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Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

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ISBN: 9783039210848 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-06-26 08:44:06
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

Lignans

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ISBN: 9783038979081 9783038979098 Year: Pages: 384 DOI: 10.3390/books978-3-03897-909-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Organic Chemistry
Added to DOAB on : 2019-06-26 10:09:00
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Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

Keywords

lignans --- chemometrics --- neolignans --- flavonolignans --- chemical space --- drug-like --- Lespedeza cuneata --- lignan glycoside --- flavonoid glycoside --- cytotoxicity --- adipocyte and osteoblast differentiation --- Bursera --- Burseraceae --- lignans --- lignan --- molecular dynamics --- intermolecular interactions --- graph theory --- lignans --- heilaohu --- tujia ethnomedicine --- chemical characterization --- cytotoxicity --- antioxidant --- cultivar --- environment --- flax --- flavonol --- genetic --- hydroxycinnamic acid --- lignan --- seed --- aryldihydronaphthalene lignan --- arylnaphthalene lignan --- oxidation --- synthesis --- lignans --- dibenzyl butyrolactones --- anti-proliferative --- acyl-Claisen --- stereoselective synthesis --- Schisandra rubriflora --- Schisandra chinensis --- red-flowered Chinese magnolia vine --- Chinese magnolia vine --- lignans --- phytochemical analysis --- UHPLC-MS/MS --- anti-inflammatory activity --- LOX --- COX --- sPLA2 --- lignans --- neolignans --- Lauraceae --- chemical components --- chemical structures --- dietary lignans --- national databases --- food groups --- dietary intake --- harmonized databases --- lignans --- in silico studies --- podophyllotoxin --- antibacterial activity --- acetylcholinesterase inhibitors --- antioxidant activity --- cytotoxicity --- natural products --- total synthesis --- lignan --- Bursera fagaroides --- podophyllotoxin-type lignans --- cell cycle --- cell migration --- epiboly --- microtubules --- F-actin --- cancer --- lignans --- animal health --- cattle --- enterolignan --- human health --- pharmacokinetic --- ruminant --- secoisolariciresinol diglucoside --- Lignan --- bitterness --- taste-active compound --- quantification --- oak ageing --- lignans --- norlignans --- 9-norlignans --- semisynthesis --- hydroxymatairesinol --- bioactivity --- lignans --- oxidation --- lignans --- diet --- antioxidants --- health promotion --- chronic diseases --- Schisandrae Chinensis Fructus --- wild --- cultivated --- multiple bioactive components --- simultaneous quantitation

Natural Products and Drug Discovery

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ISBN: 9783039287468 / 9783039287475 Year: Pages: 392 DOI: 10.3390/books978-3-03928-747-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Keywords

cytotoxicity-guided --- phenolic derivatives --- Dryopteris fragrans --- chemical derivatization --- immuno-regulation activity --- Imperata cylindrica --- HPLC --- ESI-MS/MS --- growth inhibitory activity --- cancer --- cardamonin --- antinociceptive --- TRPV1 --- glutamate --- opioid --- siphonous green algae --- sulfated coumarins --- Dasycladus vermicularis --- isolation and quantification --- Orobanche s.l. --- Orobanchaceae --- Lamiales --- natural products --- secondary metabolites --- phenylpropanoid glycosides --- phenylethanoid glycosides --- bioactivities of natural products --- chemosystematics --- FSE --- T2DM --- GLUT4 --- Ca2+ --- L6 cell --- marine peptides --- proliferation --- migration --- angiogenesis --- zebrafish --- antioxidant activity --- flavonoids --- isoflavones --- phenolics --- proanthocyanidins --- Trifolium --- Leea indica --- HPLC-ESI-microTOF-Q-MS/MS --- phenolics --- dihydrochalcones --- Humulus lupulus --- prenylated phenolic compounds --- antimicrobial agents --- methicillin-resistant Staphylococcus aureus --- Leishmania mexicana mexicana --- Trypanosoma brucei brucei --- Astragalus boeticus L. --- spectroscopic analysis --- cytotoxic activity --- human colon cancer cell lines --- acetylated astragalosides --- Fabaceae --- aging --- cancer --- cardiovascular disease --- dementia --- diabetes --- inflammation --- oxidative stress --- Harpagophytum procumbens --- devil’s claw --- harpagoside --- spagyric tincture --- antioxidant activity --- Cleistocalyx operculatus --- 2?,4?-dihydroxy-6?-methoxy-3?,5?-dimethylchalcone (DMC) --- pPancreatic cancer --- PANC-1 --- ACE inhibitory peptide --- antihypertensive --- bioactive peptides --- hypertension --- marine resources --- terpenes --- terpenoids --- antimicrobial resistance --- synergy --- Phyllanthus orbicularis --- C-glycoside --- flavonoid --- natural products --- traditional medicine --- Cuba --- Phyllanthus chamacristoides --- chromatography --- mass spectrometry --- NMR --- circular dichroism --- stereochemistry --- Fideloside --- cytokines --- anti-inflammatory activity --- metabolomics --- multivariate data analysis --- molecular network --- Bacopa monnieri --- LC-MS --- diabetic neuropathy --- neuropathic pain --- glucosinolates --- Eruca sativa --- glucoerucin --- H2S --- Kv7 potassium channels --- artemisinin --- Physcomitrella patens --- sesquiterpenoids --- malaria --- biotechnology --- ketamine --- psychosis --- cerebellum --- celastrol --- oxidative stress --- NADPH oxidases --- n/a

