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Genetic Determinants of Human Longevity

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ISBN: 9783039216789 / 9783039216796 Year: Pages: 118 DOI: 10.3390/books978-3-03921-679-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2019-12-09 11:49:16
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In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes.

Proceedings of the 3rd International Conference on Genetics of Aging and Longevity

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199266 Year: Pages: 88 DOI: 10.3389/978-2-88919-926-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2016-01-19 14:05:46
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In this book, we present a collection of articles covering a wide range of current aging research and highlighting its prospects and future directions. These articles are based on or related to the topics of the 3rd International Conference «Genetics of aging and longevity». The Conference took place 6-10 April, 2014 in Sochi, the city located on the Black Sea coast near the Caucasian mountains, in Russia. Top gerontologists and geneticists from 31 countries around the world came together to discuss current problems in many areas related to the genetics of longevity and mechanisms of aging. We would like to thank those of them who contributed to this e-Book by sharing latest achievements, ideas and hypotheses. We hope that this e-Book will come to notice of scientists interested in the development of genetics of aging and longevity and in the search for life-beneficial environments and life-prolonging interventions.

Mechanisms Underpinning the Link between Emotion, Physical Health and Longevity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452743 Year: Pages: 185 DOI: 10.3389/978-2-88945-274-3 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Science (General) --- Psychology
Added to DOAB on : 2018-02-27 16:16:44
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The 1990’s was designated as ‘the decade of the brain’ and now, common mental disorders are described as ‘brain disorders’. Yet intense research interest on the brain has largely side-lined the body as a passive observer, disconnecting mental from physical health and contributing to further societal stigma on the nature of psychiatric illness and mental distress. The biopsychosocial pathway to premature mortality or longevity is a complex one, involving a host of closely intertwined mechanisms and moderating factors, some of which are investigated in this special issue. All the articles published here provide new insights into the pathways linking emotion, physical health and longevity, highlighting the tight linkage between mind, brain and body.

Actuarial and Financial Risks in Life Insurance, Pensions and Household Finance

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ISBN: 9783038427308 9783038427292 Year: Pages: 164 DOI: 10.3390/books978-3-03842-729-2
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Business and Management
Added to DOAB on : 2018-03-16 13:44:41
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The recent regulatory changes, together with the increasing awareness of the variety of sources of uncertainty that affect the activities of insurance and pension funds, have generated increasing attention towards insurance risk management theory and practice. Against this background, this Special Issue collects relevant contributions on a variety of issues encompassing longevity risk modelling, solvency requirements, risk management, and risk sharing. This collection of papers provides insights, from both a theoretical and a practical perspective, into the modeling and management of actuarial and financial risks for institutions and households.

New Vision 2050: A Platinum Society

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Book Series: Science for Sustainable Societies ISSN: 2197-7348 ISBN: 9784431566229 9784431566236 Year: Pages: 179 DOI: https://doi.org/10.1007/978-4-431-56623-6 Language: English
Publisher: Springer Grant: Mitsubishi Research Institute, Inc.
Subject: Economics --- Environmental Sciences
Added to DOAB on : 2018-06-29 12:59:47
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This book presents the "New Vision 2050," which adds the concept of the “platinum society” to the “Vision 2050”.The 20th century was a century in which energy led the development of material civilization, resulting in deletion of resources, global warming and climate change. What form should sustainable material and energy take to protect the Earth? The "Vision 2050" was established 20 years ago as a model that we should pursue for the next half century. Fortunately, the world is on course for the Vision 2050.The 21st century will be a century in which we seek qualitative richness, with the Vision 2050 as the material basis. That is, a “platinum society” that has resource self-sufficiency and resource symbiosis, and where people remain active throughout their lives and have a wide range of choices and opportunities for free participation. Since the author presented the concept of "Vision 2050" in 1999, the idea has been introduced in two books entitled Vision 2050: Roadmap for a Sustainable Earth (2008) and Beyond the Limits to Growth: New Ideas for Sustainability from Japan (2014). The latter includes a chapter that sheds light on the concept of a “platinum society”. In this publication, the author presents the "New Vision 2050" in more detail.

Bioactive and Therapeutic Dental Materials

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ISBN: 9783039214198 / 9783039214204 Year: Pages: 216 DOI: 10.3390/books978-3-03921-420-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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This book focus principally on ions-releasing and other smart dental materials for application in preventive and restorative dentistry, as well as in endodontics in the form of adhesives, resin-based composites, pastes, varnishes, liners and dental cements. Special attention has been given to bioactive materials developed to induce cells differentiation/stimulation, hard tissue formation and exert antimicrobial actions. New innovations are necessary to continue to help reinforcing existing technologies and to introduce new paradigms for treating dental disease and restoring teeth seriously compromised by caries lesions via biomimetic and more biological operative approaches. Dental bioactive materials is arguably the latest research area in dentistry and thus the amount of new research is overwhelming. However, in this day and age of evidence based practice it important for this new information to be distilled into a practical and understandable format.

