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Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198191 Year: Pages: 147 DOI: 10.3389/978-2-88919-819-1 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses such as the “Pediatric Cancer Translational Genomics” conference (Phoenix, Arizona, 2012), the ESF-EMBO workshop on “Molecular Biology and Innovative Therapies in Sarcomas” (Pultusk, Poland, 2012), and the AACR special meeting on “Pediatric Cancer at the Crossroads – Translating Discovery into Improved Outcomes” (San Diego, California, 2013) further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and that it would have great potential to receive numerous contributions of outstanding experts of the field. The proposed Frontiers Research Topic shall provide a platform for active and interdisciplinary discussion, summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and offer new perspectives of how to further promote and accelerate the translational process. We welcome high-quality original research articles, brief reports, as well as opinion, hypothesis, and review articles, and especially encourage submissions from early-career scientists.

Soft Tissue and Bone Sarcoma

ISBN: 9783906980461 9783906980584 Year: Pages: 156 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 11:17:42
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Soft tissue and bone sarcomas disproportionately affect children, adolescents, and young adults. Although considered a rare disease, sarcomas continue to have a devastating effect on these patients and their loved ones, and their impact on our society far exceed their relatively low prevalence. Because of its rarity and heterogeneity, clinical decision making on management of sarcomas are often individualized and without a consensus treatment strategy. Furthermore, research to improve clinical outcomes are particularly challenging as sizeable studies are hard to produce. By improving our knowledge about the molecular biology of sarcomas, we hope to identify new treatment strategies and targets for further drug development. [...]

Plastic Surgery for the Oncological Patient

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199877 Year: Pages: 76 DOI: 10.3389/978-2-88919-987-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology --- Surgery
Added to DOAB on : 2016-01-19 14:05:46
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The develoment of plastic surgery techniques allows for preserving and reconstruction of function after resection of malignant tumors. From split thickness skin grafts to pedicled and free tissue transfer multiple techniques are at hand to restore body integrity. Sufficient soft tissue coverage allows for adjuvant radiation therapy or can cure its sequelae. Nerve, tendon and muscle transfers are used to regain motor function of the extremities. Even large bony defects can be treated by microsurgically transferring fibula, pelvic and femoral bone. In case main vessels need to be resected reconstruction is possible with autologous and artificial grafts. By means of plastic surgery thoracic and abdominal defects can be covered so that foremost unresectable tumors become curable. Unfortunately the knowledge of these techniques is not very popular with oncologic surgeons. Therefore we suggest as a clinical topic the role of reconstructive surgery in the multimodal treatment of oncologic patients. The focus will be on different areas of the body, therefore articels for reconstructional procedures at the head, the extremities, the trunk, the thoracic wall, the breast, and the foot will be invited. Another focus will be the role of reconstructive procedures in the multimodal treatment concept consisting of radiation and chemotherapy as well. By knowing and applying the opportunities of plastic surgery the quality of live of the oncologic patient can be significantly improved.

Advances in Near Infrared Spectroscopy and Related Computational Methods

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ISBN: 9783039280520 / 9783039280537 Year: Pages: 496 DOI: 10.3390/books978-3-03928-053-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2020-01-30 16:39:46
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In the last few decades, near-infrared (NIR) spectroscopy has distinguished itself as one of the most rapidly advancing spectroscopic techniques. Mainly known as an analytical tool useful for sample characterization and content quantification, NIR spectroscopy is essential in various other fields, e.g. NIR imaging techniques in biophotonics, medical applications or used for characterization of food products. Its contribution in basic science and physical chemistry should be noted as well, e.g. in exploration of the nature of molecular vibrations or intermolecular interactions. One of the current development trends involves the miniaturization and simplification of instrumentation, creating prospects for the spread of NIR spectrometers at a consumer level in the form of smartphone attachments—a breakthrough not yet accomplished by any other analytical technique. A growing diversity in the related methods and applications has led to a dispersion of these contributions among disparate scientific communities. The aim of this Special Issue was to bring together the communities that may perceive NIR spectroscopy from different perspectives. It resulted in 30 contributions presenting the latest advances in the methodologies essential in near-infrared spectroscopy in a variety of applications.

