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Microbial polysaccharides represent an attractive alternative to those from plants or macro algae. They can be produced from renewable sources including lignocellulosic waste streams. Their production does not depend on geographical constraints and/or seasonal limitations. Additionally the manipulation of biosynthetic pathways to enhance productivity or to influence the chemi-cal polysaccharide composition is comparatively easy in bacteria. Microbial exopolysaccharides represents a valuable resource of biogenic and biodegradable polymers, suitable to replace petro based polymers in various technical applications. Furthermore, biocompatible exopolysaccha-rides are very attractive in medical applications, such as drug delivery systems, use as vaccines or nanoparticles. This research topic will depict the status quo, as well as the future needs in the field of EPS and biofilm research. Starting from the unexplored diversity of microbial polysaccharide producers to production processes and possibilities for modifications, to enhance the already high number of functionalities based on the chemical structures. An overview of the recent and future applications will be given, and the necessity in unravelling the biosynthesis of microbial exopolysaccharide producers is depicted, highlighting the future trend of tailor made polymers. Constraints in structure analysis of these highly complex biogenic polymers are described and different approaches to solve the restrictions in imaging and NMR analysis will be given. Therefore; this research topic comprises the whole process from genes to applications.
Microbial polysaccharides --- exopolysaccharide biosynthesis --- alginate --- polysaccharide modifying enzymes --- polysaccharide applications --- biofilm --- structural analysis of polysaccharides --- screening for microbial exopolysaccharide producers --- tailor made exopolysaccharides --- rare sugars
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Oceans include the greatest extremes of pressure, temperature and light, and habitats can range from tropical waters to ocean trenches, several kilometers below sea level at high pressure. With its 70% of the surface of our planet marine ecosystem still remains largely unexplored, understudied and underexploited in comparison with terrestrial ecosystems, organisms and bioprocesses. The biological adaptation of marine organisms to a wide range of environmental conditions in the specific environment (temperature, salinity, tides, pressure, radiation, light, etc.) has made them an enormous reservoir of interesting biological material for both basic research and biotechnological improvements. As a consequence marine ecosystem is valued as a source of enzymes and other biomolecules exhibiting new functions and activities to fulfill human needs. Indeed, in recent years it has been recognised as an untapped source of novel enzymes and metabolites even though, with regard to the assignment of precise biological functions to genes, proteins and enzymes, it is still considered as the least developed. Using metagenomics to recover genetic material directly from environmental samples, this biogenetic diversification can be accessed but despite the contributions from metagenomic technologies the new field requires major improvements. A few words on the complexity of marine environments should be added here. This complexity ranges from symbiotic relationships to biology and chemistry of defence mechanisms and from chemoecology of marine invasions up to the strategies found in prokaryotes to adapt to extreme environments. The interdisciplinary study of this complexity will enable researchers to find an arsenal of enzymes and pathways greatly demanded in biotechnological applications. As far as marine enzymes are concerned they may carry novel chemical and stereochemical properties, thus biocatalytically oriented studies (testing of suitable substrates, appropriate checking of reaction conditions, study of stereochemical asset of catalysis) should be performed to appropriately reveal this “chemical biodiversity” which increases interest for these enzymes. Among other biomolecules, polysaccharides are the most abundant renewable biomaterial found on land and in oceans. Their molecular diversity is very interesting; except polysaccharides used traditionally in food and non-food industries, the structure and the functionality of most of them are unknown and unexplored. Brown seaweeds synthesize unique bioactive polysaccharides: laminarans, alginic acids and fucoidans. A wide range of biological activities (anticoagulant, antitumor, antiviral, anti-inflammation, etc.) have been attributed to fucoidans and their role with respect to structure-activity relationship is still under debate. In this Research Topic, we wish to centralize and review contributions, idea and comments related to the issues above. In particular results of enzymatic bioprospecting in gross marine environment will be acknowledged along with research for structural characterization and biological function of biomolecules such as marine polysaccharides and all kind of research related to the complexity of bioprocesses in marine environments. Inter- and multi-disciplinary approach to this field is favoured in this Research Topic and could greatly be facilitated by the web and open access nature as well.
Marine enzymes --- marine polysaccharides --- marine bioprocesses --- algae and microalgae --- Biofuels --- Marine Natural Products --- Olfaction --- Biodiversity --- triterpene glycosides --- sulfatase
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The cell surface of fungi, bacteria and sea organisms is highly glycosylated. These glycans are oligo- or polysaccharide molecules that can be secreted or attached to protein or lipids forming glycoconjugates. They present extraordinary structural diversity that could explain their involvement in many fundamental cellular processes, including growth, differentiation and morphogenesis. Considerable advances have been made on the structural elucidation of these glycans. Their primary structures were determined based on a combination of mass spectrometry and NMR spectroscopy techniques. The combination of these sensitive and powerful techniques has allowed us to increase our structural knowledge of a wide variety of glycans expressed by different fungi, bacteria and sea organisms.
