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Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455393 Year: Pages: 385 DOI: 10.3389/978-2-88945-539-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
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Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs.This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

Mehrskalenmodellierung von Schädigung in gummimodifizierten thermoplastischen Kunststoffen

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Book Series: Schriftenreihe des Instituts für Mechanik, Karlsruher Institut für Technologie ISSN: 23634936 ISBN: 9783731505716 Year: Volume: 3 Pages: XI, 105 p. DOI: 10.5445/KSP/1000057977 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-28 18:37:01
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In this work crazing in amorphous thermoplastics is investigated. Experiments on an ABS-material are used to characterize the deformation and fracture behavior. A homogenized material model for distributed crazing is developed. Simulation of macroscopic crack growth and the comparison with experiments are used to investigate the plastic zone at the crack tip and the fracture behavior.

Skalenübergreifende Modellierung und Optimierung vom atomistischen kristallinen Phasenfeldmodell bis zur mesoskopischen Phasenfeldmethode

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Book Series: Schriftenreihe des Instituts für Angewandte Materialien, Karlsruher Institut für Technologie ISSN: 21929963 ISBN: 9783731504160 Year: Volume: 49 Pages: IX, 242 p. DOI: 10.5445/KSP/1000048186 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
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Expansion of the phase field crystal model for multi-component mixtures, as ternary dendritic and lamellar eutectic crystallization. Comparison of crystal growth with molecular dynamics and phase field simulations. Parameters and initial data structures are used to simulate, starting from a small atom cluster to a ternary dendrites with side arms. Optimization techniques to reduce the amount of computation are developed.

The Emerging Discipline of Quantitative Systems Pharmacology

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196425 Year: Pages: 97 DOI: 10.3389/978-2-88919-642-5 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2016-08-16 10:34:25
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In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.

Future Space-Transport-System Components under High Thermal and Mechanical Loads

Authors: --- --- --- --- et al.
Book Series: Notes on Numerical Fluid Mechanics and Multidisciplinary Design ISBN: 9783030538477 Year: Pages: 419 DOI: 10.1007/978-3-030-53847-7 Language: English
Publisher: Springer Nature
Subject: Agriculture (General)
Added to DOAB on : 2020-11-19 00:20:02
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This open access book presents the findings of Collaborative Research Center Transregio 40 (TRR40), initiated in July 2008 and funded by the German Research Foundation (DFG). Gathering innovative design concepts for thrust chambers and nozzles, as well as cutting-edge methods of aft-body flow control and propulsion-component cooling, it brings together fundamental research undertaken at universities, testing carried out at the German Aerospace Center (DLR) and industrial developments from the ArianeGroup. With a particular focus on heat transfer analyses and novel cooling concepts for thermally highly loaded structures, the book highlights the aft-body flow of the space transportation system and its interaction with the nozzle flow, which are especially critical during the early phase of atmospheric ascent. Moreover, it describes virtual demonstrators for combustion chambers and nozzles, and discusses their industrial applicability. As such, it is a timely resource for researchers, graduate students and practitioners.

Flow and Transport Properties of Unconventional Reservoirs 2018

Authors: --- --- ---
ISBN: 9783039211166 9783039211173 Year: Pages: 364 DOI: 10.3390/books978-3-03921-117-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.

