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Rabies is an ancient zoonotic viral disease that still exerts a high impact on human and animal health. The disease is almost 100% fatal after clinical signs appear, and it kills tens of thousands of people per year worldwide, particularly in Africa and many parts of Asia. Although the disease in humans can be prevented by timely post-exposure prophylaxis, its access and affordability is limited in rabies endemic countries. With 99% of infections in humans caused by rabid domestic dog bites, controlling the infection in this reservoir population has been proven to be most effective to reduce and eliminate human rabies cases. In this context, this Research Topic invited contributions on the control and elimination of dog mediated human rabies. Publications on epidemiological, educational, policy-related and economic aspects of dog and human rabies surveillance, implementation of control in dogs and humans and scientific documentation of success stories were consolidated. We hope that these articles contribute to reaching the ambitious goal, set by key players in global health, of the elimination of dog mediated human rabies by 2030.

canine --- cost-effectiveness --- dog --- elimination --- global health --- neglected tropical disease --- one health --- rabies --- vaccination --- zoonosis

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Friendships between humans and non-human animals were once dismissed as sentimental anthropomorphism. After decades of research on the emotional and cognitive capacities of animals, we now recognize human–animal friendships as true reciprocal relationships. Friendships with animals have many of the same characteristics as friendships between humans. Both parties enjoy the shared presence that friendship entails along with the pleasures that come with knowing another being. Both friends develop ways of communicating apart from, or in addition to, spoken language. Having an animal as a best friend can take the form of relationship known as the “pet”, but it can also take other forms. People who work with animals often characterize their non-human partners as friends. People who work with search-and-rescue dogs, herding dogs, or police dogs develop and depend on the closeness of friendship. The same holds for equestrians, as horses and riders must understand each other’s bodies and movements intimately. In some situations, animals provide the sole source of affection and interaction in people’s lives. Homeless people who live on the streets with animal companions experience togetherness 24/7. This book explores the various forms these friendships take. It sheds light on what these friendships mean and how they expand the interdisciplinary knowledge of the roles of animals in society.

human-animal interaction --- dog --- sleep --- chronic pain --- content analysis --- hydraulic fracturing --- animal studies --- environmental sociology --- environmental justice --- companion animals --- energy development --- biocentrism --- biophilia --- conservation ethics --- friendship --- human–animal relationships --- narrative ethics --- pig --- relational ethics --- young adult literature --- dog–human friendship --- companion animals --- interspecies hierarchy --- media and crime --- voluntary childlessness --- women --- pets --- “peternal” --- animal law --- human-animal bond --- legal status of companion animals --- animal protection --- family --- CBT --- autoethnography --- pets --- homophobia --- LGBT

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This special issue entitled “Soft and hard tissue regeneration” will cover both periodontal and implant therapies. Regenerative periodontal treatment goal is to restore functional periodontal support offering a valuable treatment alternative even for teeth with large periodontal destruction, which may be successfully treated and maintained in health for long periods. In most cases where teeth are extracted for periodontal reasons, implant therapy will demand large bone augmentation procedures. Lack of sufficient bone volume may prevent placement of dental implants. In extreme cases, large bone reconstruction is indispensable before implant placement can be performed. Although, most bone grafts are only able to fill and maintain a space, where bone regeneration can occur (“osseoconductive”), the ideal bone graft will also promote osseous regeneration (“osseoinductive”). Several bone augmentation procedures have been described, each, presenting advantages and shortcomings. Success of bone augmentation procedures depends on the presence of bone forming cells, primary wound closure over the augmented area, space creation and maintenance where bone can grow and proper angiogenesis of the grafted area. Factors that influence the choice of the surgical technique are the estimated duration of surgical procedure, its complexity, cost, total estimated length of procedure until the final rehabilitations may be installed and the surgeons’ experience. This special issue will have a definite clinical orientation, and be entirely dedicated to soft and hard tissue regenerative treatment alternatives, both in periodontal and implant therapy, discussing their rationale, indications and clinical procedures. Internationally renowned leading researchers and clinicians will contribute with articles in their field of expertize.

n/a --- Smart Dentin Grinder --- tooth particles --- autogenous particulate tooth graft --- socket preservation --- dog study --- Alveolar ridge preservation --- ?-tricalcium phosphate --- bone regeneration --- bone substitutes --- animal study --- minimally invasive --- videoscope --- periodontal surgery --- bone regeneration --- bone grafts --- biologics --- periodontal regeneration --- connective tissue graft --- enamel matrix proteins derivative --- root coverage --- combination therapy --- soft tissue management --- periodontal surgery --- periodontal regeneration --- aggressive periodontitis --- deproteinized bovine bone --- enamel matrix derivatives (Emdogain®) --- guided tissue regeneration (GTR) --- platelet-rich plasma --- platelets --- aggregation --- spectrophotometer --- quality assurance

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This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.

