Search results: Found 14

Listing 1 - 10 of 14 << page
of 2
>>
Sort by
La production de la culture : Le cas des musiques amplifiées en France : genèse, structurations, industries, alternatives

Author:
ISBN: 9782913169487 DOI: 10.4000/books.ms.554 Language: French
Publisher: Éditions Mélanie Seteun
Added to DOAB on : 2019-12-06 13:15:38
License: OpenEdition Licence for Books

Loading...
Export citation

Choose an application

Abstract

Secteur professionnel, scènes locales, under­ground, acteurs publics s'y côtoient. Ils agissent parfois de concert, parfois de manière antagoniste. À la lecture de ce livre, on comprend ainsi de quelles manières et par quels mécanismes la musique que nous partageons quotidiennement est produite. Proposant une sociologie qui tient compte de données culturelles, sociales, historiques et économiques, cet ouvrage analyse les processus d'élaboration des musiques amplifiées en France. Il montre d'abord comment s'est structurée dès la première moitié du XXe siècle une industrie de la musique, centrée sur Paris, par la montée en puissance d'un secteur économique et l'institutionnalisation de fonctions spécifiques dans les secteurs du disque, des médias, et du spectacle. Il met ensuite en évidence la manière dont ont pu émerger, suite au développement générationnel de la pratique de ces musiques et à la structuration de scènes locales sur le territoire français, des sources de production et de diffusion se revendiquant alternatives à cette industrie. Enfin, à travers une enquête de terrain, il explicite comment se déploient aujourd'hui les cultures musicales amplifiées qui touchent à la fois, le plus souvent au sein de collectifs, des musiciens amateurs et d'autres qui cherchent à se professionnaliser. En interrogeant l'articulation entre phénomènes globaux et pratiques quotidiennes liées à la musique en France, l'étude met ainsi à jour comment les normes et les usages technologiques, économiques ou juridiques influencent la production de la culture.

Magnetic Materials Based Biosensors

Author:
ISBN: 9783038972549 9783038972556 Year: Pages: 212 DOI: 10.3390/books978-3-03897-255-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Internal medicine
Added to DOAB on : 2018-10-19 10:59:48
License:

Loading...
Export citation

Choose an application

Abstract

ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Selective and quantitative detection of different kinds of biocomponents plays an important role in biomedical applications, clinical diagnostics, environmental monitoring, toxicology, regenerative medicine and drug delivery. Therefore, multidisciplinary area of magnetic biosensing have been extensively developed in recent years, aiming to create compact analytical devices for non-expensive and low time consuming analysis provided at the point of care by non-skilled personnel. Biological samples exhibit very low magnetic background, and thus highly sensitive measurements of magnetic labels or magnetic nanoparticles enriched units can be performed without further processing. A magnetic biosensor is a compact analytical device in which magnetic transducer converts a magnetic field variation into a change of frequency, current, voltage, etc. Different types of magnetic effects are capable of creating magnetic biosensors with extra high sensitivity. This book describes interesting examples of magnetic materials based biosensors, including the synthesis of model materials for biosensor development, new engineering solutions and theoretical contributions on the magnetic biosensor sensitivity. Book contains 13 research works representing international multidisciplinary teams from Austria, China, Germany, Greece, Iran, Russia, Serbia, Spain, Taiwan and United States of America. It can be useful for PHD students and researches working in the field of magnetic nanomaterials and biomedical applications.

Phenotypic screening in the 21st century

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194698 Year: Pages: 67 DOI: 10.3389/978-2-88919-469-8 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
License:

Loading...
Export citation

Choose an application

Abstract

In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples. Specific topics include: • The need for systems-based approaches in drug development • Phenotypic screening strategies • Compound libraries (natural product inspired compound collections) • Target deconvolution and identification • Target agnostic lead discovery and optimization • Multi-target approaches and decoding the phenotype (understanding biological interactions and multiscale systems modelling) • Translational aspects • Early evaluation of selectivity and safety in a target agnostic manner

Creating and Governing Cultural Heritage in the European Union

Authors: --- --- --- --- et al.
ISBN: 9780367148355 Year: Pages: 300 Language: English
Publisher: Taylor & Francis
Subject: History --- Information theory --- Archaeology
Added to DOAB on : 2020-05-04 10:28:34
License:

Loading...
Export citation

Choose an application

Abstract

Creating and Governing Cultural Heritage in the European Union provides an interdisciplinary examination of the ways in which European cultural heritage is created, communicated, and governed via the European Heritage Label scheme. Drawing on ethnographic field research conducted at sites in ten countries that have been awarded with the European Heritage Label, the authors of the book approach heritage as an entangled social, spatial, temporal, discursive, narrative, performative, and embodied process. Recognising that heritage is inherently political and used by diverse actors as a tool for re-imagining communities, identities, and borders, and for generating notions of inclusion and exclusion in Europe, the book also considers the idea of Europe itself as a narrative. Chapters tackle issues such as multilevel governance of heritage; geopolitics of border-crossings and border-making; participation and non-participation; and embodiment and affective experience of heritage. Creating and Governing Cultural Heritage in the European Union advances heritage studies with an interdisciplinary approach that utilises and combines theories and conceptualizations from critical geopolitics, political studies, EU and European studies, cultural policy research, and cultural studies. As such, the volume will be of interest to scholars and students engaged in the study of heritage, politics, belonging, the EU, ideas and narratives of Europe.

