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Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

doxorubicin --- MG63 --- Vitamin D --- DOX-Vit D --- hypoxia-induced chemoresistance --- cisplatin --- polymeric micelle --- EGFR-targeted therapy --- STAT3 --- HIF-1 --- GE11 peptide --- pharmacological Inhibitors of HIF-1 and STAT3 --- combination therapy --- pharmacokinetics --- antibodies --- radiolabeling --- biodistribution --- mouse models --- oral formulation --- amphotericin B --- fungal infections --- parasitic infections --- developing world --- drug delivery --- liposomes --- drug delivery systems --- innovation --- lipid nanoparticles --- Metaplex --- triggered drug release --- liposomes --- ultrasound --- magnetic fields --- radiation --- oral delivery --- biological barriers --- co-delivery --- throughput --- sustained delivery --- phospholipid complex --- rosmarinic acid --- bioaccessibility --- dissolution --- TNO gastrointestinal model --- gastrointestinal simulator --- phytosterols --- tocopherols --- liposomes --- canola oil deodorizer distillate --- model orange juice --- virus --- plant --- bacteriophage --- phage display --- drug discovery --- encapsulation --- drug delivery --- blood-brain barrier --- intra-arterial chemotherapy --- malignant gliomas --- primary central nervous system lymphomas --- transdermal drug delivery --- Canada --- skin --- permeation enhancers --- oral, head and neck squamous cell carcinoma --- targeted therapies --- drug delivery systems --- nanoparticles --- controlled drug delivery --- circadian clock --- chronotherapy --- precision medicine --- cationic gemini surfactant --- melphalan --- inclusion complex --- ROESY NMR spectroscopy --- 3D spheroid --- drug-resistant melanoma --- liposome --- water miscible solvents --- remote loading --- staurosporine --- cancer --- gambogic acid --- loading gradients --- mefloquine --- child friendly formulation --- blood-brain barrier (BBB) --- drug delivery --- transient modulation --- HAV6 cadherin peptide --- adenanthin --- magnetic resonance imaging (MRI) --- medulloblastoma --- drug delivery --- pharmaceutics --- drug development --- formulation and dosage form development --- translational research --- biologicals --- small molecules --- clinical trials --- pharmacokinetics --- medical devices --- route of administration --- nifedipine --- emulsion --- flavonoids --- topical formulation --- quercetin --- photostabilizers

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Nanomedicine represents one of the most investigated areas in the last two decades in the field of pharmaceutics. Several nanovectors have been developed and a growing number of products have been approved. It is well known that many biomaterials are able to self-organize under controlled conditions giving rise nanostructures. Polymers, lipids, inorganic materials, peptides and proteins, and surfactants are examples of such biomaterials and the self-assembling property can be exploited to design nanovectors that are useful for drug delivery. The self-organization of nanostructures is an attractive approach to preparing nanovectors, avoiding complex and high-energy-consuming preparation methods, and, in some cases, facilitating drug loading procedures. Moreover, preparations based on these biocompatible and pharmaceutical grade biomaterials allow an easy transfer from the lab to the industrial scale. This book reports ten different works, and a review, aiming to cover multiple strategies and pharmaceutical applications in the field of self-organizing nanovectors for drug delivery.

chitosan --- polyelectrolyte complexes --- doxorubicin --- zoledronic acid --- multidrug resistance --- polypeptides --- amphiphilic random copolymers --- nanoparticles --- C-peptide --- encapsulation --- diabetes --- in situ gelling systems --- photo-thermal therapy --- gold reduction --- localized heating effect --- irradiation cycles --- syringeable implant --- mixed polymeric micelles --- pH/redox-responsive --- drug delivery --- controlled release --- anticancer --- vapor nanobubbles --- laser treatment --- triggered release --- liposomes --- gold nanoparticles --- graphene quantum dots --- biofilms --- diffusion barrier --- Oral antimicrobials --- caries prevention --- natural extracts --- nanovesicles --- eukaryotic vaults --- nanoparticle --- drug delivery systems --- nanocage --- protein self-assembly --- hydrogel --- drug delivery system --- self-assembly --- bolaform amphiphilic lipids --- bolalipids --- aerogel --- chorioallantoic membrane model --- antimicrobial photodynamic therapy --- nano-assemblies --- trehalose --- squalene --- betulinic acid --- autophagy induction --- siRNA delivery --- nanoparticles --- pulmonary surfactant --- drug delivery --- astaxanthin --- resveratrol --- curcumin --- hyaluronan --- nanohydrogels --- oxidative stress --- intracellular therapy

