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Recent Advances and Perspectives in Deoxynivalenol Research

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ISBN: 9783038424703 9783038424710 Year: Pages: X, 290 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-08-23 08:50:49
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Mycotoxins are secondary metabolites produced by molds. Although the primary role of these toxins is thought to be related to the colonisation of the environment by the fungi—mycotoxins are able to kill other micro-organisms (antimicrobial effect) and/or plant cells (mycotoxin-producing fungi being necrophagic)—the exposure of animals and humans to mycotoxins through the consumption of mycotoxin-contaminated food and feeds leads to diseases and death. Among the different mycotoxins described (more than 350 mycotoxins have been identified), deoxynivalenol (DON or vomitoxin) produced by Fusarium species has attracted the most attention due to its prevalence and toxicity. DON is part of a family of mycotoxins called trichothecenes that are small sesquiterpenoids with an epoxide group at positions 12–13 allowing their binding to ribosomes causing the so-called ribosome stress response, characterized by the activation of various protein kinases that lead to alterations in gene expression and cellular toxicity in animals, humans and plants. Here, we compiled very recent findings regarding DON and its derivatives: i) their prevalence in human food; ii) the estimation of the exposure of humans to them using biological markers; iii) their roles during plant–fungi interaction; iv) the alteration caused by them in animals and humans, particularly at low doses that are close to those observed in farm animals and human consumers; v) possible strategies to decrease their presence in food and feeds. Overall, this book will give the reader a clear and global view on this important mycotoxin produced by Fusarium species which is responsible for huge economic loss and health issues.

Effects of Mycotoxins on the Intestine

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ISBN: 9783038977827 9783038977834 Year: Pages: 262 DOI: 10.3390/books978-3-03897-783-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-05-09 17:16:14
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Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.

Keywords

mice --- aflatoxin B1 --- intestinal bacterial flora --- response --- Clostridium sp. WJ06 --- deoxynivalenol --- pig --- intestinal morphology --- microbial diversity --- aflatoxin M1 --- ochratoxin A --- intestinal epithelial cells --- tight junction --- permeability --- ileum --- jejunum --- deoxynivalenol --- piglet --- contaminated feed --- tight junction --- aflatoxin B1 --- small intestine --- histopathological lesions --- ultrastructural changes --- toll-like receptors --- T-2 toxin --- enteric nervous system --- pig --- vasoactive intestinal polypeptide --- mycotoxins --- zearalenone --- deoxynivalenol --- histology --- ultrastructure --- large intestine --- pig --- Claviceps --- liver --- digestive tract --- mycotoxin --- sclerotia --- ergot alkaloids --- toxicity --- deoxynivalenol --- Saccharomyces cerevisiae boulardii CNCM I-1079 --- intestine --- transcriptome --- inflammation --- oxidative stress --- lipid metabolism --- fumonisin --- microbiota --- pigs --- MiSeq 16S rDNA sequencing --- intestinal microbiota --- hydrogen-rich water --- lactulose --- Fusarium mycotoxins --- piglets --- functional oligosaccharides --- mycotoxins --- swine --- explant technique --- intestinal morphology --- goblet cells --- deoxynivalenol --- zearalenone --- pig --- colon microbiota --- Lactobacillus --- detoxification --- zearalenone --- doses --- caecal water --- genotoxicity --- pre-pubertal gilts --- atlantic salmon --- deoxynivalenol --- feed --- intestine --- PCR --- proliferating cell nuclear antigen --- suppressor of cytokine signaling --- tight junctions --- Zearalenone --- N-acetylcysteine --- SIEC02 cells --- Mitochondrial apoptosis --- n/a

Novel Approaches to Minimising Mycotoxin Contamination

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ISBN: 9783039289370 / 9783039289387 Year: Pages: 244 DOI: 10.3390/books978-3-03928-938-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2020-06-09 16:38:57
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Contamination of foods and agricultural commodities by various types of toxigenic fungi is a concerning issue for human and animal health. Moulds naturally present in foods can produce mycotoxins and contaminate foodstuffs under favourable conditions of temperature, relative humidity, pH, and nutrient availability. Mycotoxins are, in general, stable molecules that are difficult to remove from foods once they have been produced. Therefore, the prevention of mycotoxin contamination is one of the main goals of the agriculture and food industries. Chemical control or decontamination techniques may be quite efficient; however, the more sustainable and restricted use of fungicides, the lack of efficiency in some foods, and the consumer demand for chemical-residue-free foods require new approaches to control this hazard. Therefore, food safety demands continued research efforts for exploring new strategies to reduce mycotoxin contamination. This Special Issue contains original contributions and reviews that advance the knowledge about the most current promising approaches to minimize mycotoxin contamination, including biological control agents, phytochemical antifungal compounds, enzyme detoxification, and the use of novel technologies.

