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Looking Forward to the Future of Heparin: New Sources, Developments and Applications

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ISBN: 9783038429494 9783038429500 Year: Pages: 282 DOI: 10.3390/books978-3-03842-950-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:28
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This book is a printed edition of the Special Issue Looking Forward to the Future of Heparin: New Sources, Developments and Applications that was published in Molecules

Keywords

thrombin inhibition --- LMWH --- antithrombin --- heparin oligosaccharides --- ternary complex --- heparin --- hepcidin --- iron homeostasis --- anemia --- heparin-induced thrombocytopenia --- diagnosis --- functional assay --- platelets --- heparin --- heparan sulphate --- TGF-? --- bone morphogenetic protein (BMP) --- growth and differentiation factor (GDF) --- GDNF --- BMP antagonists --- noggin --- sclerostin --- gremlin --- heparin --- enoxaparin --- subarachnoid hemorrhage --- edema --- brain injury --- inflammation --- cisplatin --- low molecular weight heparin (LMWH) --- ovarian cancer --- resistance --- heparin --- glycosaminoglycans --- chondroitin sulfate --- perylene diimide dyes --- dermatan sulfate --- fluorescent probe --- Heparin Red --- assay --- dermatan sulfate --- human plasma --- heparin --- alginate --- sulfated alginate --- biomaterials --- heparin --- heparan sulfate --- serglycin --- proteoglycan --- recombinant expression --- bioreactor --- theranostics --- solid lipid nanoparticles --- iron oxide nanoparticles --- heparin coating --- intestinal lymphatic absorption --- heparin --- heparin process --- manufacturing methods --- industrial --- super paramagnetic iron oxide nanoparticles (SPION) --- hyaluronic acid (HA) --- bovine serum albumin (BSA) --- Fe3O4·DA-BSA/HA --- paclitaxel (PTX) --- magnetic resonance imaging (MRI) --- low-molecular-weight heparin --- dalteparin --- NMR --- LC-MS --- affinity chromatography --- danaparoid sodium --- low molecular weight glycosaminoglycans --- orthogonal multi-analytical methods --- sequence and compositional investigations --- component quantitative analysis --- heparin --- crude heparin --- NMR --- quantitative NMR --- PCA --- chemometric --- HSQC --- bovine heparin --- porcine heparin --- molecular weight --- size exclusion chromatography --- pharmacopeia --- Fondaparinux sodium --- extended physicochemical characterization --- qNMR --- single crystal X-ray structure --- reference standard --- iduronic acid conformation --- Arixtra® --- n/a --- n/a --- n/a

Tribological Performance of Artificial Joints

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ISBN: 9783039210787 9783039210794 Year: Pages: 178 DOI: 10.3390/books978-3-03921-079-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Surgery
Added to DOAB on : 2019-08-28 11:21:27
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Joint replacement is a very successful medical treatment. However, the survivorship of the implants could be adversely affected due to the loss of materials in the form of particles or ions as the bearing surfaces articulate against earch other. The consequent tissue and immune response to the wear products, remain one of the key factors of their failure. Tribology has been defined as the science and technology of interacting surfaces in relative motion and all related wear products (e.g., particles, ions, etc.). Over the last few decades, in an attempt to understand and improve joint replacement technology, the tribological performance of several material combinations have been studied experimentally and assessed clinically. In addition, research has focused on the biological effects and long term consequences of wear products. Improvements have been made in manufacturing processes, precision engineering capabilities, device designs and materials properties in order to minimize wear and friction and maximize component longevity in vivo.

Processing-Structure-Properties Relationships in Polymers

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ISBN: 9783039218806 9783039218813 Year: Pages: 400 DOI: 10.3390/books978-3-03921-881-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-01-07 09:08:26
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This collection of research and review papers is aimed at depicting the state of the art on the possible correlations between processing variables, obtained structure and special properties which this structure induces on the plastic part. The extraordinary capacity of plastics to modify their properties according to a particular structure is evidenced for several transformation processes and for many applications. The final common goal is to take profit of this peculiar capacity of plastics by inducing, through a suitable processing, a specific spatial organization.

