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Histamine in the Brain

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194346 Year: Pages: 99 DOI: 10.3389/978-2-88919-434-6 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Biogenic amines in fermented foods

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195930 Year: Pages: 75 DOI: 10.3389/978-2-88919-593-0 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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Biogenic amines (BA) are sources of nitrogen and precursors for synthesis of hormones, alkaloids, nucleic acids and proteins, occurring in all organisms. Under normal condition in humans the consumption of food or beverages containing these compounds have not toxic effects because they are rapidly detoxified by the activity of the amine oxidizing enzymes, monoamine (MAO) and diamine oxidases (DAO). However in presence of high BA content, in allergic individuals or if MAO inhibitors are applied the detoxification system is not capable of metabolizing dietary intake of BA. This fact can induce toxicological risks and health troubles, but the European Union established regulation for just only histamine levels in fish and fishery products. The presence of BA in foods is due to the enzymatic decarboxylation of free amino acids by microorganisms that possess this activity. Many foods such as meat products, cheeses, fishes, fermented products and beverages could contain high levels of these compounds. Determination of BA rates in food are important as indicators of the degree of freshness or spoilage other then from the point of view of their toxicology. The content of the E-Book deals the presence of BA in some fermented and non fermented foods and the measures to control their content.

Keywords

Biogenic Amines --- Histamine --- Tyramine --- Sausage --- fish --- Cheese --- WIN

Biogenic Amines on Food Safety

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ISBN: 9783039210541 9783039210558 Year: Pages: 202 DOI: 10.3390/books978-3-03921-055-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-08-28 11:21:27
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Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high concentrations of biogenic amines can present a health hazard. Additionally, they have been used to establish indexes in various foods in order to signal the degree of freshness and/or deterioration of food. Nowadays, there has been an increase in the number of food poisoning episodes in consumers associated with the presence of these biogenic amines, mainly associated with histamines. Food safety is one of the main concerns of the consumer and safety agencies of different countries (EFSA, FDA, FSCJ, etc.), which have, as one of their main objectives, to control these biogenic amines, principally histamine, to assure a high level of food safety.Therefore, it is necessary to deepen our understanding of the formation, monitoring and reduction of biogenic amines during the development, processing and storage of food, even the effect of biogenic amines in consumers after digestion of foods with different levels of these compounds.With this aim, we are preparing a Special Issue on the topic of ""Biogenic Amines in Food Safety"", and we invite researchers to contribute original and unpublished research articles and reviews articles that involve studies of biogenic amines in food, which can provide an update to our knowledge of these compounds and their impacts on food quality and food safety.

Roles and Functions of ROS and RNS in Cellular Physiology and Pathology

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ISBN: 9783039287826 / 9783039287833 Year: Pages: 230 DOI: 10.3390/books978-3-03928-783-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Pathology
Added to DOAB on : 2020-06-09 16:38:57
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Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments.

Keywords

human neuroblastoma SH-SY5Y cells --- TRPM2 channel --- ROS --- neuronal cell death --- histamine --- calcium --- endothelial cells --- NADPH-oxidase --- VAS2870 --- von Willebrand factor --- aorta --- relaxation --- reactive oxygen species (ROS) --- oxidative stress --- lipid peroxidation --- acrolein --- 4-hydroxynonenal (4-HNE) --- oxidative burst --- granulocytes --- cancer cells --- growth control --- cancer regression --- hydroxyapatite-based biomaterials --- osteoblast growth --- redox balance --- vitamins --- lipid peroxidation --- 4-hydroxynonenal --- oxidative stress --- oxidative stress --- nuclear factor erythroid 2–related factor 2 --- heme-oxygenase-1 --- macrophages --- plaque vulnerability --- optical coherence tomography --- reactive oxygen species --- free radicals --- DNA damage --- cyclopurines --- DNA and RNA polymerases --- nucleotide excision repair --- LC-MS/MS --- xeroderma pigmentosum --- cancer --- intermittent hypoxia --- mitochondria --- Ca2+, ROS --- antioxidant --- free radicals --- antimicrobial --- toll-like receptors --- cannabidiol --- UV radiation --- keratinocytes --- antioxidants --- inflammation --- intracellular signaling --- Nrf2 --- NF?B --- glucose deprivation --- glutamine deprivation --- viability --- proliferation --- ROS --- NRF2-NQO1 axis --- IMR-90 --- NQO1 transcript variants --- rs1800566 --- TP53 mutation --- oxidative stress --- MFN2 --- mitochondria --- fusion/fission --- oxidative stress --- blood–brain barrier --- bEnd5 --- bEnd.3 --- glutathione --- viability --- free radicals --- redox balance --- cell signaling --- growth --- toxicity --- antioxidants --- oxidative homeostasis --- oxidative metabolism of the cells --- pathophysiology of oxidative stress

Biomedical Applications of Nanoparticles

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ISBN: 9783039285426 / 9783039285433 Year: Pages: 366 DOI: 10.3390/books978-3-03928-543-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
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This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.

Keywords

curcumin --- mitoxantrone --- synergism --- PEG --- chitosan nanoparticles --- hybrid Fe-Si nanoparticles --- laser pyrolysis --- Caco2 cells --- cytotoxicity --- oxidative stress --- upconversion nanoparticles --- nanocarriers --- drug delivery --- gene delivery --- photolysis --- cancer imaging --- cytoreduction surgery --- fluorescent nanoparticle --- near-infrared --- short-wave infrared --- Candida glabrata --- extracellular --- mycosynthesis --- MIC --- MBC --- MFC --- membrane integrity --- TEM --- FTIR --- surface-enhanced Raman spectroscopy (SERS) --- Ag-film --- Hg2+ ions detection --- SERS sensor --- nanocomposites --- medical devices --- middle ear prosthesis --- silver nanoparticles --- biocompatibility --- thermoplastic polymer --- dihydroartemisinin --- liposomes --- autophagy --- apoptosis --- breast cancer --- surface-enhanced Raman scattering (SERS) --- metal-enhanced fluorescence (MEF) --- dual functional imaging nanoprobe --- UiO-66 --- nanoparticles --- glioblastoma --- biocompatibility --- drug delivery --- alginate --- chitosan --- layer-by-layer --- magnetic nanoparticles --- drug delivery --- cancer --- curcumin --- lignin --- nanoparticle --- protein --- nanocellulose --- fibril --- enzyme --- heat --- self-assembly --- cross-link --- antibiotics --- nanoparticles --- biogenic nanoparticles --- antimicrobial --- antibiotic resistance --- multidrug resistant (MDR) microorganisms --- plasma --- nanomaterials --- nanomaterial synthesis --- plasma liquid Interactions --- non-thermal plasma --- biomedical applications --- core-shell nanoparticles --- biocompatible --- drug delivery --- anticancer --- SERS --- histamine --- nanostars --- nanophotonics --- computational electromagnetism --- surface enhanced Raman scattering --- SERS --- finite element method --- density functional theory calculations --- cell labeling --- cancer --- iron oxide superparamagnetic nanoparticles --- trans-resveratrol derivative --- drug delivery --- glioma --- gold nanoparticles --- radiosensitization --- thioredoxin reductase --- radiation --- prognosis --- biochemical mechanism --- nanodiamond --- targeted nanoparticles --- in vivo application --- cancer cell targeting --- antimiR --- nano-bio interaction

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