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Building Strategies for Porcine Cancer Models

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456505 Year: Pages: 75 DOI: 10.3389/978-2-88945-650-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2019-01-23 14:53:43
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The eBook "Building Strategies for Porcine Cancer Models" presents a series of articles demonstrating the state-of-the-art developments in pig models for cancer research. Renowned researchers dedicated to the reproduction, genomic and biological engineering of the pig model for biomedicine contribute to this special research area. Although advances in these areas are occurring at surprising speeds, they are still far from realizing all the potential benefits that this biological model could provide to science. The current biomedical models may limit the frontier of knowledge in the cancer research.

Environmental Enrichment of Pigs

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ISBN: 9783039280780 9783039280797 Year: Pages: 174 DOI: 10.3390/books978-3-03928-079-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2020-04-07 23:07:08
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Pigs have a strong motivation to explore and root. In conventional pig husbandry systems, this need is difficult to fulfil, unless adequate enrichment materials are provided. This book summarises how enrichment strategies for pigs have evolved over the last few decades in different countries and provides a vast array of possibilities to enhance the exploratory needs of pigs. The role of enrichment material on avoidance of tail biting outbreaks or as an element triggering positive emotions in pigs is also discussed.

Tracing the Melanesian Person: Emotions and Relationships in Lihir

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ISBN: 9781922064448 Year: Pages: 324 DOI: 10.20851/lihir Language: English
Publisher: University of Adelaide Press
Added to DOAB on : 2013-05-01 09:31:29
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Through this engaging ethnographic account of connections, conflicts and loss in Lihir, Hemerâ s own fieldwork journey of making relationships, experiencing disputes and finally leaving the field, is mirrored. Structured into three parts, the book works through the complexities of creating and sustaining relationships, the evaluation of conduct as moral and the practices of conflict, and the experiences and transformations of death and grief. Throughout these parts various emotions are highlighted and interrogated for their relationship to psychological understandings and definitions: love, anger, jealousy, sadness. Emotions are also understood in a historical context and as connected to social changes wrought by interactions with global phenomena such as religion.

One Health and Zoonoses

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ISBN: 9783039212958 9783039212965 Year: Pages: 140 DOI: 10.3390/books978-3-03921-296-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Public Health
Added to DOAB on : 2019-12-09 16:10:12
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The One Health concept recognizes that the health of humans, animals, and their ecosystems are interconnected, and that a coordinated, collaborative, multidisciplinary, and cross-sectoral approach is necessary to fully understand and respond to potential or existing risks that originate at the animal–human–ecosystems interfaces. Thus, the One Health concept represents a holistic vision for addressing some of the complex challenges that threaten human and animal health, food safety, and the environments in which diseases flourish. There are many examples showing how the health of humans is related to the health of animals and the environment. Diseases shared between humans and animals are zoonoses. Some zoonoses have been known for many years, whereas others have emerged suddenly and unexpectedly. Over 70% of all new emerging diseases over the past few decades have been zoonoses that have emerged from wildlife, most often from bats, rodents, or birds. Examples of zoonoses are many and varied, ranging from rabies to bovine tuberculosis, and from Japanese encephalitis to SARS. Clearly, a One Health approach is essential for understanding their ecology, and for outbreak response and the development of control strategies. However, the One Health concept and approach is much broader than zoonoses; it extends to including antimicrobial resistance, food safety, and environmental health and, consequently, impacts on global health security, economic wellbeing, and international trade. It is this breadth of One Health that connects the papers in this Special Issue.

