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Multiscale Modeling of the Ventricles: From Cellular Electrophysiology to Body Surface Electrocardiograms

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Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783866447141 Year: Volume: 13 Pages: XIII, 248 p. DOI: 10.5445/KSP/1000023886 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
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This work is focused on different aspects within the loop of multiscale modeling:On the cellular level, effects of adrenergic regulation and the Long-QT syndrome have been investigated.On the organ level, a model for the excitation conduction system was developed and the role of electrophysiological heterogeneities was analyzed.On the torso level a dynamic model of a deforming heart was created and the effects of tissue conductivities on the solution of the forward problem were evaluated.

Fortgeschrittene Methoden zur Beschreibung der Wirbelschicht-Sprühgranulation

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ISBN: 9783731500872 Year: Pages: VIII, 216 p. DOI: 10.5445/KSP/1000036117 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Chemical Engineering
Added to DOAB on : 2019-07-30 20:02:02
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A multiscale simulation model is developed by combining the CFD Simulation and the population balance equations to describe a transient process of fluidized bed spray granulation. In this model, the CFD simulation generates the particle growth and nucleation rates in consideration of fluid dynamics, drying and multiple interactions, such as drops deposition, dust integration and nucleation between different particles (drops, dust and granules).

Evaluation of Systems’ Irregularity and Complexity: Sample Entropy, Its Derivatives, and Their Applications across Scales and Disciplines

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ISBN: 9783038973324 9783038973331 Year: Pages: 264 DOI: 10.3390/books978-3-03897-333-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-12-10 11:20:37
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[enter Summary/Description]Based on information theory, a number of entropy measures have been proposed since the 1990s to assess systems’ irregularity, such as approximate entropy, sample entropy, permutation entropy, intrinsic mode entropy, and dispersion entropy, to cite only a few. Among them, sample entropy has been used in a very large variety of disciplines for both univariate and multivariate data. However, improvements to the sample entropy algorithm are still being proposed because sample entropy is unstable for short time series, may be sensitive to parameter values, and can be too time-consuming for long data. At the same time, it is worth noting that sample entropy does not take into account the multiple temporal scales inherent in complex systems. It is maximized for completely random processes and is used only to quantify the irregularity of signals on a single scale. This is why analyses of irregularity—with sample entropy or its derivatives—at multiple time scales have been proposed to assess systems’ complexity. This Book presents contributions related to new and original research based on the use of sample entropy or its derivatives.

Micromechanical Modeling and Simulation of Forming Processes

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Book Series: Schriftenreihe Kontinuumsmechanik im Maschinenbau / Karlsruher Institut für Technologie, Institut für Technische Mechanik - Bereich Kontinuumsmechanik ISSN: 2192693X ISBN: 9783731506027 Year: Volume: 8 Pages: IX, 133 p. DOI: 10.5445/KSP/1000061958 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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The deep drawing of an aluminum alloy used in the packaging industry for the beverage can manufacturing process is investigated. In this work, the effective constitutive behavior is based on a crystal plasticity model in combination with a non-linear Hashin-Shtrikman type homogenization scheme in which a reference stiffness controls the stress and strain fluctuations. The simulation results are compared to experiments in terms of deep drawing earing profiles, texture evolution, and localization.

Hybrid Solutions for the Modelling of Complex Environmental Systems

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450558 Year: Pages: 184 DOI: 10.3389/978-2-88945-055-8 Language: English
Publisher: Frontiers Media SA
Subject: Environmental Sciences --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Systems studied in environmental science, due to their structure and the heterogeneity of the entities composing them, often exhibit complex dynamics that can only be captured by hybrid modeling approaches. While several concurrent definitions of “hybrid modeling” can be found in the literature, it is defined here broadly as the approach consisting in coupling existing modelling paradigms to achieve a more accurate or efficient representation of systems. The need for hybrid models generally arises from the necessity to overcome the limitation of a single modeling technique in terms of structural flexibility, capabilities, or computational efficiency. This book brings together experts in the field of hybrid modelling to demonstrate how this approach can address the challenge of representing the complexity of natural systems. Chapters cover applied examples as well as modeling methodology.Systems studied in environmental science, due to their structure and the heterogeneity of the entities composing them, often exhibit complex dynamics that can only be captured by hybrid modeling approaches. While several concurrent definitions of “hybrid modeling” can be found in the literature, it is defined here broadly as the approach consisting in coupling existing modelling paradigms to achieve a more accurate or efficient representation of systems. The need for hybrid models generally arises from the necessity to overcome the limitation of a single modeling technique in terms of structural flexibility, capabilities, or computational efficiency. This book brings together experts in the field of hybrid modelling to demonstrate how this approach can address the challenge of representing the complexity of natural systems. Chapters cover applied examples as well as modeling methodology.