Keywords

carbon nanotube --- homogeneous dispersion --- ethylene vinyl acetate --- mechanical performance --- electrical conductivity --- microencapsulation --- melamine polyphosphate --- polyurethane --- composite --- flame retardant --- biodegradable nanofibers --- PLGA --- collagen --- epinephrine --- lidocaine --- polyimide film --- linear coefficient of thermal expansion (CTE) --- copper clad laminate --- structure and properties --- polymorphism --- isotactic polypropylene --- deformation --- phase transitions --- uniaxial compression --- uniaxial tensile deformation --- temperature --- in situ X-ray --- cavitation --- indentation --- Harmonix AFM --- polymer morphology --- mechanical properties --- ultra-high molecular weight polyethylene (UHMWPE) --- microcellular injection molding --- supercritical fluid --- supercritical N2 --- supercritical CO2 --- tissue engineering and regenerative medicine --- bioresorbable polymers --- 3D printing/additive manufacturing --- fused filament fabrication/fused deposition modelling --- degradation --- physicochemical characterization --- polycaprolactone --- layered double hydroxides --- ionic liquids --- PLA --- reactive blending --- biobased films --- graphene --- nanoreinforcement --- curing rate --- epoxy microstructure --- fatigue --- composites --- critical gel --- poly(lactic acid) --- carbon black --- graphite --- polymer blend --- poly(ethylene terephthalate) --- intrinsic viscosity --- polyolefin --- compatibilizer --- isotactic polypropylene --- stress-induced phase transitions --- structural analysis --- X-ray diffraction --- polyoxymethylene (POM) --- octakis[(3-glycidoxypropyl)dimethylsiloxy]octasilsesquioxane (GPOSS) --- composites --- morphology --- mechanical properties --- conductive filler --- orientation --- conductive polymer composites --- foam --- model --- PLLA --- bioresorbable vascular scaffolds --- stretch blow molding --- biaxial elongation --- SAXS --- WAXS --- microfibrillar composites --- crystalline morphology --- crystallinity --- mechanical properties --- crystallisation --- morphology --- nanoparticles --- shear --- flow --- orientation --- poly(?-caprolactone) --- polyvinyl butyral --- hydrophobicity --- contact angle --- polypropylene --- atomic force microscopy --- injection molding --- mold temperature evolution --- polycaprolactone --- ultra-high molecular weight polyethylene --- incremental forming --- SPIF --- XRD --- chain orientation --- temperature sensitive --- gel --- controllable gas permeability --- breathable film --- polymer composite --- processing --- polyamide 6 --- compression molding --- polymorphism --- polyamide 6 --- injection molding --- polymorphism --- humidity --- mechanical properties

Siloxane-Based Polymers

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ISBN: 9783038971252 9783038971269 Year: Pages: 188 DOI: 10.3390/books978-3-03897-126-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This book, a collection of 12 original contributions and 4 reviews, provides a selection of the most recent advances in the preparation, characterization, and applications of polymeric nanocomposites comprising nanoparticles. The concept of nanoparticle-reinforced polymers came about three decades ago, following the outstanding discovery of fullerenes and carbon nanotubes. One of the main ideas behind this approach is to improve the matrix mechanical performance. The nanoparticles exhibit higher specific surface area, surface energy, and density compared to microparticles and, hence, lower nanofiller concentrations are needed to attain properties comparable to, or even better than, those obtained by conventional microfiller loadings, which facilitates processing and minimizes the increase in composite weight. The addition of nanoparticles into different polymer matrices opens up an important research area in the field of composite materials. Moreover, many different types of inorganic nanoparticles, such as quantum dots, metal oxides, and ceramic and metallic nanoparticles, have been incorporated into polymers for their application in a wide range of fields, ranging from medicine to photovoltaics, packaging, and structural applications.

Keywords

fabrication --- multielectrode array (MEA) --- PDMS --- PDMS etching --- plateau-shaped electrode --- recessed electrode --- spinal cord signal recording --- underexposure --- organosilane --- quartz microcrystal --- encapsulant --- refractive index --- thermal conductivity --- poly(dimethylsiloxanes) --- surface modification --- nanosilica --- diethyl carbonate --- carbon content --- morphology --- coatings --- fillers --- hybrid hydrogel --- MAPOSS --- mechanical properties --- swelling --- drug release --- dental resin --- methacryl POSS --- shrinkage --- hardness --- scratch resistance --- ceramizable silicone rubber --- borate --- halloysite --- composite --- ceramizable mechanism --- polysiloxanes --- mortar --- basalt fibre --- roughness --- surface free energy --- poly(ethylene glycol) (PEG) --- hydrophilic --- non-releasable --- polydimethylsiloxane --- coatings --- cross-linking --- surface --- amphiphilic --- anti-bioadhesion --- hyperbranched poly(methylhydrosiloxanes) --- hydrolytic polycondensation --- 29Si-NMR --- topology of polysiloxane chains --- polyhedral oligomeric silsesquioxanes --- high molecular weight --- nanoparticles --- PDMS --- sugar templating process --- 3D porous network --- thermal stability --- TG-FTIR --- X-ray (Micro-CT) microtomography --- sol-gel --- hybrids --- chlorogenic acid --- bioactivity --- FTIR --- TG --- polysiloxanes --- theranostics --- drug delivery --- nanomedicine --- PDMS --- silicon --- ultraviolet (UV) curable coatings --- low surface energy materials --- fluorinated siloxane resin

Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms

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ISBN: 9783039280445 9783039280452 Year: Pages: 186 DOI: 10.3390/books978-3-03928-045-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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This Special Issue Book ""Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms"" is aimed at collecting literature on the below-mentioned keyword topics, which can significantly increase our basic understanding of marine-derived compounds in cosmeceutical product development and increases the value of marine products at the industrial level.

Intrinsically Biocompatible Polymer Systems

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ISBN: 9783039284207 9783039284214 Year: Pages: 270 DOI: 10.3390/books978-3-03928-421-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy, which reflects current developments in the area of intrinsically biocompatible polymer systems. Polymeric biomaterials are presently used as, for example, long-term implantable medical devices, degradable implantable systems, transient invasive intravascular devices, and, recently, as tissue engineering scaffolds. This Special Issue welcomes full papers and short communications highlighting the aspects of the current trends in the area of intrinsically biocompatible polymer systems.

Keywords

antimicrobial peptides --- biodegradable polymers --- biocompatible polymers --- drug delivery systems --- controlled release --- citropin --- temporin --- ionic liquids --- chitooligosaccharide --- polyurethane --- biodegradability --- physicochemical properties --- hemocompatibility --- biological activity --- crosslinking --- drug delivery --- cosmetic --- food-supplement --- functionalization --- hyaluronan applications --- hyaluronan derivatives --- hyaluronan synthases --- hyaluronic acid --- hyaluronidases --- physico-chemical properties --- cyclohexanone --- ?-butyrolactone --- chloroform --- extraction --- polyhydroxyalkanoates --- PHB --- electrospraying --- biodegradable nano/microparticles --- drug delivery --- septic arthritis --- release characteristics --- biopolymers --- silk fibroin --- konjac glucomannan --- porous beads --- scaffolds --- tissue engineering --- microcarriers --- Poly (l-lactic) acid --- Chitosan --- nanohydroxyapatite --- osteoblasts --- ion-releasing materials --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- enzymatic polymerization --- chemical polymerization --- poly(benzyl malate) --- biocompatible nanoparticles --- cell uptake --- cytotoxicity --- HepaRG cells --- human macrophages --- star polymers --- solution behavior --- ATRP --- SPION --- contrast agent --- MRI --- cancer diagnosis --- folate receptor --- pluronic F127 --- polylactide --- hydrolytic degradation --- mechanical properties --- PEEK copolymer synthesis --- PEEK composite --- Spine cage application --- In vitro biosafety --- degradation --- saliva --- mechanical properties --- molecular weight --- thermal properties --- activation energy of thermal decomposition --- anterior cruciate ligament reconstruction --- bone tunnel enlargement --- X-ray microtomography --- polylactide --- n/a

Characterization of Bioactive Components in Edible Algae

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ISBN: 9783039285600 / 9783039285617 Year: Pages: 226 DOI: 10.3390/books978-3-03928-561-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
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Algae have been used since ancient times as food for humans, animal feed, agricultural fertilizer, and as a source of substances for therapeutic use. Currently, seaweed represents a vast source of raw materials used in the pharmaceutical, food, traditional medicine, and cosmetics industries. They are nutritionally valuable, both fresh and dried, or as ingredients in a wide variety of pre-made foods. In particular, seaweed contains significant amounts of protein, lipids, minerals, and vitamins. Information is limited on the role of algae and their metabolites in therapy. Only a few taxa have been studied for use in medicine. Many traditional cultures report the healing powers of selected algae in tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. However, currently, only a few genera and species of algae are involved in aspects of medicine and therapy. The beneficial uses of seaweed or seaweed products include those that can mimic specific manifestations of human disease, production of antibiotic compounds, or improved human nutrition.

