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Farmaci oppioidi e Cannabis nella terapia del dolore

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Book Series: Phármakon ISBN: 9788868870256 Year: Volume: 2 Pages: 224 DOI: 10.6093/978-88-6887-025-6 Language: Italian
Publisher: FedOA - Federico II University Press
Subject: Therapeutics
Added to DOAB on : 2018-06-08 16:37:47
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Opioid and Cannabis in Pain Control is the result of studies performed by the Pharmacy Department and the “Centro Interdipartimentale di Ricerca in Farmacoeconomia e Farmacoutilizzazione” (CIRFF) of the University of Naples, “Federico II”. This book is aimed to those who work in a pharmacy and who, scholars, teachers or students, are interested in delve into the issue. The text analyzes different topics with an interdisciplinary approach. A large part is devoted to the chemical and pharmacological aspects related to this topic. Subsequently, the text focuses the theme, still very debated, of using opioids and Cannabis in therapy through an exhaustive analysis of the entire existing legislation: from the first laws promulgated by the Kingdom of Italy until the last ministerial circulars by Italian republic. Finally yet importantly, an important part of the book focuses on medical and therapeutic interpretation with regard to the effects on pain control, where opioids and Cannabis are not only a fruitful frontier of research, but also a consolidated and effective tool to counteract some types of pain

Keywords

Opioid --- Cannabis --- Pain control

Opioids: Addiction, Narrative, Freedom

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ISBN: 9781947447837 9781947447844 Year: Pages: 190 DOI: 10.21983/P3.0210.1.00 Language: English
Publisher: punctum books
Subject: Social Sciences
Added to DOAB on : 2019-03-26 11:21:04
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An epidemic is a feeling set within time as much as it is a matter of statistics and epidemiology: it is the feeling of many of us in the same desperate place at the same desperate time. Opioid epidemic thus names a present moment — at once historic and historical — centered on the substance of opioids as much as it names the urgency of all of us who are currently in proximity to these substances. What is the relationship between these historic and historical moments, the present moment, the history of pharmacological capitalism, and a set of repeated neurological activities, as well as human loss and desire, that has fueled the exponential rise in the rates of opioid use and abuse between 2000-2018? Opioids: Addiction, Narrative, Freedom is an auto-ethnography written from deep within—biologically within—this opioid epidemic. Tracing opioids around and through the bodies, governmental, and medical structures they are moving and being moved through, Opioids is an examination of what it means to live within an environment saturated with a substance of deep economic, political, neuroscientific, and pharmacological implications. From exploring media coverage of the epidemic and emerging medical narratives of addiction to detailing the legal inscription of differences between “pain patients” and people addicted to drugs, Opioids consistently asks: what is it like to live within an epidemic? What forms of freedom become possible when continually modulated by our physical experiences of the material proximities of an epidemic? How do you live with something for a long time

Low Back Pain: Recent Advances and Perspectives

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ISBN: 9783038426578 9783038426561 Year: Pages: 218 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-01-12 11:29:42
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This text will provide the most recent knowledge and advances in the area of chronic low back pain. The articles will range from topics such as the growing epidemic of chronic low back pain, to intervention for it, as well as specific biopsychosocial characteristics that can be used in its assessment, treatment, and outcomes monitoring.

Monitoring endogenous GPCRs: lessons for drug design

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196517 Year: Pages: 134 DOI: 10.3389/978-2-88919-651-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2016-08-16 10:34:25
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G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them specifically and single out their response to physiological or drug-elicited stimulations. Hence, studies mostly focused on recombinant receptors expressed in a variety of cellular models that do not always closely reflect the receptor natural environment and often deal with levels of expression exceeding by far physiological ranges. Recent technological developments combining for example genetically modified animals and advanced imaging approaches have improved our ability to visualize endogenous GPCRs. To date, trailing receptor activation, subsequent intracellular redistribution, changes in signaling cascade up to integrated response to a drug-elicited stimulation is at hand though the impact of a physiological challenge on receptor dynamics remains a major issue. Data however suggest that the receptor may embrace a different fate depending on the type of stimulation in particular if sustained or repeated. This suggests that current drugs may only partially mimic the genuine response of the receptor and may explain, at least in part, their secondary effects. Commonalities and specificities between physiological and drug-induced activation can thus represent valuable guidelines for the design of future drugs.

Implementing Pediatric Integrative Medicine in Practice

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ISBN: 9783038977629 9783038977636 Year: Pages: 204 DOI: 10.3390/books978-3-03897-763-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Pediatrics --- Medicine (General)
Added to DOAB on : 2020-01-30 16:39:46
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This Special Issue provides an overview of pediatric integrative medicine, an emerging field that blends conventional and evidence based complementary therapies with an emphasis on preventive health and wellbeing.