Manufacturing and Surface Engineering

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ISBN: 9783038429791 9783038429807 Year: Pages: VI, 134 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Materials --- Chemistry (General)
Added to DOAB on : 2018-08-09 15:59:11
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The desired properties of surface components include the improvement of different properties, such as aesthetic appearance, oxidation resistance, wear resistance, mechanical properties, electronic or electrical properties, thermal insulation, wear, triboemission and corrosion resistance through barriers.These properties can be enhanced using different methods, such as by adding a coating. Nevertheless, the bulk of the material or substrate cannot be considered independent of the surface treatment. Metal cutting is one of the general machining methods used to achieve high accuracy and productivity for metal parts.The topics of the book “Manufacturing and Surface Engineering” include the full range of surface engineering aspects, i.e., surface integrity, contact mechanics, friction and wear, coatings and surface treatments, multiscale tribology, computational methods, and optimization techniques applied in surface engineering.Recent experimental works by Zhang, Li, Zhang, Zhang and Duan, and by other researchers outlined that coating layer surface treatments may increase the damping behavior of thin-walled mechanical components vibrating in flexural conditions. Nevertheless, it was also experimentally found by the authors that most of these coating surface treatments had a negligible or null effect with respect to the vibrational damped response in testing or operating conditions. Ciniero, Le Rouzic and Reddyhoff report the potential of measuring charged particle emissions and/or tribocharging for the study or monitoring of the failure of coatings. The spatial information of triboemission allows the identification of the exact time and location of the failure. The evolution of the failure during sliding and the change in the characteristics of the contact are also monitored. After studying the effect of the Ti content on the performance of FeCoCrNiAlTix, He, Zhang, Lin, Zhang, Dong and Li establish that the structure of FeCoCrNiAlTix coatings consists of two kinds of BCC phases. With the continuous increase in Ti content, the number of eutectic structures decreases, accompanying the increase in the proeutectic phase and the Ti-rich second phase is precipitated out. Abutaha, Abdul Razak, and Ibrahim developed an experimental investigation into the engineering properties of concrete incorporating POC as an aggregate and filler material. This approach offers an environmentally-friendly solution to the ongoing waste problems associated with palm oil waste material.Liu and Janssen studied the effects of impact on the wear of the structural steel S235 in various liquids. When the impact is small, corrosion plays a dominant role, thus the sample in seawater wears the least due to the beneficial interaction with abrasion. However, when the impact is large, the wear rates of three liquids do not show a noticeable difference, because the wear mechanism changes from material removal to mainly plastic deformation. The influence of corrosion becomes a minor influencing factor when subject to impact.Vázquez Martínez, Salguero Gómez, Batista Ponce and Botana Pedemonte analyzed the different treatments obtained through setup parameter combinations to obtain samples with widely varying features, according to the thickness of the treated layer and the incidence depth of the laser beam. This diversity of samples shows a range of color tonalities from soft gold to medium gray and blue. Microstructural changes and oxidation layer generation provide a significant increase in the material hardness, reaching Vickers hardness values close to 1000 HV for high intensity treatments.Takada and Sasahara studied the FSB process using four levels of tip radius burnishing tools and investigated their effect on surface roughness, hardness and residual stress for a 0.45% C steel shaft. The thickness of the hardened layer increased as the tool tip radius decreased. The hardness value of the processed layer reached 600 HV. The residual stress on the processed surface was compressive when a radius tool with a smaller tip was used, and the residual stress turned tensile when a radius tool with a larger tip was used.Vereschaka, Kataeva, Sitnikov, Aksenenko, Oganyan and Sotova searched for patterns that allow a reliable justification for the choice of the composition of coatings and their micro- and nanostructures depending on the material being machined and the cutting regimes (in particular, the cutting speed).Amadori, Catania and Casagrande investigated experimentally eight different innovative composite solutions. A significant increase in the damping behavior was observed for all of these solutions with respect to the uncoated components, and with respect to the already known solutions that have previously been investigated by these authors and other researchers. The coating solution employing an Al2O3 powder + matrix, made using a screen-printing and curing technology on an Al alloy substrate, proved to be the most effective technology with respect to the aim of this work. Catania and Strozzi investigated the performance of different solutions in a free and forced flexural vibration response; they propose a simple model based on the assumption of a multi-layer, zig-zag beam, which also locally models the dissipative actions at the interface between the layers. Some virtual prototyping application examples are also reported.

