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Cancer Metabolomics 2018

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ISBN: 9783039213450 9783039213467 Year: Pages: 184 DOI: 10.3390/books978-3-03921-346-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 11:49:15
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The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Chemical/Instrumental Approaches to the Evaluation of Wine Chemistry

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ISBN: 9783039287345 / 9783039287352 Year: Pages: 148 DOI: 10.3390/books978-3-03928-735-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2020-06-09 16:38:57
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Wine is a widely consumed beverage due to its unique and pleasant sensory properties. Wine is composed of more than one thousand chemical compounds (e.g., alcohols, esters, acids, terpenoids, phenolic compounds, flavonoids, anthocyanins, minerals, and vitamins, among others) resulting from several chemical and biochemical processes. Microextraction techniques in tandem with high-resolution analytical instruments have been applied by wine researchers to expand the knowledge of wine’s chemical composition with the purposes of improving wine quality, supporting winemaker decisions related to the winemaking process, and guaranteeing the authenticity of wine. As a result, we proposed “Chemical/Instrumental Approaches to the Evaluation of Wine Chemistry” as a topic for a Special Issue in Molecules. This Special Issue aims to provide an update on state-of-the-art extraction procedures (e.g., solid-phase microextraction (SPME)) and analytical tools (e.g., nuclear magnetic resonance (NMR), inductively coupled plasma mass spectrometry (ICP-MS), ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)), emphasizing their use as suitable platforms for the establishment of the chemical composition of wine (volatomic profile, antioxidants, phenolic pattern, and elemental composition, among others). Information related to wine sensorial properties, contaminants, authenticity, and chemometric tools used for data treatment are described in this Issue.

Solid-Phase Microextraction

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ISBN: 9783039282623 9783039282630 Year: Pages: 266 DOI: 10.3390/books978-3-03928-263-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2020-04-07 23:07:08
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This book covers the most recent research activities and achievements regarding to the solid phase microextraction (SPME) technique. It is a powerful sample preparation tool that addresses the new challenges of analytical laboratories. Among others, its fundamental applications involved the sampling of volatile compounds from various matrixes. The demonstrated topics ranged from aroma characterization of various fruits, essential oils to the utilization of SPME for in-tube extraction and isolation of selected compounds from complex samples followed by state-of-the-art analytical techniques.

Keywords

mango germplasm --- volatile compound --- HS-SPME-GC-MS --- multivariate analysis --- cubeb berry --- principal component analysis (PCA) --- solid-phase microextraction (SPME) --- hydro-distillation (HD) --- simultaneous distillation/extraction (SDE) --- gas chromatography-mass spectrometry-olfactometry (GC-MS-O) --- SPME --- OH-PAHs --- gas-chromatography --- MTBSTFA --- in-tube solid-phase microextraction (IT-SPME) --- nanoliquid chromatography (nanoLC) --- contact trace analysis --- cannabis --- THC --- solid-phase microextraction --- air sampling --- air analysis --- volatile organic compounds --- COMSOL --- time-weighted average --- terpenes --- terpenoids --- headspace solid phase microextraction --- glandular source --- Monomorium chinense --- DI-SPME --- GC-MS --- Mediterranean fruit fly --- extraction solvent --- metabolites --- leave-one-solute-out (LOSO) cross-validation --- leave-one-out (LOO) cross-validation --- linear free-energy relationship (LFER) model --- membrane-coated fiber (MCF) approach --- partition coefficient --- quantitative structure-activity relationship (QSAR) --- metalworking fluid --- volatile organic compounds --- torrefaction --- waste to carbon --- biochar --- municipal solid waste --- SPME --- aromatic water --- hydrolat --- volatile compounds --- metabolic fingerprint --- eucalyptol --- SPME --- retracted SPME --- TWA SPME --- GC–MS --- on-site sampling --- air quality --- air monitoring --- VOCs --- odor --- environmental analysis --- biogenic emissions --- veraison --- viticulture --- nondestructive analysis --- wine aroma --- diffusion --- grape skin --- vacuum-assisted extraction --- solid-phase microextraction --- VOCs --- historical foods --- preserves --- volatile organic compounds (VOCs) --- bisphenol-A (BPA) --- essential oil --- drying --- SPME --- true lavender --- volatile constituents --- in-tube SPME-MS/MS --- dual ligand organic-silica hybrid monolith capillary --- amino acids --- plasma samples --- pears --- HS-SPME --- volatile compounds --- GC

Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

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ISBN: 9783038974161 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Solid Phase Extraction: State of the Art and Future Perspectives

