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If numeric data from the Web are brought together, natural scientists can compare climate measurements with estimations, financial analysts can evaluate companies based on balance sheets and daily stock market values, and citizens can explore the GDP per capita from several data sources. However, heterogeneities and size of data remain a problem. This work presents methods to query a uniform view - the Global Cube - of available datasets from the Web and builds on Linked Data query approaches.

Web, Optimierung analytischer Datenbankabfragen, Datenintegration, Linked Data, Datenwürfel, analytical query optimisation, data integration, Data Cube

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The articles in this Research Topic provide a state-of-the-art overview of the current progress in integrating computational and empirical research on visual object recognition. Developments in this exciting multidisciplinary field have recently gained momentum: High performance computing enabled breakthroughs in computer vision and computational neuroscience. In parallel, innovative machine learning applications have recently become available for datamining the large-scale, high resolution brain data acquired with (ultra-high field) fMRI and dense multi-unit recordings. Finally, new techniques to integrate such rich simulated and empirical datasets for direct model testing could aid the development of a comprehensive brain model. We hope that this Research Topic contributes to these encouraging advances and inspires future research avenues in computational and empirical neuroscience.

object recognition --- computational neuroscience --- Computer Vision --- fMRI --- Neurophysiology --- Feature representation --- ventral visual pathway --- invariance --- neural networks --- multimodal data integration

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A “genotype"" is essentially an organism's full hereditary information which is obtained from its parents. A ""phenotype"" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.

tissue-specific expressed genes --- transcriptome --- tissue classification --- support vector machine --- feature selection --- bioinformatics pipelines --- algorithm development for network integration --- miRNA–gene expression networks --- multiomics integration --- network topology analysis --- candidate genes --- gene–environment interactions --- logic forest --- systemic lupus erythematosus --- Gene Ontology --- KEGG pathways --- enrichment analysis --- proteomic analysis --- plot visualization --- Alzheimer’s disease --- dementia --- cognitive impairment --- neurodegeneration --- Gene Ontology --- annotation --- biocuration --- amyloid-beta --- microtubule-associated protein tau --- artificial intelligence --- genotype --- phenotype --- deep phenotype --- data integration --- genomics --- phenomics --- precision medicine informatics --- epigenetics --- chromatin modification --- sequencing --- regulatory genomics --- disease variants --- machine learning --- multi-omics --- data integration --- curse of dimensionality --- heterogeneous data --- missing data --- class imbalance --- scalability --- genomics --- pharmacogenomics --- cell lines --- database --- drug sensitivity --- data integration --- omics data --- genomics --- RNA expression --- non-omics data --- clinical data --- epidemiological data --- challenges --- integrative analytics --- joint modeling --- multivariate analysis --- multivariate causal mediation --- distance correlation --- direct effect --- indirect effect --- causal inference --- n/a

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Advances in the knowledge of the tangible components (position, size, shape) and intangible components (identity, habits) of an historic building or site involves fundamental and complex tasks in any project related to the conservation of cultural heritage (CH). In recent years, new geotechnologies have proven their usefulness and added value to the field of cultural heritage (CH) in the tasks of recording, modeling, conserving, and visualizing. In addition, current developments in building information modeling (HBIM), allow integration and simulation of different sources of information, generating a digital twin of any complex CH construction. As a result, experts in the area have increased the number of available sensors and methodologies. However, the quick evolution of geospatial technologies makes it necessary to revise their use, integration, and application in CH. This process is difficult to adopt, due to the new options which are opened for the study, analysis, management, and valorization of CH. Therefore, the aim of the present Special Issue is to cover the latest relevant topics, trends, and best practices in geospatial technologies and processing methodologies for CH sites and scenarios as well as to introduce the new tendencies. This book originates from the Special Issue “Data Acquisition and Processing in Cultural Heritage”, focusing primarily on data and sensor integration for CH; documentation/restoration in CH; heritage 3D documentation and modeling of complex CH sites; drone inspections in CH; software development in CH; and augmented reality in CH. It is hoped that this book will provide the advice and guidance required for any CH professional, making the best possible use of these sensors and methods in CH.

frescoed vault --- planar representation of vault --- cultural heritage documentation --- cultural heritage --- virtual restoration --- spatial geometric features --- skeleton line --- regression analysis --- Dazu Thousand-Hand Bodhisattva statue --- community --- heritage resources management --- open-source software --- web-based GIS --- Arches-HIP --- augmented reality --- navigation --- instant tracking --- 3D reconstruction --- cultural heritage --- computer graphics --- CATCHA --- camera tracking --- cultural heritage --- real-time --- point clouds --- heritage --- photogrammetry --- laser scanning --- tropical --- vernacular --- multi-scale --- multi-sensor --- terrestrial laser scanning --- unmanned aerial vehicle photogrammetry --- integrated three-dimensional modeling --- digital documentation --- cultural heritage site --- 4D modeling --- cultural heritage --- data fusion --- monitoring --- visualization --- out of plumb --- close range photogrammetry --- cultural heritage preservation --- cylinder fitting --- point cloud --- lost heritage --- drones --- photogrammetry --- thermal imaging --- thermal dynamics --- dry-stone walls --- terraces --- heritage --- landscape --- geomatics --- UNESCO --- 3D models --- multisensor --- multiscale --- SLAM --- MMS --- LiDAR --- UAV --- data integration --- data fusion --- cultural heritage --- cultural heritage --- replica --- photogrammetry --- laser-scanning --- 3D printing