Keywords

burnout --- pediatrics --- residents --- preventive lifestyle behaviors --- resilience --- headache --- migraine --- integrative medicine --- complementary therapies --- pediatric --- mind-body --- clinic model --- multidisciplinary --- implementation --- mindful eating --- obesity --- adolescents --- Kneipp --- kindergarten --- PIMR --- pediatric integrative nursing --- program development --- pediatric blood and marrow transplant --- integrative medicine --- hypnosis --- mindfulness --- biofeedback --- acupuncture --- yoga --- guided imagery --- self-regulation --- complementary --- education --- pediatric integrative medicine --- vision --- clinical practice --- education --- advocacy --- complementary therapies --- qualitative --- mindfulness --- meditation --- chronic illness --- adolescents --- eHealth --- integrative medicine --- pediatrics --- clinical practice --- n/a --- infant --- premature --- pain --- acupuncture --- skin-to-skin contact --- sucrose --- massage --- musical therapy --- breastfeeding --- Integrative therapies --- art therapy --- music therapy --- yoga therapy --- acupuncture --- pastoral care --- creative arts therapy --- pediatrics --- opioid therapy --- weaning of opioids --- withdrawal --- assessment of withdrawal --- pediatric --- integrative medicine --- academic medicine --- multidisciplinary pain management strategies --- opioid reduction therapy --- non-pharmacological therapy --- cognitive behavioral therapy --- hypnosis --- mindfulness-based stress reduction --- acupuncture --- pain rehabilitation

Pharmacist Services

Authors: ---
ISBN: 9783039217540 9783039217557 Year: Pages: 436 DOI: 10.3390/books978-3-03921-755-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pharmacy and materia medica
Added to DOAB on : 2019-12-09 11:49:16
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The overall goal of this book is to give the reader a state-of-the-art synopsis of the pharmacist services domain. To accomplish this goal, the authors have addressed the social, psychosocial, political, legal, historic, clinical, and economic factors that are associated with pharmacist services. In this book, you will gain cutting-edge insights from learning about the research of experts throughout the world. The findings have relevance for enhancing pharmacist professionalism, pharmacist practice, and the progression of pharmacist services in the future.

Keywords

ambulatory care --- pharmacy practice faculty --- pharmacy learners --- clinical practice --- pharmacist services --- community pharmacy practice --- dispensing --- counselling --- pharmaceutical intervention --- pharmaceutical care --- observation --- immunization programs --- mobile health units --- experiential learning --- billing --- healthy people 2020 --- pharmacy --- emergency unit --- health workers --- cystic fibrosis --- pharmacists --- pharmacy services, medication management --- medication use burden --- travel --- immunization --- vaccination --- pharmacist --- community pharmacy --- pharmacy intern --- student pharmacist --- primary care --- interprofessional --- federally qualified health center --- serviced marketing --- design thinking --- medication synchronization --- community pharmacists --- innovation science --- adherence --- competitive advantage --- age disparities --- gender disparities --- job satisfaction --- job-related preferences --- pharmacist workforce --- pharmacists --- pharmacy education --- interprofessional practice and education --- community pharmacy --- medication therapy management --- medication-related problems --- medication discrepancies --- continuity of patient care --- cost avoidance --- Comprehensive Medication Management --- pharmaceutical care --- primary health care --- chronic diseases --- clinical results --- naltrexone --- opioid use disorder --- implementation --- service process --- regulatory --- community pharmacy --- pharmacist services --- opioid --- communication --- naloxone --- misuse --- disposal --- safety --- counseling --- comprehensive medication review --- community pharmacy --- collaboration --- community pharmacy --- pharmaceutical care --- medication therapy management --- pharmacy practice --- pharmacy education --- grants --- pharmacy benefit manager (PBM) --- ethics --- pharmaceutical regulation --- health care policy --- decision-making --- organizations --- ethical models --- code of ethics --- pharmacist --- adverse drug events --- brown bag --- pharmacy --- medication reconciliation --- pharmacy clinical services --- comprehensive medication management services --- medication experience --- pharmaceutical care practice --- documentation --- focus groups --- community pharmacy --- retail clinics --- pharmacists --- nurse practitioners --- interprofessional training --- primary care --- healthcare access --- community pharmacy --- pharmacist services --- wellness programs --- medication adherence --- quality measurement/benchmarking --- multiple chronic conditions --- CMS Star rating --- chronic kidney disease --- interprofessional care --- quality assurance --- pharmacy communication --- cue orientation --- focus group interviews --- Denmark --- transitions in care --- pharmacist --- medication therapy problems --- medication safety --- comprehensive medication management --- readmissions --- intention --- medication therapy management --- pharmacy services --- South Asian --- theory of planned behavior. --- pharmacist services --- community pharmacy --- care plan --- compensation --- primary health care --- information sharing --- qualitative research --- comparative case study --- value --- human papilloma virus --- HPV vaccination --- pharmacy --- coordinated care --- history of pharmacy --- 20th century history --- 21st century history --- community pharmacy services --- pharmacy education --- pharmacist --- services marketing --- management --- value-added services --- community-based pharmacy --- community-based pharmacist practitioners --- community pharmacy services --- health policy --- interrupted time series analysis --- medication reconciliation --- mental health care --- pharmacy staff --- mental health first aid --- mental illness --- pharmacist roles --- n/a --- collaborative practice --- clinical pharmacy --- advanced practice pharmacist provider

