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Regulation of red cell life-span, erythropoiesis, senescence and clearance

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193486 Year: Pages: 117 DOI: 10.3389/978-2-88919-348-6 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Physics (General) --- Physiology --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Amyloid-beta clearance in Alzheimer's disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194438 Year: Pages: 111 DOI: 10.3389/978-2-88919-443-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

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ISBN: 9783039215829 9783039215836 Year: Pages: 212 DOI: 10.3390/books978-3-03921-583-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Cardiovascular
Added to DOAB on : 2019-12-09 11:49:16
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The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

Keywords

PCSK9 --- natriuretic peptides --- adipose tissue --- lipid metabolism --- LDL receptor --- insulin --- natriuretic peptides --- hypertension --- stroke --- cardiac hypertrophy --- linkage analysis --- genetic variants --- animal models --- BNP --- NT-proBNP --- heart failure --- cardiac dysfunction --- forensic medicine --- postmortem biochemistry --- angiotensin receptor–neprilysin inhibitor --- natriuretic peptides --- renin–angiotensin system --- heart failure --- arterial hypertension --- natriuretic peptide --- vascular --- endothelial cell --- cardiomyocyte --- fibroblast --- inflammation --- heart failure --- hypertension --- angiogenesis --- heart failure --- natriuretic peptides --- preserved ejection fraction --- natriuretic peptides --- heart failure --- atrial fibrillation --- remodeling --- Idiopathic Pulmonary Arterial Hypertension (IPAH) --- Natriuretic Peptide Clearance Receptor (NPR-C) signaling --- atrial natriuretic peptide --- hypertension --- heart failure --- cardiometabolic disease --- obesity --- metabolic syndrome --- cGMP --- guanylyl cyclase receptor A --- natriuretic peptides --- natriuretic peptide --- cardiorenal syndrome --- vasopressor --- vasodilator --- kidney --- medulla --- renin-angiotensin-aldosterone system --- Atrial Natriuretic peptide --- natriuretic peptides --- cardiac remodelling --- cardiac hypertrophy --- vascular homeostasis --- atrial natriuretic peptide --- guanylyl cyclase/natriuretic peptide receptor-A --- gene-knockout --- gene-duplication --- hypertension --- congestive heart failure --- natriuretic peptides --- arterial hypertension --- pulmonary arterial hypertension --- heart failure --- stroke --- atrial fibrillation --- ARNi --- MANP

Venom and Toxin as Targeted Therapy

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ISBN: 9783039211890 9783039211906 Year: Pages: 180 DOI: 10.3390/books978-3-03921-190-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Keywords

disintegrin --- blood vessel formation --- VEGF --- antioxidant enzymes --- oxidative stress biomarkers --- bicarinalin --- antimicrobial peptide --- Helicobacter pylori --- gastric cells --- bacterial adhesion --- SEM --- atopic dermatitis (AD) --- house dust mite extract (DFE) --- 2,4-dinitrochlorobenzene (DNCB) --- bee venom phospholipase A2 (bvPLA2) --- skin inflammation --- CD206 --- mannose receptor --- immunotoxin --- Moxetumomab pasudotox --- targeted therapy --- CD22 --- B cell non-Hodgkin lymphoma --- acute lymphoblastic leukemia --- mantle cell lymphoma --- ribosome-inactivating protein --- BLF1 --- eIF4A --- MYCN --- cancer --- neuroblastoma --- apoptosis --- antimicrobial peptide (AMP) --- dermaseptin --- anuran skin secretion --- drug design --- antimicrobial activity --- anticancer activity --- antiviral activity --- Bougainvillea --- bouganin --- cancer therapy --- immunotherapy --- immunotoxins --- ribosome-inactivating proteins --- rRNA N-glycosylase activity --- VB6-845 --- orellanine --- clearance --- fungal toxin --- half-life --- toad toxins --- Chansu --- Huachansu --- cane toad --- bufadienolides --- indolealkylamines --- inflammation --- cancer --- obsessive–compulsive disorder (OCD) --- snake venom --- cancer --- target therapy --- snake venom --- Malaysian cobras --- N. kaouthia --- N. sumatrana --- O. hannah --- anticancer --- Apis mellifera syriaca --- bee venom --- melittin --- LC-ESI-MS --- solid phase extraction --- in vitro effects --- frog --- mass spectrometry --- molecular cloning --- bombesin-related peptide --- smooth muscle --- Bee venom --- complement system --- decay accelerating factor --- atopic dermatitis --- complement dependent cytotoxicity --- membrane attack complex --- n/a

Smart Sensors for Structural Health Monitoring

Authors: --- ---
ISBN: 9783039217588 9783039217595 Year: Pages: 342 DOI: 10.3390/books978-3-03921-759-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:16
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Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities. The objective of this Special Issue is to generate discussions on the latest advances in research on smart sensing technologies for structural health monitoring applications, with a focus on decision-enabling systems. This Special Issue covers a wide range of related topics such as innovative sensors and sensing technologies for crack, displacement, and sudden event monitoring, sensor optimization, and novel sensor data processing algorithms for damage and defect detection, operational modal analysis, and system identification of a wide variety of structures (bridges, transmission line towers, high-speed trains, masonry light houses, etc.).