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ISBN: 9783039211586 9783039211593 Year: Pages: 176 DOI: 10.3390/books978-3-03921-159-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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This book is a collection of 13 innovative papers describing the state of the art and the future perspectives in solid-phase extraction covering several analytical fields prior to the use of gas or liquid chromatographic analysis. New sorptive materials are presented including carbon nanohorn suprastructures on paper support, melamine sponge functionalized with urea–formaldehyde co-oligomers, chiral metal–organic frameworks, UiO-66-based metal–organic frameworks, and fabric phase sorptive media for various applications. Solid-phase extraction can be applied in several formats aside from the conventional cartridges or mini-column approach, e.g., online solid-phase extraction, dispersive solid-phase microextraction, and in-syringe micro-solid-phase extraction can be very helpful for analyte pre-concentration and sample clean-up. Polycyclic musks in aqueous samples, 8-Nitroguanine in DNA by chemical derivatization antibacterial diterpenes from the roots of salvia prattii, perfluoroalkyl substances (PFASs) in aater samples by bamboo charcoal-based SPE, parabens in environmental water samples, benzotriazoles as environmental pollutants, organochlorine pesticide residues in various fruit juices and water samples and synthetic peptide purification are among the applications cited in this collection. All these outstanding contributions highlight the necessity of this analytical step, present the advantages and disadvantages of each method and focus on the green analytical chemistry guidelines that have to be fulfilled in current analytical practices.

Removal of Organic Pollution in Water Environment

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ISBN: 9783039218400 9783039218417 Year: Pages: 154 DOI: 10.3390/books978-3-03921-841-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:16
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The development of civilization entails a growing demand for consumer goods. A side effect of the production and use of these materials is the production of solid waste and wastewater. Municipal and industrial wastewater usually contains a large amount of various organic compounds and is the main source of pollution of the aquatic environment. Therefore, the search for effective methods of wastewater and other polluted water treatment is an important element of caring for the natural environment. This book presents research on the determination and removal of environmentally hazardous organic compounds from aqueous samples. The articles included in this book describe the results of examinations, at the laboratory scale, of the efficiency of chemical as well as physical processes for the removal or degradation of selected model pollutants. Environmental studies, especially those concerning the determination of trace impurities, require effective isolation and concentration procedures. The methods used for this purpose should meet the requirements of green chemistry. The liquid phase microextraction procedures and use of electrochemical methods described in this book seem to be proper for environmental studies, as they are effective and environmentally friendly.

Food Authentication: Techniques, Trends and Emerging Approaches

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ISBN: 9783039287482 / 9783039287499 Year: Pages: 182 DOI: 10.3390/books978-3-03928-749-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
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Multiple factors can directly influence the chemical composition of foods and, consequently, their organoleptic, nutritional, and bioactive properties, including their geographical origin, the variety or breed, as well as the conditions of cultivation, breeding, and/or feeding, among others. Therefore, there is a great interest in the development of accurate, robust, and high-throughput analytical methods to guarantee the authenticity and traceability of foods. For these purposes, a large number of sensorial, physical, and chemical approaches can be used, which must be normally combined with advanced statistical tools. In this vein, the aim of the Special Issue “Food Authentication: Techniques, Trends, and Emerging Approaches” is to gather original research papers and review articles focused on the development and application of analytical techniques and emerging approaches in food authentication. This Special Issue comprises 12 valuable scientific contributions, including one review article and 11 original research works, dealing with the authentication of foods with great commercial value, such as olive oil, Iberian ham, and fruits, among others.

Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

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ISBN: 9783039210848 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-06-26 08:44:06
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

Modern Sample Preparation Approaches for Separation Science

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ISBN: 9783039214112 9783039214129 Year: Pages: 282 DOI: 10.3390/books978-3-03921-412-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Analytical Chemistry
Added to DOAB on : 2019-12-09 11:49:15
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This book will provide the most recent knowledge and advances in Sample Preparation Techniques for Separation Science. Everyone working in a laboratory must be familiar with the basis of these technologies, and they often involve elaborate and time-consuming procedures that can take up to 80% of the total analysis time. Sample preparation is an essential step in most of the analytical methods for environmental and biomedical analysis, since the target analytes are often not detected in their in-situ forms, or the results are distorted by interfering species. In the past decade, modern sample preparation techniques have aimed to comply with green analytical chemistry principles, leading to simplification, miniaturization, easy manipulation of the analytical devices, low costs, strong reduction or absence of toxic organic solvents, as well as low sample volume requirements.Modern Sample Preparation Approaches for Separation Science also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and forensic sciences.

