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Colorectal Cancer - From Pathogenesis to Treatment

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ISBN: 9789535125440 9789535125457 9789535141846 Year: Pages: 440 DOI: 10.5772/61359 Language: English
Publisher: IntechOpen
Subject: Surgery
Added to DOAB on : 2019-10-03 07:51:49

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Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

Colorectal Cancer - Diagnosis, Screening and Management

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ISBN: 9781789231007 9781789231014 Year: Pages: 128 DOI: 10.5772/intechopen.68430 Language: English
Publisher: IntechOpen
Subject: Surgery
Added to DOAB on : 2019-10-03 07:51:51

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With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Proctological Diseases in Surgical Practice

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ISBN: 9781789236347 9781789236354 Year: Pages: 170 DOI: 10.5772/intechopen.71454 Language: English
Publisher: IntechOpen
Subject: Surgery
Added to DOAB on : 2019-10-03 07:51:51

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The prevalence of anorectal disorders in the general population is probably much higher than that seen in clinical practice. Anorectal diseases have for a long time been considered of little interest, with their treatment considered of little prestige despite the social impact they cause to patients. Proctology was initiated late and developed slowly over the years. However, in the last 20 years, a renewed interest has begun, and today, we can say that proctology is a specialized branch of general surgery. This book ""Proctological Diseases in Surgical Practice"" provides a practical introduction to proctology, with a particular attention to the topics that have not yet been investigated. This book may be useful for the general physician as well as for the specialist.

Towards a molecular classification of colorectal cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195671 Year: Pages: 62 DOI: 10.3389/978-2-88919-567-1 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2016-02-05 17:24:33
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In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field.

MicroRNA as Biomarkers in Cancer Diagnostics and Therapy

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ISBN: 9783039212491 9783039212507 Year: Pages: 166 DOI: 10.3390/books978-3-03921-250-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue celebrates the 25th anniversary of the discovery of the first microRNA. The size of the microRNome and complexity of animal body plans and organ systems suggests a role for microRNAs in cell fate determination and differentiation. More than 2000 sequences have been proposed to represent unique microRNA genes in humans, with an increasing number of mechanistic roles identified in developmental, physiological, and pathological processes. Thus, dysregulation of a few key microRNAs can have a profound global effect on the gene expression and molecular programs of a cell. This great potential for clinical intervention has captured the interest and imagination of researchers in many fields. However, very few fields have been as prolific as the field of cancer research. This Special Issue provides but a glimpse of the large body of literature of microRNA biology in cancer research, containing 4 original research studies and 4 review articles that focus on specific hematologic or solid tumors in disease. Collectively, these articles highlight state-of-the-art approaches and methodologies for microRNA detection in tissue, blood, and other body fluids in a range of biomarkers applications, from early cancer detection to prognosis and treatment response. The articles also address some of the challenges regarding clinical implementation.

Cancer Biomarkers and Targets in Digestive Organs

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ISBN: 9783039214631 9783039214648 Year: Pages: 146 DOI: 10.3390/books978-3-03921-464-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:15
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Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.

Keywords

colorectal cancer --- intestinal disorder --- intestinal tumors --- zebrafish --- stereotactic body radiation therapy --- immunotherapy --- biomarkers --- Asian Cancer Research Group (ACRG) --- gastric carcinoma --- molecular profiling --- precision therapy --- pembrolizumab --- predictive biomarkers --- ramucirumab --- The Cancer Genome Atlas (TCGA) --- therapeutic targets --- trastuzumab --- biliary tract carcinoma --- chemotherapy --- clinical trial --- colorectal carcinoma --- gastric carcinoma --- gastrointestinal oncology --- hepatocellular carcinoma --- immunotherapy --- pancreatic carcinoma --- targeted therapy --- Liver transplantation --- liver graft injury --- intragraft gene expression profiles --- cell adhesion molecules --- CD274 --- HFE --- hepatocellular carcinoma --- immunohistochemistry --- molecular profiling --- next-generation sequencing --- precision medicine --- predictive biomarkers --- gastrointestinal oncology --- pancreatic carcinoma --- hepatocellular carcinoma --- biliary tract carcinoma --- gastric carcinoma --- colorectal carcinoma --- stereotactic body radiation therapy --- liver transplant --- targeted therapy --- psychosocial support --- G protein–coupled receptors --- cholecystokinin --- gastrin --- gastrin-releasing peptide --- bombesin --- neurokinin --- neurotensin --- somatostatin --- circulating tumor cells --- colorectal carcinoma --- CAM invasion assay --- phenotypic mosaics --- tumor progenitor --- biomarker --- gastrointestinal malignancies --- immunotherapy --- n/a

Wine and Vine Components and Health

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ISBN: 9783039211388 9783039211395 Year: Pages: 154 DOI: 10.3390/books978-3-03921-139-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-08-28 11:21:27
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While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.

