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Current Challenges in Modeling Cellular Metabolism

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197545 Year: Pages: 115 DOI: 10.3389/978-2-88919-754-5 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Science (General) --- Biotechnology --- General and Civil Engineering
Added to DOAB on : 2016-04-07 11:22:02
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Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Manufacturing and Surface Engineering

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ISBN: 9783038429791 9783038429807 Year: Pages: VI, 134 Language: english
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Materials --- Chemistry (General)
Added to DOAB on : 2018-08-09 15:59:11
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The desired properties of surface components include the improvement of different properties, such as aesthetic appearance, oxidation resistance, wear resistance, mechanical properties, electronic or electrical properties, thermal insulation, wear, triboemission and corrosion resistance through barriers.These properties can be enhanced using different methods, such as by adding a coating. Nevertheless, the bulk of the material or substrate cannot be considered independent of the surface treatment. Metal cutting is one of the general machining methods used to achieve high accuracy and productivity for metal parts.The topics of the book “Manufacturing and Surface Engineering” include the full range of surface engineering aspects, i.e., surface integrity, contact mechanics, friction and wear, coatings and surface treatments, multiscale tribology, computational methods, and optimization techniques applied in surface engineering.Recent experimental works by Zhang, Li, Zhang, Zhang and Duan, and by other researchers outlined that coating layer surface treatments may increase the damping behavior of thin-walled mechanical components vibrating in flexural conditions. Nevertheless, it was also experimentally found by the authors that most of these coating surface treatments had a negligible or null effect with respect to the vibrational damped response in testing or operating conditions. Ciniero, Le Rouzic and Reddyhoff report the potential of measuring charged particle emissions and/or tribocharging for the study or monitoring of the failure of coatings. The spatial information of triboemission allows the identification of the exact time and location of the failure. The evolution of the failure during sliding and the change in the characteristics of the contact are also monitored. After studying the effect of the Ti content on the performance of FeCoCrNiAlTix, He, Zhang, Lin, Zhang, Dong and Li establish that the structure of FeCoCrNiAlTix coatings consists of two kinds of BCC phases. With the continuous increase in Ti content, the number of eutectic structures decreases, accompanying the increase in the proeutectic phase and the Ti-rich second phase is precipitated out. Abutaha, Abdul Razak, and Ibrahim developed an experimental investigation into the engineering properties of concrete incorporating POC as an aggregate and filler material. This approach offers an environmentally-friendly solution to the ongoing waste problems associated with palm oil waste material.Liu and Janssen studied the effects of impact on the wear of the structural steel S235 in various liquids. When the impact is small, corrosion plays a dominant role, thus the sample in seawater wears the least due to the beneficial interaction with abrasion. However, when the impact is large, the wear rates of three liquids do not show a noticeable difference, because the wear mechanism changes from material removal to mainly plastic deformation. The influence of corrosion becomes a minor influencing factor when subject to impact.Vázquez Martínez, Salguero Gómez, Batista Ponce and Botana Pedemonte analyzed the different treatments obtained through setup parameter combinations to obtain samples with widely varying features, according to the thickness of the treated layer and the incidence depth of the laser beam. This diversity of samples shows a range of color tonalities from soft gold to medium gray and blue. Microstructural changes and oxidation layer generation provide a significant increase in the material hardness, reaching Vickers hardness values close to 1000 HV for high intensity treatments.Takada and Sasahara studied the FSB process using four levels of tip radius burnishing tools and investigated their effect on surface roughness, hardness and residual stress for a 0.45% C steel shaft. The thickness of the hardened layer increased as the tool tip radius decreased. The hardness value of the processed layer reached 600 HV. The residual stress on the processed surface was compressive when a radius tool with a smaller tip was used, and the residual stress turned tensile when a radius tool with a larger tip was used.Vereschaka, Kataeva, Sitnikov, Aksenenko, Oganyan and Sotova searched for patterns that allow a reliable justification for the choice of the composition of coatings and their micro- and nanostructures depending on the material being machined and the cutting regimes (in particular, the cutting speed).Amadori, Catania and Casagrande investigated experimentally eight different innovative composite solutions. A significant increase in the damping behavior was observed for all of these solutions with respect to the uncoated components, and with respect to the already known solutions that have previously been investigated by these authors and other researchers. The coating solution employing an Al2O3 powder + matrix, made using a screen-printing and curing technology on an Al alloy substrate, proved to be the most effective technology with respect to the aim of this work. Catania and Strozzi investigated the performance of different solutions in a free and forced flexural vibration response; they propose a simple model based on the assumption of a multi-layer, zig-zag beam, which also locally models the dissipative actions at the interface between the layers. Some virtual prototyping application examples are also reported.

Dynamics Days Latin America and the Caribbean 2018

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ISBN: 9783039215034 9783039215041 Year: Pages: 142 DOI: 10.3390/books978-3-03921-504-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2019-12-09 16:10:12
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This book contains various works presented at the Dynamics Days Latin America and the Caribbean (DDays LAC) 2018. Since its beginnings, a key goal of the DDays LAC has been to promote cross-fertilization of ideas from different areas within nonlinear dynamics. On this occasion, the contributions range from experimental to theoretical research, including (but not limited to) chaos, control theory, synchronization, statistical physics, stochastic processes, complex systems and networks, nonlinear time-series analysis, computational methods, fluid dynamics, nonlinear waves, pattern formation, population dynamics, ecological modeling, neural dynamics, and systems biology. The interested reader will find this book to be a useful reference in identifying ground-breaking problems in Physics, Mathematics, Engineering, and Interdisciplinary Sciences, with innovative models and methods that provide insightful solutions. This book is a must-read for anyone looking for new developments of Applied Mathematics and Physics in connection with complex systems, synchronization, neural dynamics, fluid dynamics, ecological networks, and epidemics.

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