Plant Natural Products for Human Health

Authors: ---
ISBN: 9783038977124 Year: Pages: 514 DOI: 10.3390/books978-3-03897-713-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Keywords

heat-process --- onion --- calorie restriction --- Amadori rearrangement compounds --- hyperglycemia --- A549 cells --- hinokitiol --- MMPs --- p53/Bax --- antioxidant enzymes --- caspases --- migration --- cannabinoid type 1 receptor --- endoplasmic reticulum stress --- gluconeogenesis --- gomisin N --- lipogenesis --- insulin resistance --- garlic --- ischemia --- heme oxygenase --- reperfusion --- heart --- Keap1 --- Nrf2 --- Neuroprotective --- PC12 cells --- PhGs --- anti-malaria activity --- plants --- natural products --- ethnopharmacology --- Plasmodium parasites --- copaiba --- oleoresin --- essential oil --- sesquiterpenoids --- diterpenoids --- biological activity --- molecular targets --- Astragali Radix --- astragaloside IV --- genistein --- mitochondrial bioenergetics --- oxygen consumption rate --- natural products --- drug design and development --- innovation --- automation --- computational softwares --- bioinformatics --- precision medicine --- omics --- global health --- sweet orange --- bitter orange --- neroli --- orange petitgrain --- mandarin --- lemon --- lime --- grapefruit --- bergamot --- yuzu --- kumquat --- cannabigerol --- Cannabis sativa --- neuroinflammation --- oxidative stress --- phytocannabinoid --- iridoids --- nuclear factor-kappaB --- mitogen-activated protein kinase --- anti-inflammation --- Ziziphus jujuba --- triterpenic acids --- pharmacokinetic study --- acute liver injury --- A? --- AD --- lychee seed --- neuroinflammation --- catechin --- procyanidin A2 --- apoptosis --- cinnamamides --- antistaphylococcal activity --- time-kill assay --- biofilm --- antitubercular activity --- MTT assay --- antifungal activity --- PET inhibition --- toxicity --- structure–activity relationship --- bleeding time --- flavonoid --- morin hydrate --- OH· free radical --- platelet activation --- protein kinase --- thromboembolism --- Glycyrrhiza uralensis --- prenylated flavonoids --- antiproliferation --- differentiation --- melanoma cell --- adjuvant-induced arthritis --- arthritis --- celastrol --- curcumin --- dietary supplements --- EGCG --- green tea --- inflammation --- liposomes --- microbiome --- nanoparticles --- natural products --- resveratrol --- rheumatoid arthritis --- targeted delivery --- traditional medicine --- Tripterygium wilfordii --- triptolide --- Penthorum chinense Pursh --- NAFLD --- hepatic steatosis --- flavonoids --- SIRT1 --- AMPK --- dihydromyricetin --- myocardial hypertrophy --- oxidative stress --- sirtuin 3 --- ginseng --- human-hair-follicle dermal papilla cells --- WNT/?-catenin --- Shh/Gli --- TGF-? --- BMP/Smad --- mouse-hair growth --- Panax notoginseng saponins --- aspirin --- HepaRG cells --- herb–drug interactions --- P. eryngii --- glucans --- inflammation --- inflammatory bowel disease --- medicinal plants --- phytochemicals --- scoulerine --- bergapten --- immunomodulator --- adjuvant --- cytoxicity --- dendritic cells --- immune modulation --- APAP --- acetaminophen --- hepatotoxicity --- hpatoprotection --- paracetamol --- animals --- preclinical studies --- natural products --- small molecules --- phytochemicals --- plants --- fucoidan --- acetaminophen --- Nrf2 --- oxidative stress --- hepatotoxicity --- plant natural product --- drug discovery --- human health