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The rapid increase in the emergence of antibiotic-resistant bacterial strains, combined with a dwindling rate of discovery of novel antibiotic molecules, has created an alarming issue worldwide. Although the occurrence of resistance in microbes is a natural process, the overuse of antibiotics is known to increase the rate of resistance evolution. Under antibiotic treatment, susceptible bacteria inevitably die, while resistant microorganisms proliferate under reduced competition. Therefore, the out-of-control use of antibiotics eliminates drug-susceptible species that would naturally limit the expansion of resistant species. In addition, the ability of many microbial species to grow as a biofilm has further complicated the treatment of infections with conventional antibiotics. A number of corrective measures are currently being explored to reverse or slow antibiotic resistance evolution, Among which one of the most promising solutions is the development of polymer-based antimicrobial compounds. In this Special Issue, different polymer systems able to prevent or treat biofilm formation, including cationic polymers, antibacterial peptide-mimetic polymers, polymers or composites able to load and release bioactive molecules, and antifouling polymers able to repel microbes by physical or chemical mechanisms are reported. Their applications in the design and fabrication of medical devices, in food packaging, and as drug carriers is investigated.

cationic polymers --- imidization --- quaternization --- antimicrobial properties --- hemolytic activity --- coatings from nanoparticles --- biocompatible polymer --- antimicrobial polymer --- dynamic light scattering --- coatings wettability --- microbicidal coatings --- bacteria viability --- bactericidal coatings --- Escherichia coli --- Staphylococcus aureus --- Acinetobacter baumannii --- multidrug-resistant --- antimicrobial peptide --- antibiofilm activity --- physiological salt --- biofilm --- anti-biofilm surface --- surface functionalization --- ?-chymotrypsin --- proteinase --- antimicrobial polymers --- quaternary ammonium --- 2-hydroxyethyl methacrylate --- thermal stability --- polymers --- antibacterial --- drug delivery --- periodontitis --- periodontal biofilms --- polyamide 11 --- antibacterial --- polymeric biocide --- thermal stability --- biofilm --- antifouling --- copper paint --- additives --- biofilm --- lipopeptides --- biofilm --- persister cells --- ocular infections --- biofilm on contact lenses --- cuprous oxide nanoparticles --- linear low-density polyethylene --- composites --- adhesives --- antibacterial activity --- water disinfection --- active packaging --- antimicrobial peptides --- food shelf-life --- foodborne pathogens --- plastic materials --- antibacterial peptides --- halictine --- circular dichroism --- fluorescence --- infrared spectroscopy --- segmented polyurethanes --- polyethylene glycol --- microbial biofilm --- antifouling materials --- medical device-related infections --- wound dressings --- additive manufacturing --- antibacterial polymers --- biocompatible systems --- drug delivery systems --- 3D printing --- amorphous materials --- ordered mesoporous silica --- sol-gel preparation --- drug carrier --- multifunctional hybrid systems --- olive mill wastewater --- antibacterial properties --- layered double hydroxides --- bionanocomposites --- acrylates --- antibacterial activity --- copolymerization --- polymeric films --- polymerizable quaternary ammonium salts --- quaternary ammonium salts --- UV-induced polymerization --- antimicrobial resistance --- antimicrobial polymers --- ESKAPE pathogens --- anti-biofilm surfaces --- polymeric surfaces --- biofilm methods --- biofilm analysis --- biofilm devices --- n/a