pheochromocytoma --- paraganglioma --- adrenocortical carcinoma --- adrenal tumor --- pan-cancer analysis --- neural crest --- neuroendocrine --- paraganglioma --- head and neck --- radiotherapy --- 18F-FDOPA --- PET --- GTV --- SDHB --- SDHD --- mortality --- paraganglioma --- pheochromocytoma --- radiofrequency ablation --- cryoablation --- percutaneous ethanol injection --- neuroendocrine tumor --- minimally invasive procedure --- percutaneous ablation --- PASS --- GAPP --- histology --- meta-analysis --- paraganglioma --- pheochromocytoma --- carotid body --- angiogenesis --- mitochondria --- neural crest --- neurogenesis --- paraganglioma --- stem-like tumor cells --- vasculogenesis --- xenograft --- pheochromocytoma --- catecholamine --- global longitudinal strain --- speckle-tracking echocardiography --- subclinical systolic dysfunction --- pheochromocytoma --- paraganglioma --- neuroendocrine tumor --- targeted therapy --- therapy resistance --- FGF21 --- pheochromocytoma --- paraganglioma --- diabetes mellitus --- obesity --- energy metabolism --- calorimetry --- chromogranin A --- metanephrines --- pheochromocytoma --- paraganglioma --- hypoxia --- pseudohypoxia --- spheroids --- HIF --- EPAS1 --- catecholamine --- pheochromocytoma and paraganglioma --- phosphorylation tyrosine hydroxylase --- dog --- pheochromocytoma --- paraganglioma --- SDHB --- SDHD --- mutation --- chromosomal alteration --- comparative genomics --- pheochromocytoma --- paraganglioma --- metastatic --- immunotherapy --- innate immunity --- adaptive immunity --- toll-like receptor --- pathogen-associated molecular patterns --- neutrophil --- T cell --- pheochromocytoma --- paraganglioma --- hypertension --- blood pressure variability --- average real variability --- weighted standard deviation --- paraganglioma --- somatostatinoma --- polycythemia --- EPAS1 --- transgenic mice --- erythropoietin --- pheochromocytoma --- paraganglioma --- TCA cycle --- germline mutation --- metastatic OR malignant pheochromocytoma --- paraganglioma --- ectopic secretion --- lL-6 --- normetanephrines --- VHL --- NF1 --- EPAS1 --- hypoxia-inducible factor --- inflammation --- radiosensitization --- succinate dehydrogenase --- mouse pheochromocytoma cells --- immunohistochemistry --- fluorescence imaging --- pheochromocytoma --- paraganglioma --- next-generation sequencing --- sporadic --- hereditary --- CNV detection --- pheochromocytoma --- paraganglioma --- PET-CT --- 11C-hydroxy-ephedrine --- adrenal incidentaloma --- pheochromocytoma --- paraganglioma --- 177Lu-DOTATATE --- peptide receptor radiotherapy --- PRRT --- neuroendocrine tumor --- NET --- PCC --- PGL --- postoperative --- pheochromocytoma --- hypertension --- hypotension --- arrhythmia --- PPGL --- catecholamines --- adrenomedullary function --- n/a

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The scientific advances in life sciences and engineering are constantly challenging, expanding, and redefining concepts related to the biocompatibility and safety of medical devices. New biomaterials, new products, and new testing regimes are being introduced to

carbonate apatite --- hydroxyapatite --- ?-tricalcium phosphate --- artificial bone substitute --- crystallite size --- dissolution rate --- hybrid dog --- bone levels --- dental implants --- neck design --- soft tissue dimensions --- peri-implantitis --- biofilm --- dental implants --- in vitro model --- MSN --- biopolymer --- drug delivery system --- in vitro kinetic studies --- articular cartilage defect --- bioplolymers --- C-reactive protein --- haptoglobin --- in vivo testing --- serum amyloid A --- serum protein fractions --- sheep --- contact lens --- materials --- biomedical implant --- smart dentin grinder --- autogenous particulate dentin graft --- tooth graft --- ground teeth --- human teeth --- bone grafts --- autologous graft --- dolomitic marble --- seashell --- CaCO3 derived-calcium phosphates --- modulated synthesis set-up --- SEM --- image analysis --- pre-osteoblasts --- titanium implants --- dental implants --- antibacterial coating --- gentamicin --- silver --- zinc --- cytotoxicity --- MC3T3-E1 --- Staphylococcus aureus --- plasma chemical oxidation --- bone infection --- local drug delivery --- bone graft --- demineralized bone matrix --- gentamicin --- regeneration --- colon cancer cells --- copper ions --- hydrogel sphere --- sodium alginate --- polyethyleneimine --- surface modification --- biocompatible metals --- coating techniques --- hydroxyapatite --- real-time live-cell imaging technology --- in vitro study --- biocompatibility --- 3D printing --- flow cytometry --- adipogenic mesenchymal stem cells --- porous SHS TiNi --- biocompatibility --- rheological similarity --- corrosion resistance --- bone substitution --- superparamagnetic scaffold --- composite --- laser direct writing --- static magnetic field --- extracellular matrix mineralization --- bone tissue engineering --- three-dimensional co-culture --- osteoblast --- endothelial cell --- microfiber scaffold --- osteogenesis --- angiogenesis --- tissue engineering --- diamond nanoparticles --- fish gelatin --- adipose-derived stem cells --- biocompatibility --- spaced TiO2 nanotubes --- osteoblast --- cell adhesion and morphology --- cell proliferation --- osteogenic differentiation --- protein–polymer matrices --- nanowelding --- single-walled carbon nanotubes --- point defects --- absorption --- laser radiation --- cell membrane --- mesenchymal stem cells --- osteogenic differentiation --- lactoferrin --- polymer composite --- bioceramics --- in vitro testing --- hydroxyapatite --- angiogenesis --- osteogenesis --- signaling pathways --- microRNA --- bioceramics --- bioactive glass --- hydroxyapatite --- root canal sealer --- bioactive glass --- mechanism --- caries --- review