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Electrospun and Electrosprayed Formulations for Drug Delivery

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ISBN: 9783038979128 9783038979135 Year: Pages: 190 DOI: 10.3390/books978-3-03897-913-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 10:09:00
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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

Recent Development of Electrospinning for Drug Delivery

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ISBN: 9783039281404 9783039281411 Year: Pages: 206 DOI: 10.3390/books978-3-03928-141-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-04-07 23:07:09
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Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

Keywords

electrospinning --- gentamicin sulfate --- polylactide-co-polycaprolactone --- drug release kinetics --- tissue engineering --- growth factor --- diabetic --- wound healing --- nanocomposite --- electrospinning --- coaxial spinning --- core-sheath nanofibers --- biomedical --- drug delivery --- electrospinning --- scale-up --- processability --- biopharmaceuticals --- oral dosage form --- grinding --- aceclofenac --- nanofiber --- electrospinning --- scanning electron microscopy --- fourier transform infrared spectroscopy --- differential scanning calorimetry --- nanotechnology --- biotechnology --- probiotics --- Lactobacillus --- Lactococcus --- electrospinning --- nanofibers --- drying --- local delivery --- viability --- antibacterial activity --- bacterial bioreporters --- drug release --- electrospinning --- microfibers --- nanofibers --- UV imaging --- wetting --- in situ drug release --- nanofibers --- electrospinning --- poorly water-soluble drug --- piroxicam --- hydroxypropyl methyl cellulose --- polydextrose --- scanning white light interferometry --- nanotechnology --- nanofibers --- traditional electrospinning --- ultrasound-enhanced electrospinning --- drug delivery system --- haemanthamine --- plant-origin alkaloid --- electrospinning --- amphiphilic nanofibers --- self-assembled liposomes --- physical solid-state properties --- drug release --- electrospinning --- PCL --- gelatin --- clove essential oil --- antibacterial --- biocompatibility --- artificial red blood cells --- electrospinning and electrospray --- pectin --- oligochitosan --- hydrogel --- microcapsules --- electrospinning --- wound dressings --- solvent casting --- 3D printing --- polymeric carrier --- n/a

Electrospun Nanofibers for Biomedical Applications

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ISBN: 9783039287741 / 9783039287758 Year: Pages: 308 DOI: 10.3390/books978-3-03928-775-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-06-09 16:38:57
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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

Keywords

sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- electrospinning --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- electrospinning --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- electrospinning --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- electrospinning --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- electrospinning --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- electrospinning --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- electrospinning --- nanofibers --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-? capture --- human articular chondrocytes --- rheumatoid arthritis --- nanofibers --- microfluidic chip --- electrospinning --- live assay --- hepatocellular carcinoma cells --- PLA95 --- biocompatibility --- guided tissue regeneration (GTR) --- electrospinning --- electrospun fiber mats --- mechanobiology --- glioblastoma --- biomaterials --- finite element modeling --- electrospun nanofibers --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

Electrospun Polymer Nanofibers for Food and Health Applications

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ISBN: 9783039281923 9783039281930 Year: Pages: 74 DOI: 10.3390/books978-3-03928-193-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-04-07 23:07:08
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The electrospinning method has the unique ability to produce structured polymeric fibers on the micro or nano scale and to generate novel materials for food and healthcare purposes. The potential of electrospun nanofibers for human healthcare applications is promising, for example, in tissue/organ repair and regeneration, in medical diagnostics and instrumentation, and as vectors to deliver drugs and therapeutics, as biocompatible and biodegradable medical implant devices, as protective fabrics against environmental and infectious agents in hospitals and general surroundings. Furthermore, considerable effort has been directed toward developing scaffolds using biodegradable and biocompatible synthetic, natural polymers or renewable materials that enhance in vitro cell growth, while killing pathogenic bacteria cells. This Special Issue ""Electrospun Polymer Nanofibers for Food and Health Applications” will cover the latest research of electrospun nanofibres in this field including shape-memory electrospun fibre meshes with programmable cell orientation, water-absorbing nano?ber meshes for e?cient removal of excess water from kidney failure patients, and hydrogel nano?bers which can be used as a drug carrier for methylene blue.