Fungal pathogens --- sea organisms --- fungal glycoconjugates --- sulfated polysaccharides --- NMR --- Mass Spectrometry --- Adhesion --- Plant-Bacterium Interaction --- carbohydrate-based drug development --- Pattern Recognition Receptors --- innate immunity
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Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.
rutin oligomers --- laccase activity --- aqueous solubility --- antioxidant activity --- xanthine oxidase inhibition --- MALDI-TOF --- HPSEC --- glycosyltransferase --- glycodiverfication --- sulfuretin --- OcUGT1 --- amine transaminases --- asymmetric synthesis --- benzoxathiepins --- biocatalysis --- biotransamination --- stereoselective synthesis --- esterase --- stereoselective --- ester hydrolysis --- antimuscarinic agents --- pig liver esterase (PLE) --- microalgae --- Spirulina --- Alcalase® --- amino acid --- extraction --- nutraceutical --- cholesterol --- coprostanol --- reduction reaction --- bacteria --- metabolic pathways --- biocatalysis --- biotransformations --- statins --- pleiotropic effects --- photooxidation --- cascade --- alcohol --- reductive amination --- ?-transaminase --- lyases --- chondroitin sulfates --- glycosaminoglycan --- polysaccharides --- Ribavirin --- Tecadenoson --- Cladribine --- purine nucleoside phosphorylase --- transglycosylation reaction --- 7-methylguanosine iodide --- 7-methyl-2?-deoxyguanosine iodide --- 7-methylguanine arabinoside iodide --- biocatalysis --- glycosidases --- chitinases --- chitosanases --- chitosan oligosaccharides --- deacetylation degree --- anti-inflammatory --- n/a
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The bioeconomy initially focused on resource substitution, including the production of biomass from various resources; its conversion, fractionation, and processing by means of biotechnology; and chemistry and process engineering towards the production and marketing of food, feed, fuel, and fibre. Nevertheless, although resource substitution is still considered important, the emphasis has been recently shifted to the biotechnological innovation perspective of the bioeconomy, in terms that ensure environmental sustainability. It is estimated that around one-third of the food produced for human consumption is wasted throughout the world, posing not only a sustainability problem related to food security but also a significant environmental problem. Food waste streams, mainly derived from fruits and vegetables, cereals, oilseeds, meat, dairy, and fish processing, have unavoidably attracted the interest of the scientific community as an abundant reservoir of complex carbohydrates, proteins, lipids, and functional compounds, which can be utilized as raw materials for added-value product formulations. This Special Issue focuses on innovative and emerging food and by-products processing methods for the sustainable transition to a bioeconomy era.
blood plasma protein powder --- heat-induced gelation --- drying method --- ash content --- texture --- arabinoxylan --- films --- biodegradability --- hydrophilicity --- food packaging --- sustainability --- clarified butter sediment waste --- hydrophobic substrates --- oleaginous yeast --- lipids --- biodiesel --- fatty acid methyl esters --- Morchella --- morel mushrooms --- bioprocess development --- solid state fermentation --- food processing --- glucosamine --- polysaccharides --- bioactive compounds --- emulsifier --- olive waste --- size exclusion chromatography (SEC) --- emulsion --- compost --- Ostwald ripening --- glucoamylase --- sorghum milling waste --- submerged fungal fermentation --- Aspergillus awamori --- hydrolysis --- waste valorization --- food-processing --- circular economy --- bioprocess development --- Rhodosporidium toruloides --- microbial oil --- oleic acid --- food processing --- integrated biorefineries --- circular-economy --- whey proteins --- lactose esters --- prebiotics --- hydrogels --- edible films --- bacterial cellulose --- carotenoids --- biorefineries --- circular economy --- bioeconomy --- food processing --- food biotechnology --- bioprocesses --- bioactive compounds --- food waste valorization --- sustainability
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Natural products and the preparations based on them play a stable and ever-increasing role in human and veterinary medicine, agriculture, in food and the cosmetic industry, and in an increasing number of other fields. Their importance is based on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, inter alia. At the same time, natural products provide the origin of stereochemistry, optical activity, regioselectivity, chirality, and many other concepts and directions within science, development, and industry in a scope, which is indispensable. They serve as a constant powerful stimulus and model that inspires researchers to create new effective tools, similar to natural ones, for controlling bioregulation mechanisms and solving practical problems. This was the reason for organizing this Special Issue aimed at underlining the current developments in all the fields connected to natural products.
