Search results: Found 3

Listing 1 - 3 of 3
Sort by
Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery

Author:
ISBN: 9783039287529 / 9783039287536 Year: Pages: 206 DOI: 10.3390/books978-3-03928-753-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections.

Keywords

furosemide --- electrospinning --- hydroxypropyl cellulose --- poly (vinylpyrrolidone) --- storage and loss moduli --- scanning electron microscopic images --- gellan gum --- pectin --- resveratrol --- mucoadhesive microspheres --- cytotoxicity --- in vitro permeability --- Caco-2 cells --- triple co-culture model --- Carbopol --- clobetasol --- Eudragit® E PO --- interpolyelectrolyte complex --- mucoadhesion --- oral lichen planus --- oral lyophilisates --- maltodextrin --- resuspendibility --- chitosan --- acrylated chitosan --- nanoparticles --- mucoadhesion --- mucosal membranes --- mucoadhesive polymers --- retention --- buccal mucosa drug delivery --- cyclodextrins --- films --- l-arginine --- mucoadhesive polymer --- omeprazole --- paediatric --- clotrimazole --- liposphere --- alkyl lactate --- xanthan gum --- Candida albicans --- mucoadhesion --- poly(2-ethyl-2-oxazoline) --- Carbopol® --- mucoadhesion --- interpolymer complexes --- thiolated hyaluronic acid --- hydrogel --- mucoadhesive --- biocompatibility --- controlled release --- drug delivery --- wound healing --- pluronic f127 --- thermoresponsive polymers --- thermogelling polymers --- detachment force --- rheology --- texture profile analysis --- chitosan derivatives --- mucosal drug delivery --- mucoadhesion --- trimethyl chitosan --- thiolated chitosan --- chitosan-catechol --- acrylated chitosan --- nanoparticles --- pioglitazone --- PLGA-PEG --- transmucosal permeations --- Alzheimer’s disease

Marine Chitin 2019

Authors: ---
ISBN: 9783039360727 / 9783039360734 Year: Pages: 288 DOI: 10.3390/books978-3-03936-073-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

In 2019, we sent out a call for submissions to a Special Issue of Marine Drugs entitled “Marine Chitin 2019”, and we are pleased that this issue has now been published. Over 16 high-impact papers were included in this issue, which we now plan to publish as a book. In addition, we now seek to publish a further Special Issue of Marine Drugs, “Marine Chitin 2020–2021”. As before, we plan to produce an authoritative and exciting issue that will encompass breakthroughs in scientific and industrial chitin and chitosan research. Significant advances in chitin and chitosan research have been made since the 1970s, and current overviews in recent publications involving chitin and chitosan research advances are in need of an update.

Keywords

chitosan --- cytotoxicity --- polymer film --- sodium carbonate --- soluble chitosan complex --- chitin --- chitosan --- protease --- chitinase --- chitosan oligomers --- chitooligosaccharides --- anti-inflammatory action --- RAW264.7 macrophage --- chitosan oleate salt --- amphiphilic polymer --- PLGA --- nanoparticles --- mucoadhesion --- Caco-2 cell culture --- nile red --- curcumin --- chitooligosaccharide --- immunostimulatory activity --- RAW 264.7 cells --- mitogen-activated protein kinases (MAPK) --- phosphoinositide 3-kinases (PI3K)/Akt --- chitosan oligosaccharides --- streptomycin --- Pseudomonas aeruginosa --- biofilms --- conjugation --- chitin --- marine sponges --- scaffolds --- Aplysina archeri --- express method --- bromotyrosines --- crude oil --- blood --- methylene blue --- chitin --- chitosan --- Paenibacillus --- chitosanase --- chitosan oligomers --- ?-glucosidase inhibitor --- antioxidant --- Polybius henslowii --- marine resources --- chitosan --- chitooligosaccharides --- antifungal activity --- antioxidant activity --- chitin --- collagen --- electrospinning --- mechanical property --- 2D correlation spectroscopy --- polymorph --- chitosan lactate --- chitosan tartrate --- chitosan citrate --- Eudragit® S100 --- layer-by-layer film --- mucoadhesive film --- Tenofovir controlled release --- pH responsive release --- vaginal preexposure prophylaxis --- HIV sexual transmission --- chitin --- chitosan --- wound treatment --- derivatization --- nanocomposites --- chitosan --- antibacterial activity --- Clostridium perfringens --- pork sausage --- chitin --- chitosan --- chitooligosaccharides --- enzymatic modification --- biotechnology --- chitinase --- chitosanase --- lytic polysaccharide monooxygenase --- chitin deacetylase --- chitosan-coated liposomes --- chitosan hydrogel --- mucoadhesion --- vaginal infections --- antibacterial activity --- Staphylococcus epidermidis --- Staphylococcus aureus --- chitin --- roller compaction --- ball milling --- direct compression --- compression work --- crushing strength --- Hausner ratio --- Kawakita analysis --- bulk density --- dissolution

