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Physiology and Pathophysiology of Musculoskeletal Aging

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193905 Year: Pages: 87 DOI: 10.3389/978-2-88919-390-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2015-12-03 13:02:24
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Abstract

We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing.

Acupuncture – Basic Research and Clinical Application

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ISBN: 9783038972341 9783038972358 Year: Pages: 170 DOI: 10.3390/books978-3-03897-235-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2018-10-09 11:13:34
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This book focuses on the investigation, development, and modernization of acupuncture in basic research settings as well as in clinical applications. The book contains 13 chapters reporting the latest evidence-based results of acupuncture research and exploring acupuncture in general. Altogether, 44 authors from all over the world contributed to this book.

Research of Pathogenesis and Novel Therapeutics in Arthritis

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ISBN: 9783038970651 / 9783038970668 Year: Pages: 366 DOI: 10.3390/books978-3-03897-066-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.

Keywords

biosimilars --- Th9 lymphocytes --- rheumatoid arthritis --- infliximab --- rheumatoid arthritis --- bone erosion --- osteoblasts --- next-generation sequencing --- bioinformatics --- microRNA --- messenger RNA --- osteoarthritis --- cell signaling --- IL1? --- WNT --- antagonists --- computational modeling --- nitric oxide --- clodronate --- gene expression --- osteoarthritis --- progenitor cells --- SOX9 --- spondyloarthropathies --- inflammation --- mesenchymal stem cells --- visfatin --- IL-6 --- TNF-? --- osteoarthritis --- miR-199a-5p --- Epstein-Barr virus --- glycoprotein 42 --- rheumatoid arthritis --- shared epitope --- triptolide --- rheumatoid arthritis --- basic research --- clinical translation --- osteoarthritis (OA) --- articular cartilage --- molecular pathology --- therapeutics --- rheumatoid arthritis --- antibodies --- collagen --- glycosylation --- disease pathways --- therapy --- experimental arthritis --- TNF? --- etanercept --- infliximab --- adalimumab --- certolizumab pegol --- golimumab --- rheumatoid arthritis --- therapeutic antibody --- structure --- fraxinellone --- collagen-induced arthritis --- rheumatoid arthritis --- inflammatory arthritis --- osteoclastogenesis --- sclareol --- rheumatoid arthritis --- synovial cell --- collagen --- mice --- cytokines --- Th17 --- MAPK --- arthritis --- osteoarthritis --- rheumatoid arthritis --- small-molecule inhibitor --- chondrocytes --- tumor necrosis factor-alpha --- inflammation --- rheumatoid arthritis --- osteoarthritis --- angiogenesis --- cytokines --- chemokines --- early osteoarthritis --- articular cartilage --- proliferation --- fibroblast growth factor 2 --- mitogen activated protein kinase --- transforming growth factor ? --- SMA- and MAD-related protein --- interleukin --- nuclear factor kappa B --- miRNA --- adjuvant arthritis --- arthritis --- biomarkers --- celastrol --- inflammation --- microRNA --- miRNA --- rat --- rheumatoid arthritis --- Traditional Chinese medicine --- tripterine --- triterpenoid --- spinal fusion --- biological --- osteoblast --- osteoclast --- bisphosphonate --- parathyroid hormone --- bone morphogenetic protein --- receptor activator of nuclear factor ?B --- stem cell --- drug delivery system --- anticitrullinated peptide antibodies --- antirheumatic drug --- autoimmune --- disease-modifying --- immunology --- pathology --- rheumatoid factor --- rheumatoid arthritis --- osteoarthritis --- adipokines --- obesity --- rheumatoid arthritis --- osteoarthritis --- anti-arthritis --- biomarkers

Blood-Derived Products for Tissue Repair/Regeneration

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ISBN: 9783039218608 / 9783039218615 Year: Pages: 178 DOI: 10.3390/books978-3-03921-861-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:08:26
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This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.

Keywords

platelets --- burns --- growth factors --- platelet rich plasma --- quantification --- articular cartilage --- cartilage repair --- redifferentiation --- collagen hydrogels --- biologics --- hyperacute serum --- platelet-rich plasma --- fibrosis --- myoblasts --- myofibroblasts --- myogenesis --- Platelet-Rich Plasma (PRP) --- Platelet-Poor Plasma (PPP) --- satellite cells --- skeletal muscle regeneration --- stem cell niche --- regenerative medicine --- hyperacute serum --- platelet-rich plasma --- blood derived products --- composition --- meniscus --- meniscus repair --- meniscus tear --- trephination --- platelet-rich plasma --- PRP --- chronic meniscal lesion --- horizontal meniscal tear --- periosteal sheet --- platelet-rich fibrin --- growth --- differentiation --- bone grafting material --- PRGF --- Carprofen --- dog --- fracture --- bone healing --- wrist osteoarthritis --- microfat --- platelet-rich plasma --- cell therapy --- adipose tissue --- PRP --- knee arthrosis --- growth factors --- autologous platelet concentrates --- bone defects --- bone grafting --- bone regeneration --- furcation defects --- periodontal defects --- periodontal regeneration --- periodontal surgery --- platelet-rich plasma --- platelet-rich fibrin --- plasma rich in growth factors --- tissue healing --- corneal epithelial defect --- cornea regeneration --- serum eye drops --- plasma rich plasma (PRP) --- serum derived from plasma rich in growth factors (s-PRGF) --- hyaluronic acid (NaHA) --- wound healing --- bone regeneration --- bone repair --- fibrin sealant --- biomaterial --- photobiomodulation therapy --- low-level laser therapy --- n/a

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