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Genetic Determinants of Human Longevity

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ISBN: 9783039216789 9783039216796 Year: Pages: 118 DOI: 10.3390/books978-3-03921-679-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes.

The Origin and Early Evolution of Life: Prebiotic Chemistry of Biomolecules

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ISBN: 9783039216062 9783039216079 Year: Pages: 288 DOI: 10.3390/books978-3-03921-607-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:16
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Studying the origin of life is one of man’s greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems.

Keywords

origin of life --- systems chemistry --- Chemomimesis --- Molecular Darwinism --- origin of life --- prebiotic chemistry --- thiol-rich peptides --- cysteine --- aminonitriles --- imidazoles --- origin of life --- prebiotic chemistry --- nucleotide and nucleoside synthesis --- protein design --- novel metalloproteins --- binary patterned amino acid sequences --- prebiotic chemistry --- population growth --- replication --- growth order --- Darwinian evolution --- selection --- origin of life --- abiogenesis --- carbon fixation --- hydrothermal vents --- electrochemistry --- reduction --- digit multiplicity --- information --- transmission --- encoding --- translation --- diversity --- function --- origin of life --- layered double hydroxide (LDH) clay --- pentose diphosphate --- pentopyranose nucleic acid --- arabinopyranose nucleic acid --- RNA --- base pairing --- purine precursor --- inosine --- AICAR --- peptide/RNA world --- prebiotic information system --- translation and the genetic code --- bridge peptide and aaRS --- ribozyme and tRNA --- tRNA and mRNA --- coevolution of translation machine and the genetic code --- MVC architecture pattern and biological information --- numerical codons --- AnyLogic software for computer simulation of translation machine --- phosphoryl transfer --- metabolism --- energy currency --- mixed anhydride --- origin of life --- hypercycle --- Monte Carlo --- prebiotic chemistry --- carbamic acid --- carbon dioxide-ammonia ices --- infrared spectra --- anharmonicity --- origin of life --- metabolism --- phosphates --- network expansion simulation --- thermodynamic bottleneck --- molecular clocks --- ab initio molecular dynamics --- catalysis --- prebiotic soup --- origins of life --- aldol reaction --- mechanochemistry --- minerals --- monosaccharides --- prebiotic chemistry --- prebiotic polymerization --- nucleotide oligomerization --- abasic oligomers --- nucleotide stability --- stability as a selection pressure --- dry-wet cycles --- genetic code origin --- tRNA accretion model --- tRNA-synthetase --- metabolism --- thioester --- nucleotidyltransferases --- early peptides --- ribosome --- n/a

Biomaterials and Implant Biocompatibility

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ISBN: 9783039282166 9783039282173 Year: Pages: 420 DOI: 10.3390/books978-3-03928-217-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Physics (General) --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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The scientific advances in life sciences and engineering are constantly challenging, expanding, and redefining concepts related to the biocompatibility and safety of medical devices. New biomaterials, new products, and new testing regimes are being introduced to

Keywords

carbonate apatite --- hydroxyapatite --- ?-tricalcium phosphate --- artificial bone substitute --- crystallite size --- dissolution rate --- hybrid dog --- bone levels --- dental implants --- neck design --- soft tissue dimensions --- peri-implantitis --- biofilm --- dental implants --- in vitro model --- MSN --- biopolymer --- drug delivery system --- in vitro kinetic studies --- articular cartilage defect --- bioplolymers --- C-reactive protein --- haptoglobin --- in vivo testing --- serum amyloid A --- serum protein fractions --- sheep --- contact lens --- materials --- biomedical implant --- smart dentin grinder --- autogenous particulate dentin graft --- tooth graft --- ground teeth --- human teeth --- bone grafts --- autologous graft --- dolomitic marble --- seashell --- CaCO3 derived-calcium phosphates --- modulated synthesis set-up --- SEM --- image analysis --- pre-osteoblasts --- titanium implants --- dental implants --- antibacterial coating --- gentamicin --- silver --- zinc --- cytotoxicity --- MC3T3-E1 --- Staphylococcus aureus --- plasma chemical oxidation --- bone infection --- local drug delivery --- bone graft --- demineralized bone matrix --- gentamicin --- regeneration --- colon cancer cells --- copper ions --- hydrogel sphere --- sodium alginate --- polyethyleneimine --- surface modification --- biocompatible metals --- coating techniques --- hydroxyapatite --- real-time live-cell imaging technology --- in vitro study --- biocompatibility --- 3D printing --- flow cytometry --- adipogenic mesenchymal stem cells --- porous SHS TiNi --- biocompatibility --- rheological similarity --- corrosion resistance --- bone substitution --- superparamagnetic scaffold --- composite --- laser direct writing --- static magnetic field --- extracellular matrix mineralization --- bone tissue engineering --- three-dimensional co-culture --- osteoblast --- endothelial cell --- microfiber scaffold --- osteogenesis --- angiogenesis --- tissue engineering --- diamond nanoparticles --- fish gelatin --- adipose-derived stem cells --- biocompatibility --- spaced TiO2 nanotubes --- osteoblast --- cell adhesion and morphology --- cell proliferation --- osteogenic differentiation --- protein–polymer matrices --- nanowelding --- single-walled carbon nanotubes --- point defects --- absorption --- laser radiation --- cell membrane --- mesenchymal stem cells --- osteogenic differentiation --- lactoferrin --- polymer composite --- bioceramics --- in vitro testing --- hydroxyapatite --- angiogenesis --- osteogenesis --- signaling pathways --- microRNA --- bioceramics --- bioactive glass --- hydroxyapatite --- root canal sealer --- bioactive glass --- mechanism --- caries --- review

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