Neuroproteomics

Authors: ---
ISBN: 9783039281060 9783039281077 Year: Pages: 318 DOI: 10.3390/books978-3-03928-107-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2020-04-07 23:07:08
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The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.

Keywords

proteomics --- basal ganglia --- synapses --- synapse specificity --- neuronal circuits --- axons --- dendrites --- neurodegeneration --- synapse --- postsynaptic --- proteome --- mass spectrometry --- protein interaction networks --- connectome --- neurodegeneration --- Alzheimer’s disease --- cerebrospinal fluid --- plasma --- serum --- proteomics --- biomarkers --- LC-MS/MS --- cocaine --- addiction --- cytokine --- neuroimmune --- ventral tegmental area --- peptidylglycine ?-amidating monooxygenase --- cilia --- mating --- signal peptide --- prohormone convertase --- carboxypeptidase --- matrix metalloproteinase --- subtilisin --- pherophorin --- morphine --- opioid receptors --- conformational antibody --- analgesia --- GPCR signaling --- phosphorylation --- AMPA receptor complex --- transmembrane AMPA receptor regulatory protein --- synaptic plasticity --- adolescence --- corticosterone --- proteomics --- yohimbine --- progressive ratio --- reinstatement --- ethanol --- nicotinic receptor --- CaMKII --- PKA --- quantitative phosphoproteomics --- mouse --- phosphorylation --- nicotine --- proteomics --- proteome --- mass spectrometry --- Alzheimer’s disease --- protein aggregation --- laser capture microdissection --- splicing --- U1 snRNP --- synapse --- synaptic cleft --- trans-synaptic adhesion --- proximity labeling --- SynCAM --- Cadm --- Receptor-type tyrosine-protein phosphatase zeta --- R-PTP-zeta --- Ptprz1 --- neuroproteome --- drug abuse --- neuropeptidomics --- phosphorylation --- interactome --- cell type --- neuroscience --- proteomics --- mass spectrometry --- neuron --- proximity labeling --- affinity chromatography --- neuroproteomics --- biotinylation --- amphetamine --- spinophilin --- protein phosphatase-1 --- dopamine --- striatum --- mass spectroscopy --- bioinformatics --- FGF14 --- voltage gated channels --- schizophrenia --- autism --- Alzheimer’s Disease --- sex-specific differences --- synaptic plasticity --- cognitive impairment --- excitatory/inhibitory tone --- n/a --- postsynaptic density --- PSD --- parallel reaction monitoring --- PRM --- targeted proteomics --- data-independent acquisition --- DIA --- quantitative mass spectrometry --- n/a

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

Authors: --- ---
ISBN: 9783039282883 9783039282890 Year: Pages: 406 DOI: 10.3390/books978-3-03928-289-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Keywords