Advances in Food Analysis

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ISBN: 9783039217427 9783039217434 Year: Pages: 488 DOI: 10.3390/books978-3-03921-743-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-12-09 11:49:16
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This Topical Collection of Molecules provides the most recent advancements and trends within the framework of food analysis, confirming the growing public, academic, and industrial interest in this field. The articles broach topics related to sample preparation, separation science, spectroscopic techniques, sensors and biosensors, as well as investigations dealing with the characterization of macronutrients, micronutrients, and other biomolecules. It offers the latest updates regarding alternative food sources (e.g., algae), functional foods, effects of processing, chiral or achiral bioactive compounds, contaminants, and every topic related to food science that is appealing to readers. Nowadays, the increasing awareness of the close relation among diet, health, and social development is stimulating demands for high levels of quality and safety in agro-food production, as well as new studies to fill gaps in the actual body of knowledge about food composition. For these reasons, modern research in food science and human nutrition is moving from classical methodologies to advanced instrumental platforms for comprehensive characterization. Nondestructive spectroscopic and imaging technologies are also proposed for food process monitoring and quality control in real time.

Keywords

cuprous oxide nanoparticles --- reduced graphene oxide --- modified electrode --- sunset yellow --- second-derivative linear sweep voltammetry --- clenbuterol --- systematic evolution of ligands by exponential enrichment --- real-time quantitative PCR --- high-throughput sequencing technology --- aptamers --- gold nanoparticles biosensor --- carbamates --- multiple reaction monitoring (MRM) --- enhanced product ion (EPI) --- mass fragmentation --- confirmatory method --- pesticide residues --- Croatian wines --- biogenic amines --- HPLC --- geographical origin --- polyelectrolyte composite film --- nitrite detection --- differential pulse voltammetry --- cyclic voltammetry --- mycotoxin --- dimerization --- HRMS --- NMR --- fruit jams --- food security --- phenolic acids --- quercetin --- agro-biodiversity --- HPLC fingerprint --- Polygonatum cyrtonema --- saccharides --- oligosaccharides --- fructose --- HPLC–QTOF–MS/MS --- steaming --- essential oil --- extraction techniques --- hops extracts --- hydrodistillation --- Marynka strain --- microwave-assisted hydrodistillation --- anthocyanins --- bioactive compounds --- Box–Behnken design --- microwave-assisted extraction --- myrtle --- Myrtus communis --- phenolic compounds --- Chia seed oil --- polyunsaturated fatty acid --- antioxidant --- lipid-lowering effect --- collagen peptide --- HPLC fingerprint --- antioxidant --- anti-inflammatory --- spectrum-effect relationship --- amino acids --- carbohydrates --- acidity --- polarity --- molecular weight --- Tricholoma matsutake --- Pol gene --- qualitative and quantitative PCR --- DNA extraction --- ?-blockers --- metabolites --- milk powder --- Q-Orbitrap --- rosé wines --- white wines --- bottle aging --- flavor profile --- closures --- anthocyanins --- bioactive compounds --- Box–Behnken design --- ultrasound-assisted extraction --- myrtle --- Myrtus communis L. --- phenolic compounds --- food safety --- kiwifruit (Actinidia chinensis) --- molecular identification --- phylogeny --- DNA barcode --- hard clams --- Meretrix lyrata --- lipid classes --- fatty acids --- phospholipids --- molecular species of phospholipid --- high resolution mass spectrometry --- impedimetric aptasensor --- screen-printed interface --- bifunctional polymer arms --- PAT detection --- apple juice --- chiral --- chiral stationary phases --- enantiomers --- food --- review --- Piper methysticum (kava) --- kavalactones --- flavokavains --- UHPLC-UV --- mass spectra --- isomerization --- single-laboratory validation --- quality control --- Lactarius deliciosus --- chemical composition --- antioxidant --- antihyperglycemic --- ?13C-IRMS --- fatty acids composition --- 1H-NMR --- walnut varieties --- poultry eggs --- thiamphenicol --- florfenicol --- florfenicol amine --- ASE --- UPLC-FLD --- Sojae semen praeparatum (SSP) --- fermentation --- conversion --- ultra-fast liquid chromatography (UFLC)–TripleTOF MS --- principal component analysis (PCA) --- microalgae --- Scenedesmus --- supercritical fluid extraction --- carotenoids --- fat-soluble vitamins --- antioxidants --- fruit juice --- blends --- adulteration --- 1H NMR --- PLS --- chemometrics --- natural mature honey --- immature honey --- chemometric analysis --- multi-physicochemical parameters --- food quality --- IMS --- food composition --- food process control --- food authentication --- food adulteration --- food safety --- antibiotics --- liquid chromatography mass spectrometry --- milk --- muscle --- validation

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