Plant Protein and Proteome Altlas--Integrated Omics Analyses of Plants under Abiotic Stresses

Authors: --- --- --- --- et al.
ISBN: 9783039219605 / 9783039219612 Year: Pages: 558 DOI: 10.3390/books978-3-03921-961-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Botany
Added to DOAB on : 2020-06-09 16:38:57
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Integrative omics of plants in response to stress conditions play more crucial roles in the post-genomic era. High-quality genomic data provide more deeper understanding of how plants to survive under environmental stresses. This book is focused on concluding the recent progress in the Protein and Proteome Atlas in plants under different stresses. It covers various aspects of plant protein ranging from agricultural proteomics, structure and function of proteins, and approaches for protein identification and quantification.

Keywords

proteomic --- postharvest freshness --- ATP synthase --- ATP synthase CF1 alpha subunit (chloroplast) --- chlorophyll fluorescence parameters --- photosynthetic parameters --- drought stress --- Triticum aestivum L. --- comparative proteomic analysis --- iTRAQ --- VIGS --- Jatropha curcas --- phosphoproteomics --- seedling --- chilling stress --- regulated mechanism --- Alternanthera philoxeroides --- proteomic --- stem --- potassium --- stress --- Salinity stress --- Dunaliella salina --- isobaric tags for relative and absolute quantitation --- differentially abundant proteins --- proteomics --- arbuscular mycorrhizal fungi --- salt stress --- E. angustifolia --- proteomics --- wheat --- root --- wood vinegar --- drought stress --- ROS --- ABA --- proteome --- maize --- AGPase --- phosphorylation --- brittle-2 --- phos-tagTM --- MIPS --- exon-intron structure diversity --- Gossypium hirsutum --- loss-of-function mutant --- root cell elongation --- CHA-SQ-1 --- cytomorphology --- pollen abortion --- proteomics --- wheat --- cotton --- somatic embryogenesis --- transdifferentiation --- quantitative proteomics --- regulation and metabolism --- molecular basis --- concerted network --- maize --- phosphoproteomics --- salt tolerance --- label-free quantification --- root and shoot --- sugar beet --- salt stress --- S-adenosylmethionine decarboxylase --- ROS --- antioxidant enzyme --- cotton --- somatic embryogenesis --- transdifferentiation --- widely targeted metabolomics --- purine metabolism --- flavonoid biosynthesis --- molecular and biochemical basis --- transcript-metabolite network --- leaf sheath --- maturation --- transcriptional dynamics --- transcriptome --- abiotic stress --- silicate limitation --- diatom --- iTRAQ --- proteomics --- photosynthesis --- carbon fixation --- natural rubber biosynthesis --- mass spectrometry --- rubber grass --- rubber latex --- shotgun proteomics --- Taraxacum kok-saghyz --- two-dimensional gel electrophoresis --- visual proteome map --- proteomics --- wheat --- drought --- leaf --- iTRAQ --- micro-exons --- constitutive splicing --- alternative splicing --- ancient genes --- domain --- radish --- heat stress --- transcriptome sequencing --- lncRNA --- miRNA --- physiological response --- Millettia pinnata --- woody oilseed plants --- seed development --- miRNA --- nitrogen fertilizer --- rice --- proteome --- cultivars --- nitrogen use efficiency (NUE) --- Nelumbo nucifera --- phylogeny --- genomics --- molecular mechanisms --- model plant --- proteomes --- iTRAQ --- filling kernel --- drought stress --- heat shock proteins --- Zea mays L. --- wucai --- low-temperature stress --- high-temperature stress --- proteomics --- redox homeostasis --- GLU1 --- glutathione --- heat response --- heat-sensitive spinach variety --- proteomics --- ROS scavenging --- inositol --- phosphatidylinositol --- phosphatase --- stress --- signaling pathway --- integrated omics --- plants under stress --- post-genomics era --- proteome atlas --- quantitative proteomics

Plant Proteomic Research 2.0

Author:
ISBN: 9783039210626 9783039210633 Year: Pages: 594 DOI: 10.3390/books978-3-03921-063-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2019-06-26 08:44:07
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Abstract

Advancements in high-throughput “Omics” techniques have revolutionized plant molecular biology research. Proteomics offers one of the best options for the functional analysis of translated regions of the genome, generating a wealth of detailed information regarding the intrinsic mechanisms of plant stress responses. Various proteomic approaches are being exploited extensively for elucidating master regulator proteins which play key roles in stress perception and signaling, and these approaches largely involve gel-based and gel-free techniques, including both label-based and label-free protein quantification. Furthermore, post-translational modifications, subcellular localization, and protein–protein interactions provide deeper insight into protein molecular function. Their diverse applications contribute to the revelation of new insights into plant molecular responses to various biotic and abiotic stressors.