Keywords

hyperspectral imaging --- variety discrimination --- Chrysanthemum --- deep convolutional neural network --- DNA --- FTIR spectroscopy --- rapid identification --- PLS-DA --- animal origin --- near-infrared hyperspectral imaging --- raisins --- support vector machine --- pixel-wise --- object-wise --- maize kernel --- hyperspectral imaging technology --- accelerated aging --- principal component analysis --- support vector machine model --- standard germination tests --- blackberries --- Rubus fructicosus --- phenolics --- carotenoids --- bioanalytical applications --- near infrared --- chemometrics --- VIS/NIR hyperspectral imaging --- corn seed --- classification --- freeze-damaged --- image processing --- imaging visualization --- wavelength selection --- NIR spectroscopy --- binary dragonfly algorithm --- ensemble learning --- quantitative analysis modeling --- NIR --- SCiO --- pocket-sized spectrometer --- cheese --- fat --- moisture --- multivariate data analysis --- Fourier-transform near-infrared spectroscopy --- glucose --- fructose --- dry matter --- partial least square regression --- Ewing sarcoma --- Fourier transform infrared spectroscopy --- FTIR --- chemotherapy --- bone cancer --- calibration transfer --- NIR spectroscopy --- PLS --- quantitative analysis model --- melamine --- FT-IR --- NIR spectroscopy --- quantum chemical calculation --- anharmonic calculation --- overtones --- combination bands --- near infrared spectroscopy --- Trichosanthis Fructus --- geographical origin --- chemometric techniques --- crude drugs --- prepared slices --- support vector machine-discriminant analysis --- near-infrared fluorescence --- fluorescent probes --- Zn(II) --- di-(2-picolyl)amine --- living cells --- cellular imaging --- near-infrared (NIR) spectroscopy --- calibration transfer --- affine invariance --- multivariate calibration --- partial least squares (PLS) --- NIR --- direct model transferability --- MicroNIR™ --- SVM --- hier-SVM --- SIMCA --- PLS-DA --- TreeBagger --- PLS --- calibration transfer --- agriculture --- photonics --- imaging --- spectral imaging --- spectroscopy --- handheld near-infrared spectroscopy --- pasta/sauce blends --- partial least squares calibration --- nutritional parameters --- bootstrapping soft shrinkage --- partial least squares --- extra virgin olive oil --- adulteration --- FT-NIR spectroscopy --- near-infrared spectroscopy --- ethanol --- anharmonic quantum mechanical calculations --- isotopic substitution --- overtones --- combinations bands --- seeds vitality --- rice seeds --- near-infrared spectroscopy --- hyperspectral image --- discriminant analysis --- near-infrared spectroscopy --- counter propagation artificial neural network --- detection --- auxiliary diagnosis --- BRAF V600E mutation --- colorectal cancer --- tissue --- paraffin-embedded --- deparaffinized --- stained --- ultra-high performance liquid chromatography --- Folin–Ciocalteu --- total hydroxycinnamic derivatives --- phytoextraction --- near-infrared spectroscopy --- origin traceability --- data fusion --- Paris polyphylla var. yunnanensis --- Fourier transform mid-infrared spectroscopy --- near-infrared spectroscopy --- aquaphotomics --- water --- light --- near infrared spectroscopy --- water-mirror approach --- perturbation --- biomeasurements --- biodiagnosis --- biomonitoring --- Vitis vinifera L. --- proximal sensing --- precision viticulture --- near infrared --- chemometrics --- non-destructive sensor --- NIRS --- osteopathy --- late preterm --- brain --- splanchnic --- Raman spectroscopy --- hyperspectral imaging --- analytical spectroscopy --- counterfeit and substandard pharmaceuticals --- DFT calculations --- chemometrics --- PLSR --- API --- lumefantrine --- artemether --- antimalarial tablets --- FT-NIR spectroscopy --- PLS-R --- water --- glucose --- test set validation --- RMSEP --- hyperspectral image processing --- perfusion measurements --- clinical classifications --- n/a

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