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Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

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ISBN: 9783038974161 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Abstract

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Responsive Architecture

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ISBN: 9783039216987 9783039216994 Year: Pages: 204 DOI: 10.3390/books978-3-03921-699-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Arts in general --- Architecture
Added to DOAB on : 2019-12-09 11:49:16
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This book is a collection of articles that have been published in the Special Issue “Responsive Architecture” of the MDPI journal Buildings. The eleven articles within cover various areas of sensitive architecture, including the design of packaging structures reacting to supporting components; structural efficiency of bent columns in indigenous houses; roof forms responsive to buildings depending on their resiliently transformed steel shell parts; creative design of building free shapes covered with transformed shells; artistic structural concepts of the architect and civil engineer; digitally designed airport terminal using wind analysis; rationalized shaping of sensitive curvilinear steel construction; interactive stories of responsive architecture; transformed shell roof constructions as the main determinant in the creative shaping of buildings without shapes that are sensitive to man-made and natural environments; thermally sensitive performances of a special shielding envelope on balconies; quantification of generality and adaptability of building layout using the SAGA method; and influence of initial conditions on the simulation of the transient temperature field inside a wall.

Keywords

bent piles --- structural systems --- vernacular houses --- Ammatoan houses --- building structure --- effectivity --- strength --- corrugated shell roof --- free-form building --- architectural form --- folded sheet --- thin-walled profile --- shape transformation --- steel construction --- building free-form structure --- corrugated shell roof --- architectural form --- thin-walled open profile --- shape transformation --- folded sheet --- steel construction --- performance-oriented design --- parametric architecture --- form-finding --- CFD --- wind analysis --- digital tools --- steel bar structures --- structural analysis --- parametric design --- algorithmic-aided shaping --- responsive architecture --- shadows --- Grasshopper --- Karamba 3D --- interactive architecture --- interaction narrative --- user experience --- situatedness --- agent-based theory --- building free form structure --- corrugated shell roof --- integrated architectural form --- thin-walled open profile --- shape transformation --- folded sheet --- adaptive envelope --- thermal performances --- spanish balcony --- simulation and computational design studies --- responsive architecture --- kinetic envelope --- adaptive design --- interactive architecture --- moveable facade components --- carrier component structures --- sensor interaction --- digital fabrication --- adaptability --- generality --- flexibility --- evaluation tool --- network analysis --- Space Syntax --- justified plan graphs --- spatial analysis --- architectural morphology --- space plan --- boundary conditions for simulation --- initial conditions --- thermal conditions --- heat flow --- numerical analysis --- experimental measurement --- outdoor test cells

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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english (2)


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2019 (2)