Search results: Found 8

Listing 1 - 8 of 8
Sort by
Expert Views on HPV Infection

Authors: ---
ISBN: 9783038428374 9783038428381 Year: Pages: X, 384 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-05-04 12:00:02
License:

Loading...
Export citation

Choose an application

Abstract

Human papillomavirus (HPV) infections cause approximately 5% of all human cancers. While there are efficacious prophylactic vaccines that prevent infections with the most common cancer-associated HPVs, these vaccines are not widely available in low-resource settings and in many countries, including the US, HPV vaccination rates have remained disappointingly low. Moreover, vaccination does not modify existing HPV infections and the incidence of HPV-associated anal and oropharyngeal cancers has steadily increased and is projected to overtake the caseload of cervical cancer in the next two years. Hence, infections with cancer-associated HPVs will remain a major cause of morbidity and mortality, worldwide. This book provides state-of-the-art summaries and expert viewpoints on unresolved, controversial or emerging topics related to the natural history, evolution, biology, and disease association of papillomavirus infection. The individual chapters cover a wide range of thought provoking topics.

Clinical Application of Stereotactic Body Radiotherapy (SBRT): Cranium to Prostate

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198467 Year: Pages: 85 DOI: 10.3389/978-2-88919-846-7 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

Stereotactic radiosurgery is a relatively recent radiation technique initially developed using a frame-based system in 1949 by a Swedish neurosurgeon, Lars Leksell, for lesions not amendable to surgical resection. Radiosurgery is founded on principles of extreme radiation dose escalation, afforded by precise dose delivery with millimeter accuracy. Building upon the success of frame-based radiosurgery techniques, which were limited to cranial tumors and invasive head-frame placement, advances in radiation delivery and image-guidance have lead to the development of stereotactic body radiotherapy (SBRT). SBRT allows for frameless delivery of dose distributions akin to frame-based cranial stereotactic radiosurgery to both cranial and extra-cranial sites and has emerged as a important treatment strategy for a variety of cancers from the cranium to prostate. Herein we highlight ongoing investigations for the clinical application of SBRT for a variety of primary and recurrence cancers aimed at examining the growing clinical evidence supporting emerging roles for SBRT in the ever growing oncologic armamentarium.

Pleiotropic Action of Selenium in the Prevention and Treatment of Cancer, and Related Diseases

Author:
ISBN: 9783038976929 Year: Pages: 166 DOI: 10.3390/books978-3-03897-693-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2019-04-05 11:07:22
License:

Loading...
Export citation

Choose an application

Abstract

This book will cover topics related to the preparation and use of heterogeneous catalytic systems for the transformation of renewable sources, as well as of materials deriving from agro-industrial wastes and by-products. At the same time, the ever-increasing importance of bioproducts, due to the acceptance and request of consumers, makes the upgrade of biomass into chemicals and materials not only an environmental issue, but also an economical advantage.

Mass Spectrometric Proteomics

Author:
ISBN: 9783038978268 9783038978275 Year: Pages: 192 DOI: 10.3390/books978-3-03897-827-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-04-25 16:37:17
License:

Loading...
Export citation

Choose an application

Abstract

As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles  published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of  new procedures for the  optimization of the experimental conditions that should be applied  for the identification of proteins present in complex mixtures.  Other applications  described in these articles show  the huge potential of  these strategies in the protein profiling of organs and  range from  to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.

Diagnosis and Management of Pediatric Diseases

Author:
ISBN: 9783039219667 / 9783039219674 Year: Pages: 146 DOI: 10.3390/books978-3-03921-967-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-01-07 09:08:26
License:

Loading...
Export citation

Choose an application

Abstract

A screenshot of some the most rapidly evolving fields in Neonatology and Pediatrics with articles reviewing some metabolic dysregulations as well as non-oncologic diseases that may occur in infancy, childhood, youth. The illustrative material with original photographs and drawings highlighting some pathogenetic concepts are keystones of this book.

Pheochromocytoma (PHEO) and Paraganglioma (PGL)

Authors: ---
ISBN: 9783039216543 / 9783039216550 Year: Pages: 380 DOI: 10.3390/books978-3-03921-655-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.

