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Structure-Based Drug Design for Diagnosis and Treatment of Neurological Diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451234 Year: Pages: 204 DOI: 10.3389/978-2-88945-123-4 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Abstract

European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

Heat and Mass Transfer in Energy Systems

Authors: ---
ISBN: 9783039219827 9783039219834 Year: Pages: 234 DOI: 10.3390/books978-3-03921-983-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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In recent years, the interest of the scientific community towards efficient energy systems has significantly increased. One of the reasons is certainly related to the change in the temperature of the planet, which has increased by 0.76 °C with respect to preindustrial levels, according to the Intergovernmental Panel on Climate Change (IPCC), and is still increasing. The European Union considers it vital to prevent global warming from exceeding 2 °C with respect to pre-industrial levels, as it has been proven that this will result in irreversible and potentially catastrophic changes. These changes in climate are mainly caused by greenhouse gas emissions related to human activities, and can be drastically reduced by employing energy systems for the heating and cooling of buildings, as well as for power production, characterized by high efficiency levels and/or based on renewable energy sources. This Special Issue, published in the Energies journal, includes 13 contributions from across the world, including a wide range of applications such as hybrid residential renewable energy systems, desiccant-based air handling units, heat exchanges for engine WHR, solar chimney systems, and other interesting topics.

Keywords

bubble absorber --- absorption cooling --- ammonia-lithium nitrate --- plate heat exchanger --- bentonite buffer material --- Ca-type bentonite --- thermal conductivity --- predictive models --- thermosyphon --- two-phase flow --- startup --- phase change --- operating state --- visualization --- fast thermal simulation --- crude oil pipeline --- batch transportation --- body-fitted coordinate-based proper orthogonal decomposition reduced-order model (BFC-POD-ROM) --- transport scheme determination --- waste heat recovery --- exhaust steam --- heat exchanger --- protracted fin --- turbo-electric generator --- exhaust emissions --- R744 --- two-phase ejector --- refrigeration --- dynamic simulation --- low-order model --- object-oriented modelling --- desiccant wheel --- solar heating and cooling --- hygroscopic materials --- dynamic simulations --- energy and environmental analysis --- solar chimney --- air flow --- analytical and experimental solutions --- method of calculation --- steelmaking --- electric arc furnace --- consumption --- electric energy --- melting --- refining --- tapping --- modeling --- linear regression --- genetic programming --- renewables --- ancillary services --- hybrid systems --- thermal storage --- energy storage --- microgrids --- heat pump --- model predictive control --- optimization --- Biot number --- genetic algorithms --- drying --- air-cooled steam turbine generator --- single-channel ventilation --- backflow --- radial ventilation duct --- fluid field --- ground source heat pump --- numerical and experimental studies --- ground-air heat exchanger --- geothermal energy --- computational fluid dynamics --- spirally corrugated pipe

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