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Methods in Computational Biology

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ISBN: 9783039211630 9783039211647 Year: Pages: 214 DOI: 10.3390/books978-3-03921-164-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Computer Science
Added to DOAB on : 2019-08-28 11:21:27
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Abstract

Modern biology is rapidly becoming a study of large sets of data. Understanding these data sets is a major challenge for most life sciences, including the medical, environmental, and bioprocess fields. Computational biology approaches are essential for leveraging this ongoing revolution in omics data. A primary goal of this Special Issue, entitled “Methods in Computational Biology”, is the communication of computational biology methods, which can extract biological design principles from complex data sets, described in enough detail to permit the reproduction of the results. This issue integrates interdisciplinary researchers such as biologists, computer scientists, engineers, and mathematicians to advance biological systems analysis. The Special Issue contains the following sections:•Reviews of Computational Methods•Computational Analysis of Biological Dynamics: From Molecular to Cellular to Tissue/Consortia Levels•The Interface of Biotic and Abiotic Processes•Processing of Large Data Sets for Enhanced Analysis•Parameter Optimization and Measurement

The Origin and Early Evolution of Life: Prebiotic Chemistry of Biomolecules

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ISBN: 9783039216062 9783039216079 Year: Pages: 288 DOI: 10.3390/books978-3-03921-607-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:16
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Studying the origin of life is one of man’s greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems.

Keywords

origin of life --- systems chemistry --- Chemomimesis --- Molecular Darwinism --- origin of life --- prebiotic chemistry --- thiol-rich peptides --- cysteine --- aminonitriles --- imidazoles --- origin of life --- prebiotic chemistry --- nucleotide and nucleoside synthesis --- protein design --- novel metalloproteins --- binary patterned amino acid sequences --- prebiotic chemistry --- population growth --- replication --- growth order --- Darwinian evolution --- selection --- origin of life --- abiogenesis --- carbon fixation --- hydrothermal vents --- electrochemistry --- reduction --- digit multiplicity --- information --- transmission --- encoding --- translation --- diversity --- function --- origin of life --- layered double hydroxide (LDH) clay --- pentose diphosphate --- pentopyranose nucleic acid --- arabinopyranose nucleic acid --- RNA --- base pairing --- purine precursor --- inosine --- AICAR --- peptide/RNA world --- prebiotic information system --- translation and the genetic code --- bridge peptide and aaRS --- ribozyme and tRNA --- tRNA and mRNA --- coevolution of translation machine and the genetic code --- MVC architecture pattern and biological information --- numerical codons --- AnyLogic software for computer simulation of translation machine --- phosphoryl transfer --- metabolism --- energy currency --- mixed anhydride --- origin of life --- hypercycle --- Monte Carlo --- prebiotic chemistry --- carbamic acid --- carbon dioxide-ammonia ices --- infrared spectra --- anharmonicity --- origin of life --- metabolism --- phosphates --- network expansion simulation --- thermodynamic bottleneck --- molecular clocks --- ab initio molecular dynamics --- catalysis --- prebiotic soup --- origins of life --- aldol reaction --- mechanochemistry --- minerals --- monosaccharides --- prebiotic chemistry --- prebiotic polymerization --- nucleotide oligomerization --- abasic oligomers --- nucleotide stability --- stability as a selection pressure --- dry-wet cycles --- genetic code origin --- tRNA accretion model --- tRNA-synthetase --- metabolism --- thioester --- nucleotidyltransferases --- early peptides --- ribosome --- n/a

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