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Microbial Biofilms in Healthcare: Formation, Prevention and Treatment

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ISBN: 9783039284108 9783039284115 Year: Pages: 166 DOI: 10.3390/books978-3-03928-411-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

Biofilms are ubiquitous and their presence in industry can lead to production losses. However, nowhere do biofilms impact human health and welfare as much as those that are found contaminating the healthcare environment, surgical instruments, equipment, and medical implantable devices. Approximately 70% of healthcare-associated infections are due to biofilm formation, resulting in increased patient morbidity and mortality. Biofilms formed on medical implants are recalcitrant to antibiotic treatment, which leaves implant removal as the principal treatment option. In this book, we investigate the role of biofilms in breast and dental implant disease and cancer. We include in vitro models for investigating treatment of chronic wounds and disinfectant action against Candida sp. Also included are papers on the most recent strategies for treating biofilm infection ranging from antibiotics incorporated into bone void fillers to antimicrobial peptides and quorum sensing.

The Molecular and Cellular Basis for Parkinson's Disease

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ISBN: 9783039215485 9783039215492 Year: Pages: 230 DOI: 10.3390/books978-3-03921-549-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:15
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The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Keywords

epigenetics --- Parkinson’s disease --- brain --- DNA methylation --- Parkinson’s disease --- fatty acid ?-oxidation --- long-chain acylcarnitine --- Parkinson’s disease --- fatty acyls --- glycerolipids --- glycerophospholipids --- sphingolipids --- sterol lipids --- lipoproteins --- ?-synuclein-mediated pathology --- disease-modifying effects --- neuroprotection --- autophagy --- cysteinyl-dopamine --- hypochlorite --- oxidative stress --- Parkinson’s disease --- redox cycling --- Parkinson’s disease --- brain iron --- motor dysfunction --- neurometabolites --- magnetic resonance imaging --- magnetic resonance spectroscopy --- GABA --- spectroscopy --- Parkinson’s disease --- neuroinflammation --- alpha-Synuclein --- immunotherapy --- mesenchymal stem cells --- secretome --- exosomes --- Parkinson’s disease --- microRNAs --- Parkinson disease --- multiprofessional therapy --- inpatient treatment --- multimodal complex treatment --- caffeic acid --- chlorogenic acid --- rotenone --- Parkinson’s disease --- neuroprotection --- dopaminergic neuron --- myenteric plexus --- enteric glial cell --- metallothionein --- Parkinson’s disease --- microbiota --- molecular mimicry --- microbiome --- alpha-synuclein --- curli --- gut-brain axis --- neurodegeneration --- glucocerebrosidase --- Parkinson’s disease --- Gaucher’s disease --- Lewy Body Dementia --- REM sleep behavior disorders --- [123I]FP-CIT-SPECT --- DAT --- nigral cells --- Parkinson’s disease --- parkinsonisms --- cell line --- differentiation --- HOG --- immature oligodendrocyte --- Krabbe’s disease --- oligodendrocyte --- mature oligodendrocyte --- MO3.13 --- myelin --- multiple sclerosis --- schizophrenia --- SH-SY5Y

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