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Circadian Rhythms and Metabolism

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452828 Year: Pages: 188 DOI: 10.3389/978-2-88945-282-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Internal medicine --- Science (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:44
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One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.

Salicylic Acid Signaling Networks

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198276 Year: Pages: 188 DOI: 10.3389/978-2-88919-827-6 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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The small phenolic compound salicylic acid (SA) is critical for plant defense against a broad spectrum of pathogens. SA is also involved in multi-layered defense responses, from pathogen-associated molecular pattern triggered basal defense, resistance gene-mediated defense, to systemic acquired resistance. Recent decades have witnessed tremendous progress towards our understanding of SA-mediated signaling networks. Many genes have been identified to have direct or indirect effect on SA biosynthesis or to regulate SA accumulation. Several SA receptors have been identified and characterization of these receptors has shed light on the mechanisms of SA-mediated defense signaling, which encompass chromosomal remodeling, DNA repair, epigenetics, to transcriptional reprogramming. Molecules from plant-associated microbes have been identified, which manipulate SA levels and/or SA signaling. SA does not act alone. It engages in crosstalk with other signaling pathways, such as those mediated by other phytohormones, in an agonistic or antagonistic manner, depending on hormones and pathosystems. Besides affecting plant innate immunity, SA has also been implicated in other cellular processes, such as flowering time determination, lipid metabolism, circadian clock control, and abiotic stress responses, possibly contributing to the regulation of plant development. The multifaceted function of SA makes it critically important to further identify genes involved in SA signaling networks, understand their modes of action, and delineate interactions among the components of SA signaling networks. In addition, genetic manipulation of genes involved in SA signaling networks has also provided a promising approach to enhance disease resistance in economically important plants. This ebook collects articles in the Research Topic "Salicylic Acid Signaling Networks". For this collection we solicited reviews, perspectives, and original research articles that highlight recent exciting progress on the understanding of molecular mechanisms underlying SA-mediated defense, SA-crosstalk with other pathways and how microbes impact these events.

Drug Delivery Technology Development in Canada

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ISBN: 9783039280049 9783039280056 Year: Pages: 352 DOI: 10.3390/books978-3-03928-005-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:21:22
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Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

Keywords

doxorubicin --- MG63 --- Vitamin D --- DOX-Vit D --- hypoxia-induced chemoresistance --- cisplatin --- polymeric micelle --- EGFR-targeted therapy --- STAT3 --- HIF-1 --- GE11 peptide --- pharmacological Inhibitors of HIF-1 and STAT3 --- combination therapy --- pharmacokinetics --- antibodies --- radiolabeling --- biodistribution --- mouse models --- oral formulation --- amphotericin B --- fungal infections --- parasitic infections --- developing world --- drug delivery --- liposomes --- drug delivery systems --- innovation --- lipid nanoparticles --- Metaplex --- triggered drug release --- liposomes --- ultrasound --- magnetic fields --- radiation --- oral delivery --- biological barriers --- co-delivery --- throughput --- sustained delivery --- phospholipid complex --- rosmarinic acid --- bioaccessibility --- dissolution --- TNO gastrointestinal model --- gastrointestinal simulator --- phytosterols --- tocopherols --- liposomes --- canola oil deodorizer distillate --- model orange juice --- virus --- plant --- bacteriophage --- phage display --- drug discovery --- encapsulation --- drug delivery --- blood-brain barrier --- intra-arterial chemotherapy --- malignant gliomas --- primary central nervous system lymphomas --- transdermal drug delivery --- Canada --- skin --- permeation enhancers --- oral, head and neck squamous cell carcinoma --- targeted therapies --- drug delivery systems --- nanoparticles --- controlled drug delivery --- circadian clock --- chronotherapy --- precision medicine --- cationic gemini surfactant --- melphalan --- inclusion complex --- ROESY NMR spectroscopy --- 3D spheroid --- drug-resistant melanoma --- liposome --- water miscible solvents --- remote loading --- staurosporine --- cancer --- gambogic acid --- loading gradients --- mefloquine --- child friendly formulation --- blood-brain barrier (BBB) --- drug delivery --- transient modulation --- HAV6 cadherin peptide --- adenanthin --- magnetic resonance imaging (MRI) --- medulloblastoma --- drug delivery --- pharmaceutics --- drug development --- formulation and dosage form development --- translational research --- biologicals --- small molecules --- clinical trials --- pharmacokinetics --- medical devices --- route of administration --- nifedipine --- emulsion --- flavonoids --- topical formulation --- quercetin --- photostabilizers

