Search results: Found 3

Listing 1 - 3 of 3
Sort by
Bone Marrow T Cells at the Center Stage in Immunological Memory

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450930 Year: Pages: 84 DOI: 10.3389/978-2-88945-093-0 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2017-07-06 13:27:36
License:

Loading...
Export citation

Choose an application

Abstract

Increasing evidence supports the notion that bone marrow (BM) represents a relevant player in T cell responses, particularly in its role as a specialized organ for long-term memory. Memory T cells are enriched in the BM over long times after priming, and can be recruited to the periphery upon antigenic challenge. The articles in this research topic include discussions of whether these T cells are passing-through or truly resident, as well as a debate on the extent of proliferation of BM memory T cells. Original research articles in this collection include an analysis of the number of memory T cells found in different bones as well as effects of B cell depletion on T cell memory in the BM. T cells in the BM can influence a number of processes, from bone remodeling, control of cancer, to effects on hemopoiesis or Graft versus Host Disease (GVHD). This research topic contains several contributions to these topics including discussions on how to translate BM T cell knowledge into medicine.

Progenitor diversity and neural cell specification in the central nervous system

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196838 Year: Pages: 107 DOI: 10.3389/978-2-88919-683-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
License:

Loading...
Export citation

Choose an application

Abstract

The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential.

Governing Integrated Water Resources Management: Mutual Learning and Policy Transfer

Authors: ---
ISBN: 9783039281565 / 9783039281572 Year: Pages: 284 DOI: 10.3390/books978-3-03928-157-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Philosophy
Added to DOAB on : 2020-01-30 16:39:46
License:

Loading...
Export citation

Choose an application

Abstract

Integrated Water Resources Management (IWRM) has become a global paradigm for the governance of surface, coastal and groundwaters. This Special Issue contains twelve articles related to the transfer of IWRM policy principles. The articles explore three dimensions of transfer—causes, processes, outcomes—and offer a theoretically inspiring, methodologically rich and geographically diverse engagement with IWRM policy transfer around the globe. As such, they can also productively inform a future research agenda on the ‘dimensional’ aspects of IWRM governance. Regarding the causes, the contributions apply, criticise, extend or revise existing approaches to policy transfer in a water governance context, asking why countries adopt IWRM principles and what mechanisms are in place to understand the adoption of these principles in regional or national contexts. When it comes to processes, articles in this Special Issue unpack the process of policy transfer and implementation and explore how IWRM principles travel across borders, levels and scales. Finally, this set of papers looks into the outcomes of IWRM policy transfer and asks what impact IWRM principles, once implemented, gave on domestic water governance, water quality and water supply, and how effective IWRM is at addressing critical water issues in specific countries.

Keywords

dam --- local communities --- lived experiences --- environmental narratives --- Cambodia --- transitions --- water management regimes --- water resource management --- niches --- visions --- agency --- ocean governance --- fisheries management --- ecosystem-based management --- overfishing --- sustainable fishing --- European Union --- Turkey --- Europeanisation --- institutions --- policy transfer --- Water Framework Directive --- drinking water --- agriculture --- EU policy --- governance --- integrated scientific support --- water quality --- nitrates --- pesticides --- environmental policy --- policy coherence --- environmental governance --- integrated catchment management --- catchment --- conservation authorities --- governance --- governmentality --- integrated water resources management (IWRM) --- watershed councils --- Ontario --- Oregon --- Integrated Water Resources Management --- Integrated Urban Water Management --- urban water security --- governance --- Singapore --- Hong Kong --- process tracing --- Water Framework Directive --- policy implementation --- integrated water resources management --- river basin planning --- public participation --- water governance --- scale --- top-down and bottom-up --- estuaries --- governance --- sustainability --- governance models --- integrated water resources management --- IWRM --- Water Framework Directive --- WFD --- participation --- United Kingdom --- England --- water governance --- IWRM --- integrated water resources management --- drivers --- EU water framework directive --- implementation --- coordination --- participation --- Germany --- water governance --- polycentricity --- integrated water resources management --- IWRM --- policy transfer --- water governance --- Water Framework Directive --- learning

Listing 1 - 3 of 3
Sort by
Narrow your search
-->