Molecular Science for Drug Development and Biomedicine

ISBN: 9783906980836 9783906980843 Year: Pages: 356
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 06:15:53
License:

Loading...
Export citation

Choose an application

Abstract

With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the areas associated with drug development and biomedicine, both experimental and theoretical. The current thematic issue was launched with the focus on the topic of “Molecular Science for Drug Development and Biomedicine”, in hopes to further stimulate more useful techniques and findings from various approaches of molecular science for drug development and biomedicine.

Marine Natural Products and Obesity

Authors: ---
ISBN: 9783039211913 9783039211920 Year: Pages: 194 DOI: 10.3390/books978-3-03921-192-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
License:

Loading...
Export citation

Choose an application

Abstract

Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

Analysis of Sensory Properties in Foods

Author:
ISBN: 9783039214334 9783039214341 Year: Pages: 132 DOI: 10.3390/books978-3-03921-434-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

The sensory properties of foods are the most important reason people eat the foods they eat. What those properties are and how we best measure those properties are critical to understanding food and eating behavior. Appearance, flavor, texture, and even the sounds of food can impart a desire to eat or cause us to dismiss the food as unappetizing, stale, or even inappropriate from a cultural standpoint. This Special Issue focuses on how sensory properties are measured, the specific sensory properties of various foods, and consumer behavior related to which properties might be most important in certain situations and how consumers use sensory attributes to make decisions about what they will eat. This Special Issue contains both research papers and review articles.

Glassy Materials Based Microdevices

Authors: ---
ISBN: 9783038976189 Year: Pages: 284 DOI: 10.3390/books978-3-03897-619-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Electrical and Nuclear Engineering --- General and Civil Engineering --- Technology (General)
Added to DOAB on : 2019-03-21 15:50:41
License:

Loading...
Export citation

Choose an application

Abstract

Microtechnology has changed our world since the last century, when silicon microelectronics revolutionized sensor, control and communication areas, with applications extending from domotics to automotive, and from security to biomedicine. The present century, however, is also seeing an accelerating pace of innovation in glassy materials; as an example, glass-ceramics, which successfully combine the properties of an amorphous matrix with those of micro- or nano-crystals, offer a very high flexibility of design to chemists, physicists and engineers, who can conceive and implement advanced microdevices. In a very similar way, the synthesis of glassy polymers in a very wide range of chemical structures offers unprecedented potential of applications. The contemporary availability of microfabrication technologies, such as direct laser writing or 3D printing, which add to the most common processes (deposition, lithography and etching), facilitates the development of novel or advanced microdevices based on glassy materials. Biochemical and biomedical sensors, especially with the lab-on-a-chip target, are one of the most evident proofs of the success of this material platform. Other applications have also emerged in environment, food, and chemical industries. The present Special Issue of Micromachines aims at reviewing the current state-of-the-art and presenting perspectives of further development. Contributions related to the technologies, glassy materials, design and fabrication processes, characterization, and, eventually, applications are welcome.

Keywords

micro-crack propagation --- severing force --- quartz glass --- micro-grinding --- microfluidics --- single-cell analysis --- polymeric microfluidic flow cytometry --- single-cell protein quantification --- glass molding process --- groove --- roughness --- filling ratio --- label-free sensor --- optofluidic microbubble resonator --- detection of small molecules --- chalcogenide glass --- infrared optics --- precision glass molding --- aspherical lens --- freeform optics --- micro/nano patterning --- 2D colloidal crystal --- soft colloidal lithography --- strain microsensor --- vectorial strain gauge --- compound glass --- microsphere --- resonator --- lasing --- sensing --- microresonator --- whispering gallery mode --- long period grating --- fiber coupling --- distributed sensing --- chemical/biological sensing --- direct metal forming --- glassy carbon micromold --- enhanced boiling heat transfer --- metallic microstructure --- microspheres --- microdevices --- glass --- polymers --- solar energy --- nuclear fusion --- thermal insulation --- sol-gel --- Ag nanoaggregates --- Yb3+ ions --- down-shifting --- photonic microdevices --- alkali cells --- MEMS vapor cells --- optical cells --- atomic spectroscopy --- microtechnology --- microfabrication --- MEMS --- microfluidic devices --- laser materials processing --- ultrafast laser micromachining --- ultrafast laser welding --- enclosed microstructures --- glass --- porous media --- fluid displacement --- spray pyrolysis technique --- dielectric materials --- luminescent materials --- photovoltaics --- frequency conversion --- device simulations --- europium --- luminescence --- hybrid materials --- microdevices --- light --- photon --- communications --- waveguides --- fibers --- biosensors --- microstructured optical fibers --- whispering gallery modes --- light localization --- optofluidics --- lab-on-a-chip --- femtosecond laser --- laser micromachining --- diffusion

Adipokines 2.0

Author:
ISBN: 9783039285860 / 9783039285877 Year: Pages: 406 DOI: 10.3390/books978-3-03928-587-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.