Jasmonic Acid Pathway in Plants

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ISBN: 9783039284887 / 9783039284894 Year: Pages: 346 DOI: 10.3390/books978-3-03928-489-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2020-06-09 16:38:57
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The plant hormone jasmonic acid (JA) and its derivative, an amino acid conjugate of JA (jasmonoyl isoleucine, JA-Ile), are signaling compounds involved in the regulation of defense and development in plants. The number of articles studying on JA has dramatically increased since the 1990s. JA is recognized as a stress hormone that regulates the plant response to biotic stresses such as herbivore and pathogen attacks, as well as abiotic stresses such as wounding and ultraviolet radiation. Recent studies have remarkably progressed the understanding of the importance of JA in the life cycle of plants. JA is directly involved in many physiological processes, including stamen growth, senescence, and root growth. JA regulates production of various metabolites such as phytoalexins and terpenoids. Many regulatory proteins involved in JA signaling have been identified by screening for Arabidopsis mutants. However, much more remains to be learned about JA signaling in other plant species. This Special Issue, “Jasmonic Acid Pathway in Plants”, contains 5 review and 15 research articles published by field experts. These articles will help with understanding the crucial roles of JA in its response to the several environmental stresses and development in plants.

Keywords

albino --- aroma --- Camellia sinensis --- chloroplast --- jasmonic acid --- light-sensitive --- stress --- tea --- volatile --- Panax ginseng --- gene expression --- ginsenoside --- methyl jasmonate --- MYB transcription factor --- dammarenediol synthase --- jasmonic acid --- signaling pathway --- environmental response --- biological function --- MeJA --- priming --- rice --- proteomics --- ROS --- chlorophyll fluorescence imaging --- MAP kinase --- jasmonate --- rice bacterial blight --- salicylic acid --- grain development --- Prunus avium --- Tuscan varieties --- jasmonic acid --- lipoxygenase --- bioinformatics --- gene expression --- heterotrimeric G proteins --- AtRGS1 --- jasmonates --- endocytosis --- diffusion dynamics --- Chinese flowering cabbage --- leaf senescence --- JA --- transcriptional activation --- adventitious rooting --- auxin --- ectopic metaxylem --- ectopic protoxylem --- ethylene --- hypocotyl --- jasmonates --- nitric oxide --- xylogenesis --- transcriptional regulators --- plant development --- jasmonic acid signaling --- gene expression --- Jasmonate-ZIM domain --- JAZ repressors --- Jas domain --- TIFY --- degron --- phylogenetic analysis --- ancestral sequences --- circadian clock --- jasmonic acid --- crosstalk --- jasmonic acid --- fatty acid desaturase --- multiseeded --- msd --- grain number --- MutMap --- sorghum --- Ralstonia solanacearum --- type III effector --- jasmonic acid --- salicylic acid --- Nicotiana plants --- PatJAZ6 --- jasmonic acid (JA) signaling pathway --- Pogostemon cablin --- patchouli alcohol --- biosynthesis --- jasmonate --- salt response --- Zea mays --- ROS --- proline --- ABA biosynthesis --- jasmonic acid --- crosstalk --- gibberellic acid --- cytokinin --- auxin --- jasmonic acid --- opr3 --- stress defense --- quantitative proteomics --- abiotic stresses --- jasmonates --- JA-Ile --- JAZ repressors --- transcription factor --- signaling --- antioxidant enzyme activity --- elicitor --- methyl jasmonate --- secondary metabolite --- signal molecules --- n/a

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