Application and Behavior of Nanomaterials in Water Treatment

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ISBN: 9783039211715 9783039211722 Year: Pages: 174 DOI: 10.3390/books978-3-03921-172-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2019-12-09 11:49:15
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The book compiles scientific articles describing advances in nanomaterial synthesis and their application in water remediation. The publications treat diverse problems such as dye degradation, heavy metal ion, as well as radioactive element capture and sequestration. There are 10 original research articles and one review article. The latter proposes graphene/CNT and Prussian blue nanocomposites for radioactive 137-cesium extraction from aqueous media. All reports thoroughly characterize the nanomaterials post-synthesis and describe their catalytic, photocatalytic, or ion exchange activities in contaminated water. The dyes studied in the collection are azo dyes, i.e. methylene blue and orange, rhodamine B, phenolic dyes viz. bromophenol blue, and other dyes with sulfonyl groups. Extraction of radioactive elements, including cationic 137Cs+ and anionic 125I?, is also investigated. The omnipresence of ZnO nanoparticles in everyday products and their effects in wastewater are also evaluated. Layered double hydroxide are capable of capturing Ag ions, which then has a catalytic effect on dye degradation. The nanomaterials considered are varied, viz., graphene, CNT, Prussian blue, nanoporous carbon, layered double hydroxides, magnetite, ferrites, organic powders, polymer membranes, bacteria, and inorganic nanomaterials such as MnO and Ag. The book targets an interdisciplinary readership.

Nanocelluloses: Synthesis, Modification and Applications

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ISBN: 9783039287840 / 9783039287857 Year: Pages: 142 DOI: 10.3390/books978-3-03928-785-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2020-06-09 16:38:57
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Nanocelluloses: Synthesis, Modification and Applications is a book that provides some recent enhancements of various types of nanocellulose, mainly bacterial nanocellulose, cellulose nanocrystals and nanofibrils, and their nanocomposites. Bioactive bacterial nanocellulose finds applications in biomedical applications, https://doi.org/10.3390/nano9101352. Grafting and cross-linking bacterial nanocellulose modification emerges as a good choice for improving the potential of bacterial nanocellulose in such biomedical applications as topical wound dressings and tissue-engineering scaffolds, https://doi.org/10.3390/nano9121668. On the other hand, bacterial nanocellulose can be used as paper additive for fluorescent paper, https://doi.org/10.3390/nano9091322, and for the reinforcement of paper made from recycled fibers, https://doi.org/10.3390/nano9010058. Nanocellulose membranes are used for up-to-date carbon capture applications, https://doi.org/10.3390/nano9060877. Nanocellulose has been applied as a novel component of membranes designed to address a large spectrum of filtration problems, https://doi.org/10.3390/nano9060867. Poly(vinyl alcohol) (PVA) and cellulose nanocrystals (CNC) in random composite mats prepared using the electrospinning method are widely characterized in a large range of physical chemical aspects, https://doi.org/10.3390/nano9050805. Similarly, physical chemical aspects are emphasized for carboxylated cellulose nanofibrils produced by ammonium persulfate oxidation combined with ultrasonic and mechanical treatment, https://doi.org/10.3390/nano8090640. It is extraordinary how nanocellulose can find application in such different fields. Along the same lines, the contributions in this book come from numerous different countries, confirming the great interest of the scientific community for nanocellulose.

Food Packaging. Materials and Technologies

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ISBN: 9783038977667 9783038977674 Year: Pages: 216 DOI: 10.3390/books978-3-03897-767-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2019-04-25 16:37:17
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Because of the increasing pressure on both food safety and packaging/food waste, the topic is important both for academics, applied research, industry and also for environment protection. Different materials, such as glass, metals, paper and paperboards, and non-degradable and degradable polymers, with versatile properties, are attractive for potential uses in food packaging. Food packaging is the largest area of application within the food sector. Only the nanotechnology-enabled products in the food sector account for ~50% of the market value, with and the annual growth rate is 11.65%. Technological developments are also of great interest. In the food sector, nanotechnology is involved in packaging materials with extremely high gas barriers, antimicrobial properties, and also in nanoencapsulants for the delivery of nutrients, flavors, or aromas, antimicrobial, and antioxidant compounds. Applications of materials, including nanomaterials in packaging and food safety, are in forms of: edible films, polymer nanocomposites, as high barrier packaging materials, nanocoatings, surface biocides, silver nanoparticles as potent antimicrobial agents, nutrition and neutraceuticals, active/bioactive packaging, intelligent packaging, nanosensors and nanomaterial-based assays for the detection of food relevant analytes (gasses, small organic molecules and food-borne pathogens) and bioplastics.

Smart Coatings on Fibers and Textiles

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ISBN: 9783039284627 9783039284634 Year: Pages: 190 DOI: 10.3390/books978-3-03928-463-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Smart textiles are the textiles that are sensitive to any environmental conditions and can respond accordingly. Using passive and active coatings to generate high sensitivity to textiles is among the most recent research trends by engineers around the World. This has resulted in expansion in the application of smart textiles in various industrial fields including medicals, electronics and protective clothing. The aim of this special issue is to introduce the most state-of-the-art research and review articles by distinguished researchers in the field of smart coatings on textiles. The guest editor hopes that content will be useful for researchers, students and companies for continuation of research and development with the concept of smart textiles.

