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Suzuki–Miyaura Cross-Coupling Reaction and Potential Applications

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ISBN: 9783038425564 9783038425571 Year: Pages: VIII, 264 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2017-12-04 11:24:07
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Suzuki–Miyaura cross-coupling remains a powerful tool in organic synthesis for C–C bond formation and has various industrial applications, for example, the synthesis of pharmaceuticals and materials. Intensive research efforts are being made into finding ways of improving and expanding the scope of this process, and the development of more efficient catalytic systems for this extremely important reaction is still a hot research topic of enormous academic and industrial interest. This Special Issue, consisting of four reviews, two communications and six articles, focuses on recent promising research and novel trends in the broad field of Suzuki–Miyaura cross-coupling employing a range of different palladium catalysts. Homogeneous or heterogeneous catalysis in organic or aqueous medium, using conventional conditions or non-conventional techniques such as microwave and ultrasound irradiation, grinding and photo-activated processes as green chemistry approaches, as well as continuous flow technology are included. The catalysts described herein are unsupported metal complexes, catalysts immobilized on solid supports, ligand-free catalytic systems or metal nanoparticles.

Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile

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ISBN: 9783039213153 9783039213160 Year: Pages: 204 DOI: 10.3390/books978-3-03921-316-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
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For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.

Special Issue Dedicated to Late Professor Takuo Okuda. Tannins and Related Polyphenols Revisited: Chemistry, Biochemistry and Biological Activities

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ISBN: 9783038978343 9783038978350 Year: Pages: 316 DOI: 10.3390/books978-3-03897-835-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 10:09:00
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Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.

Keywords

Dittrichia viscosa --- antifungal activities --- Candida spp. --- Malassezia spp. --- Microsporum canis --- Aspergillus fumigates --- Ephedra sinica --- proanthocyanidin --- oligomer --- thiolysis --- phloroglucinolysis --- TDDFT --- ECD --- neuraminidase --- inhibition --- tannins --- oseltamivir carboxylate --- zanamivir --- crystal structure --- molecular interactions --- oenothein B --- ellagitannin --- macrocyclic oligomer --- Onagraceae --- Myrtaceae --- Lythraceae --- antioxidants --- antitumor effect --- immunomodulatory effect --- anti-inflammation --- tannin composition --- purple prairie clover --- conservation method --- protein precipitation --- Escherichia coli --- Cynanchum wilfordii --- phenolic glycoside --- 2-O-?-laminaribiosyl-4-hydroxyacetophenone --- cynandione A --- thin layer chromatography --- Cynanchum auriculatum --- Acacia mearnsii bark --- wattle tannin --- proanthocyanidins --- biological activities --- tannins --- vegetable tanning --- European historic leathers --- colorimetric tests --- spectroscopy --- UV-Vis --- FTIR --- triple-negative breast cancer --- fatty acid synthase --- FASN inhibition --- polyphenolic FASN inhibitors --- (?)-epigallocatechin 3-gallate --- synthetic analogues --- apoptosis --- anticancer activity --- 1H-NMR --- quantitative NMR --- ellagitannin --- Geranium thunbergii --- geraniin --- Aluminum ion --- blue color development --- 5-O-caffeoylquinic acid --- 3-O-glucosyldelphinidin --- Hydrangea macrophylla --- ESI-mass --- metal complex --- Coreopsis lanceolata L. --- chalcone --- flavanone --- flavonol --- aurone --- Horner–Wadsworth–Emmons reaction --- condensed tannin --- bioactivity --- methanogenesis --- grape marc --- fatty acids --- in vitro batch fermentation --- neuroprotection --- PC12 --- NGF --- differentiation --- amyloid-? peptide --- taxanes --- hormesis --- polyphenol --- bamboo leaf extract --- overlay method --- ellagitannin --- structure --- revision --- (?)-epigallocatechin gallate --- immune checkpoint --- interferon-? --- epidermal growth factor --- lung tumor --- proanthocyanidins --- condensed tannins --- thiolysis --- NMR spectroscopy --- ultrahigh-resolution negative mode MALDI-TOF mass spectrometry --- antioxidant --- ORAC assay --- Acacia --- forage legume --- Trapa taiwanensis Nakai --- hydrolysable tannin --- stability --- gallotannin --- ellagitannin