Keywords

pheochromocytoma --- paraganglioma --- adrenocortical carcinoma --- adrenal tumor --- pan-cancer analysis --- neural crest --- neuroendocrine --- paraganglioma --- head and neck --- radiotherapy --- 18F-FDOPA --- PET --- GTV --- SDHB --- SDHD --- mortality --- paraganglioma --- pheochromocytoma --- radiofrequency ablation --- cryoablation --- percutaneous ethanol injection --- neuroendocrine tumor --- minimally invasive procedure --- percutaneous ablation --- PASS --- GAPP --- histology --- meta-analysis --- paraganglioma --- pheochromocytoma --- carotid body --- angiogenesis --- mitochondria --- neural crest --- neurogenesis --- paraganglioma --- stem-like tumor cells --- vasculogenesis --- xenograft --- pheochromocytoma --- catecholamine --- global longitudinal strain --- speckle-tracking echocardiography --- subclinical systolic dysfunction --- pheochromocytoma --- paraganglioma --- neuroendocrine tumor --- targeted therapy --- therapy resistance --- FGF21 --- pheochromocytoma --- paraganglioma --- diabetes mellitus --- obesity --- energy metabolism --- calorimetry --- chromogranin A --- metanephrines --- pheochromocytoma --- paraganglioma --- hypoxia --- pseudohypoxia --- spheroids --- HIF --- EPAS1 --- catecholamine --- pheochromocytoma and paraganglioma --- phosphorylation tyrosine hydroxylase --- dog --- pheochromocytoma --- paraganglioma --- SDHB --- SDHD --- mutation --- chromosomal alteration --- comparative genomics --- pheochromocytoma --- paraganglioma --- metastatic --- immunotherapy --- innate immunity --- adaptive immunity --- toll-like receptor --- pathogen-associated molecular patterns --- neutrophil --- T cell --- pheochromocytoma --- paraganglioma --- hypertension --- blood pressure variability --- average real variability --- weighted standard deviation --- paraganglioma --- somatostatinoma --- polycythemia --- EPAS1 --- transgenic mice --- erythropoietin --- pheochromocytoma --- paraganglioma --- TCA cycle --- germline mutation --- metastatic OR malignant pheochromocytoma --- paraganglioma --- ectopic secretion --- lL-6 --- normetanephrines --- VHL --- NF1 --- EPAS1 --- hypoxia-inducible factor --- inflammation --- radiosensitization --- succinate dehydrogenase --- mouse pheochromocytoma cells --- immunohistochemistry --- fluorescence imaging --- pheochromocytoma --- paraganglioma --- next-generation sequencing --- sporadic --- hereditary --- CNV detection --- pheochromocytoma --- paraganglioma --- PET-CT --- 11C-hydroxy-ephedrine --- adrenal incidentaloma --- pheochromocytoma --- paraganglioma --- 177Lu-DOTATATE --- peptide receptor radiotherapy --- PRRT --- neuroendocrine tumor --- NET --- PCC --- PGL --- postoperative --- pheochromocytoma --- hypertension --- hypotension --- arrhythmia --- PPGL --- catecholamines --- adrenomedullary function --- n/a

Drug Delivery Technology Development in Canada

Authors: ---
ISBN: 9783039280049 / 9783039280056 Year: Pages: 352 DOI: 10.3390/books978-3-03928-005-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:21:22
License:

Loading...
Export citation

Choose an application

Abstract

Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

Keywords

doxorubicin --- MG63 --- Vitamin D --- DOX-Vit D --- hypoxia-induced chemoresistance --- cisplatin --- polymeric micelle --- EGFR-targeted therapy --- STAT3 --- HIF-1 --- GE11 peptide --- pharmacological Inhibitors of HIF-1 and STAT3 --- combination therapy --- pharmacokinetics --- antibodies --- radiolabeling --- biodistribution --- mouse models --- oral formulation --- amphotericin B --- fungal infections --- parasitic infections --- developing world --- drug delivery --- liposomes --- drug delivery systems --- innovation --- lipid nanoparticles --- Metaplex --- triggered drug release --- liposomes --- ultrasound --- magnetic fields --- radiation --- oral delivery --- biological barriers --- co-delivery --- throughput --- sustained delivery --- phospholipid complex --- rosmarinic acid --- bioaccessibility --- dissolution --- TNO gastrointestinal model --- gastrointestinal simulator --- phytosterols --- tocopherols --- liposomes --- canola oil deodorizer distillate --- model orange juice --- virus --- plant --- bacteriophage --- phage display --- drug discovery --- encapsulation --- drug delivery --- blood-brain barrier --- intra-arterial chemotherapy --- malignant gliomas --- primary central nervous system lymphomas --- transdermal drug delivery --- Canada --- skin --- permeation enhancers --- oral, head and neck squamous cell carcinoma --- targeted therapies --- drug delivery systems --- nanoparticles --- controlled drug delivery --- circadian clock --- chronotherapy --- precision medicine --- cationic gemini surfactant --- melphalan --- inclusion complex --- ROESY NMR spectroscopy --- 3D spheroid --- drug-resistant melanoma --- liposome --- water miscible solvents --- remote loading --- staurosporine --- cancer --- gambogic acid --- loading gradients --- mefloquine --- child friendly formulation --- blood-brain barrier (BBB) --- drug delivery --- transient modulation --- HAV6 cadherin peptide --- adenanthin --- magnetic resonance imaging (MRI) --- medulloblastoma --- drug delivery --- pharmaceutics --- drug development --- formulation and dosage form development --- translational research --- biologicals --- small molecules --- clinical trials --- pharmacokinetics --- medical devices --- route of administration --- nifedipine --- emulsion --- flavonoids --- topical formulation --- quercetin --- photostabilizers

