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Molecular Features Distinguishing Gastric Cancer Subtypes

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ISBN: 9783038974048 9783038974055 Year: Pages: 326 DOI: 10.3390/books978-3-03897-405-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Oncology
Added to DOAB on : 2018-12-07 10:22:34
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Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Stomach cancers are 90% adenocarcinoma; lymphoma, carcinoid, and stromal tumours may occur. Adenocarcinoma can be subdivided into histological Lauren and the World Health Organization (WHO) classifications, but this information has not led to the development of histologic subtype-specific treatment options. One way to potentially improve treatment for gastric cancers is to better understand the pathogenesis of this disease, the contribution of Helicobacter pylori infection, and host immune response to lead to the development of integrated histological and molecular classification schemes for gastric cancer. The hope is that these studies may facilitate the development of clinical trials to explore therapies in defined sets of patients, ultimately improving survival from this deadly disease.

Knowledge, Spirit, Law, Book 2: The Anti-Capitalist Sublime

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ISBN: 9781947447349 9781947447356 Year: Pages: 270 DOI: 10.21983/P3.0191.1.00 Language: English
Publisher: punctum books
Subject: Performing Arts
Added to DOAB on : 2019-06-12 09:24:32

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Knowledge, Spirit, Law // Book 2: The Anti-capitalist Sublime takes up where Knowledge, Spirit, Law // Book 1: Radical Scholarship (2015) left off, foremost in terms of a critique of neo-liberal academia and its demotion of the book in favor of various mediatic practices that substitute, arguably, for the one form of critical inquiry that might safeguard speculative intellectual inquiry as long-form and long-term project, especially in relationship to the archive or library (otherwise known as the “public domain”). This ongoing critique of neo-liberal academia is a necessary corrective to processes underway today toward the further marginalization of radical critique, with many of the traditional forms of sustained analysis being replaced by pseudo-empirical studies that abandon themes only presentable in the Arts and Humanities through the “arcanian closure” that the book as long-form inquisition represents (whether as novel, non-fictional critique, or something in-between). As a tomb for thought, this privileging of the shadowy recesses of the book preserves, through the very apparatuses of long- and slow-form scholarship, the premises presented here as indicative of an anti-capitalist project embedded in works that might otherwise shun such a characterization.

Progress in Physical activity and Exercise and Affective and Anxiety Disorders: Translational Studies, Perspectives and Future Directions

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194711 Year: Pages: 78 DOI: 10.3389/978-2-88919-471-1 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:33
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Physical activity and exercise were receiving a great attention as a strategy of prevention and treatment of affective and some anxiety disorders. Many studies have showed the efficacy of exercise in major depression and at depressed episode of bipolar patients, as well as, some authors shows the benefits of exercise in some anxiety disorders like Generalized Anxiety Disorder and Panic. Despite their efficacy, little is known concerning the main mechanisms related to the antidepressant and anxiolytic effects of exercise. Several studies in an animal model using Neurotrophic Factors, Oxidative Stress, Immunologic response and other biological markers reveal promising results. However, few studies were conducted in clinical samples. Additional to the antidepressant and anxiolytic effects, exercise appears improve QoL in major depressed, bipolar and anxiety patients. Theoretically, this increase may be associated with cognitive improvements, improvements at sleep quality, physical functioning, as well as other psychological issues as self-esteem, self-concept, and general well-being. The propose of this topic is to address the novelty and most recent research, related to antidepressant and anxiolytic effects of physical activity and exercise in patients with affective and anxiety disorders, as well as the issues associated with QoL improvement.The topic is looking for: – Clinical trials using exercise and physical activity as a treatment affective and anxiety disorders. – Studies investigating the optimal prescription factors (dose, volume, intensity, setting, frequency) associated with antidepressant and anxiolytic effects of physical activity and exercise for affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning the mechanisms of antidepressant and anxiolytic effects of physical activity and exercise in affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning other benefits of physical activity and exercise like : cognition, weight gain prevention and QoL in affective and anxiety disorder patients. – Translational research. – Studies of cost-efficacy analysis

Twenty Years After the Iowa Gambling Task: Rationality, Emotion, and Decision-Making

