between host and microbial symbionts will be obtained and important areas of future research will be identified. This research topic includes original research, review and opinion articles that bring together the knowledge from different aspects of biology and highlight advances in our understanding of the diversity and function of the microbiomes on marine sessile hosts.
marine microbiology --- Symbiosis --- Microbial Interactions --- Microbial Diversity --- Sponges --- seaweeds --- macroalgae --- oysters --- marine diseases
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Seaweeds are recognized as highly nutritious, and their use in gastronomy is increasing. Their health benefits and their potential to prevent several diseases have also been established. In this Special Issue several health effects are discussed, with more emphasis on their antitumor activity and potential use to treat Alzheimer’s disease. The key bioactive metabolites, from which phlorotannins can be highlighted, are presented, as well as some important in vivo studies. Altogether, the chapters provide in-depth information about the biological activities of seaweed metabolites, contributing to elucidate the health effects of seaweed.
Padina pavonica --- osteosarcoma --- apoptosis --- algae --- chemo-preventive agent --- phytol --- fucosterol --- fatty acid --- laurinterol --- Laurencia --- antitumoral --- breast cancer explants --- organotypic culture --- ex vivo --- phlorotannin --- eckmaxol --- high-speed counter-current chromatography --- NMR spectroscopy --- mass spectrometry --- isolation and purification --- Ecklonia maxima --- fucoidan --- age-related macular degeneration --- VEGF --- oxidative stress --- Saccharina latissima --- Fucus vesiculosus --- Fucus distichus subsp. evanescens --- Fucus serratus --- Laminaria digitata --- Symphyocladia latiuscula --- bromophenols --- mushroom tyrosinase --- B16F10 --- melanin --- red seaweed --- bioactives --- extraction --- biorefinery --- seaweed --- gut microbiota --- prebiotics --- dietary fibre --- complex polysaccharides --- polyphenols --- polyunsaturated fatty acids --- carotenoids --- phytochemicals --- Padina pavonica --- marine algae --- osteoporosis --- bone metabolism --- bone health --- nutraceutical --- Bifurcaria bifurcata --- linear diterpenes --- extraction --- identification --- biological activities --- macroalgae --- high value applications --- phlorotannin --- amyloid-? aggregation --- insulin glycation --- dynamic simulation --- kidney --- ischemia-reperfusion injury --- Ecklonia cava --- phlorotannins --- Alzheimer’s disease --- seaweeds --- cholinesterases --- beta-secretase --- beta-amyloid aggregation --- neuroprotection --- K14HPV16 --- genotoxicity assay --- papillomavirus --- cancer --- seaweeds --- hyperpigmentation --- skin aging --- skincare --- photo-protection --- seaweeds --- secondary metabolites --- in vivo studies --- clinical trials --- health effects --- dieckol --- eckol --- fucoxanthin --- kahalalide F
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.
Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds
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Algae have been used since ancient times as food for humans, animal feed, agricultural fertilizer, and as a source of substances for therapeutic use. Currently, seaweed represents a vast source of raw materials used in the pharmaceutical, food, traditional medicine, and cosmetics industries. They are nutritionally valuable, both fresh and dried, or as ingredients in a wide variety of pre-made foods. In particular, seaweed contains significant amounts of protein, lipids, minerals, and vitamins. Information is limited on the role of algae and their metabolites in therapy. Only a few taxa have been studied for use in medicine. Many traditional cultures report the healing powers of selected algae in tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. However, currently, only a few genera and species of algae are involved in aspects of medicine and therapy. The beneficial uses of seaweed or seaweed products include those that can mimic specific manifestations of human disease, production of antibiotic compounds, or improved human nutrition.
low molecular weight fucoidan --- Mycoplasma pneumoniae --- NK cell --- antigen-specific antibody --- adjuvant --- Osmundea pinnatifida --- Sargassum muticum --- enzymatic extracts --- minerals --- mono and polysaccharides --- FTIR-ATR --- NMR --- cytotoxicity --- Ulva rigida --- ulvan --- chemical sulfation --- anticoagulant activity --- alginate --- Cystoseira barbata --- Black Sea --- heavy metals adsorption --- diffusion model --- phlorotannin --- particulate matter --- reactive oxygen species --- keratinocytes --- alkaline phosphatase --- Ecklonia cava --- phlorofucofuroeckol A --- osteoblast --- huBM-MSC --- seaweeds --- chlorophylls --- carotenoids --- n-3 PUFAs --- EPA --- marine algae --- macro algae --- bromophenols --- HPLC --- quantification --- isolation --- raw laver --- processed laver product --- edible seaweed --- nutritional value --- functional substance --- health functionality --- processing technology --- microbial risk --- chemical risk --- omics-based technology --- macroalgae/seaweed --- natural resources --- health --- food --- feed --- agriculture --- carrageenan --- TC --- HDL-C --- LDL-C --- TC reduction --- TG --- antitumour activity --- carrageenan --- colorectal cancer --- cancer stem cells --- n/a
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Due to increasing global food needs as a result of population growth, the use of new food sources has gained interest in the last decade. However, the inclusion of new foods in our diet, as well as the increased interest of the population in consuming foods with better nutritional properties, has increased the need for adequate food analytical methods. This monographic issue presents innovative methods of chemical analysis of foods, as well as the nutritional and chemical characterization of foods whose consumption is expected to increase worldwide in the coming years.
refined commercial salmon oil --- n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) concentration --- EPA --- DHA --- EPA+DHA --- total FA yield --- process variable maximization --- response surface methodology (RSM) --- multiple response optimization --- desirability function --- avocado oil --- oil extraction --- antioxidants compounds --- fatty acid profile --- water holding capacity --- seaweeds --- Gracilaria --- carbohydrates --- fatty acids --- vitamins --- deep eutectic solvents --- Artemisia argyi leaves --- phenolic acids --- extraction --- response surface methodology --- amaranth protein --- flavourzyme --- alcalase --- bioactive peptides --- hydrolysates --- N-carbamylglutamate --- feeds --- animal products --- milk --- HPLC-MS/MS --- acrylamide --- crisps --- temperature --- frying time --- blanching --- thickness --- scorpion (Buthus martensii Karsch) protein --- ultrasonic extraction --- response surface methodology --- scanning electron microscopy --- functional properties --- Amazonian fruits --- antioxidant --- phenolic compounds --- UPLC-MSE --- bioactive compounds --- prebiotic --- polysaccharides --- seaweed --- Rhodophyceae --- Phaeophyceae --- Chlorophyceae --- n/a
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