Transmucosal Absorption Enhancers in the Drug Delivery Field

Authors: --- ---
ISBN: 9783039218486 9783039218493 Year: Pages: 406 DOI: 10.3390/books978-3-03921-849-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-01-30 16:39:46
License:

Loading...
Export citation

Choose an application

Abstract

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Keywords

absorption enhancers --- sugar-based surfactants --- biocompatibility studies --- transmucosal drug delivery --- intestinal permeation enhancers --- sodium cholate (NaC) --- N-dodecyl-?-D-maltoside (DDM) --- small intestine --- enterocyte --- brush border --- tryptophan --- oral delivery --- insulin --- GLP-1 --- intestinal absorption --- amino acid --- cell-penetrating peptide --- combined microsphere --- chitosan --- cyclodextrin --- nasal delivery --- nose to brain transport --- penetration enhancer --- nasal formulation --- in vivo studies --- nose to brain delivery --- antiepileptic drug --- drug delivery --- block copolymers --- thermogel system --- chitosan derivatives --- amphiphilic polymers --- polymeric micelles --- quaternization --- curcumin --- intestinal delivery --- mucoadhesiveness --- cervicovaginal tumors --- cationic functionalization --- imatinib --- nanocrystals --- in situ hydrogel --- bioenhancer --- cytochrome P450 --- drug absorption enhancer --- efflux --- metabolism --- P-glycoprotein --- pharmacokinetic interaction --- tight junction --- Aloe vera --- gel --- whole leaf --- absorption enhancement --- Caco-2 --- confocal laser scanning microscopy --- F-actin --- FITC-dextran --- tight junctions --- transepithelial electrical resistance --- permeation enhancer --- oral delivery --- formulation --- permeability --- safety --- simulated intestinal fluid --- hydrophobization --- epithelium --- compound 48/80 --- chitosan --- nanoparticles --- mast cell activator --- vaccine adjuvant --- nasal vaccination --- absorption enhancer --- antimicrobial peptide --- Caco-2 --- claudin --- cell-penetrating peptide (CPP) --- drug delivery --- intestinal epithelial cells --- KLAL --- PN159 --- tight junction modulator --- oral macromolecule delivery --- oral peptides --- sodium caprate --- salcaprozate sodium --- epithelial permeability --- epithelial transport --- nasal permeability --- nose-to-brain --- simvastatin --- nanocapsules --- mucoadhesion --- CNS disorders --- chitosan --- nasal --- pulmonary --- drug administration --- absorption enhancers --- nanoparticle --- and liposome --- absorption enhancer --- gemini surfactant --- intestinal absorption --- poorly absorbed drug --- Caco-2 cells --- PTH 1-34 --- teriparatide --- nasal delivery --- pharmacokinetics --- osteoporosis --- man --- sheep --- clinical trial --- preclinical --- Caco-2 --- intestinal absorption --- nanomedicine --- nanoparticle --- oral delivery --- transferrin --- ocular drug delivery --- cornea --- penetration enhancers --- ocular conditions --- ophthalmology --- permeation enhancers --- absorption modifying excipients --- oral delivery --- nasal delivery --- ocular delivery --- vaginal delivery --- transmucosal permeation

Listing 1 - 3 of 3
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (3)


License

CC by-nc-nd (3)


Language

eng (2)

english (1)


Year
From To Submit

2020 (3)