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Polymeric Systems as Antimicrobial or Antifouling Agents

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ISBN: 9783039284566 / 9783039284573 Year: Pages: 400 DOI: 10.3390/books978-3-03928-457-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2020-06-09 16:38:57
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Abstract

The rapid increase in the emergence of antibiotic-resistant bacterial strains, combined with a dwindling rate of discovery of novel antibiotic molecules, has created an alarming issue worldwide. Although the occurrence of resistance in microbes is a natural process, the overuse of antibiotics is known to increase the rate of resistance evolution. Under antibiotic treatment, susceptible bacteria inevitably die, while resistant microorganisms proliferate under reduced competition. Therefore, the out-of-control use of antibiotics eliminates drug-susceptible species that would naturally limit the expansion of resistant species. In addition, the ability of many microbial species to grow as a biofilm has further complicated the treatment of infections with conventional antibiotics. A number of corrective measures are currently being explored to reverse or slow antibiotic resistance evolution, Among which one of the most promising solutions is the development of polymer-based antimicrobial compounds. In this Special Issue, different polymer systems able to prevent or treat biofilm formation, including cationic polymers, antibacterial peptide-mimetic polymers, polymers or composites able to load and release bioactive molecules, and antifouling polymers able to repel microbes by physical or chemical mechanisms are reported. Their applications in the design and fabrication of medical devices, in food packaging, and as drug carriers is investigated.

Keywords

cationic polymers --- imidization --- quaternization --- antimicrobial properties --- hemolytic activity --- coatings from nanoparticles --- biocompatible polymer --- antimicrobial polymer --- dynamic light scattering --- coatings wettability --- microbicidal coatings --- bacteria viability --- bactericidal coatings --- Escherichia coli --- Staphylococcus aureus --- Acinetobacter baumannii --- multidrug-resistant --- antimicrobial peptide --- antibiofilm activity --- physiological salt --- biofilm --- anti-biofilm surface --- surface functionalization --- ?-chymotrypsin --- proteinase --- antimicrobial polymers --- quaternary ammonium --- 2-hydroxyethyl methacrylate --- thermal stability --- polymers --- antibacterial --- drug delivery --- periodontitis --- periodontal biofilms --- polyamide 11 --- antibacterial --- polymeric biocide --- thermal stability --- biofilm --- antifouling --- copper paint --- additives --- biofilm --- lipopeptides --- biofilm --- persister cells --- ocular infections --- biofilm on contact lenses --- cuprous oxide nanoparticles --- linear low-density polyethylene --- composites --- adhesives --- antibacterial activity --- water disinfection --- active packaging --- antimicrobial peptides --- food shelf-life --- foodborne pathogens --- plastic materials --- antibacterial peptides --- halictine --- circular dichroism --- fluorescence --- infrared spectroscopy --- segmented polyurethanes --- polyethylene glycol --- microbial biofilm --- antifouling materials --- medical device-related infections --- wound dressings --- additive manufacturing --- antibacterial polymers --- biocompatible systems --- drug delivery systems --- 3D printing --- amorphous materials --- ordered mesoporous silica --- sol-gel preparation --- drug carrier --- multifunctional hybrid systems --- olive mill wastewater --- antibacterial properties --- layered double hydroxides --- bionanocomposites --- acrylates --- antibacterial activity --- copolymerization --- polymeric films --- polymerizable quaternary ammonium salts --- quaternary ammonium salts --- UV-induced polymerization --- antimicrobial resistance --- antimicrobial polymers --- ESKAPE pathogens --- anti-biofilm surfaces --- polymeric surfaces --- biofilm methods --- biofilm analysis --- biofilm devices --- n/a

Transmucosal Absorption Enhancers in the Drug Delivery Field

Authors: --- ---
ISBN: 9783039218486 9783039218493 Year: Pages: 406 DOI: 10.3390/books978-3-03921-849-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-01-30 16:39:46
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Abstract

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Keywords

absorption enhancers --- sugar-based surfactants --- biocompatibility studies --- transmucosal drug delivery --- intestinal permeation enhancers --- sodium cholate (NaC) --- N-dodecyl-?-D-maltoside (DDM) --- small intestine --- enterocyte --- brush border --- tryptophan --- oral delivery --- insulin --- GLP-1 --- intestinal absorption --- amino acid --- cell-penetrating peptide --- combined microsphere --- chitosan --- cyclodextrin --- nasal delivery --- nose to brain transport --- penetration enhancer --- nasal formulation --- in vivo studies --- nose to brain delivery --- antiepileptic drug --- drug delivery --- block copolymers --- thermogel system --- chitosan derivatives --- amphiphilic polymers --- polymeric micelles --- quaternization --- curcumin --- intestinal delivery --- mucoadhesiveness --- cervicovaginal tumors --- cationic functionalization --- imatinib --- nanocrystals --- in situ hydrogel --- bioenhancer --- cytochrome P450 --- drug absorption enhancer --- efflux --- metabolism --- P-glycoprotein --- pharmacokinetic interaction --- tight junction --- Aloe vera --- gel --- whole leaf --- absorption enhancement --- Caco-2 --- confocal laser scanning microscopy --- F-actin --- FITC-dextran --- tight junctions --- transepithelial electrical resistance --- permeation enhancer --- oral delivery --- formulation --- permeability --- safety --- simulated intestinal fluid --- hydrophobization --- epithelium --- compound 48/80 --- chitosan --- nanoparticles --- mast cell activator --- vaccine adjuvant --- nasal vaccination --- absorption enhancer --- antimicrobial peptide --- Caco-2 --- claudin --- cell-penetrating peptide (CPP) --- drug delivery --- intestinal epithelial cells --- KLAL --- PN159 --- tight junction modulator --- oral macromolecule delivery --- oral peptides --- sodium caprate --- salcaprozate sodium --- epithelial permeability --- epithelial transport --- nasal permeability --- nose-to-brain --- simvastatin --- nanocapsules --- mucoadhesion --- CNS disorders --- chitosan --- nasal --- pulmonary --- drug administration --- absorption enhancers --- nanoparticle --- and liposome --- absorption enhancer --- gemini surfactant --- intestinal absorption --- poorly absorbed drug --- Caco-2 cells --- PTH 1-34 --- teriparatide --- nasal delivery --- pharmacokinetics --- osteoporosis --- man --- sheep --- clinical trial --- preclinical --- Caco-2 --- intestinal absorption --- nanomedicine --- nanoparticle --- oral delivery --- transferrin --- ocular drug delivery --- cornea --- penetration enhancers --- ocular conditions --- ophthalmology --- permeation enhancers --- absorption modifying excipients --- oral delivery --- nasal delivery --- ocular delivery --- vaginal delivery --- transmucosal permeation

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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eng (1)

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2020 (2)