Keywords

vitamins --- extraction --- determination --- review --- sample preparation --- matrix solid phase dispersion --- sorbent --- miniaturization --- on-line --- blueberry --- non-anthocyanin polyphenol --- vortex-assisted dispersive liquid-liquid microextraction --- response surface methodology --- desirability function approach --- nail --- curie temperature --- high-frequency heating --- liquid chromatography–tandem mass spectrometry --- caffeine --- amlodipine --- gas chromatography --- hydrogel --- hormones --- pectin --- polyvinyl alcohol --- sample preparation --- in-tube SPME --- UHPLC-MS/MS --- organic-based monoliths --- antipsychotics --- plasma samples --- schizophrenic’ patients --- salting-out assisted liquid–liquid extraction --- sugaring-out assisted liquid–liquid extraction --- hydrophobic-solvent assisted liquid–liquid extraction --- subzero-temperature assisted liquid–liquid extraction --- phenolic compounds --- sorbent-based techniques --- multi-spheres adsorptive micro-extraction (MSA?E) --- floating sampling technology --- caffeine and acetaminophen tracers --- environmental water matrices --- vortex-assisted dispersive liquid-liquid microextraction --- China herbal tea --- pesticides residue --- aflatoxins --- UPLC-MS/MS --- vortex-synchronized matrix solid-phase dispersion --- crab shells --- ionic liquids --- anthraquinones --- Cassiae Semen --- sample preparation --- nanocomposite --- pathogenic --- enrichment --- nucleic acid isolation --- sample preparation with TLC/HPTLC --- solvent front position extraction --- solvent delivery with a moving pipette --- automation --- LC–MS/MS --- environmental analysis --- whole water --- trace analysis --- SPE --- large volume --- in-line filter --- sand --- flow rate --- pharmaceuticals --- hormones --- pesticides --- space instrumentation --- liquid chromatography --- oligopeptides --- trapping system --- membrane-based microextraction --- barbiturates --- simultaneous determination --- whole blood --- urine --- liver --- sample preparation --- oxylipins --- protein precipitation --- liquid–liquid extraction --- solid-phase extraction --- biological samples --- chlorophenoxy acid herbicides --- HPLC --- hydrophobic in-tube solid-phase microextraction --- poly (OMA-co-TRIM) monolithic column --- rice grains --- gold --- sample preparation --- preconcentration --- geological samples

Qualitative and Quantitative Analysis of Bioactive Natural Products 2018

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ISBN: 9783038977889 Year: Pages: 374 DOI: 10.3390/books978-3-03897-789-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Keywords

Talaromyces pinophilus --- talarodiolide --- macrodiolides --- GC/MS --- secondary metabolites --- anthocyanins --- red cabbage --- recycling preparative high performance liquid chromatography --- stability --- UHPLC-MS/MS --- decursin --- decursinol angelate --- nodakenin --- decursinol --- Ginkgo biloba Extract (GBE) --- chromatogram-bioactivity correlation --- bioactive compounds --- endothelial function --- wine --- volatile compounds --- terrain conditions --- odor-activity values --- SPME-GC/MS --- Bolbostemma paniculatum --- identification --- LTQ-Orbitrap --- UPLC --- multivariate statistical analysis --- cannabidiol --- CBD oil --- terpenes --- hemp seed oil --- GC-MS --- HPLC-Q-Exactive-Orbitrap-MS --- Rossa da inverno sel. Rojo Duro onion cultivar --- geographical origin --- amino acids content --- HPLC analysis --- statistical evaluations --- food traceability --- aleuritolic acid --- autophagy --- apoptosis --- HPLC --- Curcuma longa --- turmeric --- curcuminoids --- turmerone --- quantification --- Quercus acuta leaf --- antioxidant --- antibacterial activity --- Staphylococcus aureus --- Erigeron breviscapus extract --- UPLC-ESI-MS/MS --- cerebral ischemia reperfusion injury --- scutellarin --- scutellarein --- HPLC --- Podospermum --- Scorzonera --- triterpenes --- ginseng berry extract --- ginsenosides --- stereoselective and simultaneous analysis --- pharmacokinetics --- oral administration --- saffron --- crocins --- UHPLC analysis --- separation optimisation --- artificial neural network --- response surface methodology --- bioactive natural compounds --- secondary metabolites --- Alzheimer’s disease --- Olea europaea L. --- liquid chromatography --- gas chromatography --- mass spectrometry --- secondary metabolites --- olive leaves --- Moroccan region --- phenolic compounds --- liquid chromatography-mass spectrometry --- chemometrics --- metabolic profiling --- Sorbus --- fruit powders --- phenolic compounds --- carotenoids --- sugars --- organic acids --- chili --- capsaicinoids --- phenolics --- free radical-scavenging --- geographical variation --- 1-triacontanol --- HPLC-ELSD --- biostimulant --- method validation --- Myristica fragrans --- nutmeg --- essential oil --- ionic liquids --- hydrodistillation --- MODDE experimental design --- rice --- phenolic compounds --- phenolic acids --- flavonoids --- anthocyanins --- proanthocyanidins --- antioxidant activity --- extraction --- HPLC methods --- phenolic compounds --- Spondias spp. --- UPLC-MS --- antioxidant capacity --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- HPLC-Q-TOF-MS/MS --- qualitative analysis --- quantitative analysis --- C-glycosylflavone --- traditional Chinese medicine decoction --- quality evaluation --- UPLC-QTOF-MS --- UFLC-QQQ-MS --- ShenFu prescription decoction

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