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DNA Replication Stress

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ISBN: 9783039213894 / 9783039213900 Year: Pages: 368 DOI: 10.3390/books978-3-03921-390-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 16:10:12
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Abstract

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.

Keywords

barley --- chromosome --- DNA replication pattern --- EdU --- mutagens --- DNA replication --- DNA damage --- DNA repair --- genome integrity --- A549 cells --- H1299 cells --- heterogeneity --- DNA damage response --- 8-chloro-adenosine --- DNA replication --- S phase --- origin firing --- TopBP1 --- ATR --- DNA fiber assay --- APE2 --- ATR-Chk1 DDR pathway --- Genome integrity --- SSB end resection --- SSB repair --- SSB signaling --- DNA replication stress --- genome stability --- ubiquitin --- replication fork restart --- translesion synthesis --- template-switching --- homologous recombination --- Fanconi Anemia --- G protein-coupled receptor (GPCR) --- aging --- DNA damage --- ?-arrestin --- G protein-coupled receptor kinase (GRK) --- interactome --- G protein-coupled receptor kinase interacting protein 2 (GIT2) --- ataxia telangiectasia mutated (ATM) --- clock proteins --- energy metabolism --- neurodegeneration --- cellular senescence --- ageing --- Alzheimer’s disease --- multiple sclerosis --- Parkinson’s disease --- lipofuscin --- SenTraGorTM (GL13) --- senolytics --- DNA replication --- DNA repair --- DNA damage response --- DNA translocation --- DNA helicase --- superfamily 2 ATPase --- replication restart --- fork reversal --- fork regression --- chromatin remodeler --- C9orf72 --- ALS --- motor neuron disease --- R loops, nucleolar stress --- neurodegeneration --- Difficult-to-Replicate Sequences --- replication stress --- non-B DNA --- Polymerase eta --- Polymerase kappa --- genome instability --- common fragile sites --- Microsatellites --- cancer --- DNA double-strand repair --- premature aging --- post-translational modification --- protein stability --- replication stress --- Werner Syndrome --- Werner Syndrome Protein --- dormant origins --- replicative stress --- replication timing --- DNA damage --- genome instability --- cancer --- Thermococcus eurythermalis --- endonuclease IV --- AP site analogue --- spacer --- DNA repair --- DNA repair --- double strand break repair --- exonuclease 1 --- EXO1 --- mismatch repair --- MMR --- NER --- nucleotide excision repair --- strand displacements --- TLS --- translesion DNA synthesis --- POL? --- mutation frequency --- mutations spectra --- SupF --- mutagenicity --- oxidative stress --- DNA damage --- DNA repair --- replication --- 8-oxoG --- epigenetic --- gene expression --- helicase --- cell cycle checkpoints --- genomic instability --- G2-arrest --- cell death --- repair of DNA damage --- adaptation --- n/a

Ironmaking and Steelmaking

Authors: ---
ISBN: 9783039213290 / 9783039213306 Year: Pages: 464 DOI: 10.3390/books978-3-03921-330-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-12-09 16:10:12
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Steel is a critical material in our societies and will remain an important one for a long time into the future. In the last two decades, the world steel industry has gone through drastic changes and this is predicted to continue in the future. The Asian countries (e.g. China, India) have been dominant in the production of steel creating global over-capacity, while the steel industry in the developed countries have made tremendous efforts to reinforce its global leadership in process technology and product development, and remain sustainable and competitive. The global steel industry is also facing various grand challenges in strict environmental regulation, new energy and materials sources, and ever-increasing customer requirements for high quality steel products, which has been addressed accordingly by the global iron and steel community. This Special Issue, “Ironmaking and Steelmaking”, released by the journal Metals, published 33 high quality articles from the international iron and steel community, covering the state-of-the-art of the ironmaking and steelmaking processes. This includes fundamental understanding, experimental investigation, pilot plant trials, industrial applications and big data utilization in the improvement and optimization of existing processes, and research and development in transformative technologies. It is hoped that the creation of this special issue as a scientific platform will help drive the iron and steel community to build a sustainable steel industry.

Keywords

ironmaking --- microwaves --- carbothermal reduction --- iron oxides --- emission spectrum --- ore-carbon briquette --- CO–CO2 atmosphere --- simulation --- re-oxidation --- reduction --- electroslag cladding --- high speed steel --- ductile cast iron --- composite roll --- bonding interface --- high-phosphorus iron ore --- fluorapatite --- carbothermal reduction --- vaporization dephosphorization --- iron ore pellets --- compressive strength (CS) --- prediction model --- artificial neural network --- principal component analysis --- crystallization behaviors --- crystallization rate --- anosovite crystals --- silicate crystals --- titanium slag --- blast furnace --- copper stave --- hydrogen attack --- slag crust --- heat-affected zone --- high heat input welding --- Ca deoxidation --- inclusion control --- intragranular acicular ferrite --- concentrate --- iron ore --- agglomerate --- structure --- phase analysis --- Mg deoxidation --- inclusions --- Al addition --- high-heat-input welding --- heat-affected zone --- toughness --- shot peening --- Barkhausen noise --- crystallite size --- carbon composite pellet --- direct reduction --- shrinkage --- kinetics --- rotary hearth furnace --- hydrogen plasma --- smelting reduction --- HPSR --- iron oxide --- plasma arc --- ionization degree --- sulfur distribution ratio --- liquid area --- carbon-saturated iron --- phosphate capacity --- sulfide capacity --- phosphorus distribution ratio --- sulfur distribution ratio --- evaluation of coupling relationship --- secondary refining process, CaO–based slags --- iron sulfate --- TG analysis --- thermal treatment --- iron oxide --- kinetics --- activation energy --- high-aluminum iron ore --- synergistic reduction --- high-manganese iron ore --- hercynite --- fayalite --- flow velocity --- casting speed --- gas flow rate --- flow pattern --- continuous casting --- Cr recovery --- self-reduction briquette --- reaction mechanism --- mold flux --- low fluorine --- internal crack --- surface roughness --- slag film --- vanadium titano-magnetite --- gas-based reduction --- carbon monoxide --- hydrogen --- and nitrogen --- kinetics --- pellet size --- liquid steel --- non-contact measurement --- oxides --- steel-making --- blast furnace --- solid flow --- cold experiment --- direct element method --- Wilcox–Swailes coefficient --- viscosity --- BaO --- CaO/Al2O3 ratio --- modified NPL model --- ultrafine particles exposure --- steelmaking factory --- chemical composition --- devolatilization --- torrefied biomass --- bio-coal --- volatile matter --- iso-conversional method --- Al-TRIP steel --- surface depression --- cracks --- non-metallic inclusion --- mold flux --- reactivity --- hot metal pre-treatment --- desiliconisation --- dephosphorisation --- solid and gaseous oxygen --- fork --- flat steel --- inclusions --- 33MnCrTiB --- slag --- carbon dioxide --- injection --- blast furnace --- converter --- combustion --- oxygen steelmaking --- refining kinetics --- slag formation --- penetration theory --- oxygen blast furnace --- COREX --- static process model --- integrated steel plant --- material flow --- energy consumption --- CO2 emissions --- oil-pipeline steel --- Ca-treatment --- non-metallic inclusions --- electrolytic extraction --- corrosion --- n/a

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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eng (2)


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2019 (2)