Keywords

adipokines --- secreted frizzled-related protein 5 --- leptin --- ghrelin --- excessive gestational weight gain --- neonatal anthropometry --- obesity --- proteolysis --- Tango bioassay --- biologic activity --- chemerin receptors --- excessive gestational weight gain --- neonatal anthropometry --- leptin --- ghrelin --- Nonalcoholic fatty liver disease --- fatty liver --- free fatty acids --- label-free proteomic profiling --- adipokine --- obesity --- visceral fat --- sick fat --- annexins --- adipose tissue --- adiponectin --- cholesterol --- glucose homeostasis --- inflammation --- insulin --- lipid metabolism --- obesity --- triglycerides --- adipokine --- chemerin --- leukocyte --- cancer --- adipokines --- PCOS --- polycystic ovary morphology --- follicular fluid --- human granulosa cells --- chemerin --- chemerin receptors --- hypothalamus --- oestrous cycle --- early pregnancy --- pig --- alpha-fetoprotein --- liver steatosis --- hypertension --- adipokines --- SGBS adipocytes --- glucose restriction --- in vitro fat regain --- weight regain --- complement factors --- cathepsins --- extracellular remodeling --- adipokine --- rheumatic diseases --- inflammation --- osteoarthritis --- rheumatoid arthritis --- ovary --- testis --- adipose tissue --- polycystic ovary syndrome --- preeclempsia --- gestational diabetes --- testicular pathologies --- rheumatoid arthritis --- tocilizumab --- lipids --- adipokines --- adiponectin --- resistin --- leptin --- cancer --- obesity --- adipokine --- chemerin --- chemokine-like receptor 1 --- G protein-coupled receptor 1 --- C-C chemokine receptor-like 2 --- critical illness --- sepsis --- adipokines --- biomarker --- prognosis --- ICU --- adipokine --- adipose-brain axis --- brain health --- neurodegeneration --- depression --- energy metabolism --- inflammation --- hypothalamus --- microglia --- adiponectin --- adipokine --- myokine --- fitness --- metabolically healthy obese --- early-life programming --- epicardial adipose tissue (EAT) --- prostaglandin E2 (PGE2) --- EP3 receptor --- EP4 receptor --- exchange protein directly activated by cAMP isoform 2 (EPAC2) --- stimulating growth factor 2 (ST2) --- interleukin(IL)-33 --- Cardiovascular Diseases (CVDs) --- fat mass --- n/a

Nutrition, Choice and Health-Related Claims

Author:
ISBN: 9783039286485 / 9783039286492 Year: Pages: 362 DOI: 10.3390/books978-3-03928-649-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

This book presents different articles focused on the role of nutritional properties and/or health-related claims on choice preferences, choice behavior, healthy eating/healthy diet, and the willingness to pay for certain foods.

Keywords

consumer research --- carrier foods --- functional ingredients --- loglinear analysis --- qualified health claim --- older adult --- green tea --- cancer --- purchase intentions --- emotional eating --- food choices --- nutritional claims --- nutrition claims --- health claims --- portion size --- perceptions --- health halo --- food labelling --- consumer --- nudging --- qualitative --- focus groups --- trans-fatty acids --- ultra-processed food products --- food labels --- consumer --- non-communicable disease --- quantile regression --- experimental auction --- lycopene --- information --- consumer --- yoghurt --- label --- a discrete choice-based experiment --- Food Neophobia Scale (FNS) --- food neophobia --- consumer choice --- choice experiment --- allergen --- menu --- packaging --- exposure time --- plant extract --- visual appraisal --- consumer home-test --- nutritional claims --- health claims --- cluster analysis --- food choices --- functional food --- health information --- environmental information --- choice experiment --- sustainability --- consumer preferences --- nutritional labels --- biscuits --- pastries --- Aragón --- nutrition claim --- health claim --- functional food --- WTP --- segmentation --- organic consumer choices --- organic dried strawberries --- nutrient labels --- health attitudes --- consumer heterogeneity --- cross-cultural comparison --- claims --- labeling --- nutrition --- consumer behavior --- policy --- choice architecture --- dining environment --- campus --- college students --- cereal grains --- dietary fiber --- vitamins --- claim --- information --- health claims --- new product development --- nutrition claims --- market success --- food choice --- changes in quality --- changes in prices --- nutrition --- United Kingdom --- Brexit --- consumer research --- willingness to purchase --- non-communicable diseases --- binary logistic regression --- random forest --- food choices --- health consciousness --- red wine --- choice experiment --- clean labels --- alcohol content --- nutritional knowledge --- health --- local --- organic --- greenhouse gas emissions --- consumer --- choice experiment --- willingness to pay --- trade-offs --- n/a

Listing 1 - 10 of 14 << page
of 2
>>
Sort by