Keywords

deoxynivalenol --- degradation --- photocatalysis --- ?-Fe2O3 --- degradation products --- Aspergillus flavus --- Penicillium verrucosum --- AITC --- fungal growth reduction --- mycotoxin reduction --- decontamination --- mycotoxins --- Aflatoxin M1 --- milk --- binding --- stability --- zearalenone --- biological detoxification --- Bacillus --- fermentation --- roasted coffee --- mycotoxigenic fungi --- ochratoxin A --- cold plasma --- detoxification --- brine shrimp bioassay --- mycotoxins --- Fusarium sp., Botrytis sp., apple pomace --- phloridzin --- quercetin glycosides --- pinnatifidanoside D --- deoxynivalenol --- wheat --- superheated steam --- wheat quality --- crisp biscuit --- biological control --- post-harvest phytopathogen --- Penicillium digitatum --- Penicillium italicum --- Geothrichum citri-aurantii --- zearalenone --- estrogen response element --- gene expression --- cell proliferation --- estrogen receptor --- biotransformation --- Fusarium --- mycotoxins --- garlic-derived extracts --- green chemistry --- fungi --- EU limits --- abiotic factors --- storage --- wheat --- maize --- oats --- fumonisin --- enzymatic detoxification --- fumonisin esterase FumD --- enzyme kinetics --- maize --- Zearalenone --- biodegradation --- probiotics --- cell-free extracts of Aspergillus oryzae --- pig production performance --- Bacillus --- Fusarium graminearum --- antagonism --- mode of action --- essential oils --- Satureja montana --- Origanum virens --- Aspergillus flavus --- aflatoxin --- corn --- nanoparticles --- Penicillium nordicum --- biocontrol agents --- dry-cured ham --- ochratoxin A (OTA) --- n/a

Quality and Production of Forage

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ISBN: 9783039216741 9783039216758 Year: Pages: 148 DOI: 10.3390/books978-3-03921-675-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Agriculture (General)
Added to DOAB on : 2019-12-09 11:49:16
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The book ""Quality and Production of Forage"" is intended to keep readers updatedon the developments occurring in this field. As it is apparent that livestockanimals are important throughout the world because of the meat, milk and eggthey produce, knowledge about the forages available to animals must also beconsidered for increased production, quality and efficiency. This book providesinformation that readers will find considerably invaluable about forage feeds, suchas grass, legumes, and straw. The book is composed of ten papers, focusing on awide range of research activities and topics that feature the following concepts offorage: the effect of conservation method on forage protein value; Microbial thecomposition and mycotoxin content in forage; genetic diversity of forages; timelysowing to maximize yield for both grain and biomass; ensiling treatments onforage quality; the qualitative characteristics of different accessions of new foragespecies; forage policy influencing feed costs; feeding forage on animal health;high-protein tropical forages as alternative sources for poultry; impact of foragesin poultry diet and significance of forages in sustainable poultry productionsystems. This book will be an invaluable reference for students and professionalsin agricultural science and grassland and animal husbandry researches.

Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed

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ISBN: 9783038970286 9783038970279 Year: Pages: 306 DOI: 10.3390/books978-3-03897-027-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-08-28 11:21:28
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This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins

Keywords

deoxynivalenol --- epimer --- polarity --- Tri101 --- molecular --- interactions --- spores of Ganoderma lucidum --- oxidative stress --- aflatoxins --- antioxidant capability --- mycotoxin --- patulin --- biodegradation --- Pichia caribbica --- proteomics --- intracellular and extracellular enzymes --- Bacillus licheniformis CK1 --- zearalenone (ZEA) --- serum hormones --- estrogen receptor (ER) --- post-weaning female piglets --- curcumin --- aflatoxin B1 --- CYP450 --- AFBO–DNA --- chicks --- aflatoxin B1 --- photodegradation product --- TQEF-MS/MS --- cell viability --- furan rings --- mycotoxin --- toxigenic Fusarium --- biological control --- Trichoderma --- modified mycotoxin --- aflatoxin B1 --- aflatoxin biodegradation preparation --- Bacillus subtilis ANSB060 --- ameliorating effects --- growth performance --- antioxidant function --- residue --- aflatoxins --- biotransformation --- enzymatic detoxification --- laccase --- mild technologies --- food safety --- mycotoxins mitigation --- aflatoxin B1 --- aflatoxin-degrading enzyme --- biodegradation --- Bacillus shackletonii --- purification --- Sporobolomyces sp. IAM 13481 --- microbial patulin degradation --- desoxypatulinic acid --- ascladiol --- aflatoxins --- Aspergillus flavus --- Corylus avellana --- fatty acids --- thermal treatment --- Aflatoxin B1 --- Aspergillus flavus --- hyssop --- inhibition --- oxidative stress --- DBD --- atmospheric pressure --- low temperature plasma --- mycotoxins --- degradation --- maize --- aflatoxins --- neutral electrolyzed water --- detoxification --- turkey --- mycotoxins --- biotransformation --- degradation --- enzymes --- application --- mycotoxin --- detoxification --- biodegradation --- biotransformation --- enzyme --- microorganism identification --- mycotoxin --- trichothecene --- deoxynivalenol --- bioprospecting --- detoxification --- Fusarium --- cold atmospheric pressure plasma technology --- mycotoxins --- physical decontamination --- chemical decontamination --- biological decontamination --- patulin --- mycotoxin --- mitigation --- decontamination --- food and beverage --- processing --- n/a

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