Keywords

optical crack growth sensor --- digital sampling moiré --- 2D crack growth --- calibration --- concrete crack --- feature extraction --- mapping construction --- fuzzy classification --- rotary ultrasonic array --- bending stiffness --- damage identification --- environmental noise --- bridge --- test vehicle --- structural impact monitoring --- sensors distribution optimization --- NSGA-II --- energy analysis of wavelet band --- principal component analysis --- transmission tower --- settlement --- wind force --- acceleration --- modal frequencies --- sudden event monitoring --- wireless smart sensors --- demand-based nodes --- event-triggered sensing --- data fusion --- patch antenna --- sensor --- structural health monitoring --- crack identification --- resonant frequency --- damage identification --- sensor optimization --- Virtual Distortion Method (VDM) --- Particle Swarm Optimization (PSO) algorithm --- sensitivity --- structural health monitoring --- piezoelectric wafer active sensors --- active sensing --- passive sensing --- damage detection --- acoustic emission --- uniaxial stress measurement --- structural steel members --- amplitude spectrum --- phase spectrum --- shear-wave birefringence --- acoustoelastic effect --- damage detection --- smartphones --- steel frame --- shaking table tests --- wavelet packet decomposition --- low-velocity impacts --- strain wave --- impactor stiffness --- data processing --- feature selection --- impact identification --- crack --- strain --- distributed dense sensor network --- structural health monitoring --- fibre bundle --- reflective optical sensor --- tip clearance --- turbine --- aero engine --- principal component analysis --- space window --- time window --- damage detection --- length effect --- stress detection --- electromagnetic oscillation --- steel strand --- concrete structures --- SHM --- stretching method --- model updating --- displacement sensor --- helical antenna --- resonant frequency --- perturbation theory --- normal mode --- wheel minor defect --- high-speed train --- online wayside detection --- Bayesian blind source separation --- FBG sensor array

Control and Nonlinear Dynamics on Energy Conversion Systems

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ISBN: 9783039211104 9783039211111 Year: Pages: 438 DOI: 10.3390/books978-3-03921-111-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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The ever-increasing need for higher efficiency, smaller size, and lower cost make the analysis, understanding, and design of energy conversion systems extremely important, interesting, and even imperative. One of the most neglected features in the study of such systems is the effect of the inherent nonlinearities on the stability of the system. Due to these nonlinearities, these devices may exhibit undesirable and complex dynamics, which are the focus of many researchers. Even though a lot of research has taken place in this area during the last 20 years, it is still an active research topic for mainstream power engineers. This research has demonstrated that these systems can become unstable with a direct result in increased losses, extra subharmonics, and even uncontrollability/unobservability. The detailed study of these systems can help in the design of smaller, lighter, and less expensive converters that are particularly important in emerging areas of research like electric vehicles, smart grids, renewable energy sources, and others. The aim of this Special Issue is to cover control and nonlinear aspects of instabilities in different energy conversion systems: theoretical, analysis modelling, and practical solutions for such emerging applications. In this Special Issue, we present novel research works in different areas of the control and nonlinear dynamics of energy conversion systems.

Keywords

data-driven --- prediction --- neural network --- air-handling unit (AHU) --- supply air temperature --- pulverizing system --- soft sensor --- inferential control --- moving horizon estimation --- multi-model predictive control --- micro-grid --- droop control --- virtual impedance --- harmonic suppression --- power quality --- combined heat and power unit --- two-stage bypass --- dynamic model --- coordinated control system --- predictive control --- decoupling control --- power conversion --- model–plant mismatches --- disturbance observer --- performance recovery --- offset-free --- electrical machine --- electromagnetic vibration --- multiphysics --- rotor dynamics --- air gap eccentricity --- calculation method --- magnetic saturation --- corrugated pipe --- whistling noise --- Helmholtz number --- excited modes --- switched reluctance generator --- capacitance current pulse train control --- voltage ripple --- capacitance current --- feedback coefficient --- distributed architecture --- maximum power point tracking --- sliding mode control --- overvoltage --- permanent magnet synchronous motor (PMSM) --- single artificial neuron goal representation heuristic dynamic programming (SAN-GrHDP) --- single artificial neuron (SAN) --- reinforcement learning (RL) --- goal representation heuristic dynamic programming (GrHDP) --- adaptive dynamic programming (ADP) --- sliding mode observer (SMO) --- permanent magnet synchronous motor (PMSM) --- extended back electromotive force (EEMF) --- position sensorless --- bridgeless converter --- discontinuous conduction mode (DCM) --- high step-up voltage gain --- power factor correction (PFC) --- space mechanism --- multi-clearance --- nonlinear dynamic model --- planetary gears --- vibration characteristics --- new step-up converter --- ultrahigh voltage conversion ratio --- small-signal model --- average-current mode control --- slope compensation --- monodromy matrix --- current mode control --- boost-flyback converter --- explosion-magnetic generator --- plasma accelerator --- current-pulse formation --- DC-DC buck converter --- contraction analysis --- global stability --- matrix norm --- DC micro grid --- efficiency optimization --- variable bus voltage MG --- variable switching frequency DC-DC converters --- centralized vs. decentralized control --- local vs. global optimization --- buck converter --- DC motor --- bifurcations in control parameter --- sliding control --- zero average dynamics --- fixed-point inducting control --- DC-DC converters --- quadratic boost --- maximum power point tracking (MPPT) --- nonlinear dynamics --- subharmonic oscillations --- photovoltaic (PV) --- steel catenary riser --- rigid body rotation --- wave --- the load of suspension point in the z direction --- Cable3D

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