Natural Compounds as New Cancer Treatments

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ISBN: 9783039213658 9783039213665 Year: Pages: 128 DOI: 10.3390/books978-3-03921-366-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:15
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Cancer remains one of the main causes of morbidity and mortality worldwide. Although many pharmacological and clinical advances have been made, there is a constant need for new molecules to improve the overall options for treatment. Natural compounds from animal, microbial, vegetal, or fungal origin represent countless sources of new compounds that can be used as anticancer drugs, provided their activity, bioavailability, and toxicity are adequate. This book aims to compile both original articles and reviews that cover the most recent advances in the use of natural compounds for cancer treatment, and provide new objectives and advice for future research in the field of biological activity of natural compounds.

microRNA Regulation in Health and Disease

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ISBN: 9783039217144 9783039217151 Year: Pages: 154 DOI: 10.3390/books978-3-03921-715-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Genetics
Added to DOAB on : 2020-04-07 23:07:08
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MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.

Nutrition in Inflammatory Bowel Disease (IBD)

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ISBN: 9783039214396 9783039214402 Year: Pages: 370 DOI: 10.3390/books978-3-03921-440-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-12-09 11:49:15
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The purpose of this Special Issue “Nutrition in Inflammatory Bowel Disease (IBD)” is to increase knowledge regarding the role of dietary composition and effects in IBD, describing the prevalence of malnutrition in IBD and the effect on clinical outcomes, discussing methods of nutrition risk screening and assessment in IBD, and reviewing mechanisms through which diet and dietary components may affect disease severity. The articles focus on the following areas: Dietary Composition/Therapy Interventions in Ulcerative Colitis and effects on outcomes; Dietary Composition/Therapy Interventions in Crohn’s Disease and effects on outcomes; Nutrition Risk Screening and Assessment in IBD; Mechanisms of Diet in the pathogenesis of IBD.

Keywords

body composition --- obesity --- visceral adipose tissue --- fat --- osteoporosis --- osteopenia --- sarcopenia --- inflammatory bowel disease --- Crohn’s disease --- dietary intake --- malnutrition --- Mediterranean diet --- exclusive enteral nutrition --- children --- IBD --- remission --- mucosal cytokines --- dietary protein level --- colitis --- epithelial repair --- mucosa-adherent microbiota --- intestinal inflammation --- inflammatory bowel disease --- epithelial adherens junctions --- bioactive peptides --- synbiotic --- prebiotic --- probiotic --- IBD --- Bacillus spores --- dietary fibre --- sugar cane fibre --- ulcerative colitis --- colon --- high-sulfur foods --- inflammation --- metagenomics --- microbiota --- sulfur reducing --- inflammatory bowel disease --- Crohn --- ulcerative colitis --- diet --- nutrition --- exclusive enteral nutrition --- intestinal epithelial cells --- inflammation --- probiotics --- Lactobacillus acidophilus --- Bifidobacterium animalis subsp. lactis --- vitamin D --- IBD --- Crohn’s disease --- ulcerative colitis --- supplementation --- deficiency --- Inflammatory Bowel Disease (IBD) --- Mediterranean Diet --- Western-style Diet (WSD) --- Nutritional Approach --- vitamin D --- Crohn’s disease --- ulcerative colitis --- faecal calprotectin --- C-reactive protein --- diet --- inflammatory bowel disease --- microbiota --- intestinal barrier --- nutrients --- immunity --- colitis --- food additive --- diet --- emulsifiers --- high salt diet --- inflammatory bowel diseases --- inflammatory bowel disease --- dietary modification --- exclusive enteral nutrition --- lifestyle modification --- Mediterranean diet --- colorectal cancer --- inflammatory bowel disease --- colorectal cancer --- dysplasia --- berries --- chemoprevention --- Inflammatory Bowel Disease --- micronutrients --- vitamin --- mineral --- deficiency --- inflammatory bowel disease --- dietary habits --- food components --- gut microbiota --- immune homeostasis --- epigenetic changes --- inflammatory bowel disease --- malnutrition --- Mediterranean diet --- older age --- diet --- inflammatory bowel disease --- ulcerative colitis --- inflammatory bowel disease --- Westernisation --- genotypes --- nutrient deficiency --- food intolerance --- FODMAPs --- gluten --- fructose --- lactose --- brassica --- mushrooms --- n/a

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