Advances in Heterocatalysis by Nanomaterials

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ISBN: 9783039288359 / 9783039288366 Year: Pages: 166 DOI: 10.3390/books978-3-03928-836-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General)
Added to DOAB on : 2020-06-09 16:38:57
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Heterogeneous catalysis played, plays, and will continue to play, a major key role in industrial processes for large-scale synthesis of commodity chemicals of global importance, and in catalytic systems that possess a critical role in energy generation and environmental protection approaches. As a result of the ongoing progress in materials science, nanotechnology, and characterizations, great advances have been achieved in heterogeneous catalysis by nanomaterials. Efficient approaches and advanced methods for the design of nano-structured composite materials (up to atomic level), subject to specific nano-morphologies with enhanced metal–metal and metal–support interactions favorable for catalysis (that enable fine-tuning of the critical properties of the designed catalysts), provide optimized catalysts with outstanding performances in numerous eco-friendly and cost-effective applications. Accordingly, great progress has been achieved involving, for example, emissions control, waste treatment, photocatalytic, bio-refinery, CO2 utilization, and fuel cells applications, as well as hydrocarbon processing for H2, added-value chemicals, and liquid fuels production. The themed Special Issue has succeeded in collecting 10 high-quality contributions that cover recent research progress in the field for a variety of applications (e.g., environment, energy, added-value chemicals/organics synthesis, and bio-transformation) declaring the prospect and importance of nanomaterials in all the directions of heterogeneous catalysis.

Synthesis and Applications of Biopolymer Composites

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ISBN: 9783039211326 9783039211333 Year: Pages: 312 DOI: 10.3390/books978-3-03921-133-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This book, as a collection of 17 research articles, provides a selection of the most recent advances in the synthesis, characterization, and applications of environmentally friendly and biodegradable biopolymer composites and nanocomposites. Recently, the demand has been growing for a clean and pollution-free environment and an evident target regarding the minimization of fossil fuel usage. Therefore, much attention has been focused on research to replace petroleum-based commodity plastics by biodegradable materials arising from biological and renewable resources. Biopolymers—polymers produced from natural sources either chemically from a biological material or biosynthesized by living organisms—are suitable alternatives for addressing these issues due to their outstanding properties, including good barrier performance, biodegradation ability, and low weight. However, they generally possess poor mechanical properties, a short fatigue life, low chemical resistance, poor long-term durability, and limited processing capability. In order to overcome these deficiencies, biopolymers can be reinforced with fillers or nanofillers (with at least one of their dimensions in the nanometer range). Bionanocomposites are advantageous for a wide range of applications, such as in medicine, pharmaceutics, cosmetics, food packaging, agriculture, forestry, electronics, transport, construction, and many more.

Keywords

nanocellulose --- protease sensor --- human neutrophil elastase --- peptide-cellulose conformation --- aerogel --- glycol chitosan --- ?-tocopherol succinate --- amphiphilic polymer --- micelles --- paclitaxel --- chitosan --- PVA --- nanofibers --- electrospinning --- nanocellulose --- carbon nanotubes --- nanocomposite --- conductivity --- surfactant --- Poly(propylene carbonate) --- thermoplastic polyurethane --- compatibility --- toughness --- biopolyester --- compatibilizer --- cellulose --- elastomer --- toughening --- biodisintegration --- heat deflection temperature --- biopolymers composites --- MgO whiskers --- PLLA --- in vitro degradation --- natural rubber --- plasticized starch --- polyfunctional monomers --- physical and mechanical properties --- cross-link density --- water uptake --- chitosan --- deoxycholic acid --- folic acid --- amphiphilic polymer --- micelles --- paclitaxel --- silk fibroin --- glass transition --- DMA --- FTIR --- stress-strain --- active packaging materials --- alginate films --- antimicrobial agents --- antioxidant activity --- biodegradable films --- essential oils --- polycarbonate --- thermal decomposition kinetics --- TG/FTIR --- Py-GC/MS --- wheat gluten --- potato protein --- chemical pre-treatment --- structural profile --- tensile properties --- biocomposites --- natural fibers --- poly(3-hydroxybutyrate-3-hydroxyvalerate) --- biodegradation --- impact properties --- chitin nanofibrils --- poly(lactic acid) --- nanocomposites --- bio-based polymers --- natural fibers --- biomass --- biocomposites --- fiber/matrix adhesion --- bio-composites --- mechanical properties --- poly(lactic acid) --- cellulose fibers --- n/a

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2020 (12)

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