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Bildverarbeitungsunterstützte Laserknochenablation am humanen Felsenbein

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ISBN: 9783866444584 Year: Pages: VIII, 161 p. DOI: 10.5445/KSP/1000014612 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:02:02
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Für die Grenzflächenerhaltung am Innenohr als mikrochirurgische Herausforderung und wichtiger Schritt zur bestmöglichen Versorgung von Schwerhörigen mit Cochleaimplantaten wird in dieser Arbeit die bildbasierte Regelung während eines laserbasierten Knochenabtrages eingesetzt. Dabei wird der Aufbau des Systems, Bildverarbeitungsalgorithmen für die Grenzflächenerkennung, Planung, Simulation und Modellierung des mikrochirurgischen Knochenabtrages sowie die experimentelle Verifikation beschrieben.

Saint Augustin : La Numidie et la société de son temps

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ISBN: 9782356132970 DOI: 10.4000/books.ausonius.8022 Language: French
Publisher: Ausonius Éditions
Subject: History
Added to DOAB on : 2019-12-06 13:15:23
License: OpenEdition Licence for Books

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Le présent livre, coédité par Ausonius et la SEMPAM (Société d'étude du Maghreb préhistorique, antique et médiéval), rassemble les communications prononcées lors d'un colloque tenu les 10 et 11 octobre 2003 à Bordeaux dans l'auditorium du Musée d'Aquitaine, en marge de l'exposition présentée dans ce musée par les soins de son conservateur, Madame Hélène Lafont-Couturier, sur le thème : Saint Augustin, une mémoire d'Algérie. Avec l'appui d'Ausonius et de l'Université Michel de Montaigne, la SEMPAM a saisi l'occasion de cette exposition, organisée avec le soutien de « Djazaïr, une année de l'Algérie en France », pour réunir ses adhérents lors de deux journées d'étude consacrées à Saint Augustin : la Numidie et la société de son temps. À la suite d'une conférence introductive de Serge Lancel, président de la SEMPAM, on lira ici les textes présentés lors de ces journées, qui bénéficièrent de la bienveillante attention de M. Alain Juppé, alors député-maire de Bordeaux.

Mechanisms of Adiponectin Action

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ISBN: 9783039212453 9783039212460 Year: Pages: 222 DOI: 10.3390/books978-3-03921-246-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-08-28 11:21:27
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The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

microRNA Regulation in Health and Disease

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ISBN: 9783039217144 9783039217151 Year: Pages: 154 DOI: 10.3390/books978-3-03921-715-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2020-04-07 23:07:08
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MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.

Molecular Research of Endometrial Pathophysiology

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ISBN: 9783039214952 9783039214969 Year: Pages: 378 DOI: 10.3390/books978-3-03921-496-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
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The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

RANK --- endometrium --- endometrial cancer --- prognosis --- immunohistochemistry --- gene expression --- endometriosis --- developmental pathway --- pathogenomics --- mesenchymal stem cells --- endometrial cancer --- mtDNA mutations --- deficit of complex I --- antioxidant response --- mitochondrial biogenesis --- mitochondrial dynamics --- mitophagy --- miRNA --- lncRNAs --- endometrial cancer --- endometriosis --- chronic endometritis --- cell contacts --- tight junction --- adherens junction --- gap junction --- endometrium --- implantation --- decidualization --- endometriosis --- endometrial cancer --- liquid biopsy --- uterine aspirate --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- exosomes --- Vitamin D --- endometrium --- endometrial cancer --- endometrial cancer --- preclinical models --- translational research --- endometrial cancer --- type II endometrial carcinoma --- targeted therapy --- kinase inhibitor --- molecular marker --- protein kinase --- protein phosphatase --- PP2A --- PPP2R1A --- SMAP --- endometriosis --- infertility --- niche --- inflammation --- immunomodulation --- mesenchymal stem cell --- orthoxenograft --- uterine cancer --- avatar --- murine models --- personalized medicine --- targeted therapy --- preclinical studies --- translational research --- endometriosis --- TRP channels --- endometrial stromal cells --- eutopic and ectopic endometrium --- endometrial cell --- pathway --- proliferation --- decidualization --- migration --- angiogenesis --- regeneration --- breakdown --- implantation --- endometrial cancer --- orthotopic xenograft model --- estrogen dependent --- bioluminescence imaging --- contrast-enhanced CT scan --- endometrium --- adult stem cells --- endometrial regeneration --- stem cell markers --- endometriosis --- endometrial cancer --- decidualisation --- oestradiol --- aromatase --- testosterone --- dehydroepiandrosterone (DHEA) --- endometriosis --- endometrial cancer --- sulfatase --- endometriosis --- ectopic stroma --- microRNA --- small RNA sequencing --- EDN1 --- HOXA10 --- miR-139-5p --- miR-375 --- CTCF --- tumour suppressor gene --- haploinsufficiency --- zinc finger --- CRISPR/Cas9 --- cancer --- endometrial cancer --- gene editing --- phosphoinositide 3-kinase --- PIK3CA --- PIK3CB --- p110? --- p110? --- endometrial cancer --- LGR5 --- endometrium --- endometriosis --- menstrual cycle --- macrophages