Keywords

fracturing fluid --- rheology --- chelating agent --- viscosity --- polymer --- fluid-solid interaction --- velocity profile --- the average flow velocity --- flow resistance --- pore network model --- shale gas --- volume fracturing --- finite volume method --- production simulation --- multi-scale flow --- multi-scale fracture --- shale gas reservoir --- fractured well transient productivity --- succession pseudo-steady state (SPSS) method --- complex fracture network --- multi-scale flow --- analysis of influencing factors --- tight sandstones --- spontaneous imbibition --- remaining oil distributions --- imbibition front --- imbibition recovery --- NMR --- slip length --- large density ratio --- contact angle --- pseudo-potential model --- lattice Boltzmann method --- micro-fracture --- dissolved gas --- experimental evaluation --- reservoir depletion --- recovery factor --- tight oil --- Lucaogou Formation --- tight oil --- pore structure --- prediction by NMR logs --- tight oil reservoir --- SRV-fractured horizontal well --- multiporosity and multiscale --- flow regimes --- productivity contribution degree of multimedium --- equilibrium permeability --- non-equilibrium permeability --- matrix–fracture interaction --- effective stress --- coal deformation --- porous media --- non-linear flow --- conformable derivative --- fractal --- hydraulic fracturing --- tight reservoirs --- fracture diversion --- extended finite element method --- fracture network --- gas adsorption capacity --- shale reservoirs --- influential factors --- integrated methods --- sulfonate gemini surfactant --- thickener --- temperature-resistance --- clean fracturing fluid --- low-salinity water flooding --- clay mineral composition --- enhanced oil recovery --- wetting angle --- pH of formation water --- fractional diffusion --- fractal geometry --- analytical model --- shale gas reservoir --- carbonate reservoir --- petrophysical characterization --- pore types --- pore structure --- permeability --- fractal dimension --- reservoir classifications --- deep circulation groundwater --- groundwater flow --- geothermal water --- faults --- isotopes --- shale permeability --- local effect --- global effect --- matrix-fracture interactions --- nanopore --- pore structure --- shale --- tight sandstone --- mudstone --- nitrogen adsorption --- fractal --- enhanced geothermal system --- well-placement optimization --- fracture continuum method --- 0-1 programming --- unconventional reservoirs --- petrophysical characterization --- fluid transport physics

ECO-COMPASS

Authors: ---
ISBN: 9783038976905 9783038976912 Year: Pages: 219 DOI: 10.3390/books978-3-03897-691-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Media and communication --- Transportation
Added to DOAB on : 2019-08-28 11:21:28
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Today, mainly man-made materials, such as carbon and glass fibers, are used to produce composite parts in aviation. Renewable materials, such as natural fibers or bio-sourced resin systems, have not yet found their way into aviation. The project ECO-COMPASS aims to evaluate the potential applications of ecologically improved composite materials in the aviation sector in an international collaboration of Chinese and European partners. Natural fibers such as flax and ramie will be used for different types of reinforcements and sandwich cores. Furthermore, bio-based epoxy resins to substitute bisphenol-A based epoxy resins in secondary structures are under investigation. Adapted material protection technologies to reduce environmental influence and to improve fire resistance are needed to fulfil the demanding safety requirements in aviation. Modelling and simulation of chosen eco-composites aims for an optimized use of materials while a Life Cycle Assessment aims to prove the ecological advantages compared to synthetic state-of-the-art materials. This Special Issue provides selected papers from the project consortium partners.

Remote Sensing for Target Object Detection and Identification

Authors: --- ---
ISBN: 9783039283323 9783039283330 Year: Pages: 336 DOI: 10.3390/books978-3-03928-333-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Geography
Added to DOAB on : 2020-04-07 23:07:09
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Target object detection and identification are among the primary uses for a remote sensing system. This is crucial in several fields, including environmental and urban monitoring, hazard and disaster management, and defense and military. In recent years, these analyses have used the tremendous amount of data acquired by sensors mounted on satellite, airborne, and unmanned aerial vehicle (UAV) platforms. This book promotes papers exploiting different remote sensing data for target object detection and identification, such as synthetic aperture radar (SAR) imaging and multispectral and hyperspectral imaging. Several cutting-edge contributions, which provide examples of how to select of a technology or another depending on the specific application, will be detailed.

