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Fahrstrategien zur Unfallvermeidung im Straßenverkehr für Einzel- und Mehrobjektszenarien

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Book Series: Schriftenreihe / Institut für Mess- und Regelungstechnik, Karlsruher Institut für Technologie ISSN: 16134214 ISBN: 9783731501985 Year: Volume: 30 Pages: XVI, 139 p. DOI: 10.5445/KSP/1000039757 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
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The subject of this work is the determination of collision-free driving strategies. Firstly, the last possible maneuver is derived for a single object on the basis of reachable existence circles and is extended to a complete evasive maneuvre. Subsequently, the consideration is extended onto multiple objects. By the use of existence regions and kinematic configurations collision-free trajectories are determined and evaluated.

Tau oligomers

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192618 Year: Pages: 113 DOI: 10.3389/978-2-88919-261-8 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Neurology --- Medicine (General) --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer's Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a "toxic" form of tau protein. Moreover, it was suggested that a "toxic" tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, "tau oligomers" as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of "tau oligomers".

Time-efficient Simulation of Surface-excited Guided Lamb Wave Propagation in Composites

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Book Series: Schriftenreihe des Instituts für Technische Mechanik, Karlsruher Institut für Technologie ISSN: 16143914 ISBN: 9783866449350 Year: Volume: 18 Pages: X, 202 p. DOI: 10.5445/KSP/1000030760 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Physics (General)
Added to DOAB on : 2019-07-30 20:02:01
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The methods of time-efficient simulation of surface-excited wave propagation in plate-like multilayered composites are presented. The mathematical model of wave propagation in laminated plate based on the elasticity theory is transformed and then solved in wavenumber-frequency domain. The numerical methods for computation of inverse transform in time-space domain are developed and used for analysis of wave and energy propagation phenomena occurring in composite plates due to surface excitation.

Acoustical Impact of Ships and Harbours: Airborne and Underwater N&V Pollution

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889457106 Year: Pages: 57 DOI: 10.3389/978-2-88945-710-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Oceanography
Added to DOAB on : 2019-01-23 14:53:43
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Noise and vibrations generated by ships affect a wide range of receivers: crew and passengers inside the vessel, inhabitants of the coastal areas and marine fauna outside it. Recent studies suggest that a large percentage of people living in urban areas close to harbors and a number of marine species, at different evolutionary levels (in particular mammals and cephalopods), suffer from ship N&V emissions in air and in water. The present degree of knowledge of the phenomena involved in the noise emissions inside and outside ships is quite different, as a result also of the time elapsed since the negative effects were realized and therefore studied. The development of the normative framework in the various areas reflects these differences, but there are expectations for improvements on all fronts that need to be supported by the scientific community presenting the latest research results in this particular field of acoustics.

Identifying the Epileptic Network

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192960 Year: Pages: 126 DOI: 10.3389/978-2-88919-296-0 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:07
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An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, but abnormalities in subcortical structures, such as thalamus and basal ganglia, and in intercortical and intracortical connecting white matter pathways. Novel methods of treating refractory epilepsy are urgently needed. The goal of identifying for each affected individual the specific brain regions that are involved offers the promise that novel methods of treatment will one day be developed that specifically target those abnormal regions. Researchers from disparate fields are required to develop and advance this area of research, and this current topic proposes to place a spotlight on the “state of the art” of methods to identify the abnormal networks. Recent work covering a wide variety of disciplines and technologies, including dense array electroencephalography (dEEG), novel methods of analyses of both the interictal dEEG and intracranial EEG (icEEG), magnetoencephalography (MEG), high-resolution magnetic resonance imaging (MRI), functional MRI (fMRI), simultaneous fMRI-EEG, fMRI connectivity measures, simultaneous dEEG-icEEG, and techniques to coregister patient-specific MRI (including white matter pathways) and dEEG, are all examples of areas of research that have contributed to a greater understanding of potential epileptogenic regions. We asked for individuals with expertise in an area of research that expands an understanding of identifying epileptic networks to contribute to this research topic.

Theory and Applications of Ordered Fuzzy Numbers: A Tribute to Professor Witold Kosiński

Authors: --- --- --- --- et al.
Book Series: Studies in Fuzziness and Soft Computing ISSN: 1434-9922 / 1860-0808 ISBN: 9783319596136 9783319596143 Year: Pages: 322 DOI: https://doi.org/10.1007/978-3-319-59614-3 Language: English
Publisher: Springer
Subject: Mathematics --- Computer Science
Added to DOAB on : 2017-11-24 16:56:25
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This open access book offers comprehensive coverage on Ordered Fuzzy Numbers, providing readers with both the basic information and the necessary expertise to use them in a variety of real-world applications. The respective chapters, written by leading researchers, discuss the main techniques and applications, together with the advantages and shortcomings of these tools in comparison to other fuzzy number representation models. Primarily intended for engineers and researchers in the field of fuzzy arithmetic, the book also offers a valuable source of basic information on fuzzy models and an easy-to-understand reference guide to their applications for advanced undergraduate students, operations researchers, modelers and managers alike.

Abhängigkeit der Exposition von der Zellgröße beim Mobilfunk unter Gewährleistung der Versorgung

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Book Series: Karlsruher Forschungsberichte aus dem Institut für Hochfrequenztechnik und Elektronik ISSN: 18684696 ISBN: 9783731503088 Year: Volume: 76 Pages: XIX, 271 p. DOI: 10.5445/KSP/1000044724 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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The influence of the cell size of mobile communication networks onto the exposure to electromagnetic fields is investigated in this work. The exposure is assessed by means of a radio network planning. In a novel approach the path loss for the coverage and the path loss for the exposure are distinguished. The developed model is applied to different wave propagation models and cell structures. The results are discussed.

