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Selected Papers from the 9th Symposium on Micro-Nano Science and Technology on Micromachines

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ISBN: 9783039216963 9783039216970 Year: Pages: 170 DOI: 10.3390/books978-3-03921-697-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

This Special Issue presents selected papers from the 8th

Keywords

vibration-induced flow --- micro-pillar --- numerical analysis --- micro-PIV --- acoustofluidics --- microscale thermophoresis --- multiphase flow --- microfluidic channels --- nano/microparticle separation --- micro-electro-mechanical-systems (MEMS) technologies --- magneto-impedance sensor --- thin-film --- high frequency --- logarithmic amplifier --- nondestructive inspection --- microfluidics --- biofabrication --- adipose tissue --- lipolysis --- tactile display --- thermal tactile display --- thermal sensation --- thermal conductivity --- liquid metal --- flexible device --- stretchable electronic substrate --- kirigami structure --- mechanical metamaterials --- surface mounting --- flexible electronic device --- contact resistance --- contact pressure --- myoblast --- skeletal muscle --- core-shell hydrogel fiber --- cyclic stretch --- engineered muscle --- laser direct writing --- femtosecond laser --- glyoxylic acid Cu complex --- reduction --- Cu micropattern --- near-infrared --- spectroscopy --- surface plasmon resonance --- Schottky barrier --- grating --- Si --- connector --- artificial blood vessel --- medical device --- blood coagulation --- implant --- artificial kidney --- biocompatible --- 4D printing --- 3D printing --- stimuli-responsive hydrogel --- electrical impedance measurement --- three-dimensional cell culture --- adipocyte --- lipid droplet --- 3T3-L1 --- functional surface --- condensation --- molecular dynamics --- wettability --- nanoscale structure --- n/a

Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches

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ISBN: 9783039284924 9783039284931 Year: Pages: 206 DOI: 10.3390/books978-3-03928-493-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.

mTOR in Human Diseases

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ISBN: 9783039210602 9783039210619 Year: Pages: 480 DOI: 10.3390/books978-3-03921-061-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 08:44:06
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The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.

Keywords

acute myeloid leukemia --- metabolism --- mTOR --- PI3K --- phosphorylation --- epithelial to mesenchymal transition --- mTOR inhibitor --- pulmonary fibrosis --- transcriptomics --- miRNome --- everolimus --- mTOR --- thyroid cancer --- sodium iodide symporter (NIS)/SLC5A5 --- dopamine receptor --- autophagy --- AKT --- mTOR --- AMPK --- mTOR --- Medulloblastoma --- MBSCs --- mTOR --- T-cell acute lymphoblastic leukemia --- targeted therapy --- combination therapy --- mTOR --- metabolic diseases --- glucose and lipid metabolism --- anesthesia --- neurotoxicity --- synapse --- mTOR --- neurodevelopment --- mTOR --- rapamycin --- autophagy --- protein aggregation --- methamphetamine --- schizophrenia --- tumour cachexia --- mTOR --- signalling --- metabolism --- proteolysis --- lipolysis --- mTOR --- mTORC1 --- mTORC2 --- rapamycin --- rapalogues --- rapalogs --- mTOR inhibitors --- senescence --- ageing --- aging --- cancer --- neurodegeneration --- immunosenescence --- senolytics --- biomarkers --- leukemia --- cell signaling --- metabolism --- apoptosis --- miRNA --- mTOR inhibitors --- mTOR --- tumor microenvironment --- angiogenesis --- immunotherapy --- fluid shear stress --- melatonin --- chloral hydrate --- nocodazole --- MC3T3-E1 cells --- primary cilia --- mTOR complex --- metabolic reprogramming --- cancer --- microenvironment --- nutrient sensor --- oral cavity squamous cell carcinoma (OSCC) --- NVP-BEZ235 --- mTOR --- p70S6K --- mTOR --- advanced biliary tract cancers --- mTOR --- NGS --- illumina --- IonTorrent --- eIFs --- mTOR --- autophagy --- Parkinson’s disease --- mTOR --- PI3K --- cancer --- inhibitor --- therapy --- mTOR --- laminopathies --- lamin A/C --- Emery-Dreifuss muscular dystrophy (EDMD) --- Hutchinson-Gilford progeria syndrome (HGPS) --- autophagy --- cellular signaling --- metabolism --- bone remodeling --- ageing --- mTOR --- fructose --- glucose --- liver --- lipid metabolism --- gluconeogenesis --- Alzheimer’s disease --- autophagy --- mTOR signal pathway --- physical activity --- microRNA --- mTOR --- spermatogenesis --- male fertility --- Sertoli cells --- n/a

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english (3)


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2020 (1)

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