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Recent Advances in Doppler Signal Processing and Modelling Techniques for Fetal Monitoring

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455362 Year: Pages: 99 DOI: 10.3389/978-2-88945-536-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
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The guest editors of this eBook have accepted 10 very high-quality submissions for inclusion in a special issue of Frontiers in Physiology. The key difference between this eBook and contemporary fetal physiology related literature is that this Research Topic summarizes additional insights into the physiological link between physiologically understandable mathematical indices of fetal signals and the developing cardiovascular functions in fetal health and compromises. This book should be of considerable help to researchers, professionals in fetal monitoring device industries, academics, and graduate students from a wide range of disciplines. The text provides a comprehensive account of recent research in this emerging field and we anticipate that the concepts presented here will generate further research in this field.

Nutrition in Pregnancy: Volume I

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ISBN: 9783038423676 9783038423669 Pages: XX, 342 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Therapeutics
Added to DOAB on : 2017-04-28 10:00:32
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Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients. Added to this complexity is the distinction between maternal and fetal nutrition and the impact the placenta plays in nutrient metabolism and overall nutrient supply to the fetus. Together, these many variables contribute to placental development and function, fetal growth, and, where placental/fetal nutrition and growth is compromised, through poor maternal diet, and/or diet induced alterations in placental metabolism, the impact is dramatic and can lead to lifelong implications for the offspring. This Special Issue book aims to highlight research in many of these areas.

Nutrition in Pregnancy - Volume II

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ISBN: 9783038423690 9783038423683 Year: Pages: XX, 270 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2017-04-28 10:21:23
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Maternal nutrition during pregnancy is of considerable interest to women, their partners and their health care professionals. In developing countries, maternal undernutrition is a major concern. However, with the increased prevalence of abundant high calorie diets, their impact upon pregnancy outcome is of concern. In addition to the amount of nutrition available and its macronutrient composition within a diet, there is emerging evidence highlighting important roles for the lesser studied micronutrients. Added to this complexity is the distinction between maternal and fetal nutrition and the impact the placenta plays in nutrient metabolism and overall nutrient supply to the fetus. Together, these many variables contribute to placental development and function, fetal growth, and, where placental/fetal nutrition and growth is compromised, through poor maternal diet, and/or diet induced alterations in placental metabolism, the impact is dramatic and can lead to lifelong implications for the offspring. This Special Issue book aims to highlight research in many of these areas.

Fetal Therapies and Maternal-Fetal Tolerance

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199839 Year: Pages: 84 DOI: 10.3389/978-2-88919-983-9 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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The ability to diagnose and treat genetic diseases before birth represents one of the foremost breakthroughs of modern medicine. While fetal surgery has advanced in the last several decades, the prospect of applying developments in stem cell biology and gene therapy to the fetal environment remains an open frontier. This issue represents the work of international experts in the field of fetal therapy, who came together at the first meeting of the International Fetal Transplantation and Immunology Society in 2014. This meeting was convened in an effort to provide a consensus for future applications of in utero transplantation and gene therapy, as well as form an international community of colleagues to nurture this field.

New therapeutic targets for human placental angiogenesis diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194612 Year: Pages: 113 DOI: 10.3389/978-2-88919-461-2 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.

New Approaches to the Pathogenesis of Sudden Intrauterine Unexplained Death and Sudden Infant Death Syndrome