insect sex pheromone --- tea tussock moth --- total synthesis --- resource chemistry --- phycocyanin --- biosynthesis --- antioxidant --- Spirulina --- gene expression --- apo-CpcB --- Plantago depressa --- octadecanoid --- fatty acid --- natural enantiomer --- anti-inflammation --- soy protein isolate --- bromelain --- triglycidylamine --- viscosity --- water resistance --- adhesive --- Ramulus mori --- polysaccharides --- bioactivity --- synthesis of natural products --- varioxiranol A --- 4-epi-varioxiranol A --- absolute structure --- Emericella variecolor --- caffeoylquinic acids --- chlorogenic acid --- derivatives --- lipid-lowering effects --- oleic acid-elicited --- HepG2 cells --- isosorbide --- reversible urethane linkages --- cell opening --- antioxidant activity --- radical scavenger --- flexible polyurethane foam --- tomato --- SlCOMT1 --- melatonin --- genetical transformation --- salt stress --- natural product --- RiPP --- ribosomally synthesized --- post-translationally modified peptides --- rheumatoid arthritis --- natural products --- polyphenol --- flavonoids --- phenolic acid --- stilbene --- ginkgolide --- platelet-activating factor receptor --- inhibitor --- pinocembrin --- microbial biosynthesis --- pharmacological activities --- pharmacokinetic features --- research progress --- triterpenoids --- bardoxolone methyl --- anticancer drug --- mitochondria --- apoptosis --- cancer cells --- cytotoxicity --- flow cytometry --- live-cell fluorescence microscopy --- PEGylated purpurin 18 --- photodynamic therapy --- photosensitizer --- phototoxicity --- singlet oxygen --- n/a
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Seaweeds are recognized as highly nutritious, and their use in gastronomy is increasing. Their health benefits and their potential to prevent several diseases have also been established. In this Special Issue several health effects are discussed, with more emphasis on their antitumor activity and potential use to treat Alzheimer’s disease. The key bioactive metabolites, from which phlorotannins can be highlighted, are presented, as well as some important in vivo studies. Altogether, the chapters provide in-depth information about the biological activities of seaweed metabolites, contributing to elucidate the health effects of seaweed.
Padina pavonica --- osteosarcoma --- apoptosis --- algae --- chemo-preventive agent --- phytol --- fucosterol --- fatty acid --- laurinterol --- Laurencia --- antitumoral --- breast cancer explants --- organotypic culture --- ex vivo --- phlorotannin --- eckmaxol --- high-speed counter-current chromatography --- NMR spectroscopy --- mass spectrometry --- isolation and purification --- Ecklonia maxima --- fucoidan --- age-related macular degeneration --- VEGF --- oxidative stress --- Saccharina latissima --- Fucus vesiculosus --- Fucus distichus subsp. evanescens --- Fucus serratus --- Laminaria digitata --- Symphyocladia latiuscula --- bromophenols --- mushroom tyrosinase --- B16F10 --- melanin --- red seaweed --- bioactives --- extraction --- biorefinery --- seaweed --- gut microbiota --- prebiotics --- dietary fibre --- complex polysaccharides --- polyphenols --- polyunsaturated fatty acids --- carotenoids --- phytochemicals --- Padina pavonica --- marine algae --- osteoporosis --- bone metabolism --- bone health --- nutraceutical --- Bifurcaria bifurcata --- linear diterpenes --- extraction --- identification --- biological activities --- macroalgae --- high value applications --- phlorotannin --- amyloid-? aggregation --- insulin glycation --- dynamic simulation --- kidney --- ischemia-reperfusion injury --- Ecklonia cava --- phlorotannins --- Alzheimer’s disease --- seaweeds --- cholinesterases --- beta-secretase --- beta-amyloid aggregation --- neuroprotection --- K14HPV16 --- genotoxicity assay --- papillomavirus --- cancer --- seaweeds --- hyperpigmentation --- skin aging --- skincare --- photo-protection --- seaweeds --- secondary metabolites --- in vivo studies --- clinical trials --- health effects --- dieckol --- eckol --- fucoxanthin --- kahalalide F
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This Special Issue Book ""Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms"" is aimed at collecting literature on the below-mentioned keyword topics, which can significantly increase our basic understanding of marine-derived compounds in cosmeceutical product development and increases the value of marine products at the industrial level.
