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The Molecular and Cellular Basis for Parkinson's Disease

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ISBN: 9783039215485 9783039215492 Year: Pages: 230 DOI: 10.3390/books978-3-03921-549-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Keywords

epigenetics --- Parkinson’s disease --- brain --- DNA methylation --- Parkinson’s disease --- fatty acid ?-oxidation --- long-chain acylcarnitine --- Parkinson’s disease --- fatty acyls --- glycerolipids --- glycerophospholipids --- sphingolipids --- sterol lipids --- lipoproteins --- ?-synuclein-mediated pathology --- disease-modifying effects --- neuroprotection --- autophagy --- cysteinyl-dopamine --- hypochlorite --- oxidative stress --- Parkinson’s disease --- redox cycling --- Parkinson’s disease --- brain iron --- motor dysfunction --- neurometabolites --- magnetic resonance imaging --- magnetic resonance spectroscopy --- GABA --- spectroscopy --- Parkinson’s disease --- neuroinflammation --- alpha-Synuclein --- immunotherapy --- mesenchymal stem cells --- secretome --- exosomes --- Parkinson’s disease --- microRNAs --- Parkinson disease --- multiprofessional therapy --- inpatient treatment --- multimodal complex treatment --- caffeic acid --- chlorogenic acid --- rotenone --- Parkinson’s disease --- neuroprotection --- dopaminergic neuron --- myenteric plexus --- enteric glial cell --- metallothionein --- Parkinson’s disease --- microbiota --- molecular mimicry --- microbiome --- alpha-synuclein --- curli --- gut-brain axis --- neurodegeneration --- glucocerebrosidase --- Parkinson’s disease --- Gaucher’s disease --- Lewy Body Dementia --- REM sleep behavior disorders --- [123I]FP-CIT-SPECT --- DAT --- nigral cells --- Parkinson’s disease --- parkinsonisms --- cell line --- differentiation --- HOG --- immature oligodendrocyte --- Krabbe’s disease --- oligodendrocyte --- mature oligodendrocyte --- MO3.13 --- myelin --- multiple sclerosis --- schizophrenia --- SH-SY5Y

Extraintestinal Manifestations of Coeliac Disease

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ISBN: 9783038977988 9783038977995 Year: Pages: 270 DOI: 10.3390/books978-3-03897-799-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-04-25 16:37:17
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Abstract

Coeliac Disease (CD) affects at least 1% of the population. “Classical” CD refers to gastrointestinal presentations with anaemia and gastrointestinal symptoms. CD can, however, present with extraintestinal manifestations, the commonest of which are dermatitis herpetiformis and neurological presentations (e.g., ataxia, neuropathy, encephalopathy). Recognition and research into the pathophysiology of such manifestations is likely to enhance our understanding of this complex autoimmune disorder.

Keywords

dermatitis herpetiformis --- coeliac disease --- fracture --- bone health --- quality of life --- Gilles de la Tourette syndrome (GTS) --- children and adults --- motor and vocal/phonic tics --- obsessive-compulsive disorder (OCD) --- non-coeliac gluten sensitivity (NCGS) --- gluten-free diet --- one-year adherence --- dermatitis herpetiformis --- coeliac disease --- prevalence --- epidermal transglutaminase --- gluten-free diet --- long-term prognosis --- dermatitis herpetiformis --- coeliac disease --- gluten-free diet --- small bowel --- villous atrophy --- prognosis --- gluten neuropathy --- coeliac disease --- gluten free diet --- quality of life --- male --- extra-intestinal --- gastrointestinal --- celiac disease --- celiac disease --- dermatitis herpetiformis --- urticaria --- atopic dermatitis --- psoriasis --- recurrent aphtous ulceration --- rosacea --- alopecia areata --- cutaneous vasculitis --- gluten-free diet --- celiac disease --- glandular autoimmunity --- autoimmune thyroid disease --- type 1 diabetes --- polyglandular autoimmune syndrome --- coeliac disease --- osteoporosis --- fractures --- celiac disease --- non-celiac gluten sensitivity --- psychiatric disorders --- depression --- anxiety disorders --- eating disorders --- ADHD --- autism --- psychosis --- autoimmunity --- celiac hepatitis --- gut–liver axis --- liver immunity --- non-alcoholic fatty liver disease --- tolerance --- intestinal barrier --- celiac disease --- extraintestinal --- recognition --- diagnosis --- clinical presentation --- gluten-free diet --- prognosis --- movement disorders --- coeliac disease --- gluten --- gluten free diet --- celiac disease --- gluten --- gliadin --- autoantibody --- B cell --- T cell --- transglutaminase --- synapsin --- ganglioside --- gluten sensitivity --- gastrointestinal symptoms --- molecular mimicry --- intermolecular help --- biomarker --- autoimmune pancreatitis --- coeliac disease --- pancreatic disorders --- screening --- Gluten ataxia --- antigliadin antibodies --- coeliac disease --- MR spectroscopy --- gluten sensitive enteropathy --- antigliadin antibody titre --- gluten sensitivity --- coeliac disease --- gluten free diet --- migraine --- headache --- fatigue --- energy --- celiac disease --- extra-intestinal manifestations --- gluten --- latent celiac disease --- potential celiac disease --- extra-intestinal manifestations --- mild enteropathy --- early developing celiac disease --- genetic gluten intolerance --- natural history --- celiac trait --- celiac disease --- gluten neuropathy --- gluten ataxia --- prevalence --- incidence --- gluten-free diet

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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english (2)


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2019 (2)