Synthesis and Applications of New Spin Crossover Compounds

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ISBN: 9783039213610 9783039213627 Year: Pages: 254 DOI: 10.3390/books978-3-03921-362-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-12-09 11:49:15
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The crystal chemistry of spin crossover (SCO) behavior in coordination compounds can potentially be in association with smart materials—promising materials for applications as components of memory devices, displays, sensors and mechanical devices and, especially, actuators, such as artificial muscles. This Special Issue is devoted to various aspects of SCO and related research, comprising 18 interesting original papers on valuable and important SCO topics. Significant and fundamental scientific attention has been focused on the SCO phenomena in a wide research range of fields of fundamental chemical and physical and related sciences, containing the interdisciplinary regions of chemical and physical sciences related to the SCO phenomena. Coordination materials with bistable systems between the LS and the HS states are usually triggered by external stimuli, such as temperature, light, pressure, guest molecule inclusion, soft X-ray, and nuclear decay. Since the first Hofmann-like spin crossover (SCO) behavior in {Fe(py)2[Ni(CN)4]}n (py = pyridine) was demonstrated, this crystal chemistry motif has been frequently used to design Fe(II) SCO materials to enable determination of the correlations between structural features and magnetic properties.

Keywords

spin crossover --- spin transition --- cobalt(II) ion --- paramagnetic ligand --- aminoxyl --- switch --- mosaicity --- spin crossover --- X-ray diffraction --- fatigability --- single crystal --- phase transition --- structural disorder --- spin-crossover --- dinuclear triple helicate --- Fe(II) --- solvent effects --- metal dithiolene complexes --- [Au(dmit)2]?, [Au(dddt)2]? --- ion-pair crystals --- [Fe(III)(3-OMesal2-trien)]+ --- coordination complexes --- crystal structure --- magnetic properties --- magnetic susceptibility --- magnetization --- spin-crossover transition --- Fe(II) complex --- dipyridyl-N-alkylamine ligands --- high spin (HS) --- low spin (LS) --- spin cross-over (SCO) --- magnetic transition --- cobalt oxide --- spin polaron --- impurity effect --- spin-state crossover --- coordination polymer --- supramolecular isomerism --- spin crossover --- crystal engineering --- spin crossover --- X-ray absorption spectroscopy --- soft X-ray induced excited spin state trapping --- high spin --- spin-crossover --- LIESST effect --- hydrogen bonding --- ?-? interactions --- charge-transfer phase transition --- iron mixed-valence complex --- hetero metal complex --- dithiooxalato ligand --- substitution of 3d transition metal ion --- ferromagnetism --- dielectric response --- 57Fe Mössbauer spectroscopy --- Fe(III) coordination complexes --- hexadentate ligand --- Schiff base --- spin crossover --- UV-Vis spectroscopy --- SQUID --- EPR spectroscopy --- spin-crossover --- optical microscopy --- reaction diffusion --- spin crossover --- Fe(III) complex --- qsal ligand --- thermal hysteresis --- structure phase transition --- counter-anion --- solvate --- lattice energy --- optical conductivity spectrum --- spiral structure --- 1,2-bis(4-pyridyl)ethane --- supramolecular coordination polymer --- chiral propeller structure --- atropisomerism --- spin crossover --- iron(II) complexes --- C–H···? interactions --- magnetic properties --- thermochromism --- spin crossover --- linear pentadentate ligand --- iron(II) --- mononuclear --- 1,2,3-triazole --- crystal structure --- magnetic properties --- DFT calculation --- intermolecular interactions --- amorphous --- spin crossover --- Cu(II) complexes --- nitroxides --- phase transitions --- magnetostructural correlations --- iron (II), spin crossover --- X-ray diffraction --- coordination polymers --- n/a

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