Keywords

Phalaenopsis --- petal --- pollination --- senescence --- 2-DE --- ROS --- Medicago sativa --- leaf cell wall proteome --- cadmium --- quantitative proteomics --- 2D DIGE --- chloroplast --- elevated CO2 --- heat stress --- nucleotide pyrophosphatase/phosphodiesterase --- (phospho)-proteomics --- photosynthesis --- protein phosphorylation --- 14-3-3 proteins --- Oryza sativa L. --- starch --- sucrose --- N utilization efficiency --- proteomics --- 2D --- protein phosphatase --- rice isogenic line --- SnRK1 --- 14-3-3 --- lettuce --- bolting --- proteome --- high temperature --- iTRAQ --- proteome profiling --- iTRAQ --- differentially abundant proteins (DAPs) --- drought stress --- physiological responses --- Zea mays L. --- GS3 --- ? subunit --- heterotrimeric G protein --- mass spectrometric analysis --- RGG3 --- rice --- western blotting --- Dn1-1 --- ?-subunit --- heterotrimeric G protein --- mass spectrometry analysis --- RGG4 --- rice --- western blotting --- Clematis terniflora DC. --- polyphenol oxidase --- virus induced gene silencing --- photosynthesis --- glycolysis --- Camellia sinensis --- chlorotic mutation --- chlorophyll deficiency --- weakening of carbon metabolism --- iTRAQ --- proteomics --- degradome --- wheat --- cultivar --- protease --- papain-like cysteine protease (PLCP) --- subtilase --- metacaspase --- caspase-like --- wheat leaf rust --- Puccinia recondita --- Stagonospora nodorum --- iTRAQ --- proteomics --- somatic embryogenesis --- pyruvate biosynthesis --- Zea mays --- chlorophylls --- LC-MS-based proteomics --- pea (Pisum sativum L.) --- proteome functional annotation --- proteome map --- seeds --- seed proteomics --- late blight disease --- potato proteomics --- Phytophthora infestans --- Sarpo Mira --- early and late disease stages --- Simmondsia chinensis --- cold stress --- proteomics --- leaf --- iTRAQ --- Ricinus communis L. --- cold stress --- seed imbibition --- iTRAQ --- proteomics --- Morus --- organ --- gel-free/label-free proteomics --- flavonoid --- antioxidant activity --- phosphoproteome --- barley --- seed dormancy --- germination --- imbibition --- after-ripening --- sugarcane --- Sporisorium scitamineum --- smut --- proteomics --- RT-qPCR --- ISR --- holm oak --- Quercus ilex --- 2-DE proteomics --- shotgun proteomics --- non-orthodox seed --- population variability --- stresses responses --- ammonium --- Arabidopsis thaliana --- carbon metabolism --- nitrogen metabolism --- nitrate --- proteomics --- root --- secondary metabolism --- proteomics --- wheat --- silver nanoparticles --- plant pathogenesis responses --- data-independent acquisition --- quantitative proteomics --- Pseudomonas syringae --- sweet potato plants infected by SPFMV --- SPV2 and SPVG --- sweet potato plants non-infected by SPFMV --- SPV2 and SPVG --- co-infection --- transcriptome profiling --- gene ontology --- pathway analysis --- lesion mimic mutant --- leaf spot --- phenylpropanoid biosynthesis --- proteomics --- isobaric tags for relative and absolute quantitation (iTRAQ) --- rice --- affinity chromatography --- ergosterol --- fungal perception --- innate immunity --- pattern recognition receptors --- plasma membrane --- proteomics --- proteomics --- maize --- plant-derived smoke --- shoot --- Solanum tuberosum --- patatin --- seed storage proteins --- vegetative storage proteins --- tuber phosphoproteome --- targeted two-dimensional electrophoresis --- B. acuminata petals --- MALDI-TOF/TOF --- GC-TOF-MS --- qRT-PCR --- differential proteins --- n/a

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