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453016 Year: Pages: 104 DOI: 10.3389/978-2-88945-301-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:45
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Sudden Infant Death Syndrome (SIDS) is the leading cause of death among infants in the first year of age. The more known definition of SIDS is the sudden unexpected death of an infant less than 1 year of age, with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation, including performance of a complete autopsy and review of the circumstances of death and the clinical history. Despite the success of the “Back to Sleep” campaigns to reduce the risks introduced worldwide, the frequency of SIDS (striking one infant every 750-1,000 live births) has not significantly declined in the last years. Sudden Intrauterine Unexplained Death Syndrome (SIUDS), referring to fetuses that die unexpectedly, particularly in the last weeks of gestation, without any cause even after a complete autopsy, including examination of the placental disk, umbilical cord and fetal membranes, has a six-eightfold greater incidence than that of SIDS. Even if the pathogenetic mechanism of these deaths has not yet been determined, the neuropathology seems to be a consistent substrate in both SIUDS and SIDS. Subtle common developmental abnormalities of brainstem nuclei checking the vital functions have been highlighted, frequently related to environmental risk factors, such as cigarette smoke, air and water pollution, pesticides, food contamination, etc. Exogenous toxic factors can in fact interact in complex ways with the genetic constitution of the infant leading to polymorphisms and/or mutations of specific genes (as polymorphisms of the serotonin transporter gene 5-HTT, the regulator of the synaptic serotonin concentration, and of the PHOX2B, the key gene in the Congenital Central Hypoventilation Syndrome). These interactions can directly injure the development of the autonomic nervous system, frequently resulting in hypoplasia of the vital brainstem centers, and consequently in sudden death. It is very important to continue studying these syndromes and in particular identify all possible congenital alterations and their correlation with the exposure to environmental risk factors, in order to reduce their incidence and mitigate the surrounding social concern. The goal of this research topic is to propose new approaches to explain the pathogenesis of both SIUDS and SIDS and consequently new prevention strategies to decrease the incidence of these unexpected and very devastating events for families. Expert authors in the Topic field are encouraged to submit original research articles aimed to widen the current knowledge on the pathological substrates of these deaths, also considering the correlations with possible risk factors. Submissions of hypotheses, opinions and commentaries are also welcome. This Research Topic would lead to development of targeted risk-lowering strategies to reduce the incidence of both SIUDS and SIDS. Furthermore, the adoption of appropriate preventive measures could also lead to improve the quality of life in adults, promoting active and healthy aging.

Prenatal Beginnings for Better Health

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455096 Year: Pages: 107 DOI: 10.3389/978-2-88945-509-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics --- Medicine (General) --- Pediatrics
Added to DOAB on : 2019-01-23 14:53:42
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Pregnancy has significant short- and long-term health impacts for mother and child, which may lead to pediatric- and adult-onset diseases. Understanding these gestational origins of disease and currently existing platforms for prenatal care has resulted in significant advances to detect and prevent adverse maternal and fetal outcomes. Existing and emerging prenatal interventions that are instituted at critical times in gestation take advantage of unique therapeutic windows and provide an opportunity to modify the risks. This research topic encompasses a variety of approaches and interventions, such as maternal screening for fetal disease, advanced fetal imaging, biomarker development, stem cell or gene therapies, and others.

Preterm Birth - Mother and Child

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ISBN: 9789533078281 Year: Pages: 370 DOI: 10.5772/1284 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics
Added to DOAB on : 2019-10-03 07:51:48

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While there are many studies and books regarding preterm birth, both the obstetric and in the neonatal/pediatric literature, what is missing is the integration of data from obstetrics through neonatal course and into pediatrics as the neonate transverses childhood. A continued dialogue between specialties is essential in the battle against preterm birth in an attempt to relieve the effects or after-effects of preterm birth. For all of our medical advances to date, preterm birth is still all too common, and its ramifications are significant for hospitals, families and society in general.

Obstetrics

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ISBN: 9789535137030 9789535137047 9789535139980 Year: Pages: 200 DOI: 10.5772/66054 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics
Added to DOAB on : 2019-10-03 07:51:50

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Obstetrics is the field that deals with the well-being of the pregnant women as well as the labor and delivery of a healthy baby. Obstetricians work closely as neonatologists who deal with the care of the newborn baby to reduce chances of morbidity and mortality. The objective of obstetrics is to deal with diagnosis and treatment of pregnancy, antenatal care, and prevention of complication, collaborating with midwives to monitor pregnant women in labor, facilitating delivery and performing assisted procedures if needed as episiotomy, forceps delivery, vacuum extraction, and Cesarean section if indicated.

Pregnancy and Birth Outcomes

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ISBN: 9781789232424 9781789232431 Year: Pages: 88 DOI: 10.5772/intechopen.69365 Language: English
Publisher: IntechOpen
Subject: Gynecology and Obstetrics
Added to DOAB on : 2019-10-03 07:51:51

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More than 10% of the global burden of disease is due to pregnancy complications and adverse birth outcomes. Despite recent advances in obstetric medicine, pregnancy complications and adverse birth outcomes are a growing public health concern and economic burden on the healthcare system. This book will focus on the pregnancy complications and birth outcomes, from the aspects of gestational age, environmental, genetic, epigenetic risk factors, and delivery room management.

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