Keywords

anomaly detection --- hyperspectral imagery --- low-rank representation --- dictionary construction --- HSI reconstruction --- sparse coding --- adaptive weighting --- infrared small target detection --- local prior analysis --- nonconvex tensor robust principle component analysis --- partial sum of the tensor nuclear norm --- low rank sparse decomposition --- Lp-norm constraint --- non-convex optimization --- alternating direction method of multipliers --- infrared small target detection --- convolutional neural networks (CNNs) --- object detection --- remote sensing images --- contextual information --- part-based --- multi-model --- very-high-resolution (VHR) remote sensing imagery --- object detection --- multi-scale pyramidal features --- multi-scale strategies --- oil tank detection --- unsupervised saliency model --- Color Markov Chain --- bottom-up and top-down --- hazard prevention --- flood hazard --- hidden danger identification --- tower failure --- vehicle detection --- object matching --- superpixel segmentation --- unmanned aerial vehicle --- remote sensing imagery --- thermal infrared target tracking --- semantic features --- mask sparse representation --- particle filter framework --- ADMM --- satellite videos --- region proposals --- convolutional neural networks --- tiny and dim target detection --- component mixture model --- object detection --- remote sensing image --- deep learning --- convolutional neural networks (CNNs) --- hardware architecture --- processor --- ground-based detection --- infrared imaging --- observability --- detecting distance --- earth entry vehicle --- synthetic aperture radar (SAR) --- rivers water-flow elevation estimation --- pixel-tracking --- phase unwrapping --- infrared small-faint target detection --- non-independent and identical distribution (non-i.i.d.) mixture of Gaussians --- flux density --- variational Bayesian --- target detection --- target identification --- SAR --- visible --- infrared --- hyperspectral

Selected Papers from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP)

Authors: --- ---
ISBN: 9783039210404 9783039210411 Year: Pages: 194 DOI: 10.3390/books978-3-03921-041-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue contains a series of excellent research works on telecommunications and signal processing, selected from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP) which was held on July 4–6, 2018, in Athens, Greece. The conference was organized in cooperation with the IEEE Region 8 (Europe, Middle East, and Africa), IEEE Greece Section, IEEE Czechoslovakia Section, and IEEE Czechoslovakia Section SP/CAS/COM Joint Chapter by seventeen universities from the Czech Republic, Hungary, Turkey, Taiwan, Japan, Slovak Republic, Spain, Bulgaria, France, Slovenia, Croatia, and Poland, for academics, researchers, and developers, and serves as a premier international forum for the annual exchange and promotion of the latest advances in telecommunication technology and signal processing. The aim of the conference is to bring together both novice and experienced scientists, developers, and specialists, to meet new colleagues, collect new ideas, and establish new cooperation between research groups from universities, research centers, and private sectors worldwide. This collection of 10 papers is highly recommended for researchers, and believed to be interesting, inspiring, and motivating for readers in their further research.

Intermittency and Self-Organisation in Turbulence and Statistical Mechanics

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ISBN: 9783039211081 9783039211098 Year: Pages: 298 DOI: 10.3390/books978-3-03921-109-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-08-28 11:21:27
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There is overwhelming evidence, from laboratory experiments, observations, and computational studies, that coherent structures can cause intermittent transport, dramatically enhancing transport. A proper description of this intermittent phenomenon, however, is extremely difficult, requiring a new non-perturbative theory, such as statistical description. Furthermore, multi-scale interactions are responsible for inevitably complex dynamics in strongly non-equilibrium systems, a proper understanding of which remains a main challenge in classical physics. As a remarkable consequence of multi-scale interaction, a quasi-equilibrium state (the so-called self-organisation) can however be maintained. This special issue aims to present different theories of statistical mechanics to understand this challenging multiscale problem in turbulence. The 14 contributions to this Special issue focus on the various aspects of intermittency, coherent structures, self-organisation, bifurcation and nonlocality. Given the ubiquity of turbulence, the contributions cover a broad range of systems covering laboratory fluids (channel flow, the Von Kármán flow), plasmas (magnetic fusion), laser cavity, wind turbine, air flow around a high-speed train, solar wind and industrial application.

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