Fungal Infections in Immunocompromised Hosts

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ISBN: 9783038977162 Year: Pages: 212 DOI: 10.3390/books978-3-03897-717-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Microbiology --- Biology --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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This book is a printed edition of the Special Issue Fungal Infections in Immunocompromised Hosts that was published in JoF

Keywords

Candida auris --- Aspergillus fumigatus --- antifungal resistance --- multidrug resistance --- mechanisms of antifungal resistance --- liver disease --- hepatic impairment --- invasive fungal infection --- antifungal agent --- antifungal drug --- toxicity --- Immunotherapy --- invasive aspergillosis --- Aspergillus fumigatus --- fungal infections --- innate immunity --- adaptive immunity --- cell therapy --- cytokine therapy --- taxonomy --- fungal nomenclature --- phylogenetics --- species complex --- invasive fungal infections --- mycoses --- immune reconstitution inflammatory syndrome --- fungal immunity --- prognostic risk model --- prediction models --- risk score --- invasive mold disease --- hematological malignancy --- risk assessment --- antifungal stewardship --- paracoccidioidomycosis --- HIV --- cancer --- lymphoma --- kidney transplant --- TNF inhibitors --- literature review --- MALDI-ToF MS --- yeast --- fungus --- AIDS --- IRIS --- cat-transmitted sporotrichosis --- immunocompromised hosts --- mycoses of implantation --- sporotrichosis --- Sporothrix brasiliensis --- Sporothrix schenckii --- subcutaneous mycoses --- invasive fungal infection --- non-culture-based diagnostics --- aspergillosis --- candidiasis --- Aspergillus PCR --- galactomannan --- lateral flow --- beta-d-glucan --- T2 Candida --- candidemia --- Candida meningoencephalitis --- (1?3)-?-d-glucan --- T2Candida --- PCR --- liposomal amphotericin B --- micafungin --- anidulafungin --- Aspergillus --- anti-fungal agents --- hematological malignancies

Neural Microelectrodes: Design and Applications

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ISBN: 9783039213191 9783039213207 Year: Pages: 378 DOI: 10.3390/books978-3-03921-320-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Neural electrodes enable the recording and stimulation of bioelectrical activity in the nervous system. This technology provides neuroscientists with the means to probe the functionality of neural circuitry in both health and disease. In addition, neural electrodes can deliver therapeutic stimulation for the relief of debilitating symptoms associated with neurological disorders such as Parkinson’s disease and may serve as the basis for the restoration of sensory perception through peripheral nerve and brain regions after disease or injury. Lastly, microscale neural electrodes recording signals associated with volitional movement in paralyzed individuals can be decoded for controlling external devices and prosthetic limbs or driving the stimulation of paralyzed muscles for functional movements. In spite of the promise of neural electrodes for a range of applications, chronic performance remains a goal for long-term basic science studies, as well as clinical applications. New perspectives and opportunities from fields including tissue biomechanics, materials science, and biological mechanisms of inflammation and neurodegeneration are critical to advances in neural electrode technology. This Special Issue will address the state-of-the-art knowledge and emerging opportunities for the development and demonstration of advanced neural electrodes.

