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Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199846 Year: Pages: 246 DOI: 10.3389/978-2-88919-984-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters:1. General principles on the use of stem cells for regenerating craniofacial and dental tissues2. The roles of nerves, vessels and stem cell niches in tissue regeneration3. Dental pulp regeneration and mechanisms of various odontoblast functions4. Dental root and periodontal physiology, pathology and regeneration5. Physiology and regeneration of the bone using various scaffolds and stem cell populations6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells

Bioactive and Therapeutic Dental Materials

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ISBN: 9783039214198 / 9783039214204 Year: Pages: 216 DOI: 10.3390/books978-3-03921-420-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

This book focus principally on ions-releasing and other smart dental materials for application in preventive and restorative dentistry, as well as in endodontics in the form of adhesives, resin-based composites, pastes, varnishes, liners and dental cements. Special attention has been given to bioactive materials developed to induce cells differentiation/stimulation, hard tissue formation and exert antimicrobial actions. New innovations are necessary to continue to help reinforcing existing technologies and to introduce new paradigms for treating dental disease and restoring teeth seriously compromised by caries lesions via biomimetic and more biological operative approaches. Dental bioactive materials is arguably the latest research area in dentistry and thus the amount of new research is overwhelming. However, in this day and age of evidence based practice it important for this new information to be distilled into a practical and understandable format.

Keywords

orthodontic resin --- photocatalyst TiO2 --- antibacterial --- cariogenic --- early colonizer --- hydrophilic properties --- irradiation --- calcium silicate cements --- pulpal response --- mineralization --- calcific barrier --- inflammation --- odontoblastic layer --- resin cements --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- antibacterial --- calcium --- doxycycline --- nanoparticles --- zinc --- dental composites --- antibacterial properties --- silver --- mechanical properties --- degree of conversion --- sorption --- solubility --- color stability --- mechanical properties --- nanotubes --- resin composite --- Streptococcus mutans --- triclosan --- bleaching products --- diffusion --- cytotoxicity --- dental pulp --- stem cells --- nanoporous silica --- glass-ionomer cement --- calcium --- preclinical biosafety --- bone substitute --- mesenchymal stem cells --- ?-tricalcium phosphate --- tissue engineering --- dental sealant --- resin sealant --- calcium phosphate nanoparticles --- long-term ion release --- remineralization --- ion recharge --- dentin --- desmineralization --- microtensile bond strength --- adhesion --- bioactive --- cycling mechanical stress --- dentine --- longevity --- resin-modified glass ionomer cements --- polyacrylic acid treatment --- bone regeneration --- ?-tricalcium phosphate --- calcium sulfate --- bone substitutes --- animal study --- n/a --- adhesion --- cycling mechanical stress --- dentine --- longevity --- glass-ionomer cements --- universal adhesives

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