PrPSc Prions: State of the Art

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ISBN: 9783038973089 9783038973096 Year: Pages: 210 DOI: 10.3390/books978-3-03897-309-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Biology
Added to DOAB on : 2018-11-07 10:54:14
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Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of fatal and transmissible neurodegenerative disorders characterized by long incubation periods, misfolded prion protein (PrP) deposition, and usually spongiform vacuolation. These devastating diseases affect many mammals, with the best known examples being Creutzfeldt–Jakob disease (CJD), fatal familial insomnia (FFI), or Kuru in humans; and scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, and chronic wasting disease (CWD) in cervids. Despite major achievements in research of TSEs, there are still many unresolved key issues that hamper the development of effective therapies. However, the last decade has been particularly prolific in advances in the prion field. Among others, prion propagation in vitro has been achieved, leading to new diagnostic methods; the basic architecture of infectious prions has been deciphered; new prion disease types have been described in humans and other animals; and prion disorders have emerged in places that had not previously reported the disorders, as is the case for CWD in Europe.This Special Issue will focus on the state of the art of our knowledge of PrPSc: on what we know about its structure and propagation, the basis of strains and transmission barriers, the mechanisms of PrPSc toxicity, the possible function of PrPSc’s properly folded precursor, PrPC and its evolutionary history, and recent technical breakthroughs in diagnostics and therapy development among other key aspects of PrPSc prion biology.

Renewable Energy in Marine Environment

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ISBN: 9783039285280 / 9783039285297 Year: Pages: 324 DOI: 10.3390/books978-3-03928-529-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:09
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The effects of human-caused global warming are obvious, requiring new strategies and approaches. The concept of business-as-usual is now no longer beneficial. Extraction of renewable energy in marine environments represents a viable solution and an important path for the future. These huge renewable energy resources in seas and oceans can be harvested, including wind, tide, and waves. Despite the initial difficulties related mostly to the elevated operational risks in the harsh marine environment, newly developed technologies are economically effective or promising. Simultaneously, many challenges remain to be faced. These are the main issues targeted by the present book, which is associated with the Special Issue of Energies Journal entitled “Renewable Energy in Marine Environment”. Papers on innovative technical developments, reviews, case studies, and analytics, as well as assessments, and papers from different disciplines that are relevant to the topic are included. From this perspective, we hope that the results presented are of interest to for scientists and those in related fields such as energy and marine environments, as well as for a wider audience.

Keywords

WEC array --- WEC farm --- PTO system --- PTO system tuning --- linearization --- hydraulic --- WEC-sim --- PTO-sim --- model coupling --- BEM --- NEMOH --- numerical modeling --- numerical coupling --- wave propagation --- MILDwave --- wave–structure interaction --- near field --- far field --- experimental validation --- WECwakes project --- wave energy converter arrays --- turbulence --- turbulence intensity --- turbulence kinetic energy --- ADCP --- site measurements --- time scale --- length scale --- wave–structure interaction --- wave propagation model --- smoothed particle hydrodynamics --- open boundaries --- coupling --- DualSPHysics --- OceanWave3D --- Mild-slope wave propagation model --- MILDwave --- periodic lateral boundaries --- short crested waves --- offshore wind turbines --- large scale experiments --- scour protection damage --- wide-graded materials --- climate change conditions --- optical measurements --- acoustic measurements --- waves-current interaction --- moored floating wave-energy converter --- oscillating water column --- wave flume experiment --- nonlinear wave condition --- 6 degrees of freedom motion --- mooring-line tension --- renewable energy --- marine environment --- wave energy converters --- variable depth effects --- multi-DOF WECs --- design optimization --- end fitting --- unbonded flexible pipe --- sealing performance --- pressure penetration --- temperature --- Caspian Sea --- wind speed --- offshore turbines --- capacity factor --- LCOE --- offshore wind farm --- jacket --- scour --- wave-current interaction --- spatial resolution --- erosion patterns --- sediment transport --- laboratory tests --- ocean energy --- marine energy --- wave energy --- renewable energy --- wave energy converter --- control system --- cost-benefit analysis --- DC collection --- energy economics --- HVDC --- HVAC --- levelized cost of electricity (LCOE) --- offshore wind --- ocean renewable energy --- ocean renewable technologies --- ocean source potential --- Brazilian ocean energy

Sports Materials

Authors: --- --- ---
ISBN: 9783039281626 / 9783039281633 Year: Pages: 166 DOI: 10.3390/books978-3-03928-163-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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Advances in materials are crucial to the development of sports equipment, from tennis rackets to skis to running shoes. Materials-driven improvements in equipment have helped athletes perform better, while enhancing safety and making sport more accessible and enjoyable. This book brings together a collection of 10 papers on the topic of sports materials, as published in a Special Issue of Applied Sciences. The papers within this book cover a range of sports, including golf, tennis, table tennis and baseball. State-of-the-art engineering techniques, such as finite element modelling, impact testing and full-field strain measurement, are applied to help further our understanding of sports equipment mechanics and the role of materials, with a view to improving performance, enhancing safety and facilitating informed regulatory decision making. The book also includes papers that describe emerging and novel materials, including auxetic materials with their negative Poisson’s ratio (fattening when stretched) and knits made of bamboo charcoal. This collection of papers should serve as a useful resource for sports engineers working in both academia and industry, as well as engineering students who are interested in sports equipment and materials.

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