Ecklonia stolonifera --- phlorotannin --- Fucofuroeckol-A --- anti-allergy --- degranulation --- mast cells --- Hizikia fusiforme --- sulfated polysaccharides --- ultraviolet-B --- MMPs --- NF-?B --- AP-1 --- MAPKs --- skin-aging --- UVB --- low molecular-weight --- fucoidan --- antioxidant --- anti-inflammation --- MMP --- miiuy croaker (Miichthys miiuy) --- scale --- acid-soluble collagen (ASC) --- pepsin-soluble collagen (PSC) --- antioxidant activity --- radical scavenging activity --- natural --- bioactive --- marine algae --- photoprotective --- substances --- marine algae --- carbohydrates --- oligosaccharides --- monosaccharides --- skin health --- cosmeceuticals --- marine collagen peptide --- collagen hydrolysates --- antioxidant --- cosmetics --- inflammation --- Biological Effective Protection Factors (BEPFs) --- mycosporine-like amino acids --- photoprotection --- pH-thermo stability --- UV- mediated action spectra --- mycosporine-like amino acids --- mycosporine-2-glycine --- UV-absorbing compound --- sunscreen --- anti-aging --- anti-oxidation --- anti-inflammation --- anti-protein-glycation activity --- keratinocytes --- 3-bromo-4,5-dihydroxybenzaldehyde --- heme oxygenase-1 --- nuclear factor erythroid 2-related factor 2 --- cytoprotection --- ageing --- 9-cis-?-carotene --- mitochondrial function --- mobility --- lifespan --- Drosophila melanogaster --- microalgae --- Dunaliella salina
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Algae have been used since ancient times as food for humans, animal feed, agricultural fertilizer, and as a source of substances for therapeutic use. Currently, seaweed represents a vast source of raw materials used in the pharmaceutical, food, traditional medicine, and cosmetics industries. They are nutritionally valuable, both fresh and dried, or as ingredients in a wide variety of pre-made foods. In particular, seaweed contains significant amounts of protein, lipids, minerals, and vitamins. Information is limited on the role of algae and their metabolites in therapy. Only a few taxa have been studied for use in medicine. Many traditional cultures report the healing powers of selected algae in tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. However, currently, only a few genera and species of algae are involved in aspects of medicine and therapy. The beneficial uses of seaweed or seaweed products include those that can mimic specific manifestations of human disease, production of antibiotic compounds, or improved human nutrition.
low molecular weight fucoidan --- Mycoplasma pneumoniae --- NK cell --- antigen-specific antibody --- adjuvant --- Osmundea pinnatifida --- Sargassum muticum --- enzymatic extracts --- minerals --- mono and polysaccharides --- FTIR-ATR --- NMR --- cytotoxicity --- Ulva rigida --- ulvan --- chemical sulfation --- anticoagulant activity --- alginate --- Cystoseira barbata --- Black Sea --- heavy metals adsorption --- diffusion model --- phlorotannin --- particulate matter --- reactive oxygen species --- keratinocytes --- alkaline phosphatase --- Ecklonia cava --- phlorofucofuroeckol A --- osteoblast --- huBM-MSC --- seaweeds --- chlorophylls --- carotenoids --- n-3 PUFAs --- EPA --- marine algae --- macro algae --- bromophenols --- HPLC --- quantification --- isolation --- raw laver --- processed laver product --- edible seaweed --- nutritional value --- functional substance --- health functionality --- processing technology --- microbial risk --- chemical risk --- omics-based technology --- macroalgae/seaweed --- natural resources --- health --- food --- feed --- agriculture --- carrageenan --- TC --- HDL-C --- LDL-C --- TC reduction --- TG --- antitumour activity --- carrageenan --- colorectal cancer --- cancer stem cells --- n/a
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Due to increasing global food needs as a result of population growth, the use of new food sources has gained interest in the last decade. However, the inclusion of new foods in our diet, as well as the increased interest of the population in consuming foods with better nutritional properties, has increased the need for adequate food analytical methods. This monographic issue presents innovative methods of chemical analysis of foods, as well as the nutritional and chemical characterization of foods whose consumption is expected to increase worldwide in the coming years.
refined commercial salmon oil --- n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) concentration --- EPA --- DHA --- EPA+DHA --- total FA yield --- process variable maximization --- response surface methodology (RSM) --- multiple response optimization --- desirability function --- avocado oil --- oil extraction --- antioxidants compounds --- fatty acid profile --- water holding capacity --- seaweeds --- Gracilaria --- carbohydrates --- fatty acids --- vitamins --- deep eutectic solvents --- Artemisia argyi leaves --- phenolic acids --- extraction --- response surface methodology --- amaranth protein --- flavourzyme --- alcalase --- bioactive peptides --- hydrolysates --- N-carbamylglutamate --- feeds --- animal products --- milk --- HPLC-MS/MS --- acrylamide --- crisps --- temperature --- frying time --- blanching --- thickness --- scorpion (Buthus martensii Karsch) protein --- ultrasonic extraction --- response surface methodology --- scanning electron microscopy --- functional properties --- Amazonian fruits --- antioxidant --- phenolic compounds --- UPLC-MSE --- bioactive compounds --- prebiotic --- polysaccharides --- seaweed --- Rhodophyceae --- Phaeophyceae --- Chlorophyceae --- n/a
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