Positive Aspects of Animal Welfare

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ISBN: 9783039285327 / 9783039285334 Year: Pages: 180 DOI: 10.3390/books978-3-03928-533-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2020-06-09 16:38:57
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Comfort during resting, half-closed eyes when feeding on highly palatable feed, or vigorous tail wagging when being brushed are some of the positive indicators that can be used to evaluate the quality of the environment in which domestic animals live. This has been a radical shift from the past as, until now, the welfare assessment on farms has meant assessing negative indicators, namely the number of lame animals, presence of lesions, or frequency of agonistic behaviours. However, the latest research confirms that the absence of a problem or of suffering does not necessarily imply that the animals are experiencing a good life and that their level of welfare is high. To guarantee high welfare standards, animals should experience positive conditions that allow them to live a “life worth living”, and positive indicators are needed to identify these conditions. This Special Issue focuses on the development and validation of indicators of positive welfare or on the refinement of the existing ones, as well as on the identification of suitable living conditions for providing positive welfare to farmed and companion animals.

Effects of Mycotoxins on the Intestine

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ISBN: 9783038977827 9783038977834 Year: Pages: 262 DOI: 10.3390/books978-3-03897-783-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-05-09 17:16:14
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Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.

Keywords

mice --- aflatoxin B1 --- intestinal bacterial flora --- response --- Clostridium sp. WJ06 --- deoxynivalenol --- pig --- intestinal morphology --- microbial diversity --- aflatoxin M1 --- ochratoxin A --- intestinal epithelial cells --- tight junction --- permeability --- ileum --- jejunum --- deoxynivalenol --- piglet --- contaminated feed --- tight junction --- aflatoxin B1 --- small intestine --- histopathological lesions --- ultrastructural changes --- toll-like receptors --- T-2 toxin --- enteric nervous system --- pig --- vasoactive intestinal polypeptide --- mycotoxins --- zearalenone --- deoxynivalenol --- histology --- ultrastructure --- large intestine --- pig --- Claviceps --- liver --- digestive tract --- mycotoxin --- sclerotia --- ergot alkaloids --- toxicity --- deoxynivalenol --- Saccharomyces cerevisiae boulardii CNCM I-1079 --- intestine --- transcriptome --- inflammation --- oxidative stress --- lipid metabolism --- fumonisin --- microbiota --- pigs --- MiSeq 16S rDNA sequencing --- intestinal microbiota --- hydrogen-rich water --- lactulose --- Fusarium mycotoxins --- piglets --- functional oligosaccharides --- mycotoxins --- swine --- explant technique --- intestinal morphology --- goblet cells --- deoxynivalenol --- zearalenone --- pig --- colon microbiota --- Lactobacillus --- detoxification --- zearalenone --- doses --- caecal water --- genotoxicity --- pre-pubertal gilts --- atlantic salmon --- deoxynivalenol --- feed --- intestine --- PCR --- proliferating cell nuclear antigen --- suppressor of cytokine signaling --- tight junctions --- Zearalenone --- N-acetylcysteine --- SIEC02 cells --- Mitochondrial apoptosis --- n/a

Human and Animal Sensitivity: How Stock-People and Consumer Perception Can Affect Animal Welfare

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ISBN: 9783039212613 9783039212620 Year: Pages: 234 DOI: 10.3390/books978-3-03921-262-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2019-12-09 11:49:15
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This book presents cross-discipline studies covering aspects ranging from animal science to social/consumer sciences and psychology, with the aim to collect and disseminate information promoting the continuous enhancement of animal welfare by improving stakeholders’ perception of animal welfare. Although animal welfare is about how the animals perceive the surrounding environment, the actual welfare of the animals is dependent on how the stakeholders perceive and weigh animal welfare. The stakeholders can, either directly (i.e., through stock-people interaction with the animals) or indirectly (e.g., when retailers and consumers are willing to pay more for high welfare animal-based products), affect the way animals are kept and handled.