Application of Bioinformatics in Cancers

Author:
ISBN: 9783039217885 / 9783039217892 Year: Pages: 418 DOI: 10.3390/books978-3-03921-789-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible.

Keywords

comorbidity score --- mortality --- locoregionally advanced --- HNSCC --- curative surgery --- traditional Chinese medicine --- health strengthening herb --- cancer treatment --- network pharmacology --- network target --- high-throughput analysis --- brain metastases --- colorectal cancer --- KRAS mutation --- PD-L1 --- tumor infiltrating lymphocytes --- drug resistance --- gefitinib --- erlotinib --- biostatistics --- bioinformatics --- Bufadienolide-like chemicals --- molecular mechanism --- anti-cancer --- bioinformatics --- cancer --- brain --- pathophysiology --- imaging --- machine learning --- extreme learning --- deep learning --- neurological disorders --- pancreatic cancer --- TCGA --- curation --- DNA --- RNA --- protein --- single-biomarkers --- multiple-biomarkers --- cancer-related pathways --- colorectal cancer --- DNA sequence profile --- Monte Carlo --- mixture of normal distributions --- somatic mutation --- tumor --- mutable motif --- activation induced deaminase --- AID/APOBEC --- transcriptional signatures --- copy number variation --- copy number aberration --- TCGA mining --- cancer CRISPR --- firehose --- gene signature extraction --- gene loss biomarkers --- gene inactivation biomarkers --- biomarker discovery --- chemotherapy --- microarray --- ovarian cancer --- predictive model --- machine learning --- overall survival --- observed survival interval --- skin cutaneous melanoma --- The Cancer Genome Atlas --- omics --- breast cancer prognosis --- artificial intelligence --- machine learning --- decision support systems --- cancer prognosis --- independent prognostic power --- omics profiles --- histopathological imaging features --- cancer --- intratumor heterogeneity --- genomic instability --- epigenetics --- mitochondrial metabolism --- miRNAs --- cancer biomarkers --- breast cancer detection --- machine learning --- feature selection --- classification --- denoising autoencoders --- breast cancer --- feature extraction and interpretation --- concatenated deep feature --- cancer modeling --- interaction --- histopathological imaging --- clinical/environmental factors --- oral cancer --- miRNA --- bioinformatics --- datasets --- biomarkers --- TCGA --- GEO DataSets --- hormone sensitive cancers --- breast cancer --- StAR --- estrogen --- steroidogenic enzymes --- hTERT --- telomerase --- telomeres --- alternative splicing --- network analysis --- hierarchical clustering analysis --- differential gene expression analysis --- cancer biomarker --- diseases genes --- variable selection --- false discovery rate --- knockoffs --- bioinformatics --- copy number variation --- cell-free DNA --- methylation --- mutation --- next generation sequencing --- self-organizing map --- head and neck cancer --- treatment de-escalation --- HP --- molecular subtypes --- tumor microenvironment --- Bioinformatics tool --- R package --- machine learning --- meta-analysis --- biomarker signature --- gene expression analysis --- survival analysis --- functional analysis --- bioinformatics --- machine learning --- artificial intelligence --- Network Analysis --- single-cell sequencing --- circulating tumor DNA (ctDNA) --- Neoantigen Prediction --- precision medicine --- Computational Immunology

Listing 1 - 8 of 8
Sort by
Narrow your search