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455287 Year: Pages: 275 DOI: 10.3389/978-2-88945-528-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology --- Neurology
Added to DOAB on : 2019-01-23 14:53:42
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The world is full of uncertainty. In unpredictable circumstances, can emotions facilitate advantageous decision-making? A neuroscience team, led by Antonio Damasio, explored this question using the Iowa Gambling Task (IGT). To the present day, the findings of numerous IGT-related investigations strongly influence clinical and interdisciplinary research, for example, in neuroeconomics and neuromarketing.This special issue examines IGT-based research progress over the past 20 years through literature reviews, clinical examinations, model construction, theoretical integration, and brain imaging technology. Both supportive and opposing viewpoints are provided to frame correlations between rationality, emotion, decision-making, and IGT. Potential future directions for IGT studies are discussed

Das «Prohemium longum» des Erfurter Kartaeuserkatalogs aus der Zeit um 1475

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Book Series: Lateinische Sprache und Literatur des Mittelalters ISBN: 9783906769974 Year: Pages: 602 DOI: 10.3726/b14238 Language: German
Publisher: Peter Lang International Academic Publishing Group
Subject: Religion --- History --- Languages and Literatures
Added to DOAB on : 2019-01-15 13:32:13
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Als herausragendes Beispiel mittelalterlicher Bibliothekskataloge gilt der um 1475 angelegte Katalog der Erfurter Kartause. Für ihn entstand zeitgleich ein einführendes Prohemium longum. Das Prohemium longum ist ein wichtiger Text geistlicher Literatur und erweist sich als bedeutender Beitrag zum Verständnis kartäusischer Spiritualität am Ausgang des Mittelalters. Die vorliegende Arbeit liefert die erstmalige und vollständige Edition seines lateinischen Texts. Ergänzt wird diese mit Untersuchungen zu Fragen des Textverständnisses: Was weiss man über den Verfasser? Mit welcher Intention schrieb er? Ein Kapitel widmet sich der Kompilationsmethode, mit der das Prohemium verfasst wurde, ein weiteres der Darstellungsweise. Schliesslich gehen drei umfangreiche Abschnitte zentralen Begriffen des Texts und deren zeitgenössischer Bewertung nach: ignorancia, theologia mistica und lectio et studium.

Vor-Sicht im Straßenverkehr - Experimentelle Untersuchung der somatischen Antizipation von Risiko

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Book Series: Karlsruher Forschungsberichte zur Arbeitswissenschaft und Betriebsorganisation / Institut für Arbeitswissenschaft und Betriebsorganisation (ifab), Karlsruher Institut für Technologie ISSN: 23637315 ISBN: 9783731507482 Year: Volume: 2 Pages: XXI, 206 p. DOI: 10.5445/KSP/1000078302 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-28 18:37:01
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Based on the Somatic Marker Hypothesis, an attempt is made to measure the anticipation of risky traffic situations by means of the electrodermal activity. The results indicate that the strength of the anticipatory electrodermal activity is systematically related to situational factors of a traffic situation. In addition, a model was derived that postulates an inverted U-shaped relationship between driver’s experience and anticipatory electrodermal activity.

Molecular Advances in Wheat and Barley

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ISBN: 9783039213719 / 9783039213726 Year: Pages: 290 DOI: 10.3390/books978-3-03921-372-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Allohexaploid bread wheat and diploid barley are two of the most cultivated crops in the world. This book reports novel research and reviews concerning the use of modern technologies to understand the molecular bases for wheat and barley improvement. The contributions published in this book illustrate research advances in wheat and barley knowledge using modern molecular techniques. These molecular approaches cover genomic, transcriptomic, proteomic, and phenomic levels, together with new tools for gene identification and the development of novel molecular markers. Overall, the contributions for this book lead to a further understanding of regulatory systems in order to improve wheat and barley performance.