MC3R --- MC4R --- mixed pharmacology --- tetrapeptides --- melanocortins --- Plk1 --- selectivity --- polo-box domain --- peptide --- triazole --- PKA --- stapled peptide --- PKI --- pseudosubstrate --- kinase inhibitor --- IP20 --- polycationic -amino acids --- small antimicrobial peptides --- sepsis --- peptidomimetics --- VEGF165 --- neuropilin-1 --- molecular dynamics --- structure–activity relationship --- OBOC --- combinatorial chemistry --- opioid --- drug screen --- molecular rotor dye --- high throughput screening --- sensor chip --- peptide --- peptide-drug conjugate --- mixed-mode pharmacology --- GLP-1 --- GnRH --- LHRH --- chemical linker --- cancer --- diabetes --- obesity --- drug discovery --- melanocortin-4 receptor --- obesity --- peptide agonist --- cardiovascular profile --- G?S signaling --- receptor desensitization --- receptor internalization --- peptidomimetics --- azapeptides --- aza-amino acids --- ?-hairpin --- ?-sheet --- programmed cell death ligand protein 1 --- pharmacophore --- peptide --- small molecule --- anticancer peptide --- therapeutic peptides --- support vector machine --- random forest --- machine learning --- classification --- peptides --- endosomolytic --- amphiphilic --- fusogenic --- influenza hemagglutinin --- RBC lysis --- peptide permeability --- stapled peptide --- macrocyclic peptide --- D-amino acid --- helix-breaker --- adaptogenic --- autophagy --- ?-ginkgotide --- cytoprotective --- cysteine-rich peptides --- disulfide-rich scaffold --- hyperdisulfide --- hypoxia --- LIR motif --- ginkgo nuts --- ?-helix mimetics --- bis-benzamide scaffold --- protein–protein interaction --- prostate cancer --- androgen receptor --- coactivator PELP1 --- Ranalexin --- peptide therapeutics --- antibiotics --- configuration --- antimicrobial activity --- cancer vaccine --- synthetic vaccine --- adjuvant --- Toll-like receptor --- Pam2Cys --- N-acetylated Pam2Cys --- bioconjugation --- lipidation --- prostaglandin F2? --- preterm labor --- myometrium contractions --- peptidomimetic --- structure-activity --- opioids --- multifunctional ligands --- peptide design --- free energy calculation --- d-amino acid scan --- alanine scan

Natural Products and Drug Discovery

Author:
ISBN: 9783039287468 / 9783039287475 Year: Pages: 392 DOI: 10.3390/books978-3-03928-747-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Keywords

cytotoxicity-guided --- phenolic derivatives --- Dryopteris fragrans --- chemical derivatization --- immuno-regulation activity --- Imperata cylindrica --- HPLC --- ESI-MS/MS --- growth inhibitory activity --- cancer --- cardamonin --- antinociceptive --- TRPV1 --- glutamate --- opioid --- siphonous green algae --- sulfated coumarins --- Dasycladus vermicularis --- isolation and quantification --- Orobanche s.l. --- Orobanchaceae --- Lamiales --- natural products --- secondary metabolites --- phenylpropanoid glycosides --- phenylethanoid glycosides --- bioactivities of natural products --- chemosystematics --- FSE --- T2DM --- GLUT4 --- Ca2+ --- L6 cell --- marine peptides --- proliferation --- migration --- angiogenesis --- zebrafish --- antioxidant activity --- flavonoids --- isoflavones --- phenolics --- proanthocyanidins --- Trifolium --- Leea indica --- HPLC-ESI-microTOF-Q-MS/MS --- phenolics --- dihydrochalcones --- Humulus lupulus --- prenylated phenolic compounds --- antimicrobial agents --- methicillin-resistant Staphylococcus aureus --- Leishmania mexicana mexicana --- Trypanosoma brucei brucei --- Astragalus boeticus L. --- spectroscopic analysis --- cytotoxic activity --- human colon cancer cell lines --- acetylated astragalosides --- Fabaceae --- aging --- cancer --- cardiovascular disease --- dementia --- diabetes --- inflammation --- oxidative stress --- Harpagophytum procumbens --- devil’s claw --- harpagoside --- spagyric tincture --- antioxidant activity --- Cleistocalyx operculatus --- 2?,4?-dihydroxy-6?-methoxy-3?,5?-dimethylchalcone (DMC) --- pPancreatic cancer --- PANC-1 --- ACE inhibitory peptide --- antihypertensive --- bioactive peptides --- hypertension --- marine resources --- terpenes --- terpenoids --- antimicrobial resistance --- synergy --- Phyllanthus orbicularis --- C-glycoside --- flavonoid --- natural products --- traditional medicine --- Cuba --- Phyllanthus chamacristoides --- chromatography --- mass spectrometry --- NMR --- circular dichroism --- stereochemistry --- Fideloside --- cytokines --- anti-inflammatory activity --- metabolomics --- multivariate data analysis --- molecular network --- Bacopa monnieri --- LC-MS --- diabetic neuropathy --- neuropathic pain --- glucosinolates --- Eruca sativa --- glucoerucin --- H2S --- Kv7 potassium channels --- artemisinin --- Physcomitrella patens --- sesquiterpenoids --- malaria --- biotechnology --- ketamine --- psychosis --- cerebellum --- celastrol --- oxidative stress --- NADPH oxidases --- n/a

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