Advances in Computer Simulation Studies on Crystal Growth

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ISBN: 9783038973560 9783038973577 Year: Pages: 206 DOI: 10.3390/books978-3-03897-357-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-11-16 11:51:21
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Crystals are indispensable in technology, nature, and our daily lives. For example, cooking uses many kinds of crystallized products, such as salt, sugar, and fat crystals; electronic devices contain semiconductor crystals; living organisms produce mineral crystals to maintain biological processes; and snow and ice crystals play a crucial role in climate change. For these and other topics related to crystals, an especially important area of research is crystal growth. Computer simulations of crystal growth have become increasingly important as a result of rapid increases in available computing power. Computer simulations can analyze and predict various aspects of crystal growth, including molecular-scale growth and nucleation mechanisms, the structure and dynamics of surfaces and interfaces, and pattern formation. This book presents state-of-the-art research and reviews of computer simulation studies on crystal growth for hard-sphere particles, organic molecules, ice, and functional materials. The studies use a variety of simulation methodologies, including molecular simulations, first-principles simulations, continuum simulations, and multiscale simulations. This book will interest graduate students and researchers in crystal growth science and technology and will provide a helpful reference for scientists who want to familiarize themselves with computer simulations of crystal growth.

New Frontiers in Multiscale Modelling of Advanced Materials

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197552 Year: Pages: 91 DOI: 10.3389/978-2-88919-755-2 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Materials
Added to DOAB on : 2016-04-07 11:22:02
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Atomistic simulations, based on ab-initio and semi-empirical approaches, are nowadays widespread in many areas of physics, chemistry and, more recently, biology. Improved algorithms and increased computational power widened the areas of application of these computational methods to extended materials of technological interest, in particular allowing unprecedented access to the first-principles investigation of their electronic, optical, thermodynamical and mechanical properties, even where experiments are not available. However, for a big impact on the society, this rapidly growing field of computational approaches to materials science has to face the unfavourable scaling with the system size, and to beat the time-scale bottleneck. Indeed, many phenomena, such as crystal growth or protein folding for example, occur in a space/time scale which is normally out of reach of present simulations. Multi-scale approaches try to combine different scale algorithms along with matching procedures in order to bridge the gap between first-principles and continuum-level simulations. This Research Topic aims at the description of recent advances and applications in these two emerging fields of ab-inito and multi-scale materials modelling for both ground and excited states. A variety of theoretical and computational techniques are included along with the application of these methods to systems at increasing level of complexity, from nano to micro. Crossing the borders between several computational, theoretical and experimental techniques, this Research Topic aims to be of interest to a broad community, including experimental and theoretical physicists, chemists and engineers interested in materials research in a broad sense.

Small Scale Deformation using Advanced Nanoindentation Techniques

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ISBN: 9783038979661 / 9783038979678 Year: Pages: 168 DOI: 10.3390/books978-3-03897-967-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2019-06-26 08:44:06
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Small scale mechanical deformations have gained a significant interest over the past few decades, driven by the advances in integrated circuits and microelectromechanical systems. One of the most powerful and versatile characterization methods is the nanoindentation technique. The capabilities of these depth-sensing instruments have been improved considerably. They can perform experiments in vacuum and at high temperatures, such as in-situ SEM and TEM nanoindenters. This allows researchers to visualize mechanical deformations and dislocations motion in real time. Time-dependent behavior of soft materials has also been studied in recent research works. This Special Issue on ""Small Scale Deformation using Advanced Nanoindentation Techniques""; will provide a forum for researchers from the academic and industrial communities to present advances in the field of small scale contact mechanics. Materials of interest include metals, glass, and ceramics. Manuscripts related to deformations of biomaterials and biological related specimens are also welcome. Topics of interest include, but are not limited to:

Micro/Nano Materials for Clean Energy and Environment

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ISBN: 9783039211289 / 9783039211296 Year: Pages: 123 DOI: 10.3390/books978-3-03921-129-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:41:30
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The Tsinghua University–University of Waterloo Joint Research Center for Micro/Nano Energy & Environment Technology (JCMEET) is a platform. It was established on Nov.11, 2017. The Chairperson of University Council of Tsinghua University, Dr. Xu Chen, and the President of the University of Waterloo, Dr. Feridun Hamdullahpur, attended the opening ceremony and unveiled the nameplate for the joint research center on 29th of March, 2018. The research center serves as a platform for researchers at both universities to conduct joint research in the targeted areas, and to meet regularly for information exchange, talent exchange, and knowledge mobilization, especially in the fields of micro/nano, energy, and environmental technologies. The center focuses on three main interests: micro/nano energy technology, micro/nano pollution control technology, and relevant fundamental research. In order to celebrate the first anniversary of the Joint Research Center, we were invited to serve as the Guest Editors of this Special Issue of Materials focusing on the topic of micro/nano-materials for clean energy and environment. It collects research papers from a broad range of topics related to micro/nanostructured materials aimed at future energy resources, low emission energy conversion, energy storage, energy efficiency improvement, air emission control, air monitoring, air cleaning, and many other related applications. This Special Issue provides an opportunity and example for the international community to discuss how to actively address the energy and environment issues that we are facing.

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