Keywords

neural interface --- silicon carbide --- robust microelectrode --- microelectrode array --- liquid crystal elastomer --- neuronal recordings --- neural interfacing --- micro-electromechanical systems (MEMS) technologies --- microelectromechanical systems --- neuroscientific research --- magnetic coupling --- freely-behaving --- microelectrodes --- in vivo electrophysiology --- neural interfaces --- enteric nervous system --- conscious recording --- electrode implantation --- intracranial electrodes --- foreign body reaction --- electrode degradation --- glial encapsulation --- electrode array --- microelectrodes --- neural recording --- silicon probe --- three-dimensional --- electroless plating --- intracortical implant --- microelectrodes --- stiffness --- immunohistochemistry --- immune response --- neural interface response --- neural interface --- micromachine --- neuroscience --- biocompatibility --- training --- education --- diversity --- bias --- BRAIN Initiative --- multi-disciplinary --- micro-electromechanical systems (MEMS) --- n/a --- silicon neural probes --- LED chip --- thermoresistance --- temperature monitoring --- optogenetics --- microfluidic device --- chronic implantation --- gene modification --- neural recording --- neural amplifier --- microelectrode array --- intracortical --- sensor interface --- windowed integration sampling --- mixed-signal feedback --- multiplexing --- amorphous silicon carbide --- neural stimulation and recording --- insertion force --- microelectrodes --- neural interfaces --- intracortical --- microelectrodes --- shape-memory-polymer --- electrophysiology --- electrode --- artifact --- electrophysiology --- electrochemistry --- fast-scan cyclic voltammetry (FSCV) --- neurotechnology --- neural interface --- neuromodulation --- neuroprosthetics --- brain-machine interfaces --- intracortical implant --- microelectrodes --- softening --- immunohistochemistry --- immune response --- neural interface --- shape memory polymer --- deep brain stimulation --- fast scan cyclic voltammetry --- dopamine --- glassy carbon electrode --- magnetic resonance imaging --- system-on-chip --- neuromodulation --- bidirectional --- closed-loop --- sciatic nerve --- vagus nerve --- precision medicine --- neural probe --- intracortical --- microelectrodes --- bio-inspired --- polymer nanocomposite --- cellulose nanocrystals --- photolithography --- Parylene C --- impedance --- Utah electrode arrays --- electrode–tissue interface --- peripheral nerves --- wireless --- implantable --- microstimulators --- neuromodulation --- peripheral nerve stimulation --- neural prostheses --- microelectrode --- neural interfaces --- dextran --- neural probe --- microfabrication --- foreign body reaction --- immunohistochemistry --- polymer --- chronic --- electrocorticography --- ECoG --- micro-electrocorticography --- µECoG --- neural electrode array --- neural interfaces --- electrophysiology --- brain–computer interface --- in vivo imaging --- tissue response --- graphene --- n/a

The Impact of Caffeine and Coffee on Human Health

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ISBN: 9783039218349 9783039218356 Year: Pages: 322 DOI: 10.3390/books978-3-03921-835-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:21:22
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The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.

Keywords

accidental death --- caffeine --- caffeine intoxication --- intoxication --- Suicide --- HIV-HCV co-infection --- liver fibrosis --- coffee --- alcohol consumption --- coffee --- tea --- European Prospective Investigation into Cancer and Nutrition --- 24-h dietary recall --- whole-blood --- mRNA --- transcriptomics --- gene expression --- coffee --- the Norwegian Women and Cancer Cohort (NOWAC) --- caffeine --- myocardial perfusion --- coronary artery disease --- adenosine --- regadenoson --- dipyridamole --- caffeine intake --- assisted reproduction techniques --- risk factors --- implantation --- clinical pregnancy --- live birth --- epidemiology --- bias --- causation --- coffee --- pregnancy --- coffee --- depression --- cohort study --- Mendelian Randomization --- coffee --- caffeine --- behavior --- causality --- genetic epidemiology --- epidemiological methods --- cardiovascular disease --- coffee consumption --- gene-diet interaction --- longevity --- NADH dehydrogenase --- polymorphism --- serum chloride levels --- CYP1A2 --- ADORA2A --- time trial performance --- caffeine metabolism --- pharmacological ergogenic aid --- polymorphism --- anxiety --- ergogenic --- adenosine receptor --- cytochrome P450 --- caffeine --- pharmacogenomics --- coffee --- caffeine --- chlorogenic acids --- phenolic --- cognition --- cognitive --- mood --- age --- sex --- caffeine --- wine --- chocolate --- aging --- cognition --- adult --- coffee --- hearing --- protection --- tinnitus --- Caffeine --- placebo --- sport --- exercise --- health --- expectancy --- cognitions --- caffeine --- coffee --- systematic review --- pregnancy --- safety --- individual responses --- ergogenic aid --- supplement --- did not respond --- responders --- n/a --- caffeine --- coffee --- tea --- soda --- energy drinks --- mate --- guidelines --- country --- consumption --- population --- public policy --- coffee --- caffeine --- lipids --- biomarkers --- trial --- lysophosphatidylcholine --- lipidomics --- n/a

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