Keywords

Triticum durum --- Aegilops tauschii --- Triticum aestivum --- marker-trait associations --- genes --- bread wheat --- genetic biofortification --- favorable alleles --- allohexaploid --- homoeolog --- hybrid necrosis --- molecular marker --- wheat --- wheat --- rye --- 6R --- small segment translocation --- powdery mildew --- transgenic wheat --- 12-oxophytodienoate reductase --- jasmonates --- freezing tolerance --- HIGS --- transgene --- wheat --- barley --- cereal cyst nematodes --- wheat --- barely --- breeding --- biotechnology --- resistance --- Triticum aestivum --- Landrace --- Powdery mildew --- Bulked segregant analysis-RNA-Seq (BSR-Seq) --- Single nucleotide polymorphism (SNP) --- Kompetitive Allele Specific PCR (KASP) --- Blumeria graminis f. sp. tritici --- protein two-dimensional electrophoresis --- mass spectrometry --- Pm40 --- Barley --- Grain development --- Transcriptional dynamics --- RNA editing --- RNA-seq --- durum wheat --- Tunisian landraces --- center of diversity --- genetic diversity --- population structure --- DArTseq technology --- chromatin --- 3D-FISH --- nucleus --- introgression --- rye --- hybrid --- wheat --- genome stability --- wheat --- Thinopyrum --- chromosome --- ND-FISH --- oligo probe --- barley --- wheat --- protease --- germination --- grain --- abiotic stress --- antioxidant enzymes --- aquaporin --- TdPIP2 --- 1 --- histochemical analysis --- transgenic wheat --- transpiration --- wheat --- Aegilops tauschii --- Lr42 --- disease resistance --- molecular mapping --- KASP markers --- marker-assisted selection --- phytase --- wheat --- barley --- purple acid phosphatase phytase --- PAPhy --- mature grain phytase activity (MGPA) --- genome assembly --- bread wheat --- barley --- optical mapping --- BAC --- ribosomal DNA --- cereals --- CRISPR --- crops --- genetic engineering --- genome editing --- plant --- Triticeae --- n/a

Mass Spectrometric Proteomics

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ISBN: 9783038978268 9783038978275 Year: Pages: 192 DOI: 10.3390/books978-3-03897-827-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-04-25 16:37:17
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As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles&nbsp; published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of&nbsp; new procedures for the&nbsp; optimization of the experimental conditions that should be applied&nbsp; for the identification of proteins present in complex mixtures.&nbsp; Other applications&nbsp; described in these articles show&nbsp; the huge potential of&nbsp; these strategies in the protein profiling of organs and&nbsp; range from&nbsp; to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.

Biodiversity of Vegetable Crops, A Living Heritage

Authors: --- --- --- --- et al.
ISBN: 9783038977209 / 9783038977216 Year: Pages: 174 DOI: 10.3390/books978-3-03897-721-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Agriculture (General)
Added to DOAB on : 2019-08-28 11:21:27
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Intensive agriculture has generally resulted in higher productivity, but also in a trend towards decreasing levels of agro-biodiversity, which represents a key point in ensuring the adaptability and resilience of agro-ecosystems in the global challenge to produce more and better food in a sustainable way. The biodiversity of vegetable crops includes genetic diversity—both as species diversity (interspecific diversity) and as a diversity of genes within a species (intraspecific diversity) with regard to the vegetable varieties grown—and the diversity of agro-ecosystems (agro-biodiversity). The purpose of this Special Issue is to publish high-quality research papers addressing recent progress and perspectives on different aspects related to the biodiversity of vegetable crops. Original, high-quality contributions that have not yet been published, or that are not currently under review by other journals have been sought. The papers in this Special Issue cover a broad range of aspects and report recent research results regarding agro-biodiversity, which continues to be of significant relevance for both genetic and agricultural applications. All contributions are of significant relevance and could stimulate further research in this area.

Ultrasound B-mode Imaging: Beamforming and Image Formation Techniques

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ISBN: 9783039211999 / 9783039212002 Year: Pages: 146 DOI: 10.3390/books978-3-03921-200-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Ultrasound medical imaging stands out among the other diagnostic imaging modalities for its patient-friendliness, high temporal resolution, low cost, and absence of ionizing radiation. On the other hand, it may still suffer from limited detail level, low signal-to-noise ratio, and narrow field-of-view. In the last decade, new beamforming and image reconstruction techniques have emerged which aim at improving resolution, contrast, and clutter suppression, especially in difficult-to-image patients. Nevertheless, achieving a higher image quality is of the utmost importance in diagnostic ultrasound medical imaging, and further developments are still indispensable. From this point of view, a crucial role can be played by novel beamforming techniques as well as by non-conventional image formation techniques (e.g., advanced transmission strategies, and compounding, coded, and harmonic imaging). This Special Issue includes novel contributions on both ultrasound beamforming and image formation techniques, particularly addressed at improving B-mode image quality and related diagnostic content. This indeed represents a hot topic in the ultrasound imaging community, and further active research in this field is expected, where many challenges still persist.

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