Keywords

orthodontic resin --- photocatalyst TiO2 --- antibacterial --- cariogenic --- early colonizer --- hydrophilic properties --- irradiation --- calcium silicate cements --- pulpal response --- mineralization --- calcific barrier --- inflammation --- odontoblastic layer --- resin cements --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- antibacterial --- calcium --- doxycycline --- nanoparticles --- zinc --- dental composites --- antibacterial properties --- silver --- mechanical properties --- degree of conversion --- sorption --- solubility --- color stability --- mechanical properties --- nanotubes --- resin composite --- Streptococcus mutans --- triclosan --- bleaching products --- diffusion --- cytotoxicity --- dental pulp --- stem cells --- nanoporous silica --- glass-ionomer cement --- calcium --- preclinical biosafety --- bone substitute --- mesenchymal stem cells --- ?-tricalcium phosphate --- tissue engineering --- dental sealant --- resin sealant --- calcium phosphate nanoparticles --- long-term ion release --- remineralization --- ion recharge --- dentin --- desmineralization --- microtensile bond strength --- adhesion --- bioactive --- cycling mechanical stress --- dentine --- longevity --- resin-modified glass ionomer cements --- polyacrylic acid treatment --- bone regeneration --- ?-tricalcium phosphate --- calcium sulfate --- bone substitutes --- animal study --- n/a --- adhesion --- cycling mechanical stress --- dentine --- longevity --- glass-ionomer cements --- universal adhesives

Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

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ISBN: 9783039213559 / 9783039213566 Year: Pages: 322 DOI: 10.3390/books978-3-03921-356-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

The Great Debate: General Ability and Specific Abilities in the Prediction of Important Outcomes

Authors: ---
ISBN: 9783039211678 / 9783039211685 Year: Pages: 108 DOI: 10.3390/books978-3-03921-168-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Psychology
Added to DOAB on : 2019-08-28 11:21:27
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There are many different theories of intelligence. Although these theories differ in their nuances, nearly all agree that there are multiple cognitive abilities and that they differ in the breadth of content they are typically associated with. There is much less agreement about the relative importance of cognitive abilities of differing generality for predicting important real-world outcomes, such as educational achievement, career success, job performance, and health. Some investigators believe that narrower abilities hold little predictive power once general abilities have been accounted for. Other investigators contend that specific abilities are often as—or even more—effective in forecasting many practical variables as general abilities. These disagreements often turn on differences of theory and methodology that are both subtle and complex. The five cutting-edge contributions in this volume, both empirical and theoretical, advance the conversation in this vigorous, and highly important, scientific debate.

The Impact of Caffeine and Coffee on Human Health

Authors: ---
ISBN: 9783039218349 / 9783039218356 Year: Pages: 322 DOI: 10.3390/books978-3-03921-835-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:21:22
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The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.

Keywords

accidental death --- caffeine --- caffeine intoxication --- intoxication --- Suicide --- HIV-HCV co-infection --- liver fibrosis --- coffee --- alcohol consumption --- coffee --- tea --- European Prospective Investigation into Cancer and Nutrition --- 24-h dietary recall --- whole-blood --- mRNA --- transcriptomics --- gene expression --- coffee --- the Norwegian Women and Cancer Cohort (NOWAC) --- caffeine --- myocardial perfusion --- coronary artery disease --- adenosine --- regadenoson --- dipyridamole --- caffeine intake --- assisted reproduction techniques --- risk factors --- implantation --- clinical pregnancy --- live birth --- epidemiology --- bias --- causation --- coffee --- pregnancy --- coffee --- depression --- cohort study --- Mendelian Randomization --- coffee --- caffeine --- behavior --- causality --- genetic epidemiology --- epidemiological methods --- cardiovascular disease --- coffee consumption --- gene-diet interaction --- longevity --- NADH dehydrogenase --- polymorphism --- serum chloride levels --- CYP1A2 --- ADORA2A --- time trial performance --- caffeine metabolism --- pharmacological ergogenic aid --- polymorphism --- anxiety --- ergogenic --- adenosine receptor --- cytochrome P450 --- caffeine --- pharmacogenomics --- coffee --- caffeine --- chlorogenic acids --- phenolic --- cognition --- cognitive --- mood --- age --- sex --- caffeine --- wine --- chocolate --- aging --- cognition --- adult --- coffee --- hearing --- protection --- tinnitus --- Caffeine --- placebo --- sport --- exercise --- health --- expectancy --- cognitions --- caffeine --- coffee --- systematic review --- pregnancy --- safety --- individual responses --- ergogenic aid --- supplement --- did not respond --- responders --- n/a --- caffeine --- coffee --- tea --- soda --- energy drinks --- mate --- guidelines --- country --- consumption --- population --- public policy --- coffee --- caffeine --- lipids --- biomarkers --- trial --- lysophosphatidylcholine --- lipidomics --- n/a

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