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Marine Glycobiology, Glycomics and Lectins

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ISBN: 9783039218202 9783039218219 Year: Pages: 176 DOI: 10.3390/books978-3-03921-821-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 16:39:37
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Abstract

Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences.This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.

Marine Glycoconjugates: Trends and Perspectives

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ISBN: 9783039285587 / 9783039285594 Year: Pages: 272 DOI: 10.3390/books978-3-03928-559-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2020-06-09 16:38:57
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The books described marine glycoconjugates. Two articles concern microalgal metabolites such as steroid and sphingoid glycoconjugates, and a glycoprotein from a sea cucumber with interesting biological activities, respectively. One article discusses the fatty acid composition and thermotropic behavior of glycolipids and other membrane lipids of green macrophyte Ulva lactuca. Three articles cover lectin subjects. One review article analyzes perspectives of marine and freshwater lectins’ application in experimental oncology and the therapy of oncological diseases; another article describes the use of a sponge lectin in the construction of a recombinant virus. The third article concerns the function of the immunity of a lectin in producing this compound crinoid. Two articles concern steroid glycosides from star?sh, and two others concern triterpene glycosides from sea cucumbers. One article describes the e?ect of a glycosaminoglycan from the sea cucumber Apostichopus japonicus on hyperglycemia in the liver of insulin-resistant mice. One article concerns the isolation of 10 new triterpene glycosides from a fungus associated with a sea cucumber. The article by Dworaczek et al. characterizes the O-speci?c polysaccharide (O-antigen) of a bacterial pathogen of common carp by chemical and immunochemical methods. In total, the Special Issue comprises14 articles, including the editorial and two reviews.

Keywords

starfish --- Anthenea aspera --- steroidal glycosides --- colony formation --- apoptosis --- Bcl-2 proteins --- glycolipids --- phospholipids --- betaine lipid --- fatty acids --- differential scanning calorimetry --- thermal adaptation --- glycoprotein --- mitophagy --- marine antiproliferative compounds --- Alexandrium minutum --- microalgae --- sterol glycoconjugates --- glycosylceramides --- structures --- biological activities --- functions --- N-Acetyllactosamine (LacNAc) --- Anneissia japonica --- anti-biofilm activity --- cell adhesion --- crinoid --- Echinoderm --- feather star --- lectin --- signal transduction --- sghC1qDC --- Psolus fabricii --- triterpene glycosides --- psolusosides --- sea cucumber --- cytotoxic activity --- Aphrocallistes vastus lectin --- oncolytic vaccinia virus --- ERK --- Aeromonas --- fish pathogen --- lipopolysaccharide (LPS) --- structure --- O-antigen --- O-polysaccharide --- l-perosamine --- immunospecificity --- NMR spectroscopy --- mass spectrometry --- starfish --- Lethasterias fusca --- asterosaponins --- polyhydroxysteroids --- glycosides --- body components --- distribution --- Acremonium striatisporum --- secondary metabolites --- marine fungi --- diterpene glycosides --- urease activity --- Psolus fabricii --- triterpene glycosides --- psolusosides --- sea cucumber --- cytotoxic activity --- glycosaminoglycan --- Apostichopus japonicus --- glucose metabolism --- Akt --- AMPK --- marine lectins --- cancer --- cancer therapy --- in vitro studies --- in vivo studies --- natural products --- n/a

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