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Stem Cell and Biologic Scaffold Engineering

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ISBN: 9783039214976 9783039214983 Year: Pages: 110 DOI: 10.3390/books978-3-03921-498-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.

Towards a Sustainable Management of Mine Wastes: Reprocessing, Reuse, Revalorization and Repository

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ISBN: 9783039281749 9783039281756 Year: Pages: 240 DOI: 10.3390/books978-3-03928-175-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Mining and Metallurgy
Added to DOAB on : 2020-04-07 23:07:08
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The need for efficient and sustainable management methods of mine waste is continuously growing all around the world. These waste products often present serious management problems due to their more or less significant amounts and possible environmental threats. This Special Issue highlights the recent and new trends in sustainable mine waste management techniques. Currently, it is essential to sustainably manage mine waste, considering social, economic, environmental and technical aspects. In this Special Issue, insights related to the following issues are highlighted: the problems around mine waste, the fine characterization of mine waste, the latest available technical and environmental solutions to efficiently manage mine waste, including treatment and processing before disposal and high value element recovery, with the view of moving towards defining effective, low-cost and ecofriendly methods, the recycling of mine waste products as alternative resources in different sectors, and finally laboratory, pilot and/or industrial-scale studies related to these topics of research. Scientists and industry and governance stakeholders have to face these new challenges to find the best management practices for the future.

Keywords

copper tailings dump --- leaching --- pH --- mobility --- chemical species --- attenuation mechanisms --- aquatic systems --- Zgounder mine --- silver --- tailings --- low-grade silver ores --- flotation --- mineralogical characterization --- mine waste --- management --- sustainability --- bibliometric analysis --- systematic review --- valorisation --- mine waste --- soil washing --- heap leaching --- dump leaching --- mine drainage --- remediation --- acid mine drainage --- geographical information systems --- paste pH --- siderite --- multivariate analysis --- spatial mapping --- iron ore tailings --- iron recovery --- concrete composite admixtures --- reuse --- rheology --- microstructure --- flow behavior --- cemented paste backfill --- mixing --- recovering alkali --- Bayer red mud --- reaction kinetics --- magnesium oxide --- hydrotalcite-like compounds --- sustainable development --- tailings management --- industrial ecology --- sustainable resource management --- mining waste --- circular economy --- mine waste --- tailings --- gravity separation --- stamp mill --- historic tailings --- metals --- exploration --- economic potential --- LIBS --- core scanner --- acid mine drainage --- alkaline amendments --- cementitious amendments --- kinetic testing --- Joutel mine --- environmental mineralogy --- exploration --- contaminant --- geochemical behavior --- acid mine drainage --- mine tailings --- sulfides --- gold reprocessing --- desulfurization --- flotation --- kinetic test --- mining and mineral processing waste (MMPW) --- anthropogenic mineral resources (AMR) --- long-term storage --- supergene processes --- environmental damage --- loss and lost profits --- AMR processing --- n/a

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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