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Sex Hormone Receptor Signals in Human Malignancies

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ISBN: 9783039211739 9783039211746 Year: Pages: 152 DOI: 10.3390/books978-3-03921-174-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Sex steroids, including androgens, estrogens, and progestogens, are knownto have widespread physiological actions beyond the reproductive systemvia binding to the sex hormone receptors. Meanwhile, emerging evidence hasindicated that sex hormone receptor signals are involved in the outgrowth ofsome malignancies, such as prostate and breast carcinomas, as well as othersthat have not traditionally been considered as endocrine-related neoplasms. ThisSpecial Issue “Sex Hormone Receptor Signals in Human Malignancies” coversvarious aspects of the potential role of sex hormone receptors and related signalsin prostate cancer, breast cancer, and other neoplastic conditions by depictingpromising findings derived from in vitro and in vivo experiments as well as theanalyses of surgical specimens. The current observations described may thusprovide a unique insight into novel or known functions of sex hormone receptorsand related molecules.

Plasma Technology for Biomedical Applications

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ISBN: 9783039287369 / 9783039287376 Year: Pages: 174 DOI: 10.3390/books978-3-03928-737-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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There is growing interest in the use of physical plasmas (ionized gases) for biomedical applications, especially in the framework of so-called “plasma medicine”, which exploits the action of low-power, atmospheric pressure plasmas for therapeutic purposes. Such plasmas are “cold plasmas”, in the sense that only electrons have a high temperature, whereas ions and the neutral gas particles are at or near room temperature. As a consequence, the “plasma flame” can be directly applied to living matter without appreciable thermal load. Reactive chemical species, charged particles, visible and UV radiation, and electric fields are interaction channels of the plasma with pathogens, cells, and tissues, which can trigger a variety of different responses. Possible applications include disinfection, wound healing, cancer treatment, non-thermal blood coagulation, just to mention some. The understanding of the mechanisms of plasma action on living matter requires a strongly interdisciplinary approach, with competencies ranging from plasma physics and technology to chemistry, to biology and finally to medicine. This book is a collection of work that explores recent advances in this field.

Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

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ISBN: 9783038974161 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms

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ISBN: 9783039280445 9783039280452 Year: Pages: 186 DOI: 10.3390/books978-3-03928-045-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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This Special Issue Book ""Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms"" is aimed at collecting literature on the below-mentioned keyword topics, which can significantly increase our basic understanding of marine-derived compounds in cosmeceutical product development and increases the value of marine products at the industrial level.

Characterization of Bioactive Components in Edible Algae

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ISBN: 9783039285600 / 9783039285617 Year: Pages: 226 DOI: 10.3390/books978-3-03928-561-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
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Algae have been used since ancient times as food for humans, animal feed, agricultural fertilizer, and as a source of substances for therapeutic use. Currently, seaweed represents a vast source of raw materials used in the pharmaceutical, food, traditional medicine, and cosmetics industries. They are nutritionally valuable, both fresh and dried, or as ingredients in a wide variety of pre-made foods. In particular, seaweed contains significant amounts of protein, lipids, minerals, and vitamins. Information is limited on the role of algae and their metabolites in therapy. Only a few taxa have been studied for use in medicine. Many traditional cultures report the healing powers of selected algae in tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. However, currently, only a few genera and species of algae are involved in aspects of medicine and therapy. The beneficial uses of seaweed or seaweed products include those that can mimic specific manifestations of human disease, production of antibiotic compounds, or improved human nutrition.

Roles and Functions of ROS and RNS in Cellular Physiology and Pathology

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ISBN: 9783039287826 / 9783039287833 Year: Pages: 230 DOI: 10.3390/books978-3-03928-783-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pathology
Added to DOAB on : 2020-06-09 16:38:57
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Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments.

Keywords

human neuroblastoma SH-SY5Y cells --- TRPM2 channel --- ROS --- neuronal cell death --- histamine --- calcium --- endothelial cells --- NADPH-oxidase --- VAS2870 --- von Willebrand factor --- aorta --- relaxation --- reactive oxygen species (ROS) --- oxidative stress --- lipid peroxidation --- acrolein --- 4-hydroxynonenal (4-HNE) --- oxidative burst --- granulocytes --- cancer cells --- growth control --- cancer regression --- hydroxyapatite-based biomaterials --- osteoblast growth --- redox balance --- vitamins --- lipid peroxidation --- 4-hydroxynonenal --- oxidative stress --- oxidative stress --- nuclear factor erythroid 2–related factor 2 --- heme-oxygenase-1 --- macrophages --- plaque vulnerability --- optical coherence tomography --- reactive oxygen species --- free radicals --- DNA damage --- cyclopurines --- DNA and RNA polymerases --- nucleotide excision repair --- LC-MS/MS --- xeroderma pigmentosum --- cancer --- intermittent hypoxia --- mitochondria --- Ca2+, ROS --- antioxidant --- free radicals --- antimicrobial --- toll-like receptors --- cannabidiol --- UV radiation --- keratinocytes --- antioxidants --- inflammation --- intracellular signaling --- Nrf2 --- NF?B --- glucose deprivation --- glutamine deprivation --- viability --- proliferation --- ROS --- NRF2-NQO1 axis --- IMR-90 --- NQO1 transcript variants --- rs1800566 --- TP53 mutation --- oxidative stress --- MFN2 --- mitochondria --- fusion/fission --- oxidative stress --- blood–brain barrier --- bEnd5 --- bEnd.3 --- glutathione --- viability --- free radicals --- redox balance --- cell signaling --- growth --- toxicity --- antioxidants --- oxidative homeostasis --- oxidative metabolism of the cells --- pathophysiology of oxidative stress

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