Keywords

veterinary student --- animal ethics --- pain perception --- animal --- animal welfare --- Animal welfare --- husbandry practices --- lambs --- pain --- sheep farmers --- perception --- agreement --- aggression --- animal welfare --- desensitization --- perception --- pigs --- animal welfare --- young adult --- animal attitudes --- children --- farm animals --- animal welfare --- education --- technology --- animal welfare --- Asia --- knowledge --- slaughter --- transport --- training --- animal welfare --- benefit --- profit --- human health --- Asia --- livestock --- farmer perception --- citizen perception --- qualitative research --- free elicitation narrative interviews --- animal welfare --- consumer --- willingness to pay --- pig --- castration --- immunocastration --- information --- survey --- human-animal relationship --- fear --- laying hen --- stockpeople attitudes --- stockperson behaviour --- egg farm --- albumen corticosterone --- welfare --- animal welfare --- stakeholder perception --- text mining --- horse --- donkey --- goat --- sheep --- turkey --- farm animal welfare (FAW) --- willingness to pay --- food safety concerns --- ethical concerns --- perceived consumer effectiveness --- broiler --- dairy buffalo --- human-animal relationship --- animal behavior --- test-retest reliability --- avoidance distance --- milk production --- animal welfare --- animal welfare --- stunning --- religious slaughter --- veterinary students --- Halal meat --- racehorse welfare --- staff shortages --- horse–human relationship --- standards of care --- employee relations --- consumer demand --- economics --- farm animal welfare --- producer perspective

Major Histocompatibility Complex (MHC) in Health and Disease

Authors: --- ---
ISBN: 9783039280728 9783039280735 Year: Pages: 375 DOI: 10.3390/books978-3-03928-073-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-04-07 23:07:08
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The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

Keywords

MHC-I- and MHC-II-dependent inter-individual recognition --- MHC-II-associated sperm-egg recognition --- MHC-I-based mother-fetus recognition --- giant panda --- long-fragment super haplotype --- MHC --- genetic drift --- haplotype --- crested ibis --- founder effect --- bottleneck --- conservation genetics --- selection --- fish --- MHC --- polymorphism --- disease resistance --- quantitative trait loci (QTL) studies --- evolution --- HCP5 --- lncRNA --- MHC --- HLA --- human endogenous retrovirus (HERV) --- cancer --- autoimmune diseases --- competing endogenous RNA (ceRNA) --- human immunodeficiency virus (HIV) --- human papillomavirus (HPV) --- astrogliosis --- PNS/CNS interface --- microglial reaction --- synaptic covering --- ?2m knockout mice --- HLA-B27 --- viral peptides --- computational analysis --- ankylosing spondylitis --- KIR --- KIR–HLA pairs --- ethnic populations in China --- molecular dynamics simulation --- major histocompatibility complex --- antigen --- T-cell receptor --- domain movements --- autoimmunity --- risk genes --- expression --- regulation --- swine leukocyte antigen --- reproductive performance --- production trait --- haplotype --- micro-mini-pigs --- disease association --- haplotype --- HLA polymorphism --- major histocompatibility complex (MHC) --- pedigree --- phase --- protocol --- single nucleotide polymorphism (SNP) --- T1DGC --- type 1 diabetes (T1D) --- BK virus --- polyomavirus --- nephropathy --- human leukocyte antigen-E --- kidney transplantation --- MHC --- ancestral haplotype --- autoimmune disease --- cynomolgus macaque --- Macaca fascicularis --- MHC polymorphism --- experimental medicine --- nonhuman primate models --- DXO --- DOM3Z --- NELF-E --- RD --- SKIV2L --- SKI2W --- STK19 --- RP1 --- NSDK --- RLR --- miR1236 --- SVA --- RNA quality control --- 5??3? RNA decay --- 3??5? mRNA turnover --- antiviral immunity --- interferon ? --- promoter-proximal transcriptional pause --- exosomes --- nuclear kinase --- hepatocellular carcinoma --- Ski complex --- trichohepatoenteric syndrome --- melanoma --- major histocompatibility complex --- MHC --- evolution --- nonclassical --- fish --- MHC genes --- birds --- disease resistance --- orthology --- life history --- gene duplication --- long-read sequencing --- high-throughput sequencing --- concerted evolution --- ecology --- MHC --- major histocompatibility complex --- Old World camels --- camels --- dromedary --- Bactrian camel --- SNP --- n/a

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