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Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts

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ISBN: 9783039213634 9783039213641 Year: Pages: 376 DOI: 10.3390/books978-3-03921-364-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

Several species of Dinophysis produce one or two groups of lipophilic toxins: okadaic acid (OA) and its derivatives; or the dinophysistoxins (DTXs) (also known as diarrhetic shellfish poisons or DSP toxins) and pectenotoxins (PTXs). DSP toxins are potent inhibitors of protein phosphatases, causing gastrointestinal intoxication in consumers of contaminated seafood. Forty years after the identification of Dinophysis as the causative agent of DSP in Japan, contamination of filter feeding shellfish exposed to Dinophysis blooms is recognized as a problem worldwide. DSP events affect public health and cause considerable losses to the shellfish industry. Costly monitoring programs are implemented in regions with relevant shellfish production to prevent these socioeconomic impacts. Harvest closures are enforced whenever toxin levels exceed regulatory limits (RLs). Dinophysis species are kleptoplastidic dinoflagellates; they feed on ciliates (Mesodinium genus) that have previously acquired plastids from cryptophycean (genera Teleaulax, Plagioselmis, and Geminigera) nanoflagellates. The interactions of Dinophysis with different prey regulate their growth and toxin production. When Dinophysis cells are ingested by shellfish, their toxins are partially biotransformed and bioaccumulated, rendering the shellfish unsuitable for human consumption. DSP toxins may also affect shellfish metabolism. This book covers diverse aspects of the abovementioned topics—from the laboratory culture of Dinophysis and the kinetics of uptake, transformation, and depuration of DSP toxins in shellfish to Dinophysis population dynamics, the monitoring and regulation of DSP toxins, and their impact on the shellfish industry in some of the aquaculture regions that are traditionally most affected, namely, northeastern Japan, western Europe, southern Chile, and New Zealand.

Keywords

harmful algal bloom --- Diarrheic Shellfish Poisoning --- okadaic acid --- toxin accumulation --- toxin vectors --- trophic transfer --- Brazil --- diarrhetic shellfish toxins (DST) --- Mytilus galloprovincialis --- DST accumulation --- DST esterification --- suspended particulate matter (SPM) --- harmful algal blooms --- okadaic acid --- Argopecten irradians --- transcriptomic response --- deep sequencing --- pectenotoxins --- surf clam --- accumulation --- biotransformation --- depuration --- diarrhetic shellfish toxins --- accumulation --- dinophysistoxin --- Japanese scallop --- dinophysis --- LC/MS/MS --- statistical analysis --- Dinophysis --- HAB monitoring --- DSP toxins --- aquaculture --- shellfish toxicity --- human health --- time-series --- seasonality --- Scotland --- DSP toxins --- bivalves --- mussel --- resistance --- RNA-Seq --- qPCR --- metabolism --- defense --- immunity --- DSP toxins --- pectenotoxins --- Dinophysis acuminata --- Mesodinium rubrum --- bacterial community --- high throughput sequencing --- diarrhetic shellfish toxins --- Dinophysis --- wild harvest --- bivalve shellfish --- pipis (Plebidonax deltoides) --- Sydney rock oyster (Saccostrea glomerata) --- okadaic acid --- pectenotoxins --- Dinophysis toxins --- accumulation --- digestion --- biotransformation --- compartmentalization --- depuration --- kinetics --- Dinophysis --- diarrhetic shellfish poisoning --- marine toxins --- pectenotoxin --- okadaic acid --- dinophysistoxin --- okadaic acid --- pectenotoxins --- Dinophysis --- D. acuminata-complex --- D. caudata --- Argopecten purpuratus --- Dinophysis --- Mesodinium --- cryptophytes --- predator-prey preferences --- Diarrhetic Shellfish Toxins (DST) --- pectenotoxins (PTXs) --- mixotrophic cultures --- mass culture conditions --- Dinophysis acuminata --- Protoceratium reticulatum --- Reloncaví Fjord --- OMI analysis --- WitOMI analysis --- Mesodinium cf. rubrum --- El Niño Southern Oscillation --- Southern Annual Mode --- Dinophysis acuta --- Dinophysis acuminata --- DSP --- physical–biological interactions --- niche partitioning --- climatic anomaly --- Dinophysis acuminata --- Mesodinium rubrum --- lysate --- organic matter --- diarrhetic shellfish poisoning --- okadaic acid --- dinophysistoxin --- pectenotoxins --- dinophysis --- DSP --- toxins --- OA --- DTX-2 --- PTXs --- Dinophysis acuminata --- dinophysistoxins --- pectenotoxins --- Port Underwood --- New Zealand --- Dinophysis --- Diarrhetic shellfish toxins --- marine biotoxins --- blooms --- n/a

Virus Bioinformatics

Authors: --- --- ---
ISBN: 9783039218820 9783039218837 Year: Pages: 330 DOI: 10.3390/books978-3-03921-883-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-04-07 23:07:08
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Abstract

Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.

Keywords

bioinformatics --- virus --- comparative genomics --- software --- Base-By-Base --- BBB --- poxvirus --- ASFV --- MSA --- foot-and-mouth disease virus (FMDV) --- bovine soft palate --- nasopharynx --- transcriptomics --- proteomics --- bioinformatics --- virus-host interaction --- innate immune system --- interferon-stimulated genes (ISG) --- cellular immunity --- codon frequency distribution --- HPV58 --- minor capsid protein --- TLR agonist --- prophylaxis --- virus --- infection --- fluorescent reporter protein --- image quantification --- Hepatitis C virus --- Yellow Fever Virus --- polyomavirus --- Coxsackievirus B4 --- bivalve --- virome --- RNA-seq --- RNA viruses --- sncRNA --- ADAR --- RNAi --- Marek’s disease virus (MDV) --- RNA-seq --- transcriptome --- splicing --- polycistronic viral transcripts --- primary B cells --- RB1B --- CVI988/Rispens --- ICP0 --- DNA replication --- ori --- mitochondria --- Rickettsia --- gram-positive bacteria --- APMV --- Mimivirus --- giant virus --- eukaryogenesis --- flavivirus --- non-coding RNA --- secondary structure --- endogenous viral elements --- bioinformatics --- horizontal gene transfer --- virus-to-host gene transfer --- HMM --- tobacco mosaic virus --- Drosophila --- capsid protein --- deep sequencing --- virus genomics --- hepatitis C virus --- variant calling --- sequence interpretation --- drug resistance --- bioinformatics --- alignment --- assembly --- taxonomic classification --- time series --- data transformation --- DWT --- DFT --- PAA --- data compression --- compressive genomics --- RNAseq --- honey bees --- deformed wing virus --- quasispecies --- apiary pests --- recombination --- mRNA structure --- structure database --- secondary structure --- viral mRNA --- subVOG --- structurally related --- RNA structure --- structurally homogenous --- structurally related --- mRNA families --- Amebae viruses --- viral evolution --- protein domains --- mimivirus --- dsdna viruses --- translation machinery --- pandoravirus --- NCLDV --- virology --- virus bioinformatics --- software --- systems virology --- metagenomics --- virome --- viral taxonomy --- virus classification --- genome evolution --- bacteriophage --- virosphere --- chemical organization theory --- influenza A --- virus dynamics modeling --- complex networks analysis --- viral metagenome --- groundwater --- aquifer --- AquaDiva --- sequencing library preparation --- virus proteomics --- mass spectrometry --- virus diagnostics --- data analysis --- targeted proteomics --- peptide selection --- parallel reaction monitoring

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